Radiation measured during ISS-Expedition 13 with different dosimeters

Radiation in low Earth orbit (LEO) is mainly composed of galactic cosmic rays (GCR), solar energetic particles and particles in SAA (South Atlantic Anomaly). The biological impact of space radiation to astronauts depends strongly on the particles’ linear energy transfer (LET) and is dominated by high LET radiation. It is important to measure the LET spectrum for the space radiation field and to investigate the influence of radiation on astronauts. At present, the preferred active dosimeters sensitive to all LET are the tissue equivalent proportional counter (TEPC) and the silicon detectors in various configurations; the preferred passive dosimeters are CR-39 plastic nuclear track detectors (PNTDs) sensitive to high LET and thermoluminescence dosimeters (TLDs) as well as optically stimulated luminescence dosimeters (OSLDs) sensitive to low LET. The TEPC, CR-39 PNTDs, TLDs and OSLDs were used to investigate the radiation field for the ISS mission Expedition 13 (ISS-12S) in LEO. LET spectra and radiation quantities (fluence, absorbed dose, dose equivalent and quality factor) were measured for the space mission with different dosimeters. This paper introduces the role of high LET radiation in radiobiology, the operational principles for the different dosimeters, the LET spectrum method using CR-39 detectors, the method to combine the results measured with TLDs/OSLDs and CR-39 PNTDs, and presents the LET spectra and the radiation quantities measured and combined.     

Biological monitoring of radiation exposure.

Complementary to physical dosimetry, biological dosimetry systems have been developed and applied which weight the different components of environmental radiation according to their biological efficacy. They generally give a record of the accumulated exposure of individuals with high sensitivity and specificity for the toxic agent under consideration. Basically three different types of biological detecting/ monitoring systems are available: (i) intrinsic biological dosimeters that record the individual radiation exposure (humans, plants, animals) in measurable units. For monitoring ionizing radiation exposure, in situ biomarkers for genetic (e.g. chromosomal aberrations in human lymphocytes, germ line minisatellite mutation rates) or metabolic changes in serum, plasma and blood (e.g. serum lipids, lipoproteins, lipid peroxides, melatonin, antibody titer) have been used. (ii) Extrinsic biological dosimeters/indicators that record the accumulated dose in biological model systems. Their application includes long-term monitoring of changes in environmental UV radiation and its biological implications as well as dosimetry of personal UV exposure. (iii) Biological detectors/biosensors for genotoxic substances and agents such as bacterial assays (e.g. Ames test, SOS-type test) that are highly sensitive to genotoxins with high specificity. They may be applicable for different aspects in environmental monitoring including the International Space Station.     

辐射变色薄膜剂量计性能测试及加速器应用

本课题的目的是建立用于辐射加工高剂量水平吸收剂量测量的辐射变色薄膜剂量计。通过系统研究,批量制备了以尼龙为基材,副品红氰化物为染料的辐射变色薄膜剂量计。为了验证批制辐射变色薄膜剂量测量的可靠性,选择了国际上应用较广的FWT-60膜及丙氨酸薄膜剂量计与本实验室批制的辐射变色薄膜开展实验室内剂量比对,比对结果均在±4%内符合,归一化偏差En绝对值均小于1。通过在加速器上进一步应用实验表明批制辐射变色薄膜可用于电子束辐照参数测量。     

卫星舱内两类剂量计测量结果的比较

本文利用1994年和1996年两次返回式卫星的搭载条件对舱内辐射剂量进行了对比测量．通过对比测量,研究不同掺杂、不同厚度LiF剂量计测量空间辐射剂量的特点;研究GM计数管计数和LiF剂量间的转换系数以及转换系数随屏蔽状况的变化;由剂量和GM计数研究粒子平均碰撞阻止本领的估计方法．结果表明,不同掺杂、不同厚度的LiF剂量计测量结果间无显著差异,而转换系数几乎不受舱内位置和屏蔽状态的影响．不同厚度LiF剂量计,不同屏蔽状态的GM计数管计数和剂量—计数转换系数的比较研究以及对粒子平均碰撞阻止本领的估计表明,舱内辐射剂量起决定作用的是高能粒子成分,其平均碰撞阻止本领估计约为5MeV／cm．     

Austrian dose measurements onboard space station MIR and the International Space Station--overview and comparison.

The Atominstitute of the Austrian Universities has conducted various space research missions in the last 12 years in cooperation with the Institute for Biomedical Problems in Moscow. They dealt with the exact determination of the radiation hazards for cosmonauts and the development of precise measurement devices. Special emphasis will be laid on the last experiment on space station MIR the goal of which was the determination of the depth distribution of absorbed dose and dose equivalent in a water filled Phantom. The first results from dose measurements onboard the International Space Station (ISS) will also be discussed. The spherical Phantom with a diameter of 35 cm was developed at the Institute for Biomedical Problems and had 4 channels where dosimeters can be exposed in different depths. The exposure period covered the timeframe from May 1997 to February 1999. Thermoluminescent dosimeters (TLDs) were exposed inside the Phantom, either parallel or perpendicular to the hull of the spacecraft. For the evaluation of the linear energy transfer (LET), the high temperature ratio (HTR) method was applied. Based on this method a mean quality factor and, subsequently, the dose equivalent is calculated according to the Q(LET infinity) relationship proposed in ICRP 26. An increased contribution of neutrons could be detected inside the Phantom. However the total dose equivalent did not increase over the depth of the Phantom. As the first Austrian measurements on the ISS dosimeter packages were exposed for 248 days, starting in February 2001 at six different locations onboard the ISS. The Austrian dosimeter sets for this first exposure on the ISS contained five different kinds of passive thermoluminescent dosimeters. First results showed a position dependent absorbed dose rate at the ISS.     

法拉第简法校准丙氨酸对质子吸收剂量技术研究

从低能质子入手,采用基于法拉第简的质子吸收剂量校准方法,满足空间辐射对质子吸收剂量的校准需求。建立了一套法拉第筒法对薄膜剂量计的质子吸收剂量校准系统,该系统由束斑观测单元、束流散射单元、束流监测单元、旋转靶室以及法拉第筒探测单元组成,同时开展了法拉第筒法对丙氨酸薄膜剂量计的质子吸收剂量校准技术研究。     

γ-H2AX as a biomarker of DNA damage induced by ionizing radiation in human peripheral blood lymphocytes and artificial skin

Ionizing radiation (IR) exposure is inevitable in our modern society and can lead to a variety of deleterious effects including cancer and birth defects. A reliable, reproducible and sensitive assessment of exposure to IR and the individual response to that exposure would provide much needed information for the optimal treatment of each donor examined. We have developed a diagnostic test for IR exposure based on detection of the phosphorylated form of variant histone H2AX (γ-H2AX), which occurs specifically at sites of DNA double-strand breaks (DSBs). The cell responds to a nascent DSB through the phosphorylation of thousands of H2AX molecules flanking the damaged site. This highly amplified response can be visualized as a γ-H2AX focus in the chromatin that can be detected in situ with the appropriate antibody. Here we assess the usability of γ-H2AX focus formation as a possible biodosimeter for human exposure to IR using peripheral blood lymphocytes irradiated ex vivo and three-dimensional artificial models of human skin biopsies. In both systems, the tissues were exposed to 0.2–5 Gy, doses of IR that might be realistically encountered in various scenarios such as cancer radiotherapies or accidental exposure to radiation. Since the γ-H2AX response is maximal 30 min after exposure and declines over a period of hours as the cells repair the damage, we examined the time limitations of the useful detectability of γ-H2AX foci. We report that a linear response proportional to the initial radiation dose was obtained 48 and 24 h after exposure in blood samples and skin cells respectively. Thus, detection of γ-H2AX formation to monitor DNA damage in minimally invasive blood and skin tests could be useful tools to determine radiation dose exposure and analyze its effects on humans.     

便携式γ射线照射装置散射辐射特性研究

便携式γ射线照射装置对于提高固定式X、γ辐射剂量仪检定率、解决现场校准难题具有重要意义,利用蒙特卡罗模拟与实验测量协同开展便携式γ射线照射装置散射辐射特性研究。结果表明：蒙特卡罗方法可以模拟得到装置自身的散射辐射,实验测量只能获得照射装置以外辐射场中的散射辐射。利用MCNP程序F4卡和CF卡得到距放射源1 m处照射装置自身的散射贡献分别为13.07 %和4.55 %;反平方律实验和移出实验得到辐射场散射辐射贡献分别为0.2 %和3.94 %,满足ISO 4037-1:2019和GB/T 12162.1-2000的要求。该装置可用于固定式X、γ辐射剂量仪的现场校准。     

Biological dosimetry to determine the UV radiation climate inside the MIR station and its role in vitamin D biosynthesis

The vitamin D synthesis in the human skin, is absolutely dependent on UVB radiation. Natural UVB from sunlight is normally absent in the closed environment of a space station like MIR. Therefore it was necessary to investigate the UV radiation climate inside the station resulting from different lamps as well as from occasional solar irradiation behind a UV-transparent quartz window. Biofilms, biologically weighting and integrating UV dosimeters successfully applied on Earth (e.g. in Antarctica) and in space (D-2, Biopan I) were used to determine the biological effectiveness of the UV radiation climate at different locations in the space station. Biofilms were also used to determine the personal UV dose of an individual cosmonaut. These UV data were correlated with the concentration of vitamin D in the cosmonaut's blood and the dietary vitamin D intake. The results showed that the UV radiation climate inside the Mir station is not sufficient for an adequate supply of vitamin D, which should therefore be secured either by vitamin D supplementat and/or by the regular exposure to special UV lamps like those in sun-beds. The use of natural solar UV radiation through the quartz window for ‘sunbathing’ is dangerous and should be avoided even for short exposure periods.     

Verification of shielding effect by the water-filled materials for space radiation in the International Space Station using passive dosimeters

The dose reduction effects for space radiation by installation of water shielding material (“protective curtain”) of a stack board consisting of the hygienic wipes and towels have been experimentally evaluated in the International Space Station by using passive dosimeters. The averaged water thickness of the protective curtain was 6.3 g/cm². The passive dosimeters consisted of a combination of thermoluminescent detectors (TLDs) and plastic nuclear track detectors (PNTDs). Totally 12 passive dosimeter packages were installed in the Russian Service Module during late 2010. Half of the packages were located at the protective curtain surface and the other half were at the crew cabin wall behind or aside the protective curtain. The mean absorbed dose and dose equivalent rates are measured to be 327 μGy/day and 821 μSv/day for the unprotected packages and 224 μGy/day and 575 μSv/day for the protected packages, respectively. The observed dose reduction rate with protective curtain was found to be 37 ± 7% in dose equivalent, which was consistent with the calculation in the spherical water phantom by PHITS. The contributions due to low and high LET particles were found to be comparable in observed dose reduction rate. The protective curtain would be effective shielding material for not only trapped particles (several 10 MeV) but also for low energy galactic cosmic rays (several 100 MeV/n). The properly utilized protective curtain will effectively reduce the radiation dose for crew living in space station and prolong long-term mission in the future.     

Monitoring of environmental UV radiation by biological dosimeters.

As a consequence of the stratospheric ozone layer depletion biological systems can be damaged due to increased UV-B radiation. The aim of biological dosimetry is to establish a quantitative basis for the risk assessment of the biosphere. DNA is the most important target molecule of biological systems having special sensitivity against short wavelength components of the environmental radiation. Biological dosimeters are usually simple organisms, or components of them, modeling the cellular DNA. Phage T7 and polycrystalline uracil biological dosimeters have been developed and used in our laboratory for monitoring the environmental radiation in different radiation conditions (from the polar to equatorial regions). Comparisons with Robertson-Berger (RB) meter data, as well as with model calculation data weighted by the corresponding spectral sensitivities of the dosimeters are presented. Suggestion is given how to determine the trend of the increase in the biological risk due to ozone depletion.     

一种基于系留无人机的图像遥测系统设计

针对海上船舶甲板的监控需求,本文提出了一种基于系留无人机的图像遥测系统设计方法,即通过系留无人机上的图像采集装置对被监控目标进行视频信号实时采集、压缩,再经过遥测装置的编码、调制、放大后由天线进行辐射,最后由数十公里外的遥测接收机完成接收、解调、解码,可实时显示船舶甲板图像信息。文中介绍了系统的软硬件组成、关键设备的设计方法、综合性能的分析,对相关图像遥测技术应用有一定参考意义。     

一种基于系留无人机的图像遥测系统设计

针对海上船舶甲板的监控需求,本文提出了一种基于系留无人机的图像遥测系统设计方法,即通过系留无人机上的图像采集装置对被监控目标进行视频信号实时采集、压缩,再经过遥测装置的编码、调制、放大后由天线进行辐射,最后由数十公里外的遥测接收机完成接收、解调、解码,可实时显示船舶甲板图像信息。文中介绍了系统的软硬件组成、关键设备的设计方法、综合性能的分析,对相关图像遥测技术应用有一定参考意义。     

Preliminary total dose measurements on LDEF.

After spending nearly six years in Earth orbit twenty stacks consisting of radiation detectors and biological objects are now back on Earth. These stacks (Experiment A0015 Free Flyer Biostack) are part of the fifty seven science and technology experiments of the Long Duration Exposure Facility (LDEF) of NASA. The major objectives of the Free Flyer Biostack experiments are to investigate the biological effectiveness of single heavy ions of the cosmic radiation in various biological systems and to provide information about the spectral composition of the radiation field and the total dose received in the LDEF orbit. The Biostacks are mounted in two different locations of the LDEF. Up to three layers of Lithium fluoride thermoluminescence dosimeters (TLD) of different isotopic composition were located at different depths of some Biostacks. The preliminary analysis of the TLD yields maximum absorbed dose rates of 2.24 mGy day-1 behind 0.7 g cm-2 shielding and 1.17 mGy day-1 behind 12 g cm-2 shielding. A thermal neutron fluence of 1.7 n cm-2 s-1 is determined from the differences in absorbed dose for different isotopic mixtures of Lithium. The results of this experiment on LDEF are especially valuable and of high importance since LDEF stayed for about six years in the prospected orbit of the Space Station Freedom. There is no knowledge about the effectiveness of the space radiation in long-term spaceflights and the dosimetric data in this orbit are scarce.     

Quantification of biologically effective environmental UV irradiance.

To determine the impact of environmental UV radiation on human health and ecosystems demands monitoring systems that weight the spectral irradiance according to the biological responses under consideration. In general, there are three different approaches to quantify a biologically effective solar irradiance. (i) weighted spectroradiometry where the biologically weighted radiometric quantities are derived from spectral data by multiplication with an action spectrum of a relevant photobiological reaction, e.g. erythema, DNA damage, skin cancer, reduced productivity of terrestrial plants and aquatic foodweb, (ii) wavelength integrating chemical-based or physical dosimetric systems with spectral sensitivities similar to a biological response curve, and (iii) biological dosimeters that directly weight the incident UV components of sunlight in relation to the effectiveness of the different wavelengths and to interactions between them. Most biological dosimeters, such as bacteria, bacteriophages, or biomolecules, are based on the UV sensitivity of DNA. If precisely characterized, biological dosimeters are applicable as field and personal dosimeters.     

基于ANN的故障诊断专家系统的应用研究

介绍一种基于ANN的设备故障智能诊断专家系统模型,探讨了该模型的基本结构和相应的推理机制及故障诊断策略,提出将设备故障分为低层故障和高层故障的思想以及相应的分层诊断、分块进行的诊断策略,并以MK9-5卷接机组为诊断对象,研究了该模型及诊断方法在设备故障智能诊断中的具体应用.     

Instrumentation for investigation of the depth-dose distribution by the Liulin-5 instrument of a human phantom on the Russian segment of ISS for estimation of the radiation risk during long term space flights.

Described is the Liulin-5 experiment and instrumentation, developed for investigation of the space radiation doses depth distribution in a human phantom on the Russian Segment of the International Space Station (ISS). Liulin-5 experiment is a part of the international project MATROSHKA-R on ISS. The experiment MATROSHKA-R is aimed to study the depth dose distribution at the sites of critical organs of the human body, using models of human body-anthropomorphic and spherical tissue-equivalent phantoms. The aim of Liulin-5 experiment is long term (4-5 years) investigation of the radiation environment dynamics inside the spherical tissue-equivalent phantom, mounted in different places of the Russian Segment of ISS. Energy deposition spectra, linear energy transfer spectra, flux and dose rates for protons and the biologically-relevant heavy ion components of the galactic cosmic radiation will be measured simultaneously with near real time resolution at different depths of the phantom by a telescope of silicon detectors. Data obtained together with data from other active and passive dosimeters will be used to estimate the radiation risk to the crewmembers, verify the models of radiation environment in low Earth orbit, validate body transport model and correlate organ level dose to skin dose. Presented are the test results of the prototype unit. The spherical phantom will be flown on the ISS in 2004 year and Liulin-5 experiment is planned for 2005 year.     

Low fluence.

The question of the appropriate extrapolation to low dose has long been a subject of controversy. A linear no-threshold model is favored by regulatory bodies as the basis of RBE assignments and estimates of radiation hazards to the general population. This model is largely supported by extensive application of the linear-quadratic survival formula "fitted" statistically to a wide variety of experimental data obtained at doses typically exceeding 1 Gy, and then extrapolated to mGy for practical applications, and even to the prediction of hazards from single electrons. Such extrapolations are questionable at best, and may even prove hazardous for risk evaluations. Fluence and geometry rather than dose based data are proposed as a basis for a limiting "threshold" for a "low dose" extrapolation. The proposed threshold is one where the fluence of particles is one per square micron, where on average only 2/3 of the 1 micrometers2 pixels covering an irradiated area are traversed by one or more particles. The corresponding dose threshold is determined by the LET of the bombarding radiation. For relativistic electrons this dose is about 0.032 Gy.     

空间电子设备辐射屏蔽方法的研究与软件实现

研究了空间电子设备辐射屏蔽分析的方法,利用计算机辅助设计(CAD)技术和软件开发工具,将复杂繁琐的计算过程编写成流程化的程序;利用三维CAD技术的二次开发功能,从Candence软件生成的记录文件中提取出信息,在计算机图形环境中高效自动地生成电路板模型;借助计算机交互技术,实现剂量点坐标的自动提取和保存;利用办公软件个性化设置功能,设计出提取背景信息的接口,实现了最终报告文档的自动生成.开发出的软件最终成功地实现了在不同结构和布局的空间电子设备中,在不同方向和位置上累积的空间带电粒子剂量值的计算,为电子设备结构的抗辐射设计提供了参考和依据.     

Investigation of dose and flux dynamics in the Liulin-5 dosimeter of the tissue-equivalent phantom onboard the Russian segment of the International Space Station.

Described is the Liulin-5 active dosimetric telescope designed for measurement of the space radiation dose depth-distribution in a human phantom on the Russian Segment of the International Space Station (ISS). The Liulin-5 experiment is a part of the international project MATROSHKA-R on ISS. The MATROSHKA-R project is aimed to study the depth-dose distribution at the sites of critical organs of the human body, using models of human body-anthropomorphic and spherical tissue-equivalent phantoms. The aim of Liulin-5 experiment is a long term (4-5 years) investigation of the radiation environment dynamics inside the spherical tissue-equivalent phantom, mounted in different compartments. Energy deposition spectra, linear energy transfer spectra, and flux and dose rates for charged particles will be measured simultaneously with near real time resolution at different depths of the phantom by means of three silicon detectors. Data obtained together with data from other active and passive dosimeters will be used to estimate the radiation risk to the crewmembers, which verify the models of radiation environment in low Earth orbit. Presented are the test results of the prototype unit. Liulin-5 will be flown on the ISS in the year 2003.