The International Space Station human life sciences experiment implementation process.

The selection, definition, and development phases of a Life Sciences flight research experiment has been consistent throughout the past decade. The implementation process, however, has changed significantly within the past two years. This change is driven primarily by the shift from highly integrated, dedicated research missions on platforms with well defined processes to self contained experiments with stand alone operations on platforms which are being concurrently designed. For experiments manifested on the International Space Station (ISS) and/or on short duration missions, the more modular, streamlined, and independent the individual experiment is, the more likely it is to be successfully implemented before the ISS assembly is completed. During the assembly phase of the ISS, science operations are lower in priority than the construction of the station. After the station has been completed, it is expected that more resources will be available to perform research. The complexity of implementing investigations increases with the logistics needed to perform the experiment. Examples of logistics issues include- hardware unique to the experiment; large up and down mass and volume needs; access to crew and hardware during the ascent or descent phases; maintenance of hardware and supplies with a limited shelf life,- baseline data collection schedules with lengthy sessions or sessions close to the launch or landing; onboard stowage availability, particularly cold stowage; and extensive training where highly proficient skills must be maintained. As the ISS processes become better defined, experiment implementation will meet new challenges due to distributed management, on-orbit resource sharing, and adjustments to crew availability pre- and post-increment.     

Sleep in space

Manned space flights have shown it is possible to sleep in microgravity. However, some sleep disturbances have been reported which influence performance of the crew and safety of space flight. This paper reviews the main studies of in-flight sleep in animal and man. Most disturbances are related to phase lags due to operational requirements. Factors which can disturb in-flight sleep are analysed: environmental factors. Some of them are secondary to space flight ergonomics. Conversely, effects of microgravity on light-dark alternance are less known and lead to interesting problems of fundamental research, psychological factors, especially during long duration flights.     

Human missions to Mars: new psychological challenges and research issues

Human exploratory missions to Mars represent the most exciting future vision of human space flight. With respect to the distance to travel and mission duration, these missions will provide unique psychological challenges that do not compare to any other endeavor humans ever have attempted. The present paper presents outcomes of two recent projects sponsored by the European Space Agency--Humex and Reglisse--where these challenges and risks have been analyzed in some detail, and where concepts for future research have been developed. This presentation involves three steps. At first, it will be shown that our current psychological knowledge derived from orbital spaceflight and analogue environments is not sufficient to assess the specific risks of mission into outer space. Secondly, new psychological challenges of missions to Mars will be identified with respect to three different areas: (1) individual adaptation and performance, (2) crew interactions, and (3) concept and methods of psychological countermeasures. Finally, different options and issues of preparatory psychological research will be discussed.     

Considerations for development of countermeasures for physiological decrements associated with long-duration space missions

Countermeasures are necessary to offset or minimize the deleterious changes in human physiology resulting from long duration space flight. Exposure to microgravity alters musculoskeletal, neurosensory, and cardiovascular systems with resulting deconditioning that may compromise crew health and performance. Maintaining health and fitness at acceptable levels is critical for preserving performance capabilities required to accomplish specific mission tasks (e.g.—extravehicular activity) and to optimize performance after landing. To enable the goals of the exploration program, NASA is developing a new suite of exercise hardware such as the improved loading device, the SchRED. This presentation will update the status of current countermeasures, correlate hardware advances with improvements in exercise countermeasures, and discuss future activities for safe and productive exploration missions.     

Short profile for the human spacecraft Soyuz-TMA rendezvous mission to the ISS

Reduction of flight duration after insertion till docking to the ISS is considered. In the beginning of the human flight era both the USSR and the USA used short mission profiles due to limited life support resources. A rendezvous during these missions was usually achieved in 1–5 revolutions. The short-term rendezvous were made possible by the coordinated launch profiles of both rendezvousing spacecraft, which provided specific relative position of the spacecraft or phase angle conditions. After the beginning of regular flights to the orbital stations these requirements became difficult to fulfill. That is why it was decided to transfer to 1- or 2-day rendezvous profile. The long stay of a crew in a limited habitation volume of the Soyuz-TMA spacecraft before docking to the ISS is one of the most strained parts of the flight and naturally cosmonauts wish to dock to the ISS as soon as possible. As a result of previous studies the short four-burn rendezvous mission profile with docking in a few orbits was developed. It is shown that the current capabilities of the Soyuz-FG launch vehicle and the Soyuz-TMA spacecraft are sufficient to provide for that. The first test of the short rendezvous mission during Progress cargo vehicle flight to the ISS is planned for 2012. Possible contingencies pertinent to this profile are described. In particular, in the majority of the emergency cases there is a possibility of an urgent transfer to the present 2-day rendezvous profile. Thus, the short mission will be very flexible and will not influence the ISS mission plan. Fuel consumption for the nominal and emergency cases is defined by statistical simulation of the rendezvous mission. The qualitative analysis of the short-term and current 2-day rendezvous missions is performed.     

Psycho-social training for man in space.

In preparation for the international manned space station various international and national space agencies are already participating with the Russian MIR programme with short, medium, and long term presence on the MIR station. Although selection criteria for all crew include careful psychological screening, with some effort also regarding team build-up, this has proved insufficient; moreover. little or no effort is expended in the area of psycho-social- or team training. This paper propounds the authors' thesis that, in addition to the steps already being taken, psycho-social training is essential for long-duration flight. A concrete proposal is made for such a training program, with an overview of how such a program will look like; examples of past applications are given.     

Life support system development in West Germany

The delivery of fully qualified Environmental Control and Life Support System (ECLS) flight hardware for the Spacelab Flight Unit was completed in 1979, and the first Spacelab flight is scheduled for mid 1983.

With Spacelab approaching its operational stage, ESA has initiated the Follow-on Development Programme. The future evolution of Spacelab elements in a continued U.S./European cooperation is obviously linked to the U.S. STS evolution and leads from the sortie-mode improvements (Initial Step) towards pallet systems and module applications in unmanned and manned space platforms (Medium and Far Term Alternatives).

Extensive studies and design work have been accomplished on life support systems for Life Sciences Laboratories (Biorack) in Spacelab (incubators and holding units for low vertebrates).

Future long term missions require the implementation of closed loop life support systems and in order to meet the long range development cycle feasibility studies have been performed. Terrestrial applications of the life support technologies developed for space have been successfully implemented.     

The perfect boring situation—Addressing the experience of monotony during crewed deep space missions through habitability design

In contemporary orbital missions, workloads are so high and varied that crew may rarely experience stretches of monotony. However, in historical long duration missions, occurrences of monotony were, indeed, reported anecdotally by crew. Of the effective countermeasures that appear to be at hand, many rely on visual or logistical proximity to the Earth, and are not feasible in the remote context of an extended deep space mission scenario. There, particularly in- and outbound cruising stages would be characterised by longer, comparably uneventful periods of low workload, coupled with confinement and unchanging vehicle surroundings.     

The future of space medicine.

In November 2000, the National Aeronautics and Space Administration (NASA) and its partners in the International Space Station (ISS) ushered in a new era of space flight: permanent human presence in low-Earth orbit. As the culmination of the last four decades of human space flight activities. the ISS focuses our attention on what we have learned to date. and what still must be learned before we can embark on future exploration endeavors. Space medicine has been a primary part of our past success in human space flight, and will continue to play a critical role in future ventures. To prepare for the day when crews may leave low-Earth orbit for long-duration exploratory missions, space medicine practitioners must develop a thorough understanding of the effects of microgravity on the human body, as well as ways to limit or prevent them. In order to gain a complete understanding and create the tools and technologies needed to enable successful exploration. space medicine will become even more of a highly collaborative discipline. Future missions will require the partnership of physicians, biomedical scientists, engineers, and mission planners. This paper will examine the future of space medicine as it relates to human space exploration: what is necessary to keep a crew alive in space, how we do it today, how we will accomplish this in the future, and how the National Aeronautics and Space Administration (NASA) plans to achieve future goals.     

The Russian experience in medical care and health maintenance of the International Space Station crews

The main purpose of the medical support system aboard International Space Station (ISS) is crew health maintenance and high level of work capability assurance prior to during and after in space flights. In the present communication the Russian point of view dealing with the problems and achievements in this branch is presented. An overview on medical operations during flight and after finalization of the space missions based on Russian data of crew health and environment state monitoring, as well as data on the inflight countermeasures (prophylaxis) jointly with data on operational problems that are specific to ISS is presented. The report summarizes results of the medical examination of Russian members of the ISS and taxi crews during and after visits to the ISS.     

Martian manned mission: what cosmonauts think about this

The experience of cosmonauts who have participated in long-duration space flights has great value for solving problems connected with realization of the Martian manned mission. To study the cosmonauts’ opinion in relation to the Martian crew size, professional specialization of crewmembers, duration of their joint training, the possible sources of psychological tension in the flight, etc., a special questionnaire has been developed. The results of the 11 Russian cosmonauts’ survey are presented in this article.     

From Earth's orbit to the outer planets and beyond: Psychological issues in space

Current planning for the first interplanetary expedition to Mars envisions a crew of 6 or 7 people and a mission duration of around 2.5 years. However, this time frame is much less than that expected on expeditions to the outer solar system, where total mission durations of 10 years or more are likely. Although future technological breakthroughs in propulsion systems and space vehicle construction may speed up transit times, for now we must realistically consider the psychological impact of missions lasting for one or more decades.Available information largely deals with on-orbit missions. In research that involved Mir and ISS missions lasting up to 7 months, our group and others have studied the effects of psychological and interpersonal issues on crewmembers and on the crew-ground relationship. We also studied the positive effects of being in space. However, human expeditions to the outer planets and beyond will introduce a number of new psychological and interpersonal stressors that have not been experienced before. There will be unprecedented levels of isolation and monotony, real-time communication with the Earth will not be possible, the crew will have to work autonomously, there will be great dependence on computers and other technical resources located on board, and the Earth will become an insignificant dot in space or will even disappear from view entirely.Strategies for dealing with psychological issues involving missions to the outer solar system and beyond will be considered and discussed, including those related to new technologies being considered for interstellar missions, such as traveling at a significant fraction of the speed of light, putting crewmembers in suspended animation, or creating giant self-contained generation ships of colonists who will not return to Earth.     

Countermeasure of the negative effects of weightlessness on physical systems in long-term space flights

The system of countermcasure of microgravity effects has been developed in Russia that allowed to perform safely long-term space flights. This system that includes different means and methods such as special regimens of physical exercises, axial loading (“Pingiun”) and antigravity suits, low body negative pressure device (LBNP, “Chibis”) and “cuffs” and others has been used with certain variations at certain stages of flight in 27 successfully accomplished space flights that lasted from 60 to 439 days. The pre-, in- and postflight studies performed in 57 crew members of these flights have shown that the system of countermeasure is effective in preventing or diminishing to a great extent almost all the negative effects of weightlessness in flights of a year and more duration and that the intensity and duration of changes recorded in different body systems after flights do not correlate significantly to flight durations, correlating strongly to the volume and intensity of physical exercises used during flight and especially during concluding stage of it.     

Summary of medical investigations in the U.S.S.R. manned space missions.

The results of biomedical investigations carried out in the U.S.S.R. manned space missions are discussed. Their basic result is well-documented evidence that man can perform space flights of long duration. The investigations have demonstrated no direct correlation between inflight or postflight physiological reactions of crewmembers and flight duration. In all likelihood, this can be attributed to the fact that special exercises done inflight efficiently prevented adverse effects of weightlessness. However, human reactions to weightlessness need further study. They include negative calcium balance and anemia as well as vestibulo-autonomic disorders shown by crewmembers at early stages of weightlessness. Attention should be given to psychological, social-psychological and ethical problems that may also limit further increase in flight duration.     

Some Results of Monitoring the Radiation Conditions onboard the <Emphasis Type="Italic">International Space Station</Emphasis> (2000–2003)

For a reliable prediction of dose loads on a crew and its habitation environment, which, so far, cannot be calculated with sufficient accuracy, an experimental study of the dynamics of radiation situation characteristics in the modules of the manned International Space Station (ISS) is carried out. The results of prompt monitoring and individual dose control of the crews of seven basic missions in the period of flight from August 1, 2000, to October 28, 2003, are presented. This period of time coincided with the maximum phase of solar activity. On the basis of comparing the measurement data, it was shown that the value of an accumulated individual absorbed dose did not exceed the limits of readings of a two-channel standard R-16 radiometer. The power of the radiation dose absorbed by crew members lies within the range 0.017–0.02 cGy/day and mainly depends on the solar activity level.     

Revolutionary systems and technologies for missions to the outer planets

The Advanced Deep Space System Development Program is managed by the Jet Propulsion Laboratory for NASA and is also called X2000. X2000 is organized to create advanced flight and ground systems for the exploration of the outer planets and beyond; it has been created to develop the engineering elements of flight and ground systems. Payloads will be developed by another team. Each X2000 delivery gets its requirements from a set of planned missions, or “mission customers”.The X2000 First Delivery Project supports missions to the Sun (to 4 solar radii), Europa (looking for a liquid ocean), Mars (in support of several Mars missions including a sample return), a comet (including a sample return), and Pluto followed by a trip into the Kuiper belt. This set of missions leads to some outstanding requirements:

• 1.1. Long-life (10–12 years)
• 2.2. Total Ionizing Dose of 4 Mrad (for a Europa Orbiter)
• 3.3. Average power consumption less than or equal to 150 Watts
• 4.4. Autonomous operations that result in an extreme reduction in operations costs

This paper describes the X2000 first delivery and its technologies following a brief overview of the program.     

Long-term biological investigations in space

Missions in space within the next two decades will be of longer duration than those carried out up to the present time, and the effects of such long-term flights on biological organisms are unknown. Results of biological experiments that have been performed to date cannot be extrapolated to results in future flights because of the unknown influence of adaptation over a long period of time. Prior experiments with Axolotl, fishes, and vertebrates by our research team (in part with sounding rockets) showed that these specimens did not appear to be suitable for long-term missions on which minimization of expense, technique, and energy is required. Subsequent investigations have shown the suitability of the leech (Hirudo medicinalis), which consumes blood of mammals up to ten times its own weight (1 g) and can live more than 2 years without further food supply. Emphasis in the experiments with Hirudo medicinalis is placed on metabolic rhythm and motility. Resorption and diffusion in tissue, development, and growth under long-term effects of cosmic proton radiation and zero-gravity are other focal points. The constancy of cellular life in the mature animals is a point in favor of these specimens. We have also taken into account the synergistic effects of the space environment on the problems just mentioned. The life-support system constructed for the leech has been tested successfully in four sounding rocket flights and, on that basis, has been prepared for a long-term mission. Long-term investigations out of the terrestrial biosphere will provide us with information concerning the degree of adaptation of certain physiological and biochemical functions and as to what extent biological readjustment or repair processes can occur under the specific stress conditions of space flight.     

Women and couples in isolated extreme environments: applications for long-duration missions

Expedition teams provide a number of analogs relevant to crew selection for long-duration space missions. Three groups were studied that varied in team composition. Group 1 was a two woman international dyad that traversed the Antarctic continent in 97 days. Similarities in problem solving approach, respect for each other's opinions, and a collaborative process of decision making were evident. Group 2 was composed of four women, all from different countries, engaged in a six week trek across Greenland. The most important factors in overcoming interpersonal difficulties and contributing to the successful completion of the expedition were mutual respect and motivation to maintain positive and supportive relationships. Group 3 consisted of three married couples from different countries icelocked on a boat in the High Arctic for a 9 month period. The emotional support of and ability to confide in their partner were extremely important in alleviating interpersonal tensions, and contributed to the generally effective functioning of the group. Women add an element of emotional support and help to other team members that is not as evident in all-male groups. Selection of couples with strong bonds to each other is another paradigm for crew selection for extended missions.