Role of support afferentation in control of the tonic muscle activity

The paper summarizes the results of experimental studies advocating for the leading role of support afferentation in control of the functional organization of the tonic muscle system. It is shown that transition to supportless conditions is followed by a significant decline of transverse stiffness and maximal voluntary force of postural (extensor) muscles limiting their participation in locomotion and increasing involvement of phasic muscles. Mechanical stimulation of the support zones of the soles under the supportless conditions eliminates all the above-mentioned effects, including changes in transverse stiffness and maximal voluntary forces of postural muscles, and consequent loss of influence of postural muscles in the locomotor activity. It is suggested that support afferentation, facilitating (support is present) or suppressing (support is absent) the tonic motor units (MUs) activities, defines the coordination patterns of postural synergies, and ensures the optimal strategy of corrective postural responses.     

Pathophysiology of motor functions in prolonged manned space flights.

The influence of weightlessness on different parts of the motor system have been studied in crew members of 140 and 175 days space flights. It has been shown that weightlessness affects all parts of the motor system including (i) the leg and trunk muscles, in which severe atonia, a decrease of strength and an increase of electromyographic cost of contraction have been observed, (ii) the proprioceptive elements and the spinal reflex mechanisms in which decreased thresholds accompanied by decreases of maximal amplitude of reflexes and disturbances in cross reflex mechanisms have been found. and (iii) the central mechanisms that control characteristics of postural and locomotor activities. The intensities and durations of disturbances of different parts of the motor system did not correlate to each other, but did correlate with prophylactic activity during space flight. The data suggest a different nature of disturbances caused by weightlessness in different parts of the motor system.     

Mechanisms of spinal motoneurons survival in rats under simulated hypogravity on earth

It was previously shown that different cell types in vivo and in vitro may die via apoptosis under weightlessness conditions in space as well as in simulated hypogravity on the Earth. We assessed survivability of spinal motoneurons of rats after 35-day antiorthostatic hind limb suspension. Following weight bearing, unloading the total protein content in lumbar spinal cord is dropped by 21%. The electrophysiological studies of m. gastrocnemius revealed an elevated motoneurons’ reflex excitability and conduction disturbances in the sciatic nerve axons. The number of myelinated fibers in the ventral root of experimental animals was insignificantly increased by 35-day of antiorthostatic hind limb suspension, although the retrograde axonal transport was significantly decreased during the first week of simulated hypogravity. The results of the immunohistochemical assay with antibodies against proapoptotic protein caspase 9 and cytotoxicity marker neuron specific nitric oxide synthase (nNOS) and the TUNEL staining did not reveal any signs of apoptosis in motoneurons of suspended and control animals. To examine the possible adaptation mechanisms activated in motoneurons in response to simulated hypogravity we investigated immunoexpression of Hsp25 and Hsp70 in lumbar spinal cord of the rats after 35-day antiorthostatic hind limb suspension. Comparative analysis of the immunohistochemical reaction with anti-Hsp25 antibodies revealed differential staining of motoneurons in intact and experimental animals. The density of immunoprecipitate with anti-Hsp25 antibodies was substantially higher in motoneurons of the 35-day suspended than control rats and the more intensive precipitate in this reaction was observed in motoneuron neuritis. Quantitative analysis of Hsp25 expression demonstrated an increase in the Hsp25 level by 95% in experimental rats compared to the control. The immunoexpression of Hsp70 found no qualitative and quantitative differences in control and experimental lumbar spinal cords. Taken together our results show that (1) rat motoneurons survived after 35-day antiorthostatic hind limb suspension and the changes in neurons had a mostly functional character, and (2) the increased immunoexpression of Hsp25 can be considered as the anti-apoptotic factor.     

Some contributions of touch, pressure and kinesthesis to human spatial orientation and oculomotor control.

Human spatial orientation and oculomotor control are under multimodal influence. It is not possible in the normal animal to stimulate differentially the vestibular receptors without activating other receptor systems whose activity may have a profound influence on postural control and experienced orientation. Many patterns of behavior and response that have been attributed solely to vestibular function are actually dependent wholly or in part on touch, kinesthetic, and proprioceptive stimulation.     

The Skylab sleep monitoring experiment: methodology and initial results

The sleep monitoring experiment permitted an objective evaluation of sleep characteristics during the first two manned Skylab flights. Hardware located onboard the spacecraft accomplished data acquisition, analysis, and preservation, thereby permitting near-real-time evaluation of sleep during the flights and more detailed postmission analysis. The crewman studied during the 28-Day Mission showed some decrease in total sleep time an increase in the percentage of Stage 4 sleep, while the subject in the 59-Day Mission exhibited little change in total sleep time and a small decrease in Stage 4 and REM sleep. Some disruption of sleep characteristics was seen in the final days of both missions, and both subjects exhibited decreases in REM-onset latency in the immediate postflight period. The relatively minor changes seen were not of the type nor magnitude which might be expected to be associated with significant degradation of performance capability.     

Biomedical performance monitoring and assessment of astronauts by means of an ocular–vestibular monitoring system

The paper focuses on the strong correlation between unmitigated symptoms exhibited by post Space flight astronauts, and symptoms associated with postural deficiency syndrome (PDS) that can be correctly assessed, identified, and monitored via a neurophysiological ocular–vestibular monitoring system (OVMS). From examining clinical data taken over a 10-year period from patients experiencing PDS related acute and chronic post-traumatic medical conditions, the authors show the potential for current assessment and monitoring techniques to examine better the impacts on astronaut neurophysiology. The data presented provide strong evidence that this biomedical monitoring and assessment methodology along with appropriate technology can lead to a better understanding of astronaut post-flight neurophysiology, which is necessary if human exploration in Space is to continue on a successful path.     

Sunspot dynamics are reflected in human physiology and pathophysiology

Periodic episodes of increased sunspot activity (solar electromagnetic storms) occur with 10-11 and 5-6 year periodicities and may be associated with measurable biological events. We investigated whether this sunspot periodicity characterized the incidence of Pap smear-determined cervical epithelial histopathologies and human physiologic functions. From January 1983 through December 2003, monthly averages were obtained for solar flux and sunspot numbers; six infectious, premalignant and malignant changes in the cervical epithelium from 1,182,421 consecutive, serially independent, screening Pap smears (59°9″N, 4°29″E); and six human physiologic functions of a healthy man (oral temperature, pulse, systolic and diastolic blood pressure, respiration, and peak expiratory flow), which were measured ～5 times daily during ～34,500 self-measurement sessions (44°56″N, 93°8″W). After determining that sunspot numbers and solar flux, which were not annually rhythmic, occurred with a prominent 10-year and a less-prominent 5.75-year periodicity during this 21-year study span, each biological data set was analyzed with the same curve-fitting procedures. All six annually rhythmic Pap smear-detected infectious, premalignant and malignant cervical epithelial pathologies showed strong 10-year and weaker 5.75-year cycles, as did all six self-measured, annually rhythmic, physiologic functions. The phases (maxima) for the six histopathologic findings and five of six physiologic measurements were very near, or within, the first two quarters following the 10-year solar maxima. These findings add to the growing evidence that solar magnetic storm periodicities are mirrored by cyclic phase-locked rhythms of similar period length or lengths in human physiology and pathophysiology.     

Acceleration of solar cosmic rays and the fine spectral structure of type II radio bursts

On the basis of data, obtained by means of the ground-based solar service RSTN (Radio Solar Telescope Network) and the geostationary satellite system GOES, the relationship between the solar cosmic rays (SCR) intensity I _p with the proton energy E _p > 1 MeV and parameters of meter-decameter type II radio bursts in the frequency range of 25–180 MHz is studied. The process of proton acceleration by shock waves was characterized by the frequency drift velocity of radio bursts V _mII and the relative difference between radio emission frequencies at the first two harmonics b. It is shown that the coefficient of correlation between I _p and b increases with E _p growing from 0.40 to 0.70, while a similar coefficient between I _p and V _mII does not exceed 0.30. Indications in favor of the two-stage SCR acceleration model are obtained.