Biomedical study on combined effects of simulated weightlessness and emergent depressurization of spacecraft

Cabin emergent depressurization (CED) may occur in spacecraft during manned space flight. The purpose of this paper was to study the combined effects of simulated weightlessness (SW) and CED factors on humans and animals. It was found that the amplitude of T wave of human electrocardiograms (ECG) significantly decreased in bed rest and hypoxia compared with the control condition (P<0.05), and that suspension with pure O₂ induced severer edema in the lungs of rats than that in only a pure O₂ environment. SW and pure O₂ caused middle ear congestion and decreased the barofunction during pressure changes. These results indicate that human response to CED factors become more serious under SW because of the blood redistribution.     

Auroral signatures of transient processes in the outer magnetosphere

We present an analysis of sporadic and recurrent injections of magnetospheric ions in the midnight auroral oval during substorms and of the associated ionospheric ion outflows. The source of plasma sheet precipitating ions is determined using a simple method, based on the measured relation between the ion inverse velocity and time (l = v × t). This method is applied here to two typical passes of the Interball-Auroral (IA) satellite at distances of 3 R_E above the auroral regions. Substorm related ion injections are shown to be mainly due to time of flight effects. In contrast with particle trajectory computations (Sauvaud et al., 1999), the inverse velocity method does not require magnetic and electric field models and can thus be used systematically for the detection of time of flight dispersed ion structures (TDIS). This allowed us to build a large database of TDIS events and to perform a statistical analysis of their spatial distribution. For the cases presented here the source region of the injected ions is found at radial distances from 18 to 30 R_E near the equatorial magnetosphere. At Interball altitudes ( 3 R_E), ion injections detected at the poleward boundary of the nighside auroral oval are associated with shear Alfvén waves superimposed over large-scale quasi-static current structures. We show that the most poleward TDIS are collocated with a large outflow of ionospheric H⁺ and O⁺ displaying pitch-angle distributions peaked in the pitch-angle range 90°–120°. These ions are thus accelerated perpendicularly to the magnetic field not only in the main auroral acceleration region but also up to at least 3 R_E. The expanding auroral bulge thus constitutes a significant source of H⁺ and O⁺ ions for the mid-tail magnetosphere.     

曲靖地区电离层多参数变化特征

利用电波环境观测网曲靖站电离层垂直探测仪数据（2008－2018）,分析了该站电离层多参数（包括f_min,f₀E_s,h'E_s,f₀E,f₀F₁,f₀F₂,h'F,MUF(3000)F₂等）随太阳活动、季节、地方时的变化特征。结果表明,f_min,f₀E_s,h'E_s随太阳活动变化不明显,f₀E,f₀F₁,f₀F₂,h'F,MUF(3000)F₂与太阳活动变化具有相关性,f₀F₂经常发生日落增强现象,同时各自具有独立性;与拉萨、乌鲁木齐地区f₀F₂,h'F,f₀E_s变化特征对比,发现地方时与月份变化趋势相同,但是极值出现的位置有所不同,这可能与各地区的地理纬度和地形等因素有关;h'F夜间大于白天,在日出日落时段有突然上升现象,冬季的h'F一般都小于其他季节;MUF(3000)F₂与f₀F₂的变化特征相似,白天值高于夜晚值,春秋分季高于夏冬季,太阳活动高年日落后MUF(3000)F₂一直维持较高值并持续到03:00－04:00 LT。      

Effects of space flight and IGF-1 on immune function

We tested the hypothesis that insulin-like growth factor-1 (IGF-1) would ameliorate space flight-induced effects on the immune system. Twelve male, Sprague-Dawley rats, surgically implanted with mini osmotic pumps, were subjected to space flight for 10 days on STS-77. Six rats received 10 mg/kg/day of IGF-1 and 6 rats received saline. Flight animals had a lymphocytopenia and granulocytosis which were reversed by IGF-1. Flight animals had significantly higher corticosterone levels than ground controls but IGF-1 did not impact this stress hormone. Therefore, the reversed granulocytosis did not correlate with serum corticosterone. Space flight and IGF-1 also combined to induce a monocytopenia that was not evident in ground control animals treated with IGF-1 or in animals subjected to space flight but given physiological saline. There was a significant increase in spleen weights in vivarium animals treated with IGF-1, however, this change did not occur in flight animals. We observed reduced agonist-induced lymph node cell proliferation by cells from flight animals compared to ground controls. The reduced proliferation was not augmented by IGF-1 treatment. There was enhanced secretion of TNF, IL-6 and NO by flight-animal peritoneal macrophages compared to vivarium controls, however, O₂ secretion was not affected. These data suggest that IGF-1 can ameliorate some of the effects of space flight but that space flight can also impact the normal response to IGF-1.     

UV photobiochemistry of anhydrobiotic organisms at extremely low temperatures

Spores of Bacillus subtilis (TKJ 3412), cells of Deinococcus radiodurans R₁ (wild type) and conidia of Aspergillus ochraceus (strain 3174) have been UV irradiated (254 nm) in the dry state (3% relative humidity, argon) or in aqueous suspension at room temperature, at −55°C to −70°C and at −165°C to −170°C. The following effects have been analyzed: decrease in viability, occurrence of DNA strand breaks (pulsed-field gel electrophoresis) and production of DNA-protein cross-links (membrane filter method). The loss in viability is usually more pronounced at around −70°C than at room temperature, but it is lowest around −170°C. The kind of prevailing DNA damage varies from organism to organism. The amount of UV induced DNA-protein cross-link products steadily decreases with the temperature and is lowest at −170°C. The decrease in highly polymeric DNA by double strand breaks follows no universal pattern. The observed hypersensitivity of the three very different species at −70°C can therefore not be simply explained on the basis of the number of DNA lesions analyzed in the course of this work. We suggest that also the changing state of cellular water below and above about −130°C significantly contributes to the change in photosensitivity.     

A Prediction Method for△f0F2min of a Single Station From Interplanetary Parameters Based on Statistical Study

Using 86 CME-interplanetary shock events,the correlation between the peak values of （a） the solar wind parameters(B_z,E_y,P_dyn) and the geomagnetic indices（SYM-H,ASY-H,Kp）, （b） the coupling functions（Borovsky,Akasofu,Newell） and the geomagnetic indices,（c） the solar wind parameters/coupling functions/geomagnetic indices and the ionospheric parameter(Δf₀F_2min), are investigated.The statistical results show that in group（a）,B_{z min} and SYM-H_min have the best correlation,that in group（b）,the best correlation is between the peak values of Akasofu function (A_min) and SYM-H_min,and that in group（c）,the best correlation is between K_pmax andΔf₀F_2min. Based on the statistical results,a method for predicting f₀F₂ of a single station is attempted to be set up.The input is modified B_{z min} and the outputs are SYM-H_min andΔf₀F_2min.Then 25 CME-IPS events that caused geomagnetic storms in 1998 and 2009 are used to check the prediction method. The results show that our method can be used to predict SYM-H_min andΔf₀F_2min.     

Changes of deoxyribonucleoprotein in the spleen, thymus and liver of rats exposed to weightlessness and artificial gravity aboard the Cosmos biosatellites

Changes of deoxyribonucleoprotein in the spleen, thymus and liver of rats exposed to wegithlessness or artifical gravity on board biosatellites Cosmos 782 and Cosmos 936 after 20 days of flight were investigated. The level of polydeoxyribonucleotides in the spleen and thymus of rats exposed during the flight to weightlessness increased 4 – 11 hours after landing, suggesting breakdown of a part of the deoxyribonucleoprotein present. The use of artifical gravity prevented this breakdown in the thymus but not in the spleen. The breakdown was accompanied in the majority of cases by a decrease in teh deoxyribonucleoprotein content. We believe the breakdown of deoxyribonucleoprotein is due to a nonspecific stress reaction to the change from the weightless state to that of terrestrial gravity during landing. The polydeoxyribonucleotide level and amount of deoxyribonucleoprotein in the majority of cases returned to normal values during the 25 days of readaptation. No substantial change of deoxyribonucleoprotein was found in the liver. The different findings in the three organs are due to the fact that breakdown of deoxyribonucleoprotein takes place in sensitive cells underlying pycnosis. These cells are found in the spleen and thymus, but not in the liver.     

量子点与TiO2电极参数对光阳极电子寿命及性能影响

通过对P25Ti O2光阳极薄膜厚度、敏化的量子点种类及量子点敏化方法研究,探讨了使用连续离子层吸附反应法的敏化方法(SILAR)时,P25Ti O2薄膜厚度与光阳极电子寿命的关系,以及量子点种类、共敏化工艺对光阳极光电性能的影响.采用电化学阻抗(EIS)、开路电压衰减(OCVD)及紫外-可见吸收方法,对影响光阳极光电性能的Ti O2薄膜厚度、量子点种类及共敏化工艺因素进行测试分析.实验结果表明:当光阳极薄膜厚度为12μm时,电子复合几率最小,光阳极的电子寿命相对最长;采用连续离子层吸附反应法(SILAR)对多种量子点共敏化的光阳极(Ti O2/Cd S/Cd Se/Zn S)与单一量子点敏化的光阳极(Ti O2/Cd S)相比,短路电流提高了34%,光转换效率提高了42%;合适的共敏化工艺也有助于提高光阳极的电子寿命、光谱吸收范围和吸收强度.     

Energy deposition in the upper atmosphere in the EXCEDE III experiment

The EXCEDE III sounding rocket flight of April 27, 1990 used a 18 Ampere 2.5 keV electron beam to produce an artificial aurora in the region 90 to 115 km. A “daughter” sensor payload remotely monitored the low-energy X-ray spectrum while scanning photometers measured the spatial profile of prompt emissions of N₂⁺ (1N) and N₂ (2P) transitions (3914Å and 3805Å, respectively). Two Ebert-Fastie spectrometers measured the spectral region from 1800 to 8000Å. On the “mother” accelerator payload, the return current electron differential energy spectra were monitored by an electrostatic analyzer (up to 10 keV) and by a retarding potential analyzer (0 eV to 100 eV). We present an overview of the results from this experiment.     

Towards validation of SCIAMACHY lunar occultation NO2 vertical profiles

Vertical profiles of stratospheric nitrogen dioxide (NO₂) have been retrieved from moderate resolution lunar occultation transmission spectra measured by Scanning Imaging Absorption spectroMeter for Atmospheric CHartographY (SCIAMACHY) on board the European Environmental Satellite (ENVISAT). These measurements were taken over the high southern latitude of 50°–90° during the period of 2003–2005. To assess the accuracy of the retrieved NO₂ profiles, the SCIAMACHY nighttime NO₂ profiles were compared with NO₂ profiles retrieved from sunrise solar occultation spectra measured by the Halogen Occultation Experiment (HALOE) and the Stratospheric Aerosol and Gas Experiments II (SAGE II) using a photochemical correction model. The validation results show good agreement of SCIAMACHY lunar occultation NO₂ with scaled HALOE and SAGE II profiles. The relative mean differences (rmd) with scaled HALOE profiles are within −13% to +5% and standard deviations (rms) of the relative differences are within 3–19% between 25 and 38 km. The rmd and rms with scaled SAGE II NO₂ profiles are in the range of −9 to +7 and 10–17% respectively between 22 and 39 km.     

电离对高超声速热化学非平衡气动热环境的影响

高超声速飞行,激波后高温气体会发生电离,飞行器气动热环境复杂。5组元（N₂,O₂,NO,O,N）、7组元（N₂,O₂,NO,O,N,NO+,e-）和11组元（N₂,O₂,NO,O,N,N₂+,O₂+,NO+,O+,N+,e-）热化学反应采用Gupta化学反应模型,分别数值研究电离作用对高超声速热化学非平衡气动热环境影响。本文分析了不同催化壁面条件下,高超声速热化学非平衡电离流场气动热环境特性。电离作用对激波离体距离和气动力载荷的影响很小。5组元热化学非平衡不考虑电离作用,流场温度和壁面热流密度偏大。11组元热化学平衡强电离流场温度最低;7组元热化学非平衡弱电离流场NO+和e-生成量过低;11组元热化学反应能对热化学非平衡电离流场气动力和热流密度载荷可靠预测。壁面催化作用会增大壁面热流密度,但它对高超声速热化学非平衡电离流场温度和气动力载荷的影响很小。      

基于QAR数据的碳当量值适航符合性验证方法

为评估飞机碳排放水平并验证适航性,对国际民用航空组织最新的碳排放认证程序进行了研究。以比航程（SAR）和基准几何因子（RGF）组成的综合指标碳当量值作为评估适航性的度量,根据飞机最大起飞重量（MTOM）值选取试飞测量点,并确定对应的飞机碳当量值限制线。提出了一种基于快速存储记录器（QAR）数据的飞机碳当量水平快速评估方法,利用新服役飞机的QAR数据,使用多参数支持向量机回归（SVR）方法分别建立燃油消耗率和飞行速度相对于推力的修正关系,通过飞机总重换算求解3个飞行测量点条件下的SAR值,并计算碳当量值。使用一架B777-200新飞机的QAR数据进行实例分析,计算结果显示,该机型碳当量值为1.598 7,超出限制线20.5%。提出的基于QAR数据的碳当量值计算方法可以用于飞机碳排放水平的快速评估。      

低纬(海南)地区电离层偶发E层的潮汐类周期研究

基于低纬(海南)台站(19.5°N,109.1°E)电离层测高仪在2004年观测到的偶发E层(Es)临界频率(f₀E_s)和虚高(h'E_s)数据,利用谱分析方法,给出了中国低纬地区Es层在全年和不同季节内的短周期变化特性.对全年数据谱分析表明,Es层除具有非常强的24h周期外,还具有显著的12h和8h周期.对不同季节内两个参数的谱分析进一步表明,8h周期主要出现在f₀E_s参数的春秋分季和夏末及在h'E_s参数的几乎所有季节;6h周期主要出现在f₀E_s参数的11-12月.海南低纬Es层中具有显著的6h和8h周期特性,特别是这两个周期还能同时出现在冬季,这是以往研究中不曾发现的新结果.初步分析认为,Es层的6h和8h周期极可能是分别由1/4日和1/3日潮汐所造成的.      

Si对TiAl合金高温抗氧化性能的影响

利用X射线衍射、扫描电镜、能谱仪等手段研究了TiAl-Si(原子数分数为0~20%)合金在1 173 K大气中24 h的恒温氧化.结果表明:Si元素可以有效地提高TiAl合金的高温抗氧化性能;随着Si含量的增加,氧化膜厚度依次减薄,TiO₂的含量逐渐减少,Al₂O3的含量逐渐增加,添加到10%左右时就有连续致密的Al₂O₃保护膜形成;Si在0~20%的添加过程中并没发现Si的氧化物生成.分析表明:Si对抗氧化性能的贡献可归结于Si与Ti有很好的亲和力,可以有效地降低Ti离子的活度、阻碍Ti离子的向外扩散, 相对来说增强了Al离子的活度,促进连续致密的Al₂O₃保护膜生成.      

Enzyme activities and membrane lipids in Artemia cysts after a long duration space flight

In the Free Flyer Biostack Experiment (L.D.E.F. mission) investigations have shown that biological objects in a resting state can survive more than 5.5 years of exposure to the space factors in particular microgravity and cosmic rays. We have measured enzyme activities involved in metabolic pathways of sugar and lipid degradation and determined phospholipid composition. Pyruvate kinase and glucose-6-phosphate dehydrogenase activities in space-exposed cysts were higher than in earth controls after 1 hour incubation. In controls, total phospholipids remained unchanged, on the contrary they increased significantly in space-exposed cysts. The rate of metabolism of various phospholipid components was unchanged in controls allowing the development while the level of most of them decreased in space-exposed cysts except for phosphatidylcholine. Enzyme activities (acetylhydrolase, phospholipase A₂ and lyso phospholipase) involved in phospholipid degradation increased; however, activities were much higher in space-exposed cysts. In conclusion, the long duration space flight resulted in an increase of the metabolic activity correlated with a faster development within the first 20 hours of post flight incubation.     

S3 and S4 absorption cross sections in the range of 340 to 600 nm and evaluation of the S3 abundance in the lower atmosphere of Venus

S₃ absorption cross section equals 6×10⁻¹⁷ cm² at 400 nm, 6 × 10⁻¹⁹ cm² at 500 nm (less by a factor of 4 than that given by Sanko), 4×10⁻²⁰ cm² at 600 nm. That of S₄ equals 1.5 × 10⁻¹⁷ cm² at 450 nm, 8 × 10⁻¹⁷ cm² at 500 nm, and 4.7 × 10⁻¹⁷ cm² at 600 nm. Preliminary evaluation of the S₃ mixing ratio in the lower atmosphere of Venus is (8±3)×10⁻¹¹ at 5 to 25km according to the Venera 14 measurements and several times lower at the locations of the Veneras-11 and -13.     

变时延网络控制系统的鲁棒故障检测

针对具有时变时延的网络控制系统故障检测问题,提出了一种基于鲁棒H_∞思想的故障检测滤波器设计方法.将鲁棒H_∞故障检测问题归结为寻找滤波器参数矩阵,使得滤波系统内稳定并且满足鲁棒H_∞性能指标.根据残差评价函数和故障阈值判断系统是否存在故障.假设时变时延的上下界已知.基于时延相关Lyapunov-Krasovskii泛函方法给出了系统内稳定并且具有H_∞指标的时延相关条件.在外部控制输入、外界干扰和故障信号有界的情况下,所设计的故障检测滤波器能够保证生成的残差信号有界.针对HiMAT（Highly Maneuverable Technology）飞行器设计了故障检测滤波器,并通过仿真分析验证了所提出方法的有效性.     

受控生态生保系统内红萍供氧特性研究

研究红萍载人供O₂特征, 为红萍生物部件进行系统总体地面模拟试验及空间应用奠定基础,构建了受控生态生保系统密闭试验舱和红萍栽培装置, 在“红萍-鱼-人”共存情况下, 测定密闭舱内O₂, CO₂浓度的变化. 试验结果显示, 单位重量的鱼耗O₂量. 0805～0.0831 L·kg-1·h-1, 排放CO₂量为0.0705～0.0736 L·kg-1·h-1; 试验志愿者耗O₂量19.71 L·h-1, 呼吸释放CO₂量18.90 L·h-1. 人工光照保持7000～8000 lx条件下, 红萍的光合作用与人和鱼的呼吸作用相辅相成, 舱内O₂, CO₂浓度趋于平衡. 密闭舱内CO₂浓度升高对促进红萍群体净光合效率有明显效果, 红萍光合放O₂能力很强, 能有效促使密闭舱内O₂, CO₂浓度朝着有利于人生存的环境方向平衡, 进而验证了红萍的空间应用前景.      

The action of simulated and true weightlessness on the digestive tract of rats

Rats on board the Soviet Cosmos 936 satellite for 18$\text{1}\text{2}$ days showed a decreased glycoprotein secretion from the salivary mucous glands, stomach and intestine, and an increased leucine aminopeptidase and acid phosphatase content from the small intestine. Grimelius positive cells were activated. One group of rats were centrifuged at 1 g during the flight to simulate terrestrial gravity. Some investigations have suggested that under these conditions muscular and cardiac disorders diminished. In the digestive tract the benefits of centrifugation at 1 g are minimal and limited to a few glycoprotein components. The digestive changes are probably the expression of a stress response, unrelated to weightlessness. Similar changes, concomitant with a glycocorticoid hypersecretion, were found in rats after 15 days of hypokinesia on Earth. These digestive changes persisted even in adrenalectomized rats.