中国微重力科学研究回顾与展望

微重力科学主要研究微重力环境中物质运动的规律,以及不同重力环境中重力对物质运动的影响.中国微重力科学研究起步于20世纪60年代,兴起于80年代中后期,经过多年发展,目前已初具规模,在一些重要方向具有明显特色和一定优势.本文回顾了中国微重力科学研究的早期历程,评述了近年来中国微重力科学研究进展,特别是利用实践十号科学实验...     

天宫二号碲化锌晶体生长

在天宫二号飞船综合材料实验炉六工位采用碲熔剂法生长了碲化锌晶体,生长时最高温度为800℃,以0.5mm·h-1的提拉速度向炉膛内部提拉生长晶体.飞行实验后,用相同实验参数在地面进行了对比实验.结果发现,空间样品尾部有一个非常大的橙色结晶区域（约10mm×6mm×2mm）,而地面生长样品中碲化锌晶体尺寸仅为约3mm×3mm×1mm,空间生长的碲化锌晶粒尺寸明显优于地面.空间微重力环境下,由于毛细作用,空间样品的塞子处有Te和ZnTe的外延膜生成.而地面生长的锭条在塞子处只有零星点状气相生产物.因此微重力条件有利于碲化锌晶体材料的生长.      

在空间微重力下生长碲镉汞晶体

本文叙述了我国首次在空间微重力下进行的碲镉汞(MCT)晶体生长试验及一些观测结果。生长是从熔体进行的。在空间90min的加热时间内,将MCT多晶试样熔化,然后随炉冷却,最后在地面上再结晶。于是,生长出约3cm长的晶体,其表面光滑.结构致密,无孔洞,由1～3个大晶粒组成,其中单晶占74%。X射线能量色散分析(EDS)表明,其径向组分均匀性优于±0.02,其中约1cm长的一段晶体的径向组分均匀性优于±0.01。电学特性与地面上生长的样品基本相同。     

微重力燃烧研究进展

微重力燃烧是一门非常新的学科,它研究在微重力环境下的基本燃烧过程。本文概括最近几年刚发展起来的以下几方面的进展:微重力燃烧研究所用的设备;固体材料的着火性;预混气燃烧;液滴燃烧;颗粒群燃烧;空间飞行器着火安全性。最后对我国开展微重力燃烧研究提出建议。     

Free flow electrophoresis in space shuttle program (Biotex).

In the space shuttle program free flow electrophoresis will be applied for separation of proteins, biopolymers and cells. Proteins are to be separated according to the "Feldsprung-Gradienten" procedure by Prof. H. Wagner, University of Saarbruecken, biopolymers are to be separated by the isotachophoresis technique by Prof. Schmitz, University of Muenster and we intend to separate cells in order to increase the efficiency of recovery of hybrid cells after electrofusion performed under microgravity in collaboration with Prof. U. Zimmermann, University of Wuerzburg. There are supposed two ways for reaching this goal: 1) Enrichment of cells before electrofusion may enhance the probability that the cells of interest are immortalized. 2) Separation of cells after electrofusion may help to clone the hybrid cells of interest. Under microgravity, the combination of improved electrophoresis with higher electrofusion rates may provide new possibilities for immortalization of cells. This may be a new way to obtain cellular products, which are physiologically glycosylated.     

用国产装置进行的空间蛋白质结晶实验

使用国内研制的管式汽相扩散结晶装置,在我国返回式卫星上,成功地完成了两次空间蛋白质晶体生长实验,10种不同种类的蛋白质配制的48个样品在空间的出晶率分别达52%和80%,其中少数蛋白质生长出了较高质量的蛋白质晶体。结果表明,空间的微重力环境利于改善蛋白质晶体的生长,而且在结晶条件优化足够好的条件下,在空间里能生长出比地面晶体尺寸较大、形态较好和内部有序性较高的蛋白质晶体。本文还就微重力对蛋白质晶体生长的具体作用及其开发利用做了讨论。      

空间低温溶液晶体生长的地基实验

首次使用疏水型聚四氟乙烯微孔滤膜,利用其透气不透水的特性,密封晶体生长容器,采用恒温蒸发法进行晶体生长.溶剂通过蒸发离开生长容器后,被生长容器外的吸附剂吸附,使得溶液维持一定过饱和度,以实现单晶的连续生长.在此基础上研制出一套空间低温溶液晶体生长地基模拟装置.利用此装置进行了一系列地基模拟实验,获得一批高质量α-LiIO₃单晶,证实了该生长装置的溶剂蒸发量和容器密封性能够满足空间低温溶液晶体生长需要,为未来空间低温溶液晶体生长实验奠定了基础.      

空间微重力条件下碲镉汞晶体的布里支曼生长

在中国返回式卫星上进行了一台双温区空间晶体生长炉的搭载试验，成功地实现了空间微重力条件下碲镉汞晶体的布里支曼生长，取得了一些有意义的结果。文章介绍了这种晶体炉的设计和空间试验的过程；分析了回收样品的主要测试结果；并对空间材料加工装置的设计和一些相关工艺问题进行了讨论     

Science Researches of Chinese Manned Space Flight

With the complete success of the 2nd stage of Chinese Manned Space Program (CMSP), several science researches have been performed on Tiangong-1 experimental spacelab, which was docked with three Shenzhou spaceships one after another. The China's real spacelab, Tiangong-2 will be launched in 2015, docked with a Shenzhou spaceship soon. After six months, it will be docked with the first Chinese cargo ship (Tianzhou-1). More space science researches, involving with space biology, fluid physics, fundamental physics, materials science, Earth science, astronomy and space environmental science, will be operated on Tiangong-2 spacelab, and crewed and cargo spaceships. Furthermore, the considerable large-scale space utilization of Shina's Space Station is planned. The research fields include yet not limited to space medicine and physiology, space life science and biotechnology, fluid physics and combustion in microgravity, space material science, and fundamental physics in microgravity, space astronomy, Earth science, space physics and space environment utilization, technology demonstration.      

利用返回式卫星开展微重力试验

本文介绍我国首次利用返回式卫星进行微重力搭载试验和具体实施的办法,以及试验所获得的令人鼓舞的科学成果。同时还提出研制微重力卫星的新设想,为进一步开展空间微重力条件下的科学研究活动,提供新的途径。     

SJ-10卫星固体材料燃烧实验装置

为对微重力条件下固体材料着火和火焰传播特性进行研究,研制了实践十号（SJ-10）卫星固体材料燃烧实验装置.利用空间高真空条件,采用实验段内气体环境更新和控制技术,实现了在有限实验空间内对多个实验样品进行研究,并提供准确可控的实验环境条件（氧气浓度和气流速度）.通过地面试验验证,该装置可通过实验样品、氧气浓度、气流速度、点火方式等实验参数的灵活组合,实现空间实验机会的充分利用和预定科学目标.      

Solidification and Crystal Growth on the SJ-10 Recoverable Scientific Experiment Satellite

The low-gravity environment aboard the space provides a unique platform for understanding crystal-growth-related phenomena that are masked by gravity on the Earth and for exploring new crystal growth techniques. We have characterized the wetting behavior of metal alloys and carried out melt growth of compound semiconductors under the support of materials science program in the SJ-10 recoverable satellite. We found that interfacial reaction plays a significant role in the interfacial evolution of Sn-based alloys. Detached growth of InAsSb was realized under microgravity, whereas during the terrestrial experiment the crystal and the crucible wall contact with each other. Moreover, the suppression of buoyancy-driven convection results in a more uniform composition distribution in the InGaSb and Bi₂Te₃-based semiconductor alloys.      

空间站微重力流体实验设备需求分析

对国际空间站和中国科学实验卫星及载人飞行器上开展的微重力流体实验情况进行论述和分析,重点分析了国际空间站（ISS）微重力流体科学实验设备情况.根据中国空间微重力流体物理科学发展需求,结合国际空间站微重力流体科学实验对设备的需求,提出了未来在中国空间站开展微重力流体实验时空间实验设备需要重点考虑和解决的问题,同时提出相关设计建议.      

ESA microgravity payloads for the 1990s

Analysis of flight opportunities of existing and new microgravity multi-user facilities on Eureca and Spacelab and design studies of new experimental facilities for Columbus are presently in progress.

The materials and fluid sciences research community is likely to be a major user of the permanently manned Space Station/Columbus elements such as the European Attached Pressurised Module (APM) and the Man-Tended Free Flyer (MTFF).

In metallurgy, crystal growth and bioengineering initial research will be performed in the manned laboratory, whereas later on the processing will be automated and executed on unmanned platforms.

At present ESA prepares - in close cooperation with the scientific community - the hardware development of microgravity experimental facilities/laboratories for all Columbus elements through design studies. Preliminary studies which have been carried out to date are the following : Crystallisation Laboratory, Fluid Sciences Laboratory, Containerless Processing Laboratory, Thermophysical Properties Measurement Facility, Metallurgy Laboratory.

In 1998 it is planned to deepen these studies covering laboratories for the APM and for the MTFF. Details on flight opportunities in the pre-Columbus period will also be provided.     

我国首次空间微重力下的材料加工试验

1987年8月5日至10日,我国首次利用返回卫星进行了空间微重力下的材料加工实验。本次试验共有12个项目,其中砷化镓单晶生长达到国际先进水平,Y-Ba-Cu高温超导材料试验则为世界首次,HgCdTe红外材料,Insb半导体材料和难混合全都取得了地面不能得到的结果。这次试验的多用途加工炉吸收了国外空间加工技术的特点,构思巧妙、效果明显.一炉多用开创空间搭载的新路子。     

Function of the cytoskeleton in gravisensing during spaceflight.

Since astronauts and cosmonauts have significant bone loss in microgravity we hypothesized that there would be physiological changes in cellular bone growth and cytoskeleton in the absence of gravity. Investigators from around the world have studied a multitude of bone cells in microgravity including Ros 17/2.8, Mc3T3-E1, MG-63, hFOB and primary chicken calvaria. Changes in cytoskeleton and extracellular matrix (ECM) have been noted in many of these studies. Investigators have noted changes in shape of cells exposed to as little as 20 seconds of microgravity in parabolic flight. Our laboratory reported that quiescent osteoblasts activated by sera under microgravity conditions had a significant 60% reduction in growth (p<0.001) but a paradoxical 2-fold increase in release of the osteoblast autocrine factor PGE2 when compared to ground controls. In addition, a collapse of the osteoblast actin cytoskeleton and loss of focal adhesions has been noted after 4 days in microgravity. Later studies in Biorack on STS-76, 81 and 84 confirmed the increased release of PGE2 and collapse of the actin cytoskeleton in cells grown in microgravity conditions, however flown cells under 1 g conditions maintained normal actin cytoskeleton and fibronectin matrix. The changes seen in the cytoskeleton are probably not due to alterations in fibronectin message or protein synthesis since no differences have been noted in microgravity. Multiple investigators have observed actin and microtubule cytoskeletal modifications in microgravity, suggesting a common root cause for the change in cell architecture. The inability of the O g grown osteoblast to respond to sera activation suggests that there is a major alteration in anabolic signal transduction under microgravity conditions, most probably through the growth factor receptors and/or the associated kinase pathways that are connected to the cytoskeleton. Cell cycle is dependent on the cytoskeleton. Alterations in cytoskeletal structure can block cell growth either in G1 (F-actin microfilament collapse), or in G2/M (inhibition of microtubule polymerization during G2/M-phase). We therefore hypothesize that microgravity would inhibit growth in either G1, or G2/M.     

The ASTROCULTURE(TM) flight experiment series, validating technologies for growing plants in space.

A flight experiment, ASTROCULTURE(TM)-1 (ASC-1), to evaluate the operational characteristics and hardware performance of a porous tube nutrient delivery system (PTNDS) was flown on STS-50 as part of the U.S. Microgravity Laboratory-1 mission, 25 June to 9 July, 1992. This experiment is the first in a series of planned ASTROCULTURE(TM) flights to validate the performance of subsystems required to grow plants in microgravity environments. Results indicated that the PTNDS was capable of supplying water and nutrients to plants in microgravity and that its performance was similar in microgravity to that in 1g on Earth. The data demonstrated that water transfer rates through a rooting matrix are a function of pore size of the tubes, the degree of negative pressure on the 'supply' fluid, and the pressure differential between the 'supply' and 'recovery' fluid loops. A slightly greater transfer rate was seen in microgravity than in 1g, but differences were likely related to the presence of hydrostatic pressure effects at 1g. Thus, this system can be used to support plant growth in microgravity or in partial gravity as on a lunar or Mars base. Additional subsystems to be evaluated in the ASTROCULTURE(TM) flight series of experiments include lighting, humidity control and condensate recovery, temperature control, nutrient composition control, CO2 and O2 control, and gaseous contaminant control.     

微重力下胶原蛋白纤维化及羟基磷灰石结晶的初步研究

在长期空间飞行过程中, 骨质丢失是一个严重问题. 羟基磷灰石(HAP)晶体是骨骼的主要成分, 骨骼中的胶原蛋白纤维在HAP生长结晶过程中起到关键作用. 研究了胶原蛋白纤维化过程在模拟微重力和常重力条件下的变化, 对以胶原 蛋白纤维作为模板生长出的HAP晶体形貌进行了观察. 结果表明, 不同浓度胶原蛋白溶液中形成的胶原蛋白纤维, 其内部孔隙数量和尺寸在模拟微重力条件下要明显大于常重力条件下, 胶原蛋白纤维内部孔隙的分布也不同于常重力条 件下的结果. 以模拟微重力条件下形成的胶原蛋白纤维为模板生长出的HAP 晶体主要为立方体状, 而以常重力条件下形成的胶原蛋白纤维为模板生长出的 HAP晶体形貌主要为板状. 该结果有助于未来进一步阐明空间骨质丢失的机理.      

微重力条件下红外材料的空间生长

根据近年红外材料在空间生长的研究概况,分析了涵盖熔体、气相、液相外延和分子束外延等生长方法及各个方法生长红外材料的基本原理,在地面生长遇到的问题,以及在空间微重力环境中进行红外材料生长的优势.同时基于中国利用熔体法在天宫二号上已经进行的ZnTe:Cu晶体的空间生长科学实验及地基实验结果,通过对空间和地面实验结果进行对比,提出了在超高真空环境下,利用分子束外延方式生长高性能、大尺寸红外材料的可能性,以及未来在空间微重力条件下进行红外材料生长的研究方向及具体应用.      

Protein crystal growth aboard the U.S. space shuttle flights STS-31 and STS-32.

The first microgravity protein crystal growth experiments were performed on Spacelab I by Littke and John. These experiments indicated that the space grown crystals, which were obtained using a liquid-liquid diffusion system, were larger than crystals obtained by the same experimental system on earth. Subsequent experiments were performed by other investigators on a series of space shuttle missions from 1985 through 1990. The results from two of these shuttle flights (STS-26 and STS-29) have been described previously. The results from these missions indicated that the microgravity grown crystals for a number of different proteins were larger, displayed more uniform morphologies, and yielded diffraction data to significantly higher resolutions than the best crystals of these proteins grown on earth. This paper presents the results obtained from shuttle flight STS-32 (flown in January, 1990) and preliminary results from the most recent shuttle flight, STS-31 (flown in April, 1990).