共查询到20条相似文献,搜索用时 15 毫秒
1.
旋转附加力对方通道内流动与换热的影响机理 总被引:1,自引:0,他引:1
在雷诺数为25000,旋转数为0~0.24,温度比为0~0.22的范围内,数值模拟了旋转光滑径向出流通道的内流动与换热分布,分析了哥氏力与离心浮升力对旋转管流的耦合作用机理.计算结果表明,切向哥氏力推动了通道截面内的双涡二次流,径向哥氏力则使得近侧壁流体加速和中心流体减速.离心浮升力对流动与换热的作用效果与哥氏力场的分布密切相关.换热计算结果从定性趋势上吻合公开文献中的实验现象,反映了旋转附加力的基本影响规律. 相似文献
2.
同轴旋转圆台环隙内流体的流动是基于经典的两同轴旋转圆柱环隙内泰勒库特流的一种扩展研究。通过流动显示实验和PIV粒子图像测速技术对圆台环隙的内部流场进行可视化和定量化的研究,分析涡运动的周期性规律,探究圆台环隙内雷诺应力分布和水位高度对流场的影响。研究表明,随着时间的发展,涡列周期性明显且整体在下移,当脉冲数为100脉冲/s时,环隙内形成均匀分布的正反交替的涡;当脉冲数为200~500脉冲/s时,存在快慢交替的分裂周期;在3种水位高度下也都存在明显周期性分裂,只是周期时间和涡的个数不同;平均流场存在上凸型外向流和下凹型内向流2种流态,流态的差异是离心力与静压力双重作用的强弱变化所致;雷诺应力分布中,径向正应力占主导,并主要集中在环隙中部。 相似文献
3.
Chondrogenesis in aggregates of embryonic limb cells grown in a rotating wall vessel. 总被引:1,自引:0,他引:1
J Duke E Daane J Arizpe D Montufar-Solis 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1996,17(6-7):289-293
Previous studies in this lab have shown that chondrogenesis is affected in growth plates of rats exposed to microgravity, and in micromass cultures of embryonic limb mesenchyme differentiating in space. In order to provide a three dimensional aspect not seen in the micromass system, and a tissue homogeneity not possible with explants of limb or limb elements, and to alleviate certain difficulties regarding crew time and stowage, we began culturing embryonic limb cells in Rotating Wall Vessels (RWV). First, these cells were attached to beads, and grown for up to 65 days in a type of RWV known as STLV at the Johnson Space Center. During this time, the cells and beads aggregated and the aggregates continued to increase in size, and differentiated into Alcian blue staining chondrocytes. Because our intent was to use these aggregates for implanting into bony defects in addition to their use in studies of chondrogenic regulation at 1g and microgravity, aggregates of these cells without beads were grown in the commercially available version of the STLV, and their ability to ossify when subcutaneously implanted assessed. 相似文献
4.
Differentiation of cartilaginous anlagen in entire embryonic mouse limbs cultured in a rotating bioreactor. 总被引:1,自引:0,他引:1
D Montufar-Solis C R Oakley Y Jefferson P J Duke 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2003,32(8):1467-1472
Mechanisms involved in development of the embryonic limb have remained the same throughout eons of genetic and environmental evolution under Earth gravity (1 g). During the spaceflight era it has been of interest to explore the ancient theory that form of the skeleton develops in response to gravity, and that changes in gravitational forces can change the developmental pattern of the limb. This has been shown in vivo and in vitro, allowing the hypergravity of centrifugation and microgravity of space to be used as tools to increase our knowledge of limb development. In recapitulations of spaceflight experiments, premetatarsals were cultured in suspension in a bioreactor, and found to be shorter and less differentiated than those cultured in standard culture dishes. This study only measured length of the metatarsals, and did not account for possible changes due to the skeletal elements having a more in vivo 3D shape while in suspension vs. flattened tissues compressed by their own weight. A culture system with an outcome closer to in vivo and that supports growth of younger limb buds than traditional systems will allow studies of early Hox gene expression, and contribute to the understanding of very early stages of development. The purpose of the current experiment was to determine if entire limb buds could be cultured in the bioreactor, and to compare the growth and differentiation with that of culturing in a culture dish system. Fore and hind limbs from E11-E13 ICR mouse embryos were cultured for six days, either in the bioreactor or in center-well organ culture dishes, fixed, and embedded for histology. E13 specimens grown in culture dishes were flat, while bioreactor culture specimens had a more in vivo-like 3D limb shape. Sections showed excellent cartilage differentiation in both culture systems, with more cell maturation, and hypertrophy in the specimens cultured in the bioreactor. Younger limb buds fused together during culture, so an additional set of E11.5 limb buds was cultured with and without encapsulation in alginate prior to culturing in the bioreactor. Encapsulated limbs grown in the bioreactor did not fuse together, but developed only the more proximal elements while limbs grown in culture dishes formed proximal and distal elements. Alginate encapsulation may have reduced oxygenation to the progress zone of the developing limb bud resulting in lack of development of the more distal elements. These results show that the bioreactor supports growth and differentiation of skeletal elements in entire E13 limb buds, and that a method to culture younger limb buds without fusing together needs to be developed if any morphometric analysis is to be performed. 相似文献
5.
P. Annamalai R. Cole 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1983,3(5):165-168
The interaction of liquids is an important part of many processes and is often used for such purposes as causing a separation of solution components by mass transfer between phases, allowing a chemical reaction between liquids or their components, providing direct contact heating or cooling, or creating emulsions. Containerless space processing may well involve the interaction of liquids in the form of drops. For example it may be desirable to form an alloy in space by merger of two or more drops. Encapsulation of a volatile liquid by a second less volatile and immiscible liquid might be a means for avoiding volatilization. Rotation of such systems would enhance mixing where desirable and/or provide means for drop management. In this study, single drop behavior in rotating liquid bodies is studied experimentally. 相似文献
6.
A Baüerle R H Anken R Hilbig N Baumhauer H Rahmann 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2004,34(7):1598-1601
Humans taking part in parabolic aircraft flights (PAFs) may suffer from space motion sickness (SMS, a kinetosis). Since it has been repeatedly shown earlier that some fish of a given batch also reveal a kinetotic behavior during PAFs (especially so-called spinning movements and looping responses) and due to the homology of the vestibular apparatus among all vertebrates, fish can be used as model systems to investigate the origin of susceptibility to motion sickness. Therefore, we examined the utricular maculae (they are responsible for the internalization of gravity in teleosteans) of fish swimming kinetotically at microgravity in comparison with animals from the same batch who swam normally. On the histological level, it was found that the total number of both sensory and supporting cells of the utricular maculae did not differ between kinetotic animals as compared to normally swimming fish. Cell density (sensory and supporting cells/100 micrometers2), however, was reduced in kinetotic animals (p<0.0001), which seemed to be due to malformed epithelial cells (increase in cell size) of the kinetotic specimens. Susceptibility to kinetoses may therefore originate in malformed sensory epithelia. 相似文献
7.
T.L. Wilson H.-J. Blome 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2009,44(11):1345-1353
Based upon a simple cosmological model with no expansion, we find that the rotational terms appearing in the Gödel universe are too small to explain the Pioneer anomaly. Following a brief summary of the anomaly, cosmological effects on the dynamics of local systems are addressed – including a derivation of the equations of motion for an accelerated Pioneer-type observer in a rotating universe. The rotation or vorticity present in such a cosmological model is then subjected to astrophysical limits set by observations of the cosmic microwave background radiation. Although it contributes, universal rotation is not the cause of the Pioneer effect. In view of the related fly-by anomalies, frame-dragging is also discussed. The virial theorem is used to demonstrate the non-conservation of energy during transfers from bound to hyperbolic trajectories. 相似文献
8.
G.S.R. Sarma 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1983,3(5):33-36
The problem of controlling the onset of convective instability in a liquid layer due to the joint action of buoyancy and interfacial tension mechanisms by means of rotation and magnetic field is considered. Selected stability characteristics delineating the effects of both these stabilizing agencies and those of interfacial curvature and gravity waves as well as those of typical boundary conditions are illustrated. 相似文献
9.
Early and late mammalian responses to heavy charged particles. 总被引:2,自引:0,他引:2
E J Ainsworth 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1986,6(11):153-165
This overview summarizes murine results on acute lethality responses, inactivation of marrow CFU-S and intestinal microcolonies, testes weight loss, life span shortening, and posterior lens opacification in mice irradiated with heavy charged particles. RBE-LET relationships for these mammalian responses are compared with results from in vitro studies. The trend is that the maximum RBE for in vivo responses tends to be lower and occurs at a lower LET than for inactivation of V79 and T-1 cells in culture. Based on inactivation cross sections, the response of CFU-S in vivo conforms to expectations from earlier studies with prokaryotic systems and mammalian cells in culture. Effects of heavy ions are compared with fission spectrum neutrons, and the results are consistent with the interpretation that RBEs are lower than for fission neutrons at about the same LET, probably due to differences in track structure. Issues discussed focus on challenges associated with assessments of early and late effects of charged particles based on dose, RBE and LET, and with the concordance or discordance of results obtained with in vivo and in vitro model systems. Models for radiation damage/repair and misrepair should consider effects observed with in vivo as well as in vitro model systems. 相似文献
10.
Effect of HZE particles and space hadrons on bacteriophages. 总被引:2,自引:0,他引:2
S S Yurov I G Akoev G A Leont'eva 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1983,3(8):51-60
The effect of high energy (HZE) particles and high energy hadrons on T4Br+ bacteriophage was analyzed. The experiments were done in orbital flight, on high mountains, on an accelerator, and with an alpha particle source. We studied the survival rate of the bacteriophage, the mutation frequency, the mutation spectrum and the revertability under the action of chemical mutagens with a known mechanism of action on DNA. It was found that the biological efficiency of HZE particles and high energy hadrons is greater than that of gamma radiation. The spectra of mutations produced by these mutations and the mechanisms of their action are also different. These effects were local, because of the mode of interaction of the radiant energy with biological objects, and depended on the linear energy transfer (LET). The modes have now been experimentally defined. 相似文献
11.
3种转角下旋转U形方通道的局部换热 总被引:4,自引:1,他引:4
在旋转数为0~0.26内用实验方法研究了转角对旋转U形方截面通道换热特性的影响.3种通道转角分别为0°,22.5°,45°.通道转角的变化引起了通道内哥氏力二次流的变化,继而导致通道各表面换热的变化.结果表明:随通道转角的增大,前缘与后缘之间努塞尔数的差异减小,而内侧面与外侧面之间的努塞尔数差异增大;在低旋转数下,转角的变化对U形通道换热的影响较小,但高旋转数下,转角的变化对U形通道换热的影响变得明显. 相似文献
12.
在旋转状态下,研究了涡轮内冷蛇形通道的非稳态换热特性.实验主要针对旋转状态下,通道内流量的变化和系统旋转速度的变化来进行的.结果表明:对于旋转通道的非稳态过程,换热系数的变化呈波动变化过程,且主要发生在实验参数变化的阶段.加速旋转时,角加速度力的作用会加强进气通道前缘面的换热,而降低后缘面的;减速旋转时,情况相反.而且,角加速度力的作用效果容易在旋转开始变化的时刻显现.当旋转速度在2个值之间往复时,换热系数变化呈现滞后环状,旋转速度越高滞后环越大. 相似文献
13.
T Sakashita M Doi H Yasuda S Fuma D-P Hader 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2002,30(4):1023-1030
The effects of gamma-ray and high energy carbon ion irradiation on the swimming velocity of the photosynthetic flagellate Euglena gracilis strain Z were studied, focusing on a dose-effect relationship. Cells were exposed to 60Co gamma-rays at 6 doses of 10, 15, 20, 40, 100 and 200 Gy for water, and also to 290 MeV/amu carbon ions from the Heavy Ion Medical Accelerator in Chiba at 7 doses (5, 10, 15, 20, 50, 100 and 200 Gy for water). The swimming velocity was measured by a biomonitoring system, called ECOTOX. The swimming velocities of Euglena gracilis cells were significantly decreased by >40 Gy gamma-rays and >5 Gy carbon ions, respectively. The 50% effective doses for inhibition, 34 +/- 4 Gy (gamma-rays) and 13 +/- 1 Gy (290 MeV/amu carbon ions), were estimated from the best fit to data of the logistic model. The relative biological effectiveness (2.6 +/- 0.4) was calculated by the ratio of 50% effective doses. The inhibition of the swimming velocity of the cells irradiated with gamma-rays was still present after 3 days, while recovery of the swimming velocity was shown in the cells exposed to 290 MeV/amu carbon ions. It is suggested that ionizing radiation inhibits ATP production and/or increases frictional drag on beating of the flagellum, thus decreasing swimming velocity. 相似文献
14.
B M Rabin J A Joseph B Shukitt-Hale J McEwen 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2000,25(10):2065-2074
The effects of exposure to heavy particles on behaviors mediated by the central nervous system (CNS) are qualitatively different than the effects produced by exposure to other types of radiation. One behavior mediated by the CNS is the amphetamine-induced taste aversion, which is produced by pairing a novel tasting solution with injection of amphetamine. When the conditioning day is three days following irradiation, exposing rats to low doses of 56Fe particles (600 MeV/n or 1 GeV/n) eliminates the taste aversion produced by injection of amphetamine, which is dependent upon the integrity of the central dopaminergic system, but has no effect on the aversion produced by injection of lithium chloride which is mediated by the gastrointestinal system. In contrast to the effects obtained using heavy particles, exposing rats to 60CO gamma rays or to fission spectrum neutrons has no selective effect upon the acquisition of either amphetamine- or lithium chloride-induced taste aversions. When the conditioning day occurs four months following exposure to 1 GeV/n 56Fe particles, there is an enhancement of the amphetamine-induced taste aversion. The implications of these findings for approaches to risk assessment are considered. 相似文献
15.
K Eguchi-Kasai M Murakami H Itsukaichi K Fukutsu F Yatagai T Kanai H Ohara K Sato 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1998,22(4):543-549
It has been suggested that it is not simple double-strand breaks (dsb) but the non-reparable breaks which correlate well with the high biological effectiveness of high LET radiations for cell killing (Kelland et al., 1988; Radford, 1986). We have compared the effects of charged particles on cell death in 3 pairs of cell lines which are normal or defective in the repair of DNA dsbs. For the cell lines SL3-147, M10, and SX10 which are deficient in DNA dsb repair, RBE values were close to unity for cell killing induced by charged particles with linear energy transfer (LET) up to 200 keV/micrometer and were even smaller than unity for the LET region greater than 300 keV/micrometer. The inactivation cross section (ICS) increased with LET for all 3 pairs. The ICS of dsb repair deficient mutants was always larger than that of their parents for all the LET ranges, but with increasing LET the difference in ICS between the mutant and its parent became smaller. Since a small difference in ICS remained at LET of about 300 keV/micrometer, dsb repair may still take place at this high LET, even if its role is apparently small. These results suggest that the DNA repair system does not play a major role in protection against the attack of high LET radiations and that a main muse of cell death is non-reparable dsb which are produced at a higher yield compared with low LET radiations. No correlation was observed between DNA content or nuclear area and ICS. 相似文献
16.
T C Yang L M Craise M R Raju 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2000,25(10):2123-2130
For a better understanding of oncogenic cell transformation by ionizing radiation, we conducted experiments with ultrasoft X rays and low energy alpha particles. Confluent C3H10T1/2 cells were irradiated by Al-K (1.5 keV) X rays or alpha particles from plutonium through a thin mylar sheet, on which the cells attached and grew. Our results indicated that Al-K X rays were more effective in causing cell inactivation and oncogenic transformation than 60Co gamma rays but less effective than 1.0 and 3.7 MeV alpha particles. There was no significant difference between 1.0 and 3.7 MeV alpha particles in transforming cells although the latter were slightly more effective than the former in producing lethal effect. These results indicated that track structure is important in causing biological effects by ionizing radiation. 相似文献
17.
通过开展稳态实验及数值模拟探究了轴向通流旋转盘腔的流动结构与换热特性。通过改变流量系数、旋转雷诺数等参数,探究不同工况下旋转盘两侧及盘罩内侧壁面温度和努塞尔数的径向分布规律。结果表明:在轮缘加热的状态下,旋转盘两侧温度径向分布均呈凹函数形态,且旋转盘迎风面换热强度普遍高于背风面;后轴颈盘罩向两端旋转盘导热,其壁面温度径向分布呈"中间高、两侧低"的状态;随着轴向流量系数的增大,盘腔内部气体对流加剧,径向臂及涡对结构更加明显,旋转盘及轴颈表面换热效果增强;旋转盘腔内的流动换热特性受强迫对流和类Rayleigh-Benard对流2种机理的共同影响。 相似文献
18.
通过Cluster卫星在2005年3月16日观测到的一个准平行激波观测事例,研究了准平行激波上游低频等离子体波动与能量离子之间的关系.卫星观测结果表明,在准平行激波上游,离子微分能通量受到了非线性波动的调制.在磁场强度较小区域,离子微分能通量较高.产生这种现象的可能原因是准平行激波上游的非线性波动可以捕获离子,被捕获的离子在波动中来回弹跳并被电场加速,从而导致磁场强度较小区域离子微分能通量较高.这一观测结果与已有的混合模拟结果相吻合. 相似文献
19.
Charged-particle mutagenesis II. Mutagenic effects of high energy charged particles in normal human fibroblasts. 总被引:1,自引:0,他引:1
D J Chen K Tsuboi T Nguyen T C Yang 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1994,14(10):347-354
The biological effects of high LET charged particles are a subject of great concern with regard to the prediction of radiation risk in space. In this report, mutagenic effects of high LET charged particles are quantitatively measured using primary cultures of human skin fibroblasts, and the spectrum of induced mutations are analyzed. The LET of the charged particles ranged from 25 KeV/micrometer to 975 KeV/micrometer with particle energy (on the cells) between 94-603 MeV/u. The X-chromosome linked hypoxanthine guanine phosphoribosyl transferase (hprt) locus was used as the target gene. Exposure to these high LET charged particles resulted in exponential survival curves; whereas, mutation induction was fitted by a linear model. The Relative Biological Effect (RBE) for cell-killing ranged from 3.73 to 1.25, while that for mutant induction ranged from 5.74 to 0.48. Maximum RBE values were obtained at the LET of 150 keV/micrometer. The inactivation cross-section (alpha i) and the action cross-section for mutant induction (alpha m) ranged from 2.2 to 92.0 micrometer2 and 0.09 to 5.56 x 10(-3) micrometer2, respectively. The maximum values were obtained by 56Fe with an LET of 200 keV/micrometer. The mutagenicity (alpha m/alpha i) ranged from 2.05 to 7.99 x 10(-5) with the maximum value at 150 keV/micrometer. Furthermore, molecular analysis of mutants induced by charged particles indicates that higher LET beams are more likely to cause larger deletions in the hprt locus. 相似文献
20.
Panagiota Petkaki Alexander L. MacKinnon 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2011
Release of stored magnetic energy via particle acceleration is a characteristic feature of astrophysical plasmas. Magnetic reconnection is one of the mechanisms for releasing energy from magnetized plasmas. Collisionless magnetic reconnection could provide both the energy release mechanism and the particle accelerator in space plasmas. Here we studied particle acceleration when fluctuating (in-time) electric fields are superposed on an static X-type magnetic field in collisionless hot solar plasma. This system is chosen to mimic the reconnective dissipation of a linear MHD disturbance. Our results are compared to particle acceleration from constant electric field superposed on an X-type magnetic field. The constant electric field configuration represents the effects of steady state magnetic reconnection. Time evolution of ion and electron distributions are obtained by numerically integrating particle trajectories. The frequencies of the electric field represent a turbulent range of waves. Depending on the frequency and amplitude of the electric field, electrons and ions are accelerated to different degrees and have energy distributions of bimodal form consisting of a lower energy part and a high energy tail. For frequencies (ω in dimensioless units) in the range 0.5 ? ω ? 1.0 a substantial fraction (20%–30%) of the proton distribution is accelerated to gamma-ray producing energies. For frequencies in the range 1 ? ω ? 100.0 the bulk of the electron distribution is accelerated to hard X-ray producing energies. The acceleration mechanism is important for solar flares and solar noise storms but it could be applicable to all collisionless astrophysical plasmas. 相似文献