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11.
K Eguchi-Kasai M Murakami H Itsukaichi K Fukutsu T Kanai Y Furusawa K Sato H Ohara F Yatagai 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1996,18(1-2):109-118
It can be noted that it is not simple double strand breaks (dsb) but the non-reparable breaks that are associated with high biological effectiveness in the cell killing effect for high LET radiation. Here, we have examined the effectiveness of fast neutrons and low (initial energy = 12 MeV/u) or high (135 MeV/u) energy charged particles on cell death in 19 mammalian cell lines including radiosensitive mutants. Some of the radiosensitive lines were deficient in DNA dsb repair such as LX830, M10, V3, and L5178Y-S cells and showed lower values of relative biological effectiveness (RBE) for fast neutrons if compared with their parent cell lines. The other lines of human ataxia-telangiectasia fibroblasts, irs 1, irs 2, irs 3 and irs1SF cells, which were also radiosensitive but known as proficient in dsb repair, showed moderated RBEs. Dsb repair deficient mutants showed low RBE values for heavy ions. These experimental findings suggest that the DNA repair system does not play a major role against the attack of high linear energy transfer (LET) radiations. Therefore, we hypothesize that a main cause of cell death induced by high LET radiations is due to non-reparable dsb, which are produced at a higher rate compared to low LET radiations. 相似文献
12.
The motion of a spacecraft with small asymmetry relative to its center of mass is considered. The restoring aerodynamic moment of the spacecraft is described by the Fourier series in terms of the angle of attack with the two first sinusoidal and the first cosinusoidal terms. A solution for the angle of attack in the undisturbed rotational motion is found. The analytical expression is obtained for the integral of action taken along the separatrices that separate the rotational and oscillatory regions of the phase portrait of a system. The transition of the spacecraft's motion from planar rotational to oscillatory is investigated. This transition is caused by a slow variation of moment characteristic coefficients, as well as by the presence of small asymmetry and damping and slow variation of their coefficients. Analytical formulas are obtained for determining the times of transition from rotational to oscillatory motion, as well as for the critical angular velocity of beyond-the-atmosphere rotation. When this critical velocity is exceeded, body rotation proceeds for a long time interval (planar autorotation arises). 相似文献
13.
D F Smart M A Shea 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1996,17(2):113-116
We find that the heliolongitudinal distribution of solar flares associated with earth-observed solar proton events is a function of the particle measurement energy. For solar proton events containing fluxes with energies exceeding 1 GeV, we find a Gaussian distribution about the probable root of the Archimedean spiral favorable propagation path leading from the earth to the sun. This distribution is modified as the detection threshold is lowered. For > 100 MeV solar proton events with fluxes > or = 10 protons (cm2-sec-ster)-1 we find the distribution becomes wider with a secondary peak near the solar central meridian. When the threshold is lowered to 10 MeV the distribution further evolves. For > 10 MeV solar proton events having a flux threshold at 10 protons (cm2-sec-ster)-1 the distribution can be considered to be a composite of two Gaussians. One distribution is centered about the probable root of the Archimedean spiral favorable propagation path leading from the earth to the sun, and the other is centered about the solar central meridian. For large flux solar proton events, those with flux threshold of 1000 (cm2-sec-ster)-1 at energies > 10 MeV, we find the distribution is rather flat for about 40 degrees either side of central meridian. 相似文献
14.
A Fekete Gy Rontó M Hegedüs K Módos A Bérces G Kovács H Lammer C Panitz 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2004,33(8):1306-1310
The main goal of PUR experiment (phage and uracil response) is to examine and quantify the effect of specific space conditions on nucleic acid models. To achieve this an improved method was elaborated for the preparation of DNA and bacteriophage thin films. The homogeneity of the films was controlled by UV spectroscopy and microscopy. To provide experimental evidence for the hypothesis that interplanetary transfer of the genetic material is possible, phage T7 and isolated T7 DNA thin films have been exposed to selected space conditions: intense UVC radiation (lambda=254 nm) and high vacuum (10(-4) Pa). The effects of DNA hydration, conformation and packing on UV radiation damage were examined. Characteristic changes in the absorption spectrum, in the electrophoretic pattern of DNA and the decrease of the amount of PCR products have been detected indicating the photodamage of isolated and intraphage DNA. 相似文献
15.
H Rahmann R Hilbig J Flemming K Slenzka 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1996,17(6-7):121-124
This study presents qualitative and quantitative data concerning gravity-dependent changes in the swimming behaviour of developing cichlid fish larvae (Oreochromis mossambicus) after a 9 resp. 10 days exposure to increased acceleration (centrifuge experiments), to reduced gravity (fast-rotating clinostat), changed accelerations (parabolic aircraft flights) and to near weightlessness (2nd German Spacelab Mission D-2). Changes of gravity initially cause disturbances of the swimming performance of the fish larvae. With prolonged stay in orbit a step by step normalisation of the swimming behaviour took place in the fish. After return to 1g earth conditions no somersaulting or looping could be detected concerning the fish, but still slow and disorientated movements as compared to controls occurred. The fish larvae adapted to earth gravity within 3-5 days. Fish seem to be in a distinct early developmental stages extreme sensitive and adaptable to altered gravity; However, elder fish either do not react or show compensatory behaviour e.g. escape reactions. 相似文献
16.
K L Kohlmann P Westgate A Velayudhan J Weil A Sarikaya M A Brewer R L Hendrickson M R Ladisch 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1996,18(1-2):251-265
A large amount of inedible plant material composed primarily of the carbohydrate materials cellulose, hemicellulose, and lignin is generated as a result of plant growth in a Controlled Ecological Life-Support System (CELSS). Cellulose is a linear homopolymer of glucose, which when properly processed will yield glucose, a valuable sugar because it can be added directly to human diets. Hemicellulose is a heteropolymer of hexoses and pentoses that can be treated to give a sugar mixture that is potentially a valuable fermentable carbon source. Such fermentations yield desirable supplements to the edible products from hydroponically-grown plants such as rapeseed, soybean, cowpea, or rice. Lignin is a three-dimensionally branched aromatic polymer, composed of phenyl propane units, which is susceptible to bioconversion through the growth of the white rot fungus, Pluerotus ostreatus. Processing conditions, that include both a hot water pretreatment and fungal growth and that lead to the facile conversion of plant polysaccharides to glucose, are presented. 相似文献
17.
Servidia P.A. Sanchez Pena R.S. 《IEEE transactions on aerospace and electronic systems》2005,41(2):584-598
The attitude stabilization of a spacecraft using thrusters is considered from a practical point of view, i.e., when actuator constraints, uncertainties and failures, measurement noise, fuel consumption, and inertia matrix uncertainty are considered. A variable structure controller based on sliding modes is obtained first, which guarantees global exponential stability under actuator constraints, uncertainties, and failures. The design is based on a continuous average-proportional torque selection function and a set of feasible sliding surfaces, which may be adapted to improve performance. Exponential convergence towards ultimate bounds is guaranteed when all other practical issues arise. 相似文献
18.
Ahmad F. Frazer G.J. Kassam S.A. Amin M.G. 《IEEE transactions on aerospace and electronic systems》2004,40(1):206-220
A coarray-based near-field, wideband synthetic aperture beamformer using stepped-frequency signal synthesis and post-data acquisition processing is presented. While coarray techniques offer significant reduction in the number of array elements for a given angular resolution, the hybrid subarray-stepped frequency realization of wideband systems simplifies implementations and offers flexibility in beamforming. Proof of concept is provided using real data collected in an anechoic chamber for several pulse shapes and array weightings. 相似文献
19.
Wang L. Dawson J.M. Hornak L.A. Famouri P. Ghaffarian R. 《IEEE transactions on aerospace and electronic systems》2004,40(2):567-575
Closed-loop control has been successfully applied to a microelectromechanical systems (MEMS) lateral comb resonator device in real-time to perform impulse disturbance damping and sinusoidal position control, enabled by the use of a through-wafer optical microprobe to obtain position feedback. This result leverages the application of lifetime, in-situ control of MEMS in order to provide quality assurance of microsystems in safety critical applications. A position feedback signal produced by a through-wafer optical microprobe has been used for comb resonator system model identification by two independent methods to accurately determine the effective mass, damping, and spring constant values of the device. After accurate determination of system parameters, closed-loop impulse disturbance damping and proportional-integral-differential (PID) translational control were applied. Closed-loop control results presented indicate controllability of such microstructures and response times on the order of the natural frequency of the device. 相似文献
20.
The results of the experimental studies of damping characteristics of a composite torsion bar in the helicopter main rotor
hingeless hub are presented. A variant of their improvement is considered. 相似文献