Neutral buoyancy and sleep-deprived serum factors alter expression of cytokines regulating osteogenesis

We examined expression of genes associated with cytokine production, and genes implicated in regulating bone metabolism, in bone stromal and osteoblast cells incubated under standard ground conditions and under conditions of neutral buoyancy, and in the presence/absence of serum from normal or sleep-deprived mice. We observed a clear interaction between these two conditions (exposure to neutral buoyancy and serum stimulation) in promoting enhanced osteoclastogenesis. Both conditions independently altered expression of a number of cytokines implicated in the regulation of bone metabolism. However, using stromal cells from IL-1 and TNFx cytokine(r) KO mice, we concluded that the increased bone loss under microgravity conditions was not primarily cytokine mediated.     

Reduced lymphocyte activation in space: role of cell-substratum interactions.

We investigated the effect of substratum adhesiveness on stimulated lymphocyte blastogenesis by reducing and blocking cell adhesion with poly (2-hydroxyethyl methacrylate) (poly-HEMA) in a simple on-ground system. Cells grown on medium-thick and thick poly-HEMA films were rounded in shape and displayed no signs of spreading. By contrast, on tissue culture plastic and very thin poly-HEMA films, they showed clear signs of spreading. The mitogenic response of lymphocytes grown on thick poly-HEMA films was reduced by up to 68% of the control (tissue culture plastic). Interferon-gamma production was near zero when the cells were grown on the least adhesive substratum. On uncoated plastic, activated lymphocytes subjected to high gravity (20g) exhibited an increased proliferation rate (40%) compared with 1g. By contrast, on poly-HEMA, high gravity did not improve lymphocyte responsiveness. These results show that activated lymphocytes need to anchor and spread prior to achieving an optimal proliferation response. We conclude that decreased lymphocyte adhesion could contribute to the depressed in vitro lymphocyte responsiveness found in the microgravity conditions of space flight.     

Adaptive Input Filter Compensation for Switching Regulators

An input filter is frequently employed between a switching regulator and its power source. However, its presence often results in degradation of dynamic performances and stability. The detrimental interaction is between an input filter and a switching regulator and is a function of the input filter parameters and also of the supply voltage. An earlier paper presented an analysis and design procedure aimed at developing a feed-forward loop to cancel this undesirable interaction. The feed-forward design is extended here to encompass a scheme that automatically accounts for changes in the supply voltage; the result is an adaptive compensation that tracks the input voltage variations. Experimental results are presented that confirm the adaptive nature of the design.     

Analysis of the dynamic behavior of structures using the high-rate GNSS-PPP method combined with a wavelet-neural model: Numerical simulation and experimental tests

Recently, the high rate global navigation satellite system-precise point positioning (GNSS-PPP) technique has been used to detect the dynamic behavior of structures. This study aimed to increase the accuracy of the extraction oscillation properties of structural movements based on the high-rate (10?Hz) GNSS-PPP monitoring technique. A developmental model based on the combination of wavelet package transformation (WPT) de-noising and neural network prediction (NN) was proposed to improve the dynamic behavior of structures for GNSS-PPP method. A complicated numerical simulation involving highly noisy data and 13 experimental cases with different loads were utilized to confirm the efficiency of the proposed model design and the monitoring technique in detecting the dynamic behavior of structures. The results revealed that, when combined with the proposed model, GNSS-PPP method can be used to accurately detect the dynamic behavior of engineering structures as an alternative to relative GNSS method.     

Jets Downstream of Collisionless Shocks

Space Science Reviews - Particles are accelerated to very high, non-thermal energies in solar and space plasma environments. While energy spectra of accelerated electrons often exhibit a power law,...     

Comprehensive data reduction package for the Immersion GRating INfrared Spectrograph: IGRINS

We present a Python-based data reduction pipeline package (PLP) for the Immersion GRating INfrared Spectrograph (IGRINS), an instrument that covers the complete H- and K-bands in one exposure with a spectral resolving power of 40,000. The reduction steps carried out by the PLP include flat-fielding, background removal, order extraction, distortion correction, wavelength calibration, and telluric correction using spectra of A type standard stars. As the spectrograph has no moving parts, the PLP automatically reduces the data using predefined functions for the processes of order extraction, distortion correction, and wavelength calibration. Before the telluric correction of the target spectra, the intrinsic hydrogen absorption features of the standard A star are removed with a Gaussian fitting algorithm. The final result is the flux of the target as a function of wavelength. Users can customize the predefined functions for the extraction of the spectrum from the echellogram and adjust the parameters for the fitting functions for the spectra of celestial objects, using “fine-tuning” options, as necessary. Presently, the PLP produces the best results for point-source targets.     

Onboard orbit determination using GPS observations based on the unscented Kalman filter

Spaceborne GPS receivers are used for real-time navigation by most low Earth orbit (LEO) satellites. In general, the position and velocity accuracy of GPS navigation solutions without a dynamic filter are 25 m (1σ) and 0.5 m/s (1σ), respectively. However, GPS navigation solutions, which consist of position, velocity, and GPS receiver clock bias, have many abnormal excursions from the normal error range for space operation. These excursions lessen the accuracy of attitude control and onboard time synchronization. In this research, a new onboard orbit determination algorithm designed with the unscented Kalman filter (UKF) was developed to improve the performance. Because the UKF is able to obtain the posterior mean and covariance accurately by using the second-order Taylor series expansion through the sampled sigma points that are propagated by using the true nonlinear system, its performance can be better than that of the extended Kalman filter (EKF), which uses the linearized state transition matrix to predict the covariance. The dynamic models for orbit propagation applied perturbations due to the 40 × 40 geo-potential, the gravity of the Sun and Moon, solar radiation pressure, and atmospheric drag. The 7(8)th-order Runge–Kutta numerical integration was applied for orbit propagation. Two types of observations, navigation solutions and C/A code pseudorange, can be used at the user’s discretion. The performances of the onboard orbit determination were verified using real GPS data of the CHAMP and KOMPSAT-2 satellites. The results of the orbit determination were compared with the precision orbit ephemeris (POE) of the CHAMP and KOMPSAT-2 satellites.     

航空航天复合材料应用的最新进展

文章介绍了先进复合材料的最新进展情况,内容包括用于最新复合材料体系的各种增强纤维、树脂基体,及复合材料结构设计的一些新概念。重点介绍了低成本和高效的制造技术。复合材料重要结构件的制造技术在不断改进,制造出的部件不仅精度和强度更高,而且更显成本效益。文章还介绍了航空航天领域一些新研发的复合材料结构件。