Tissue responses to low protracted doses of high LET radiations or photons: early and late damage relevant to radio-protective countermeasures.

Early and late murine tissue responses to single or fractionated low doses of heavy charged particles, fission-spectrum neutrons or gamma rays are considered. Damage to the hematopoietic system is emphasized, but results on acute lethality, host response to challenge with transplanted leukemia cells and life-shortening are presented. Low dose rates per fraction were used in some neutron experiments. Split-dose lethality studies (LD 50/30) with fission neutrons indicated greater accumulation of injury during a 9 fraction course (over 17 days) than was the case for gamma-radiation. When total doses of 96 or 247 cGy of neutrons or gamma rays were given as a single dose or in 9 fractions, a significant sparing effect on femur CFU-S depression was observed for both radiation qualities during the first 11 days, but there was not an earlier return to normal with dose fractionation. During the 9 fraction sequence, a significant sparing effect of low dose rate on CFU-S depression was observed in both neutron and gamma-irradiated mice. CFU-S content at the end of the fractionation sequence did not correlate with measured LD 50/30. Sustained depression of femur and spleen CFU-S and a significant thrombocytopenia were observed when a total neutron dose of 240 cGy was given in 72 fractions over 24 weeks at low dose rates. The temporal aspects of CFU-S repopulation were different after a single versus fractionated neutron doses. The sustained reduction in the size of the CFU-S population was accompanied by an increase in the fraction in DNA synthesis. The proliferation characteristics and effects of age were different for radial CFU-S population closely associated with bone, compared with the axial population that can be readily aspirated from the femur. In aged irradiated animals, the CFU-S proliferation/redistribution response to typhoid vaccine showed both an age and radiation effect. After high single doses of neutrons or gamma rays, a significant age- and radiation-related deficiency in host defense mechanisms was detected by a shorter mean survival time following challenge with transplantable leukemia cells. Comparison of dose-response curves for life shortening after irradiation with fission-spectrum neutrons or high energy silicon particles indicated high initial slopes for both radiation qualities at low doses, but for higher doses of silicon, the effect per Gy decreased to a value similar to that for gamma rays. The two component life-shortening curve for silicon particles has implications for the potential efficacy of radioprotectants. Recent studies on protection against early and late effects by aminothiols, prostaglandins, and other compounds are discussed.     

Dynamics of a Solenoidal-Torqued Gyro-Stabilized Seeker Assembly for Guidance and Tracking

Several low-cost gyro-stabilized, bang-bang seeker assemblies for missile guidance and tracking applications have used similar physical structures. A magnetic dipole is an integral part of the gyro rotor assembly. The nominal spin axis of the gyro is colinear with the axis of a cylinder about which is wound a helix of wire. By properly modulating the current that is passed through that helix, the precession torque acting upon the gyroscope is controlled. One rather generalized model of such a seeker assembly is modeled, the equations of motion are derived, and the dominant error sources are identified and parametrically evaluated. Because this is such a commonly encountered structure, yet no such analysis has been published, to the author's knowledge, it is hoped that this is a useful contribution to the literature.     

Molecular spectroscopy of planetary atmospheres

Summary Clearly spectroscopy has already provided considerable insight into the nature of the planetary atmospheres. Several molecular constituents have been positively identified and upper limits have been placed on the abundances of others which are of particular significance in devising planetary models. But, equally clearly, the inadequacy of the spectral data, due to low spectral and/or spatial resolution, renders deductions of abundances, temperatures and pressures very uncertain. With the sole exception of the Martian CO₂ abundance, knowledge of the concentrations of planetary atmospheric constituents is unsatisfactory, and all numbers given must be regarded as only crude estimates. This latter comment applies equally well to the derived temperatures and pressures.What is urgently needed is the development of a reasonably complete theory of line formation in planetary atmospheres. This, coupled with more detailed spectroscopic work, should produce numerical values of atmospheric parameters which can be used with assurance.This work was performed with the aid of NASA Grant NsG-101-61 with funds administered by the University of California.     

Postdetection Integration Loss for Logarithmic Detectors

The effect of a logarithmic receiver on the detection performance of a radar has been determined by Green by numerical computations for up to 100 pulses integrated. It was further suggested that the loss in decibels as compared to a square-law detector would appear to be proportional to the logarithm of the number of pulses integrated. In this correspondence we show that this ?conjecture? is false, and that the additional loss when N becomes very large approaches a constant value of 2.2 dB.     

Use of Airborne Monopulse Radar as a Low Approach Aid

The potential of airborne radar to provide pictorial displays as an aid to low approach has stimulated invention of several aircraft approach systems. Early developments are reviewed briefly, and an experiment in producing and flight testing a two-dimensional, range and azimuth, pictorial radar display is described. The monopulse radar equipment and a monopulse display improvement (MDI) technique used in the flight test to enhance the B-scope display are also described in some detail. Representative radar scope photographs are used to illustrate the display available in the aircraft.     

Aeronautical use of semiconductor lasers for short optical pulses

In this paper, we investigate the feasible schemes to generate periodic optical pulses of width between several picoseconds (ps) and tens ps. Gain-switched semiconductor laser diodes are shown to be more suitable for avionics applications than mode-locked laser diodes. In the experiment, we use a low-cost Fabry-Perot laser diode to generate short optical pulse streams. A simple optical injection-locking scheme is then used to reduce the timing jitter and frequency chirp in such laser diodes, which in turn can improve the transmission performance of the generated optical pulses. It is expected that the use of gain-switched semiconductor lasers can meet the requirement of high-speed airborne communication networks or ground supporting systems at airports. Moreover, we discuss the possibility of using the pulsed semiconductor lasers to generate millimetre-wave (mm-wave) signals for future applications to airborne high-resolution, mm-wave radars.     

Biological UV dosimeters in simulated space conditions.

Polycrystalline uracil thin layers participate in the phage and uracil response (PUR) experiment, assigned to the biological dosimetry of the extraterrestrial solar radiation on the International Space Station (ISS). In ground based experiments (experiment verification tests), the following space parameters were simulated and studied: temperature, vacuum and short wavelength UV (UV-C, down to 200 nm) radiation. The closed uracil samples proved to be vacuum-tight for 7 days. In the tested temperature range (from -20 to +40 degrees C) the uracil samples are stable. The kinetic of dimer formation (dimerization) and reversion (monomerization) of uracil dimers due to short wavelength UV radiation was detected, the monomerization efficiency of the polychromatic deuterium lamp is higher than that of the germicidal lamp. A mathematical model describing the kinetic of monomerization-dimerization was constructed. Under the influence of UV radiation the dimerization-monomerization reactions occur simultaneously, thus the additivity law of the effect of the various wavelengths is not applicable.     

Features of rotational motion of a spacecraft descending in the Martian atmosphere

Angular motion at atmospheric entry is studied in the paper for a spacecraft with a bi-harmonic moment characteristic. Special attention is given to the case when the spacecraft possesses two stable balanced positions, and, hence, it can oscillate in dense atmospheric layers in the ranges of small or large angles of attack. The averaged equations of spacecraft motion are derived, which allow one to increase the speed of calculations by several orders of magnitude. A real example is presented, which concerns a spacecraft specially designed for descending in the Martian atmosphere.     

Biological effects due to weak magnetic field on plants.

Throughout the evolution process, Earth's magnetic field (MF, about 50 microT) was a natural component of the environment for living organisms. Biological objects, flying on planned long-term interplanetary missions, would experience much weaker magnetic fields, since galactic MF is known to be 0.1-1 nT. However, the role of weak magnetic fields and their influence on functioning of biological organisms are still insufficiently understood, and is actively studied. Numerous experiments with seedlings of different plant species placed in weak magnetic field have shown that the growth of their primary roots is inhibited during early germination stages in comparison with control. The proliferative activity and cell reproduction in meristem of plant roots are reduced in weak magnetic field. Cell reproductive cycle slows down due to the expansion of G1 phase in many plant species (and of G2 phase in flax and lentil roots), while other phases of cell cycle remain relatively stable. In plant cells exposed to weak magnetic field, the functional activity of genome at early pre-replicate period is shown to decrease. Weak magnetic field causes intensification of protein synthesis and disintegration in plant roots. At ultrastructural level, changes in distribution of condensed chromatin and nucleolus compactization in nuclei, noticeable accumulation of lipid bodies, development of a lytic compartment (vacuoles, cytosegresomes and paramural bodies), and reduction of phytoferritin in plastids in meristem cells were observed in pea roots exposed to weak magnetic field. Mitochondria were found to be very sensitive to weak magnetic field: their size and relative volume in cells increase, matrix becomes electron-transparent, and cristae reduce. Cytochemical studies indicate that cells of plant roots exposed to weak magnetic field show Ca2+ over-saturation in all organelles and in cytoplasm unlike the control ones. The data presented suggest that prolonged exposures of plants to weak magnetic field may cause different biological effects at the cellular, tissue and organ levels. They may be functionally related to systems that regulate plant metabolism including the intracellular Ca2+ homeostasis. However, our understanding of very complex fundamental mechanisms and sites of interactions between weak magnetic fields and biological systems is still incomplete and still deserve strong research efforts.