Future investigations onboard Soviet biosatellites of the Cosmos series.

Many rat experiments onboard Cosmos biosatellites have furnished information concerning the effects of weightlessness, artificial gravity, and ionizing radiation combined with weightlessness on structural and biochemical parameters of the animal body. The necessity to expand the scope of physiological investigations has led to the project of flight primate studies. It is planned to carry out the first primate experiments onboard the Cosmos biosatellite in 1982. At present investigations of weightlessness effects on the cardiovascular and vestibular systems, higher nervous activity, skeletal muscles and biorhythms of two rhesus monkeys are being developed and tested. It is also planned to conduct a study of weightlessness effects on embryogenesis of rats and bioenergetics of living systems onboard the same biosatellite. Further experiments onboard Cosmos biosatellites are planned.     

Skylab experiment M-092: results of the first manned mission

Blood pressure at 30-sec intervals, heart rate, and percentage increase in leg volume continuously were recorded during a 25-min protocol in the M092 Inflight Lower Body Negative Pressure (LBNP) experiment carried out in the first manned Skylab mission. These data were collected during six tests on each crewman over a 5-month preflight period. The protocol consisted of a 5-min resting control period, 1 min at -8, 1 min at -16, 3 min at -30, 5 min at -40, and 5 min at -50 mm Hg LBNP. A 5-min recovery period followed. Inflight tests were performed at approximately 3-day intervals through the 28-day mission. Individual variations in cardiovascular responses to LBNP during the preflight period continued to be demonstrated in the inflight tests. Measurements of the calf indicated that a large volume of fluid was shifted out of the legs early in the flight and that a slower decrease in leg volume, presumably due to loss of muscle tissue, continued throughout the flight. Resting heart rates tended to be low early in the flight and to increase slightly as the flight progressed. Resting blood pressure varied but usually was characterized by slightly elevated systolic blood pressure, lower diastolic pressure, and higher pulse pressures than during preflight examinations. During LBNP inflight a much greater increase in leg volume occurred than in preflight tests. Large increases occurred even at the smallest levels of negative pressure, suggesting that the veins of the legs were relatively empty at the beginning of the LBNP. The greater volume of blood pooled in the legs was associated with greater increases of heart rate and diastolic pressure and larger falls of systolic and pulse pressure than seen in preflight tests. The LBNP protocol represented a greater stress inflight, and on three occasions it was necessary to stop the test early because of impending syncopal reactions. LBNP responses inflight appeared to predict the degree of postflight orthostatic intolerance. Postflight responses to LBNP during the first 48 hours were characterized by marked elevations of heart rate and instability of blood pressure. In addition, systolic and diastolic pressures were typically elevated considerably both at rest and also during stress. The time required for cardiovascular responses to return to preflight levels was much slower than in the case of Apollo crewmen.     

The future of space medicine.

In November 2000, the National Aeronautics and Space Administration (NASA) and its partners in the International Space Station (ISS) ushered in a new era of space flight: permanent human presence in low-Earth orbit. As the culmination of the last four decades of human space flight activities. the ISS focuses our attention on what we have learned to date. and what still must be learned before we can embark on future exploration endeavors. Space medicine has been a primary part of our past success in human space flight, and will continue to play a critical role in future ventures. To prepare for the day when crews may leave low-Earth orbit for long-duration exploratory missions, space medicine practitioners must develop a thorough understanding of the effects of microgravity on the human body, as well as ways to limit or prevent them. In order to gain a complete understanding and create the tools and technologies needed to enable successful exploration. space medicine will become even more of a highly collaborative discipline. Future missions will require the partnership of physicians, biomedical scientists, engineers, and mission planners. This paper will examine the future of space medicine as it relates to human space exploration: what is necessary to keep a crew alive in space, how we do it today, how we will accomplish this in the future, and how the National Aeronautics and Space Administration (NASA) plans to achieve future goals.     

Fluxes of Quasi-trapped Electrons with Energies >0.08 MeV in the Near-Earth Space on Drift Shells <Emphasis Type="Italic">L</Emphasis> < 2

We study the characteristics of fluxes of electrons with energy >80 keV in the near-Earth space regions corresponding to the drift shells L = 1.7, 1.4, and 1.1 observed during the entire period of the GRIF experiment onboard the Spectr module of the Mir orbital station from October 1995 to June 1997. The obtained geographic maps of the distribution of electron fluxes at the height of the station flight (400 km) and, also, the estimates of the spectra indicate that the South-Atlantic Anomaly provides for a mechanism of stable replenishment for shells with L < 1.5. The mechanism of stable replenishment of shells with L < 1.5 may be due to the scattering, in the residual atmosphere, of electrons from the inner radiation belt precipitating into the region of the South-Atlantic Anomaly.     

Statistical study of interplanetary condition effect on geomagnetic storms: 2. Variations of parameters

We investigate the behavior of mean values of the solar wind’s and interplanetary magnetic field’s (IMF) parameters and their absolute and relative variations during the magnetic storms generated by various types of the solar wind. In this paper, which is a continuation of paper [1], we, on the basis of the OMNI data archive for the period of 1976–2000, have analyzed 798 geomagnetic storms with D _st ≤ −50 nT and their interplanetary sources: corotating interaction regions CIR, compression regions Sheath before the interplanetary CMEs; magnetic clouds MC; “Pistons” Ejecta, and an uncertain type of a source. For the analysis the double superposed epoch analysis method was used, in which the instants of the magnetic storm onset and the minimum of the D _st index were taken as reference times. It is shown that the set of interplanetary sources of magnetic storms can be sub-divided into two basic groups according to their slowly and fast varying characteristics: (1) ICME (MC and Ejecta) and (2) CIR and Sheath. The mean values, the absolute and relative variations in MC and Ejecta for all parameters appeared to be either mean or lower than the mean value (the mean values of the electric field E _y and of the B _z component of IMF are higher in absolute value), while in CIR and Sheath they are higher than the mean value. High values of the relative density variation sN/〈N〉 are observed in MC. At the same time, the high values for relative variations of the velocity, B _z component, and IMF magnitude are observed in Sheath and CIR. No noticeable distinctions in the relationships between considered parameters for moderate and strong magnetic storms were observed.     

Structural and functional changes in man accompanying the weightlessness in "Skylab" flights: a mathematical approach

The present paper reports a kinetic analysis of changes of some physiological parameters, obtained from international literature, after changes in gravitational environment. The overall phenomenology of the adaptation to weightlessness is characterized by a rapid process followed by a slow one. The two processes show half time values differing by about five times. Also in the case of readaptation to gravity, after recovery on the Earth, two well resolved processes, showing different half time values, are observed. It is of interest to notice that the rate of response to weightlessness is lower than that to gravity. Of course, the half time values observed depend on the different physiological parameters considered. In any case, the experimental data suggest a general trend of many adaptive changes, that may all be described by a simple mathematical model.