DNA damage and repair in oncogenic transformation by heavy ion radiation.

Energetic heavy ions are present in galactic cosmic rays and solar particle events. One of the most important late effects in risk assessment is carcinogenesis. We have studied the carcinogenic effects of heavy ions at the cellular and molecular levels and have obtained quantitative data on dose-response curves and on the repair of oncogenic lesions for heavy particles with various charges and energies. Studies with repair inhibitors and restriction endonucleases indicated that for oncogenic transformation DNA is the primary target. Results from heavy ion experiments showed that the cross section increased with LET and reached a maximum value of about 0.02 micrometer2 at about 500 keV/micrometer. This limited size of cross section suggests that only a fraction of cellular genomic DNA is important in radiogenic transformation. Free radical scavengers, such as DMSO, do not give any effect on induction of oncogenic transformation by 600 MeV/u iron particles, suggesting most oncogenic damage induced by high-LET heavy ions is through direct action. Repair studies with stationary phase cells showed that the amount of reparable oncogenic lesions decreased with an increase of LET and that heavy ions with LET greater than 200 keV/micrometer produced only irreparable oncogenic damage. An enhancement effect for oncogenic transformation was observed in cells irradiated by low-dose-rate argon ions (400 MeV/u; 120 keV/micrometer). Chromosomal aberrations, such as translocation and deletion, but not sister chromatid exchange, are essential for heavy-ion-induced oncogenic transformation. The basic mechanism(s) of misrepair of DNA damage, which form oncogenic lesions, is unknown.     

多体系统振动的传递矩阵法

本文是文献工作的继续。导得了空间运动的任意刚体的场传递矩阵，建立了多体系统振动的传递矩阵法，为多体系统振动特性的研究提供了新的理论和方法，从而有效地简化多体系统振动特性的研究，大大减小了计算工作量，并且便于解析讨论。     

飞机最快上升转弯轨迹的计算

70年代初,Miele A等人提出SGRA方法用于优化飞行轨迹计算。但方法存在时间加权系数难于确定、长时间的飞行轨迹计算积分精度不易控制及要计算数字微分等不足。对此提出一改进梯度方法,并计算了某型战斗机从亚音速三维转弯升高到超音速的最短时间飞行轨迹。结果表明,本方法稳定有效,为解决飞机最快机动轨迹的优,乜提供了一种行之有效的手段。     

Weak Signal Detection in Non-Gaussian Noise of Unknown Level

An adaptive threshold detector to test for the presence of a weak signal in additive non-Gaussian noise of unknown level is discussed. The detector consists of a locally optimum detector, a noise level estimator, and a decision device. The detection threshold is made adaptive according to the information provided by the noise level estimator in order to keep a fixed false-alarm probability. Asymptotic performance characteristics are obtained indicating relationships among the basic system parameters such as the reference noise sample size and the underlying noise statistics. It is shown that, as the reference noise sample size is made sufficiently large, the adaptive threshold detector attains the performance of a corresponding locally optimum detector for detecting the weak signal were the noise level known.     

黄海气象海况对海上发射运载火箭的影响

海上发射运载火箭的实施过程会受到气象海洋环境的影响和制约,气象海洋环境会直接影响海上发射窗口期的选择及发射安全。为避免海上发射在复杂气象海况条件下发生设备重大损坏、窗口长期延后和人员安全事故等问题,通过分析黄海海域波浪场、风场、温度场及降水场的分布特征及变化规律,对基于季节变化特征的海上发射实施阶段及季节性预防趋势进行分析总结,为以后在不同季节极端天气下海上发射运载火箭提供参考。     

永磁有限转角力矩电机的仿真与实验

随着多电飞机的快速发展及成附件轻小化、高效能的迫切需求,有限转角力矩电机(Limited Angle Torque Motor,LATM)在飞机引气系统中的应用日益迫切。一方面,有限转角力矩电机可以显著简化高温引气控制阀结构、减小体积;另一方面,可以基于系统需求实现引气压力和温度按需调节,减少燃油代偿损失。针对高温有限转角力矩电机工作特性不易预测的难题,建立了其数学模型、仿真模型,并通过实物试验验证了仿真模型的准确性。研究结果为有限转角力矩电机特性研究提供了参考依据。     

多径信道下基于恒模算法的遥测信号盲均衡

运载火箭在塔架静态测试时易受多径衰落影响,导致遥测信号产生码间干扰。本文对PCM-FM体制遥测信号的多径信道使用恒模算法(CMA)进行盲均衡研究,针对遥测信道中的码间干扰展开理论分析和Matlab仿真,并搭建盲均衡功能测试平台开展实验验证。结果表明:CMA收敛速度高、误码率低,对多径干扰具有较好的鲁棒性和实用性。     

基于基准控制的低压涡轮转静子装测一体化方法

为进行大涵道比航空发动机低压涡轮转子同心度的精确测量与控制,根据其多级耦合的结构特点和0.05 mm转子同心 度的控制需求,开展了基于基准控制的低压涡轮转静子高精度装测一体化方法研究。通过基准调节方法实现测量基准与回转轴 线重合,消除了定位误差;通过基准保持方法避免了装配操作对基准的影响,保证了测量基准姿态的一致性;结合质心对转子不平 衡量的影响,搭建了专用测试系统,实现对低压涡轮转子同心度的装配结果管控。将该方法应用于发动机低压涡轮转静子装配, 结果表明：实现了0.0125 mm转子跳动的精确测量,有效避免了低压涡轮转子初始不平衡量超差,减少了重复装分工作,提高了装 配质量和效率,对多级部件同心度的高精度测量具有工程指导意义。     

夏热冬冷地区居住建筑节能设计分析

推动建筑向节能、绿色、智能化方向发展,是国际建筑界实践可持续发展理念的大趋势,也是中国经济社会发展面临的重要任务。我国居住建筑节能,从八十年代初起步,从全国总体情况看,节能标准在北方地区推行较早,近一两年来,我省尤其是南昌市的节能标准执行力度正在不断加大。本文通过对冬冷夏热地区一栋宿舍建筑实例进行节能设计分析,得出冬冷夏热地区"宿舍"建筑节能设计外维护结构的一般设计标准。