Endocrine responses in long-duration manned space flight

The bioassay of body fluids experiment is designed to evaluate the biochemical adaptation resulting from extended exposure to space flight environment by identifying changes in hormonal and associated fluid and electrolyte parameters reflected in the blood and urine of the participating crewmen. The combined stresses of space flight include weightlessness, acceleration, confinement, restraint, long-term maintenance of high levels of performance, and possible desynchronosis. Endocrine measurements to assess the physiological cost of these stresses have been considered from two aspects. Fluid and electrolyte balance have been correlated with weight loss, changes in the excretion of aldosterone and vasopressin and fluid compartments. The second area involves the estimation of the physiological cost of maintaining a given level of performance during space flight by analysis of urinary catecholamines and cortisol. Inter-individual variability was demonstrated in most experimental indices measured; however, constant patterns have emerged which include: body weight change; increases in plasma renin activity; elevations in urinary catecholamines, ADH, aldosterone and cortisol concentrations. Plasma cortisol decreases in immediate postflight samples with subsequent increase in 24-hour urines. The measured changes are consistent with the prediction that a relative increase in thoracic blood volume upon transition to the zero-gravity environment is interpreted as a true volume expansion resulting in an osmotic diuresis. This diuresis in association with other factors ultimately results in a reduction in intravascular volume, leading to an increase in renin and a secondary aldosteronism. Once these compensatory mechanisms are effective in reestablishing positive water balance, the crewmen are considered to be essentially adapted to the null-gravity environment. Although the physiological cost of this adaptation must reflect the electrolyte deficit and perhaps other factors, it is assumed that the compensated state is adequate for the demands of the environment; however, this new homeostatic set is not believed to be without physiological cost and could, except with proper precautions, reduce the functional reserve of exposed individuals.     

Structural and functional changes in man accompanying the weightlessness in "Skylab" flights: a mathematical approach

The present paper reports a kinetic analysis of changes of some physiological parameters, obtained from international literature, after changes in gravitational environment. The overall phenomenology of the adaptation to weightlessness is characterized by a rapid process followed by a slow one. The two processes show half time values differing by about five times. Also in the case of readaptation to gravity, after recovery on the Earth, two well resolved processes, showing different half time values, are observed. It is of interest to notice that the rate of response to weightlessness is lower than that to gravity. Of course, the half time values observed depend on the different physiological parameters considered. In any case, the experimental data suggest a general trend of many adaptive changes, that may all be described by a simple mathematical model.     

Effect of physical fitness and training on physiological responses to hypogravity.

The studies on the orthostatic tolerance during the hypodynamics exposure seem to be significant in connection with the selection, training and health maintenance of astronauts. Using male human subjects of various physical fitness levels, fluctuations of their physical fitness through 2 weeks of vigorous athletic training were measured in many parameters. For some of the subjects, the effects of 6 hr thermal neutral water immersion exposure in head out supine position on the physical fitness parameters and orthostatic tolerability were compared before training with after training. The results obtained were as follows: (1) Before training, orthostatic tolerability before hypodynamics exposure increased, following the physical fitness levels; the value after the hypodynamics exposure decreased in all the cases, but no differences were observed between the physical fitness levels. (2) As a result of training an increase of the physical fitness capacity was observed. The increase of orthostatic tolerability before hypodynamics exposure was noticed except for athletes. (3) Before hypodynamics exposure the urinary excretion of noradrenaline on non-athlete subjects increased as the physicsl fitness level increased. The values were decreased by physical training, the more so the better the physical fitness. After hypodynamics exposure the same relation was observed. But for athletes the values remain more stable and the decrease by hypodynamics exposure was not so distinctive. Such decreased reaction to hypodynamic conditions seems to reveal the neuro hormonal mechanism for the detrimental adaptation of athletes to hypodynamics. These results suggest that stable athletes do not always have low orthostatic tolerability, but do not respond well to hypodynamic conditions, at least from the orthostatic point of view. The mechanism seems related to sympathetic nerve activity.     

Changes in chromatin and nucleic acids in rat tissues after two-week spaceflight

The quantitative changes in nucleic acids and chromatin breakdown were followed in blood, thymus and spleen in rats after 14 day flights on board the biosatellites Cosmos-1887 and Cosmos-2044. Quantitative nucleic acid changes within 8-11 h after landing were only mild, most statistically non-significant. An analysis at 48 h after landing showed a marked decrease in a total content of DNA and RNA in spleen and thymus. Within 8-11 h after landing, the symptoms of chromatin breakdown were found as is seen in an increased concentration of its fragments-polydeoxyribonucleotides. The obtained results show that a partial adaptation to microgravity occurs up to flight day 14 in lymphoid organs. Adaptation is accompanied with a reappearing of the sensitive cells. Their chromatin breaks down, then, in a final phase of flight due to hypergravity stress manifesting itself by a temporary increase in polydeoxyribonucleotide concentration several hours after landing. The results are discussed in relation to the changes in chosen parameters after shorter or more prolonged flights.     

一种不借助零磁线圈的星载磁强计校准方法

文章介绍一种星载磁强计校准装置及方法.首先,将高精度地面磁强计的三分量磁传感器置于标准磁场发生装置形成的磁场环境内,通过后端数据处理装置采集得到第一磁场数据,并进行不同量程下螺线管线圈常数Ci的标定;然后,将星载磁强计置于上述标准磁场环境内,并以高精度地面磁强计不同量程下获得的Ci作为基准,通过后端数据处理装置采集得到...     

Structure of the earth’s magnetosheath at small fluctuations in the interplanetary magnetic field direction

Spatial structure of the magnetosheath of the Earth was studied under the conditions when no sharp (more than 40° during 5 min) changes in the interplanetary magnetic field direction were observed. On the basis of 24 flights of the Interball-1 satellite through the magnetosheath, it is found that three regions differing from each other by parameters of the field and plasma can be observed in the magnetosheath under the above-indicated conditions. These regions also differ from the solar wind region before front of the Earth’s magnetospheric bow shock. Empirical distributions of parameters were studied in each region. Taking into account the influence of the interplanetary magnetic field direction on the processes in the magnetosheath, the cases of quasi-perpendicular and quasi-parallel shock waves were considered separately. The study showed that the distribution of parameters in the selected regions (in the solar wind before front of the bow shock, in the magnetosheath behind the bow shock (post-shock), in the region of the magnetosheath with minimal fluctuations in the field, and in the inner magnetosheath) differ from each other at any interplanetary magnetic field direction.     

Autonomic regulation of circulation and cardiac contractility during a 14-month space flight

The space flight of physician cosmonaut V.V. Polyakov, the longest to date (438 days), has yielded new data about human adaptation to long-term weightlessness. Autonomic regulation of circulation and cardiac contractility were evaluated in three experiments entitled Pulstrans, Night, and Holter. In the Pulstrans experiment electrocardiographic (ECG), ballistocardiographic (BCG), seismocardiographic (SCG), and some other parameters were recorded. In the Night experiment, only the ballistocardiogram was recorded, but a special feature of this experiment is that the BCG records were obtained with a contactless method. This method has several advantages, the most important of which are the possibility of studying slow-wave variations in physiologic parameters (ultradian rhythms) on the basis of recordings made under standard conditions over a prolonged period. The Holter experiment (24-hour electrocardiographic monitoring) used a portable cardiorecorder (Spacelab, USA). The obtained electrocardiographic data were used to analyze heart rate variability. In the first 6 months of the 14-month flight, the dynamics of cardiovascular parameters in V.V. Polyakov was virtually the same as in the other cosmonauts. The data obtained after the first 6 months of Polyakov's sojourn in space are unique and mention should be made of at least three important aspects: (1) activation of a new, additional adaptive mechanism in the 8th-9th months of flight, as is evidenced by alterations in the periodicity and power of superslow wave oscillations (ultradian rhythms) reflecting the activity of the subcortical cardiovascular centers and of the higher levels of autonomic regulation; (2) growth of cardiac contractility accompanied by a decrease in heart rate during the last few months of flight; (3) a considerable increase in the daily average values of absolute power of heart rate's variability MF component, which reflects the activity of the vasomotor center. Specific mechanisms of adaptation to weightless conditions appear to be associated with activation of higher autonomic centers. The hypothesis that central levels of circulation regulation are activated in a long-term space flight was investigated by analyzing of ultradian rhythms in nighttime. The data, received during the flight of V. V. Polyakov, show, that the process of human adaptation to long influence of weightlessness consists of a number of consecutive stages, during which the activation of more and more high levels of control system of physiological functions occurs.     

航天器空间动态磁场模拟技术

文章论述了卫星空间动态磁场模拟技术的原理和方案,阐述了对方案的工程化实现所进行的必要计算及对系统的各个部分所进行的研究设计。在此基础上建立了一套动态磁场模拟系统,为卫星空间动态磁场模拟试验提供了条件。     

Relationship of psychological and physiological parameters during an Arctic ski expedition.

Considerable data (primarily physiological) have been collected during expeditions in extreme environments over the last century. Physiological measurements have only recently been examined in association with the emotional or behavioral state of the subject. Establishing this psychophysiological relationship is essential to understanding fully the adaptation of humans to the stresses of extreme environments. This pilot study investigated the simultaneous collection of physiological, psychological and behavioral data from a two-man Greenland expedition in order to model how specific relationships between physiological and psychological adaptation to a polar environment may be identified. The data collected describes changes in adrenal and other hormonal activity and psychological functioning. Levels of cortisol and testosterone were calculated. Factors influencing the plasma profiles of the aforementioned included 24-hour sunlight, high calorific intake of more than 28 000 kJ/day and extreme physical exercise. There was a difference between individual psychological profiles as well as self-report stress and physiological stress.     

基于欧拉方法的多磁偶极子分辨技术

文章首次将欧拉反演方法应用于航天器内部多磁偶极子的分辨,通过测量航天器外围磁场及其梯度张量数据,采用欧拉反演算法来计算航天器内部主要磁性部组件的位置和磁矩参数。根据磁场梯度张量数据的测量特点,采取了网格式数据采集方式;然后推导了多点联合反演的欧拉方程组,并提出了一种在所有反演解中快速准确寻找最优解的方法;在此基础上利用遗传算法对反演最优解进行了优化。优化后的分辨结果表明:在小范围、多层次磁源分辨方面,计算出的磁源磁矩参数较为准确,且磁源位置最高分辨率优于0.01m。     

Effects of sublethal irradiation with helium ions (300 MeV/nucleon) on basic hematological parameters of mice

The aim of the experiment was to obtain new knowledge on the biological effectiveness of high-energy (300 MeV/nucleon) helium ions, which represent a part of the spectrum of cosmic rays. Male (CBA x C57BL)F1 mice, 4 months old, were exposed to a dose of 4 Gy helium ions (exposure rate 0.05 Gy/min). As a comparative standard irradiation the same dose of 4 Gy of 137Cs gamma-rays (exposure rate 0.07 Gy/min) was used. Material sampling was performed 6-8 h, 4 days and 9 days after irradiation for both experimental groups mentioned above. There were 7 animals in each group including the control group of non-irradiated mice. Eight basic hematological parameters of peripheral blood, bone marrow, spleen and thymus were studied. On day 4 after the irradiation with helium ions, the values of leukocyte counts in peripheral blood, bone marrow cellularity and spleen cellularity were reduced to about 10% of the respective control values while the decline after irradiation with gamma-rays amounted to about 50%. These and other results presented reflect a high relative biological effectiveness of 300 MeV/nucleon helium ions.     

Fine structure of interplanetary shock fronts from the data of the BMSW instrument of the PLASMA-F experiment

The paper is concerned with studying the thickness of fronts of 38 interplanetary shocks detected by the BMSW instrument, which is a part of the scientific payload of the SPEKTR-R spacecraft, which was launched into a highly elliptical orbit in 2011. The main parameters of the interplanetary shocks have been calculated as follows: the ratio of thermal pressure to magnetic pressure before the front β, the angle between the shock front normal and the undisturbed magnetic field θ_Bn, the ratio of the shock propagation velocity to the magnetosonic velocity in the undisturbed region M_ms, and the shock front velocity relative to the Earth. It has been shown that the front thickness determined from the plasma parameters approximately matches the front thickness obtained from the magnetic field measurements and lies between 0.5 and 5 proton inertial lengths. In some events, the oscillations have been observed (upstream and downstream of the shock) in plasma parameters and in the magnetic field data. The length has been found to be between 0.5 and 6 proton inertial lengths for the preceding oscillations and between 0.5 and 10 proton inertial lengths for the following oscillations. The average value of the proton inertial length is 62 km.     

Structure of current and plasma in current sheets depending on the conditions of sheet formation

The structure of current sheets created under laboratory conditions is characterized by a large variety, which depends substantially on the conditions under which the sheet if formed. In this work, we present the results of an experimental study of the structure and evolution of current sheets that were formed in magnetic configurations with a singular line of the X type. It has been shown that the change in the transverse magnetic field gradient, the strength of the longitudinal magnetic field, and the mass of the ions in plasma makes it possible to significantly vary the main parameters of the current sheets. This offers the challenges of using laboratory experimental results for analyzing and simulating the cosmophysical processes.     

中低轨道地磁动态模拟器

文章介绍了1台能为中低轨道飞行器提供动态地磁场环境的模拟器,详细论述了模拟器的系统组成、线圈结构、电源和磁强计指标参数、控制方式和调试方法,介绍了根据WMM2000地磁场模型计算出轨道上各点的磁场值,利用数值分析的方法找出输出电流与产生磁场大小的对应表达式,从而根据计算出的磁场值和输出电流,用程控电源成功实现了中低轨道地磁场的动态模拟.     

Dynamics of Quasi-Biennal Variations of Cosmic Rays and Solar Activity

The quasi-biennial variations in the flux of galactic cosmic rays (GCRs) have been studied based on the data of stratospheric sensing and measurements by neutron monitors, as well as in various manifestations of solar activity and interplanetary medium parameters. It has been shown that quasi-biennial GCR variations are caused by variations with the same period in the mean magnetic field of the Sun that coincide with them over time and have been identified in the anti-phase, which respond to the sign of this field. The variations in the quasi-biennial cosmic ray are caused by quasi-biennial variations in the mean magnetic field of the Sun via the quasi-biennial variations in the interplanetary magnetic field.     

Calculation of the Initial Magnetic Field for Mercury’s Magnetosphere Hybrid Model

Several types of numerical models are used to analyze the interactions of the solar wind flow with Mercury’s magnetosphere, including kinetic models that determine magnetic and electric fields based on the spatial distribution of charges and currents, magnetohydrodynamic models that describe plasma as a conductive liquid, and hybrid models that describe ions kinetically in collisionless mode and represent electrons as a massless neutralizing liquid. The structure of resulting solutions is determined not only by the chosen set of equations that govern the behavior of plasma, but also by the initial and boundary conditions; i.e., their effects are not limited to the amount of computational work required to achieve a quasi-stationary solution. In this work, we have proposed using the magnetic field computed by the paraboloid model of Mercury’s magnetosphere as the initial condition for subsequent hybrid modeling. The results of the model have been compared to measurements performed by the Messenger spacecraft during a single crossing of the magnetosheath and the magnetosphere. The selected orbit lies in the terminator plane, which allows us to observe two crossings of the bow shock and the magnetopause. In our calculations, we have defined the initial parameters of the global magnetospheric current systems in a way that allows us to minimize paraboloid magnetic field deviation along the trajectory of the Messenger from the experimental data. We have shown that the optimal initial field parameters include setting the penetration of a partial interplanetary magnetic field into the magnetosphere with a penetration coefficient of 0.2.     

Magnetic launching in outer space

We examine the idea of accelerating a space ship, carrying a magnetic dipole moment, in a long inhomogeneous magnetic field. It is shown that it is technically possible to impart a mass of 10 tons a speed greater than the escape velocity of the solar system. We consider the flow of energy and give a rough calculation of the main parameters of the launching device. The device can be used continually and can decelerate a spacecraft with dipole moment equally well.     

Turbulent fluctuations of plasma and magnetic field parameters in the magnetosheath and the low-latitude boundary layer formation: Multisatellite observations on March 2, 1996

The results of simultaneous analysis of plasma and magnetic field characteristics measured on the INTERBALL/Tail Probe, WIND and Geotail satellites on March 2, 1996, are presented. During these observations the INTERBALL/Tail Probe crossed the low-latitude boundary layer, and the WIND and Geotail satellites measured the solar wind’s and magnetosheath’s parameters, respectively. The plasma and magnetic field characteristics in these regions have been compared. The data of the Corall, Electron, and MIF instruments on the INTERBALL/Tail Probe satellite are analyzed. Fluctuations of the magnetic field components and plasma velocity in the solar wind and magnetosheath, measured onboard the WIND and Geotail satellites, are compared. The causes resulting in appearance of plasma jet flows in the low-latitude boundary layer are analyzed. The amplitude of magnetic field fluctuations in the magnetosheath for a studied magnetosphere boundary crossing is shown to exceed the magnetic field value below the magnetopause near the cusp. The possibility of local violation of pressure balance on the magnetopause is discussed, as well as penetration of magnetosheath plasma into the magnetosphere, as a result of magnetic field and plasma flux fluctuations in the magnetosheath.     

Motor coordination in weightless conditions revealed by long-term microgravity adaptation.

The functional approach to studying human motor systems attempts to give a better understanding of the processes behind planning movements and their coordinated performance by relying on weightlessness as a particularly enlightening experimental condition. Indeed, quantitative monitoring of sensorimotor adaptation of subjects exposed to weightlessness outlines the functional role of gravity in motor and postural organization. The recent accessibility of the MIR Space Station has allowed for the first time experimental quantitative kinematic analysis of long-term sensorimotor and postural adaptation to the weightless environment though opto-electronic techniques. In the frame of the EUROMIR'95 Mission, two protocols of voluntary posture perturbation (erect posture, EP; forward trunk bending, FTB) were carried out during four months of microgravity exposure. Results show that postural strategies for quasistatic body orientation in weightlessness are based on the alignment of geometrical body axes (head and trunk) along external references. A proper whole body positioning appears to be recovered only after months of microgravity exposure. By contrast, typically, terrestrial strategies of co-ordination between movement and posture are promptly restored and used when performing motor activities in the weightless environment. This result is explained under the assumption that there may be different sensorimotor integration processes for static and dynamic postural function and that the organisation of coordinated movement might rely stably on egocentric references and kinematics synergies for motor control.