Microscopic track structure of heavy ions videoelectronically measured.

The track of an ionizing particle in a track detector, such as silver-chloride or nuclear emulsion, contains two measurable parameters, the "track width"--which corresponds to the integrated lateral energy deposition dE/dtau(x,r) over r along dx (dE/dx or LET)--and the lateral distribution of the track density along r, the radial structure of the track. A videoelectronic device consisting of a computer-controlled microscope, developed in Frankfurt, automatically reads out consecutive lateral profiles of the optical density of a preset track, following it through the depth of the detector. For a given track length (100 microns, 400 profiles for instance) the system evaluates the mean track width MTW and the variance sigma 2 . Both quantities are correlated so that a given MTW (LET) belongs to different values of sigma 2 depending on the charge of the particle. Videosystem and results are presented.     

Dosimetry during the first IBIS facility flight.

The dosimetry of cosmic rays was performed during the first experimental flight of the IBIS facility. Different thermoluminescent detectors (TLD) have been used to measure the contribution of the low linear energy transfer component (LET < 10 keV/micrometer) and plastic nuclear track detectors (PNTD) for the high linear energy tranfer (LET) component. Several parameters of tracks have been measured to determine the LET spectra of primary and secondary charged particles. The total absorbed dose rate (TLD+PNTD) during the flight was 0.23 mGy/day and the dose equivalent rate using the ICRP 60 was 0.52 mSv/day. The corresponding mean quality factor was 2.4. These results are in agreement with those obtained aboard the MIR station with a tissue equivalent proportional counter.     

HZE-dosimetry on MIR92, IML-1 and D-2

Nuclear track detectors were used to measure the integral Linear Energy Transfer (LET) spectra above 1 GeV per cm water behind the complex material shielding inside a spacecraft. The measurements are compared with predictions of the contribution of high charge, high energy HZE particles of the galactic cosmic radiation taking into account the influence of solar and geomagnetic modulation and shielding by matter.     

一种基于系统误差自动补偿的编队目标航迹精细关联算法

为解决编队内各目标航迹精细关联的难题,按照编队目标航迹的特点,结合误差估计技术及航迹关联技术,提出了一种基于系统误差自动补偿的编队目标航迹精细关联算法,该算法首先基于循环阈值模型对各传感器获得的航迹进行编队识别,并按编队中心航迹完成编队航迹的整体预关联,然后基于编队航迹状态识别模型,搜索或建立分辩状态最接近的预关联编队航迹,并基于编队航迹系统误差估计模型和误差确认模型,获得最终的系统误差估计值,自动完成系统误差补偿,最后利用传统的航迹关联算法进行编队航迹的精细关联。经仿真数据验证,与基于目标不变信息量的模糊航迹对准关联算法和基于航迹迭代的航迹对准关联算法相比,该算法具有耗时少、关联性能有效稳定等综合优势,能较好的满足工程上对系统误差下编队内目标航迹的精确关联需求。     

一种基于系统误差自动补偿的编队目标航迹精细关联算法

为解决编队内各目标航迹精细关联的难题,按照编队目标航迹的特点,结合误差估计技术及航迹关联技术,提出了一种基于系统误差自动补偿的编队目标航迹精细关联算法,该算法首先基于循环阈值模型对各传感器获得的航迹进行编队识别,并按编队中心航迹完成编队航迹的整体预关联,然后基于编队航迹状态识别模型,搜索或建立分辩状态最接近的预关联编队航迹,并基于编队航迹系统误差估计模型和误差确认模型,获得最终的系统误差估计值,自动完成系统误差补偿,最后利用传统的航迹关联算法进行编队航迹的精细关联。经仿真数据验证,与基于目标不变信息量的模糊航迹对准关联算法和基于航迹迭代的航迹对准关联算法相比,该算法具有耗时少、关联性能有效稳定等综合优势,能较好的满足工程上对系统误差下编队内目标航迹的精确关联需求。     

Galactic cosmic rays and cell-hit frequencies outside the magnetosphere.

An evaluation of the exposure of space travelers to galactic cosmic radiation outside the earth's magnetosphere is made by calculating fluences of high-energy primary and secondary particles with various charges traversing a sphere of area 100 microns2. Calculations relating to two shielding configurations are presented: the center of a spherical aluminum shell of thickness 1 g/cm2, and the center of a 4 g/cm2 thick aluminum spherical shell within which there is a 30 g/cm2 diameter spherical water phantom with the point of interest 5 g/cm2 from the surface. The area of 100 microns2 was chosen to simulate the nucleus of a cell in the body. The frequencies as a function of charge component in both shielding configurations reflects the odd-even disparity of the incident particle abundances. For a three-year mission, 33% of the cells in the more heavily shielded configuration would be hit by at least one particle with Z greater than 10. Six percent would be hit by at least two such particles. This emphasizes the importance of studying single high-Z particle effects both on cells which might be "at risk" for cancer induction and on critical neural cells or networks which might be vulnerable to inactivation by heavy charged particle tracks. Synergistic effects with the more numerous high-energy protons and helium ions cannot be ruled out. In terms of more conventional radiation risk assessment, the dose equivalent decreased by a factor of 2.85 from free space to that in the more heavily shielded configuration. Roughly half of this was due to the decrease in energy deposition (absorbed dose) and half to the decrease in biological effectiveness (quality factor).     

用 Clohessy-Wiltshire 方程求解航天员出舱运动轨迹

应用航天器相对运动动力学Ｃｌｏｈｅｓｓｙ－Ｗｉｌｔｓｈｉｒｅ方程,求出方程的分析解,研究航天员出舱后的运动轨迹。其结论可推广到对接航天器分离后的运动轨迹、卫星和运载分离后相对运动轨迹、航天器上抛射物体的相对运动轨迹     

Radiation effects in nematodes: results from IML-1 experiments.

The nematode Caenorhabditis elegans was exposed to natural space radiation using the ESA Biorack facility aboard Spacelab on International Microgravity Laboratory 1, STS-42. For the major experimental objective dormant animals were suspended in buffer or on agar or immobilized next to CR-39 plastic nuclear track detectors to correlate fluence of HZE particles with genetic events. This configuration was used to isolate mutations in a set of 350 essential genes as well as in the unc-22 structural gene. From flight samples 13 mutants in the unc-22 gene were isolated along with 53 lethal mutations from autosomal regions balanced by a translocation eT1(III;V). Preliminary analysis suggests that mutants from worms correlated with specific cosmic ray tracks may have a higher proportion of rearrangements than those isolated from tube cultures on a randomly sampled basis. Right sample mutation rate was approximately 8-fold higher than ground controls which exhibited laboratory spontaneous frequencies.     

Biological effects of heavy ions from the standpoint of target theory.

The biological effect of heavy ions is best described through the action cross section, as a function of the end-point of interest and the charge and speed of the ion. In track theory this is called the "ion-kill" cross section, for it is the effect produced by a single heavy ion and its delta rays. As with nuclear emulsions the biological track structure passes from the grain count regime to the track width regime to the thindown region with an increase in LET. With biological cells, as with any detector capable of storing sublethal damage, with low LET irradiation the action cross section (in the ion-kill mode) is increasingly obscured by the effect of "gamma-kill", by the influence of overlapping delta rays from neighboring heavy ions. Thus at low LET response is dominated by the gamma-kill mode, so that the RBE approaches 1. The theory requires 4 radiosensitivity parameters for biological detectors, extracted from survival curves at several high LET bombardments passing through the grain count regime, and at high doses. Once these are known the systematic response of biological detectors to all high LET bombardments can be unfolded separating ion kill from gamma kill, predicting the response to a mixed radiation environment, and predicting low dose response even at the level of a single heavy ion. Cell killing parameters are now available for a variety of cell lines. Newly added is a set of parameters for cell transformation.     

Track structure in biological models.

High-energy heavy ions in the galactic cosmic radiation (HZE particles) may pose a special risk during long term manned space flights outside the sheltering confines of the earth's geomagnetic field. These particles are highly ionizing, and they and their nuclear secondaries can penetrate many centimeters of body tissue. The three dimensional patterns of ionizations they create as they lose energy are referred to as their track structure. Several models of biological action on mammalian cells attempt to treat track structure or related quantities in their formulation. The methods by which they do this are reviewed. The proximity function is introduced in connection with the theory of Dual Radiation Action (DRA). The ion-gamma kill (IGK) model introduces the radial energy-density distribution, which is a smooth function characterizing both the magnitude and extension of a charged particle track. The lethal, potentially lethal (LPL) model introduces lambda, the mean distance between relevant ion clusters or biochemical species along the track. Since very localized energy depositions (within approximately 10 nm) are emphasized, the proximity function as defined in the DRA model is not of utility in characterizing track structure in the LPL formulation.     

银河宇宙线在电离层D层中电离的全球分布

本文从带电粒子对D层大气电离出发, 给出了宇宙线相对论粒子、非相对论粒子及低能粒子在地球大气中的电离公式, 从而给出了宇宙线在电离层D层中电子产生率q(h)和电子密度N(h)的全球分布.结果表明, 宇宙线产生的q(h)和N(h)具有明显的纬度效应, 在极区产生的q(h)和N(h)要比低纬高得多, 当截止刚度R_c=10—18GV时, q(h)的变化相差很小.太阳活动11年调制对q(h)的影响是明显的, 但远小于R_c对q(h)的影响.大气密度ρ(h)对q(h)的影响主要是随高度的变化.      

Construction of lunar DEMs based on reflectance modelling

Existing lunar DEMs obtained based on laser altimetry or photogrammetric image analysis are characterised by high large-scale accuracies while their lateral resolution is strongly limited by noise or interpolation artifacts. In contrast, image-based photometric surface reconstruction approaches reveal small-scale surface detail but become inaccurate on large spatial scales. The framework proposed in this study therefore combines photometric image information of high lateral resolution and DEM data of comparably low lateral resolution in order to obtain DEMs of high lateral resolution which are also accurate on large spatial scales. Our first approach combines an extended photoclinometry scheme and a shape from shading based method. A novel variational surface reconstruction method further increases the lateral resolution of the DEM such that it reaches that of the underlying images. We employ the Hapke IMSA and AMSA reflectance models with two different formulations of the single-particle scattering function, such that the single-scattering albedo of the surface particles and optionally the asymmetry parameter of the single-particle scattering function can be estimated pixel-wise. As our DEM construction methods require co-registered images, an illumination-independent image registration scheme is developed. An evaluation of our framework based on synthetic image data yields an average elevation accuracy of the constructed DEMs of better than 20 m as long as the correct reflectance model is assumed. When comparing our DEMs to LOLA single track data, absolute elevation accuracies around 30 m are obtained for test regions that cover an elevation range of several thousands of metres. The proposed illumination-independent image registration method yields subpixel accuracy even in the presence of 3D perspective distortions. The pixel-wise reflectance parameters estimated simultaneously with the DEM reflect compositional contrasts between different surface units. Specifically, the detected variations of the parameter of the single-particle scattering function indicate small-scale variations of the regolith particle size, possibly as a result of differences in soil maturity.     

Experiment "Seeds" on Biokosmos 9. Dosimetric part.

The aim of the experiment "Seeds" on the Sowjetic satellite Biokosmos 9 was the observation of mutagenic effects caused at special loci of seeds of Arabidopsis thaliana and assigned to particles of the Cosmic radiation. Two types of exposure units were flown: A low-shielding unit Type I, mounted at the surface of the satellite (1.4 g/cm2 shielding) and, for comparison, an identical item inside (16 g/cm2 shielding), using nuclear emulsion as track detectors. A Type II unit, flown inside (18g/cm2 shielding) was mounted with AgCl track detectors. The layout will be briefly described. A first set of dosimetric data from the physical evaluation of the experiment will be presented. The subdivision into charge- and LET-groups shows a rather high contribution of the intermediate LET-group (350-1000 MeV/cm) due to medium heavy particles (Z = 6-10) and to enders of light (p, alpha) particles.     

Microdosimetric measurements of heavy ion tracks.

The biological effectiveness of radiations depends on the spatial pattern of ionizations and excitations produced by the charged particle tracks involved. Ionizations produced by both the primary ion and by energetic delta rays may contribute to the production of biologically relevant damage and to the concentration of damage which may effect the probability of repair. Although average energy concentration (dose) can be calculated using homogeneous track models, the energy is actually concentrated in small volumes containing segments of the ion and delta ray tracks. These local concentrations are studied experimentally using low pressure proportional counters, and theoretically, using Monte Carlo methods. Small volumes near an ion track may be traversed by a delta ray. If they are, the energy deposited will be similar to that produced by a single electron track in a low-energy x-ray irradiation. The probability of a delta ray interaction occurring decreases with the square of the radial distance from the track. The average energy deposited is the product of this probability and the energy deposited in an interaction. Average energy deposited calculated from measured interaction probability is in good agreement with the results of homogeneous track models.     

Investigating the cellular effects of isolated radiation tracks using microbeam techniques.

Studies of the effects of radiation at the cellular level have generally been carried out by exposing cells randomly to the charged-particle tracks of a radiation beam. Recently, a number of laboratories have developed techniques for microbeam irradiation of individual cells. These approaches are designed to remove much of the randomness of conventional methods and allow the nature of the targets and pathways involved in a range of radiation effects to be studied with greater selectivity. Another advantage is that the responses of individual cells can be followed in a time-lapse fashion and, for example, processes such as "bystander" effects can be studied clearly. The microbeam approach is of particular importance in mechanistic studies related to the risks associated with exposure to low fluences of charged particles. This is because it is now possible to determine the actions of strictly single particle tracks and thereby mimic, under in vitro conditions, exposures at low radiation dose that are significant for protection levels, especially those involving medium- to high-LET radiations. Overall, microbeam methods provide a new dimension in exploring mechanisms of radiation effect at the cellular level. Microbeam methods and their application to the study of the cellular effects of single charged-particle traversals are described.     

Stochastics of HZE-induced microlesions.

Fundamental biological experiments with bacteria, yeast, and mammalian cells irradiated with ions heavier than helium indicate that maximal probability of single-hit inactivation does not occur when the ion has LET below about 100-200 keV/micrometer. Theoretical treatments of cell inactivation data and the radiation chemistry in particle tracks are consistent with this finding. If a "microlesion" is defined as a linear array, within a tissue, of cells inactivated with maximum probability, surrounded by non-lethally damaged cells, then, by this definition, there must be an LET below which "microlesion" damage cannot be expected. In a retrospective survey of experimental literature in which single-particle effects in tissues were sought, it was found that little or no evidence has been reported supporting single-particle effects in tissues when LET was below 200 keV/micrometer, while some experimenters who irradiated tissues with particles having LET greater than 200 keV/micrometer reported effects that could be attributed to single-particle tracks.     

Monte Carlo track structure studies of energy deposition and calculation of initial DSB and RBE.

Estimation of exposure due to environmental and other sources of radiations of high-LET and low-LET is of interest in radiobiology and radiation protection for risk assessment. To account for the differences in effectiveness of different types of radiations various parameters have been used. However, the relative inadequacy of the commonly used parameters, including dose, fluence, linear energy transfer, lineal energy, specific energy and quality factor, has been made manifest by the biological importance of the microscopic track structure and primary modes of interaction. Monte Carlo track structure simulations have been used to calculate the frequency of energy deposition by radiations of high- and low-LET in target sizes similar to DNA and higher order genomic structure. Tracks of monoenergetic heavy ions and electrons were constructed by following the molecular interaction-by-interaction histories of the particles down to 10 eV. Subsequently, geometrical models of these assumed biological targets were randomly exposed to the radiation tracks and the frequency of energy depositions obtained were normalized to unit dose in unit density liquid water (l0(3) kg m-3). From these data and a more sophisticated model of the DNA, absolute yields of both single- and double-strand breaks expressed in number of breaks per dalton per Gray were obtained and compared with the measured yields. The relative biological effectiveness (RBE) for energy depositions in cylindrical targets has been calculated using 100 keV electrons as the reference radiation assuming the electron track-ends contribution is similar to that in 250 kV X-ray or Co60 gamma-ray irradiations.     

Importance of dose-rate and cell proliferation in the evaluation of biological experimental results.

The nuclei of cells within the bodies of astronauts traveling on extended missions outside the geomagnetosphere will experience single traversals of particles with high LET (e.g., one iron ion per one hundred years, on average) superimposed on a background of tracks with low LET (approximately one proton every two to three days, and one helium ion per month). In addition, some cell populations within the body will be proliferating, thus possibly providing increasing numbers of cells with "initiated" targets for subsequent radiation hits. These temporal characteristics are not generally reproduced in laboratory experimental protocols. Implications of the differences in the temporal patterns of radiation delivery between conventionally designed radiation biology experiments and the pattern to be experienced in space are examined and the importance of dose-rate and cell proliferation are pointed out in the context of radiation risk assessment on long missions in space.     

DNA fragmentation in mammalian cells exposed to various light ions.

Elucidation of how effects of densely ionizing radiation at cellular level are linked to DNA damage is fundamental for a better understanding of the mechanisms leading to genomic damage (especially chromosome aberrations) and developing biophysical models to predict space radiation effects. We have investigated the DNA fragmentation patterns induced in Chinese hamster V79 cells by 31 keV/micrometer protons, 123 keV/micrometer helium-4 ions and gamma rays in the size range 0.023-5.7 Mbp, using calibrated Pulsed Field Gel Electrophoresis (PFGE). The frequency distributions of fragments induced by the charged particles were shifted towards smaller sizes with respect to that induced by comparable doses of gamma rays. The DSB yields, evaluated from the fragments induced in the size range studied, were higher for protons and helium ions than for gamma rays by a factor of about 1.9 and 1.2, respectively. However, these ratios do not adequately reflect the RBE observed on the same cells for inactivation and mutation induced by these beams. This is a further indication for the lack of correlation between the effects exerted at cellular level and the initial yield of DSB. The dependence on radiation quality of the fragmentation pattern suggests that it may have a role in damage repairability. We have analyzed these patterns with a "random breakage" model generalized in order to consider the initial non-random distribution of the DNA molecules. Our results suggest that a random breakage mechanism can describe with a reasonable approximation the DNA fragmentation induced by gamma rays, while the approximation is not so good for light ions, likely due to the interplay between ion tracks and chromatin organization at the loop level.