Implications of an anthropic model of evolution for emergence of complex life and intelligence

Structurally complex life and intelligence evolved late on Earth; models for the evolution of global temperature suggest that, due to the increasing solar luminosity, the future life span of the (eukaryote) biosphere will be "only" about another billion years, a short time compared to the approximately 4 Ga since life began. A simple stochastic model (Carter, 1983) suggests that this timing might be governed by the necessity to pass a small number, n, of very difficult evolutionary steps, with n < 10 and a best guess of n = 4, in order for intelligent observers like ourselves to evolve. Here I extend the model analysis to derive probability distributions for each step. Past steps should tend to be evenly spaced through Earth's history, and this is consistent with identification of the steps with some of the major transitions in the evolution of life on Earth. A complementary approach, identifying the critical steps with major reorganizations in Earth's biogeochemical cycles, suggests that the Archean-Proterozoic and Proterozoic-Phanerozoic transitions might be identified with critical steps. The success of the model lends support to a "Rare Earth" hypothesis (Ward and Brownlee, 2000): structurally complex life is separated from prokaryotes by several very unlikely steps and, hence, will be much less common than prokaryotes. Intelligence is one further unlikely step, so it is much less common still.     

Measurement and assessment of wind tunnel flow quality

For decades, wind tunnel testing has been conducted in test section environments that have not been adequately or consistently documented. Since wind tunnel flow quality can adversely affect test results, accurate and consistent flow quality measurements are required, along with an understanding of the sources, characteristics, and management of flow turbulence. This paper will review turbulence measurement techniques and data obtained in subsonic, transonic, and supersonic test facilities as they relate to the determination and assessment of wind tunnel flow quality. The principles and practical application of instrumentation used in the measurement and characterization of wind tunnel turbulence will be described. Techniques used for the identification of the sources of wind tunnel disturbances, and the performance of turbulence suppression devices will be outlined. These test techniques will be illustrated with extensive measurements obtained in a number of test facilities. The measurements will provide comprehensive turbulence data that are vital to the assessment and management of flow quality. Procedures designed to assess the potential influence of adverse flow quality on wind tunnel model test performance will also be discussed.     

ATM performance measurement in Europe,the US and China

Air traffic management (ATM) performance and the metrics used in its assessment are investigated for the first time across the three largest ATM world regions: Europe, the US and China. The market structure and flow management practices of each region are presented. A wide range of performance data across these three regions is synthesised. For topological and performance assessment, the notion of a 'sufficient' sample is often non-intuitive: many metrics may behave non-monotonically as a function of sampling fraction. Missing and under-developed metrics are identified, and the need for a balance between standardisation and flexibility is proposed. Longitudinal and cross-sectional metric trade-offs are identified.     

Place learning in humans: The role of distance and direction information

Although the process of establishing a memoryof a location is necessary for navigation,relatively little is known about theinformation that humans use when forming placememories. We examined the relative importanceof distance and angular information aboutlandmarks in place learning. Participantsrepeatedly learned a target location inrelation to three distinct landmarks in animmersive computer-generated (virtual)environment. Later, during testing, theyattempted to return to that location. Theconfigurations of landmarks used during testingwere altered from those participants learned inorder to separate the effects of metricdistance information and information aboutinter-landmark angles. In general,participants showed greater reliance ondistance information than angular information. This reliance was affected by nonmetricrelationships present during learning, as wellas by the degree to which the learnedenvironment contained right or straightangles.     

Launch and Early Operation of the MESSENGER Mission

On August 3, 2004, at 2:15 a.m. EST, the MESSENGER mission to Mercury began with liftoff of the Delta II 7925H launch vehicle and 1,107-kg spacecraft including seven instruments. MESSENGER is the seventh in the series of NASA Discovery missions, the third to be built and operated by The Johns Hopkins University Applied Physics Laboratory (JHU/APL) following the Near Earth Asteroid Rendezvous (NEAR) Shoemaker and Comet Nucleus Tour (CONTOUR) missions. The MESSENGER team at JHU/APL is using efficient operations approaches developed in support of the low-cost NEAR and CONTOUR operations while incorporating improved approaches for reducing total mission risk. This paper provides an overview of the designs and operational practices implemented to conduct the MESSENGER mission safely and effectively. These practices include proven approaches used on past JHU/APL operations and new improvements implemented to reduce risk, including adherence to time-proven standards of conduct in the planning and implementation of the mission. This paper also discusses the unique challenges of operating in orbit around Mercury, the closest planet to the Sun, and what specific measures are being taken to address those challenges.     

Effects of a simulated martian UV flux on the cyanobacterium, Chroococcidiopsis sp. 029

Dried monolayers of Chroococcidiopsis sp. 029, a desiccation-tolerant, endolithic cyanobacterium, were exposed to a simulated martian-surface UV and visible light flux, which may also approximate to the worst-case scenario for the Archean Earth. After 5 min, there was a 99% loss of cell viability, and there were no survivors after 30 min. However, this survival was approximately 10 times higher than that previously reported for Bacillus subtilis. We show that under 1 mm of rock, Chroococcidiopsis sp. could survive (and potentially grow) under the high martian UV flux if water and nutrient requirements for growth were met. In isolated cells, phycobilisomes and esterases remained intact hours after viability was lost. Esterase activity was reduced by 99% after a 1-h exposure, while 99% loss of autofluorescence required a 4-h exposure. However, cell morphology was not changed, and DNA was still detectable by 4',6-diamidino-2-phenylindole staining after an 8-h exposure (equivalent to approximately 1 day on Mars at the equator). Under 1 mm of simulant martian soil or gneiss, the effect of UV radiation could not be detected on esterase activity or autofluorescence after 4 h. These results show that under the intense martian UV flux the morphological signatures of life can persist even after viability, enzymatic activity, and pigmentation have been destroyed. Finally, the global dispersal of viable, isolated cells of even this desiccation-tolerant, ionizing-radiation-resistant microorganism on Mars is unlikely as they are killed quickly by unattenuated UV radiation when in a desiccated state. These findings have implications for the survival of diverse microbial contaminants dispersed during the course of human exploratory class missions on the surface of Mars.     

Bacillus subtilis spore survival and expression of germination-induced bioluminescence after prolonged incubation under simulated Mars atmospheric pressure and composition: implications for planetary protection and lithopanspermia

Bacterial endospores in the genus Bacillus are considered good models for studying interplanetary transfer of microbes by natural or human processes. Although spore survival during transfer itself has been the subject of considerable study, the fate of spores in extraterrestrial environments has received less attention. In this report we subjected spores of a strain of Bacillus subtilis, containing luciferase resulting from expression of an sspB-luxAB gene fusion, to simulated martian atmospheric pressure (7-18 mbar) and composition (100% CO(2)) for up to 19 days in a Mars simulation chamber. We report here that survival was similar between spores exposed to Earth conditions and spores exposed up to 19 days to simulated martian conditions. However, germination-induced bioluminescence was lower in spores exposed to simulated martian atmosphere, which suggests sublethal impairment of some endogenous spore germination processes.     

应用绿色半导体量子点进行乳腺癌原位成像

乳腺癌是癌症中引起妇女死亡的首要因素。本文采用绿色量子点作为荧光显色材料，建立了一种用于早期乳腺癌诊断的原位成像技术。利用生物素标记的抗HER2／neu抗体与乳腺癌细胞表面表达的HER2结合的特点，然后用偶联绿色量子点的链霉亲和素作为荧光检测标记物，与HER2抗原抗体复合物中的生物素发生特异结合，检测出乳腺癌细胞的存在。结果表明，在荧光显微镜下用绿色量子点原位显色的乳腺癌细胞，相对有机染料组显色亮度增强，故检测灵敏度有所提高。     

Sandwich module prototype progress for space solar power

Space solar power (SSP) has been broadly defined as the collection of solar energy in space and its wireless transmission for use on earth. This approach potentially gives the benefit of provision of baseload power while avoiding the losses due to the day/night cycle and tropospheric effects that are associated with terrestrial solar power. Proponents have contended that the implementation of such systems could offer energy security, environmental, and technological advantages to those who would undertake their development. Among recent implementations commonly proposed for SSP, the modular symmetrical concentrator (MSC) and other modular concepts have received considerable attention. Each employs an array of modules for performing conversion of concentrated sunlight into microwaves or laser beams for transmission to earth. While prototypes of such modules have been designed and developed previously by several groups, none have been subjected to the challenging conditions inherent to the space environment and the possible solar concentration levels in which an array of modules might be required to operate. The research described herein details our team's efforts in the development of photovoltaic arrays, power electronics, microwave conversion electronics, and antennas for microwave-based “sandwich” module prototypes. The implementation status and testing results of the prototypes are reviewed.