中药在改善模拟失重兔主要脏器形态学变化中的作用

通过实验探讨中药作为一种新的防护措施的可能性。实验动物为53只白兔, 用头低位悬吊方法模拟失重, 时间7天。实验前将兔分为四组:对照组, 悬吊组, 川芎组, 丹黄组, 实验中分别喂水或喂中药。实验后取脑、心、肺、肾、腹主动脉、比目鱼肌等6个脏器制片, 进行组织学观察。结果是两种中药均有改善模拟失重兔主要脏器血循环和组织结构的作用, 丹黄合剂的作用优于川芎。这说明中药作为一种新的防护措施是有希望的。      

The effects of simulated microgravity on the seminiferous tubules of rats

Space flight has been shown to have many adverse effects on various systems throughout the body. Because the opportunity to place research animals on board a Space Shuttle or the International Space Station is infrequent, various techniques have been designed to simulate the effects of microgravity in Earth based laboratories. A commonly used technique is known as antiorthostatic suspension, also often referred to as hind limb suspension. In this technique the hind portion of the animal is raised so that its hind limbs are non-weight bearing. This places the animal in roughly a 30° head down tilt position. This results in cephalic fluid shifts similar to those seen in actual space flight. This technique has also been shown to mimic other physiological parameters that are affected during space flight. This study examined testicular tissue from rats subjected to a 7 day antiorthostatic suspension. This tissue was acquired through a tissue sharing program and some of the experimental animals were injected with Interleukin 1 receptor antagonist (IL-1ra) which was hoped to ameliorate some of the effects of antiorthostatic suspension. The injection of IL-1ra was not expected to have any effect on testicular tissue, however this tissue was included in the morphological and statistical analysis to conduct a more complete study. All tissues were embedded in paraffin, sectioned, and stained using standard H&E staining. The tissue was then qualitatively ranked according to the “health” of the seminiferous tubules. Our findings indicate that 7 days of antiorthostatic suspension had adverse effects on the tissue that comprises the walls of the seminiferous tubules. It has long been known that antiorthostatic suspension has deleterious effects on testicular tissue, however this research indicates that these effects occur much faster than indicated by previous researchers. This is a significant finding because it indicates that meaningful earth based studies in this area can be carried out in a shorter time span. This could result in more studies per year as well as saving money by avoiding longer than necessary animal suspensions. This is especially important as we enter an era when, without Space Shuttle, flight opportunities will become scarce. These antiorthostatic suspension studies indicate that space flight, even short duration spaceflight, may have harmful effects on the seminiferous tubules and blood-testis barrier of astronauts.     

BLSS: A contribution to future life support

For extended duration missions in space the supply of basic life-supporting ingredients represents a formidable logistics problem. Storage volume and launch weight of water, oxygen and food in a conventional non-regenerable life support system are directly proportional to the crew size and the length of the mission. In view of spacecraft payload limitations this will require that the carbon, or food, recycling loop, the third and final part in the life support system, be closed to further reduce logistics cost. This will be practical only if advanced life support systems can be developed in which metabolic waste products are regenerated and food is produced.

Biological Life Support Systems (BLSS) satisfy the space station environmental control functions and close the food cycle. A Biological Life Support System has to be a balanced ecological system, biotechnical in nature and consisting of some combination of human beings, animals, plants and microorganisms integrated with mechanical and physico-chemical hardware.

Numerous scientific space experiments have been delineated in recent years, the results of which are applicable to the support of BLSS concepts. Furthermore ecological life support systems have become subject to intensified studies and experiments both in the U.S. and the U.S.S.R. The Japanese have also conducted detailed preliminary studies.

Dornier System has in recent years undertaken an effort to define requirements and concepts and to analyse the feasibility of BLSS for space applications. Analyses of the BLSS energy-mass relation have been performed, and the possibilities to influence it to achieve advantages for the BLSS (compared with physico-chemical systems) have been determined. The major problem areas which need immediate attention have been defined, and a programme for the development of BLSS has been proposed.     

The gravitational field and brain function.

The frontal cortex is recognized as the highest adaptive control center of the human brain. The principle of the "frontalization" of human brain function offers new possibilities for brain research in space. There is evolutionary and experimental evidence indicating the validity of the principle, including it's role in nervous response to gravitational stimulation. The gravitational field is considered here as one of the more constant and comprehensive factors acting on brain evolution, which has undergone some successive crucial steps: "encephalization", "corticalization", "lateralization" and "frontalization". The dominating effects of electrical responses from the frontal cortex have been discovered 1) in experiments under gravitational stimulus; and 2) in processes potentially relating to gravitational adaptation, such as memory and learning, sensory information processing, motor programing, and brain state control. A brain research experiment during space flight is suggested to test the role of the frontal cortex in space adaptation and it's potentiality in brain control.     

Progress of Space Medicine Research in China

With the approaching of the Chinese Space Station (CSS) era, the focus of space medicine applications and related research has shifted to addressing the astronauts' health support in long-duration spaceflights, including nutrition, countermeasure against the physiological effects of weightlessness, medical monitoring and support, psychology status, etc., and accordingly the human experiments to simulate long-duration weightlessness have been carried out. Increasingly, basic research has been put forward in the key areas, such as space bone loss, cardiovascular dysfunction and the molecular mechanisms underlying radiobiological effects. Moreover, specific novel research fields, such as hypometabolism technology, were explored. The research projects in the field of space medicine experiment, as an important aspect of the Chinese Space Station's application, have been officially approved and launched.      

Observing the earth radiation budget from satellites: Past,present, and a look to the future

Satellite measurements of the radiative exchange between the planet Earth and space have been the objective of many experiments since the beginning of the space age in the late 1950's. The on-going mission of the Earth Radiation Budget (ERB) experiments has been and will be to consider flight hardware, data handling and scientific analysis methods in a single design strategy. Research and development on observational data has produced an analysis model of errors associated with ERB measurement systems on polar satellites. Results show that the variability of reflected solar radiation from changing meteorology dominates measurement uncertainties. As an application, model calculations demonstrate that measurement requirements for the verification of climate models may be satisfied with observations from one polar satellite, provided we have information on diurnal variations of the radiation budget from the ERBE mission.     

Space Research Plan of China's Space Stationormalsize

China's manned spaceflight missions have been introduced briefly, and the research planning of space sciences for China's Space Station (CSS) has been presented with the topics in the research areas, including:life science and biotechnology, microgravity fluid physics and combustion science, space material science, fundamental physics, space astronomy and astrophysics, earth sciences and application, space physics and space environment, experiments of new space technology. The research facilities, experiment racks, and supporting system planned in CSS have been described, including:multifunctional optical facility, research facility of quantum and optic transmission, and a dozen of research racks for space sciences in pressurized module, etc. In the next decade, significant breakthroughs in space science and utilization will hopefully be achieved, and great contributions will be made to satisfy the need of the social development and people's daily life.      

Quantitation of heavy ion damage to the mammalian brain: some preliminary findings.

Histological preparations of brains from rabbits and mice exposed to different doses of various HZE particles or to low-LET photons have been subjected to preliminary quantitation of radiation-induced morphometric changes. Computer assisted measurements of several brain structures and cell types have been made using the KONTRON Automated Interactive Measurement System (IBAS, Carl Zeiss, Inc., Thornwood, N.Y. 10594 U.S.A.). New Zealand white rabbits irradiated at approximately 6 weeks of age were euthanatized 6.5-25 months after exposure to 60Co gamma photons (LET infinity = approximately 0.3 keV/micrometer, 20Ne particles (LET infinity = 35 +/- 3 keV/micrometer), or 40Ar particles (LET infinity = 90 +/- 5 keV/micrometer). Measurements of stained sections of the olfactory bulbs of those animals indicate that the mean size (volume) of olfactory glomeruli is reduced in a dose-dependent (and perhaps an LET-dependent) manner as soon as 6.5 months after irradiation. Differences between mean volumes of additional structures have been noted when histological preparations of control mouse brains were compared with irradiated specimens. Quantitation of intermediate and late changes in nervous (and other) tissues exposed to low- and high-LET radiations will improve our ability to predict late effects in tissues of astronauts and others exposed to the radiation hazards of the space environment.     

空间低温溶液晶体生长的地基实验

首次使用疏水型聚四氟乙烯微孔滤膜,利用其透气不透水的特性,密封晶体生长容器,采用恒温蒸发法进行晶体生长.溶剂通过蒸发离开生长容器后,被生长容器外的吸附剂吸附,使得溶液维持一定过饱和度,以实现单晶的连续生长.在此基础上研制出一套空间低温溶液晶体生长地基模拟装置.利用此装置进行了一系列地基模拟实验,获得一批高质量α-LiIO₃单晶,证实了该生长装置的溶剂蒸发量和容器密封性能够满足空间低温溶液晶体生长需要,为未来空间低温溶液晶体生长实验奠定了基础.      

中国探月工程

"嫦娥4号"于2019年1月3日成功实现人类航天器首次在月球背面软着陆,"玉兔2号"月球车率先在月背刻上了中国足迹。至今,国际月球探测活动共实施126次,期间出现两个探月高潮。20世纪50—70年代,美苏两个航天大国之间的竞争引起第一轮探月高潮。20世纪末至今,各航天国家意识到月球探测的战略意义,纷纷提出月球探测计划并积极实施,月球成为各国争先探测的热点,掀起第二轮探月热潮。中国自2004年首次绕月探测工程立项实施以来,共开展了"嫦娥1号""嫦娥2号""嫦娥3号""嫦娥4号"及再入返回飞行试验共5次月球探测任务,实现"五战五捷",在空间技术、空间科学与应用、国际合作等方面取得了非凡成就,积累了丰富的经验,后续将继续开展以无人月球科研站为主的月球探测活动。     

Medical prevention of space motion sickness--animal model of therapeutic effect of a new medicine on motion sickness.

Space motion sickness (MS) is one of the most important problems in the field of space medicine. In order to prevent space MS, a new medicine, PMPA, has been prepared by means of synthesizing in our laboratory. The purposes of this study were to set up animal models of PMPA against MS, and to observe its effects on anti-MS, and to prove its function of antagonism to choline. Eight cats, forty rabbits and two hundred and ten rats were selected as animal subjects. The parallel swing stimulus, a method causing the reversal syndromes and tests of anti-choline function were used in our experiments. The results are as follows: (1) The score of MS symptoms in cats with PMPA or scopolamine (SCOP) is significantly lower than that in cats with placebo (p<0.01), while the incidences of efficiency and prevention of PMPA (87.5%, 75%) are higher than those of SCOP (75.0%, 50%) in cats. (2) PMPA of 1.6 mg/kg or 0.8 mg/kg could antagonize the reversal syndromes and repress reversal rotation significantly in rabbits like SCOP in comparison with placebo (p<0.01). (3) PMPA could inhibit tremor evoked by oxotremorine or by nicotine-procaine in rats like SCOP, and play an important role in the antagonism to central M-choline and N-choline receptors. The animal experiments demonstrate that PMPA is an effective medicine against MS with antagonism function to choline.     

Space Research Plan of China's Space Station

China's manned spaceflight missions have been introduced briefly,and the research planning of space sciences for China's Space Station(CSS) has been presented with the topics in the research areas,including:life science and biotechnology,microgravity fluid physics and combustion science,space material science,fundamental physics,space astronomy and astrophysics,earth sciences and application,space physics and space environment,experiments of new space technology.The research facilities,experiment racks,and supporting system planned in CSS have been described,including:multifunctional optical facility,research facility of quantum and optic transmission,and a dozen of research racks for space sciences in pressurized module,etc.In the next decade,significant breakthroughs in space science and utilization will hopefully be achieved,and great contributions will be made to satisfy the need of the social development and people's daily life.     

The extreme and far ultraviolet environment at shuttle altitudes

The astronomical data obtained by the Far Ultraviolet Space Telescope (FAUST) and the Very Wide Field Camera (VWFC) on board the Spacelab I mission have triggered questions on the natural and induced Extreme and Far Ultraviolet (EUV and FUV) environment of the space shuttle. Moreover, the recent discovery of ∼1k Rayleighs N₂ Lyman Birge Hopfield (LBH) nightglow emissions by the U. S. Air Force's S3-4 satellite, and subsequent confirmation by the Imaging Spectrometric Observatory (ISO) experiment on the Spacelab I mission have serious implications for the astronomical observations from the shuttle. Since both ISO and S3-4 experiments were conducted from shuttle altitudes, the implied EUV and FUV environment for astronomical observations can be severe. In order to address the question of the suitability of the shuttle as an astronomical platform, we have examined data from FAUST and other experiments. We conclude that the FAUST background is most likely due to the observation of tropical UV arcs, a natural airglow phenomenon. Strategies for future shuttle experiments to overcome this and other natural emissions are discussed.     

Space flight, microgravity, stress, and immune responses.

Exposure of animals and humans to space flight conditions has resulted in numerous alterations in immunological parameters. Decreases in lymphocyte blastogenesis, cytokine production, and natural killer cell activity have all been reported after space flight. Alterations in leukocyte subset distribution have also been reported after flight of humans and animals in space. The relative contribution of microgravity conditions and stress to the observed results has not been established. Antiorthostatic, hypokinetic, hypodynamic, suspension of rodents and chronic head-down tilt bed-rest of humans have been used to model effects of microgravity on immune responses. After use of these models, some effects of space flight on immune responses, such as decreases in cytokine function, were observed, but others, such as alterations in leukocyte subset distribution, were not observed. These results suggest that stresses that occur during space flight could combine with microgravity conditions in inducing the changes seen in immune responses after space flight. The biological/biomedical significance of space flight induced changes in immune parameters remains to be established. Grant Numbers: NCC2-859, NAG2-933.     

Climate studies from satellite observations: Special problems in the verification of earth radiation balance,cloud climatology,and related climate experiments

A body of techniques that have been developed and planned for use during the Earth Radiation Budget Experiment (ERBE), the International Satellite Cloud Climatology Project (ISCCP), and related climate experiments of the 1980's are reviewed. Validation and verification methods must apply for $\text{systems}$ of satellites. They include: (1) use of a normalization or intercalibration satellite, (2) special intensive observation areas located over ground-truth sites, and (3) monitoring of sun and earth by several satellites and/or several instruments at the same time. Since each climate application area has a hierarchy of user communities, validation techniques vary from very detailed methods to those that simply assure high relative accuracy in detecting space and time variations for climate studies. It is shown that climate experiments generally require more emphasis on long-term stability and internal consistency of satellite data sets than high absolute accuracy.     

The role of space communication in promoting national development with specific reference to experiments conducted in India

The paper describes the role of space communication in promoting national development with special reference to experiments conducted in India, namely SITE (1975–1976), STEP (1977–1979) and APPLE (1981 onwards). The impact of these experiments in economic, cultural and educational terms are discussed, pointing out social implications involved in using advance space communication technology for instruction and information in the areas of education, national integration and development. The paper covers special requirements which arise when a communication system covers backward and remote rural areas in a developing country. The impact on the population measured by conducting social surveys has been discussed — especially the gains of predominently illiterate new media — participants have been highlighted. Possibilities of improving skills of teachers, the quality of the primary and higher education have been covered. The preparation required both on ground as well as space to derive benefits of space technology are considered. A profile of INSAT which marks the culmination of the experimental phase and the beginning of operational domestic satellite system is sketched.     

无人飞行器三维类脑SLAM自主导航方法

随着动物大脑中导航细胞的发现以及人工智能的快速发展,受动物启发的类脑SLAM自主导航方法为突破现有导航方式的瓶颈提供了新的思路。本文针对无人飞行器类脑SLAM自主导航技术的研究进展进行了综述, 包括：1）论述无人飞行器SLAM技术研究现状;2）在二维SLAM导航技术的基础上介绍了三维空间以及单一环境下的类脑SLAM自主导航方案;3）分析了二维及三维类脑SLAM自主导航方案的关键技术;4）最后对现有三维导航方案进行分析验证并指出目前类脑SLAM在无人飞行器上应用时亟需解决的问题。类脑SLAM技术不依赖于高精度传感器、对环境适应性强、自主智能性高,更加适用于无人飞行器复杂动态的飞行环境。     

地震电磁卫星任务规划系统研究

地震电磁卫星任务规划是支持卫星在轨业务运控的核心环节. 通过对地震电磁卫星任务规划系统的研究, 提出了地震电磁探测卫星任务规划的基本原则, 设计了地震电磁探测卫星任务规划系统架构, 分析了系统功能需求和规划处理流程, 在此基础上对地震电磁卫星进行了原型实现.      

Protective effects of melatonin against C beam irradiation-induced oxidative stress and DNA injury in the mouse brain

The purpose of this experiment was to estimate the protective effects of melatonin against radiation-induced brain damages in mice induced by heavy ion beams. Kun-Ming mice were randomly divided into five groups: normal control group, irradiation control group, and three different doses of melatonin (5, 10, and 20 mg/kg, i.p.) treated groups. Apart from the normal control group, the other four groups were exposed to whole-body 4.0 Gy carbon ion beam irradiation (approximately 0.5 Gy/min) after i.p. administration of normal saline or melatonin 1 h before irradiation. The oxidative redox status of brain tissue was assessed by measurement of malondiadehyde (MDA) levels, total superoxide dismutase (T-SOD), cytosolic superoxide dismutase (Cu/ZnSOD, SOD1) and mitochondrial superoxide dismutase (MnSOD, SOD2) activities at 8 h after irradiation. DNA damages were determined using the Comet assay and apoptosis and cell cycle distribution were detected by flow cytometric analyses. A dramatic dose-dependent decrease in MDA levels, tail moment, rates of tailing cells, and apoptosis, and a dose-dependent increase in T-SOD and SOD2 activities, in brain tissues in the melatonin-treated groups were detected compared with the irradiation only group. Furthermore, flow cytometric analysis demonstrated that the percentage of brain cells in the G0/G1 phase decreased significantly, while those in the S and G2/M stage increased dramatically, with mice pretreated with melatonin compared to the irradiation control group. These data indicate that melatonin has protective effects against irradiation-induced brain injury, and that its underlying protective mechanisms may relate to modulation of oxidative stress induced by heavy ionirradiation.     

我国首次空间微重力下的材料加工试验

1987年8月5日至10日,我国首次利用返回卫星进行了空间微重力下的材料加工实验。本次试验共有12个项目,其中砷化镓单晶生长达到国际先进水平,Y-Ba-Cu高温超导材料试验则为世界首次,HgCdTe红外材料,Insb半导体材料和难混合全都取得了地面不能得到的结果。这次试验的多用途加工炉吸收了国外空间加工技术的特点,构思巧妙、效果明显.一炉多用开创空间搭载的新路子。