The European vestibular experiments in Spacelab-1.

A series of experiments were performed in the Spacelab-1 mission on November/December, 1983, pre-, in-, and postflight. These experiments covered various aspects of the functions of the vestibular system, the inflight tests comprising threshold measurements for linear movements in three orthogonal axes, optokinetic stimulation, vestibulo-ocular reflexes under linear and angular accelerations, caloric stimulation with and without linear accelerations; pre- and postflight tests repeated the inflight protocol with the addition of subjective vertical and eye counter-rotation measurements using a tilt table. One of the most surprising and significant results was the caloric test: strong caloric nystagmus on the two subjects tested was recorded inflight; this was contrary to what was expected from Barany's convection hypothesis for caloric nystagmus.     

Review of primary spaceflight-induced and secondary reloading-induced changes in slow antigravity muscles of rats.

We have examined the light and electron microscopic properties of hindlimb muscles of rats flown in space for 1-2 weeks on Cosmos biosatellite flights 1887 and 2044 and Space Shuttle missions Spacelab-3, Spacelab Life Sciences-1 and Spacelab Life Sciences-2. Tissues were obtained both inflight and postflight permitting definition of primary microgravity-induced changes and secondary reentry and gravity reloading-induced alterations. Spaceflight causes atrophy and expression of fast fiber characteristics in slow antigravity muscles. The stresses of reentry and reloading reveal that atrophic muscles show increased susceptibility to interstitial edema and ischemic-anoxic necrosis as well as muscle fiber tearing with disruption of contractile proteins. These results demonstrate that the effects of spaceflight on skeletal muscle are multifaceted, and major changes occur both inflight and following return to Earth's gravity.     

Marangoni convection when the surface tension increases with the temperature in normal and low gravity conditions

Thermocapillary convection has been studied in n-heptanol aqueous solutions whose surface tension is increasing with the temperature.

The fluid was confined in a parallelipipedic enclosure and a thermal gradient was imposed parallel to the free liquid/gas interface. The motions induced by the thermocapillary forces have been studied under low gravity conditions during Texus sounding rocket experiments and during the Spacelab D1 mission.

The combined thermocapillary and buoyancy convection have been extensively studied during ground based experiments.

The influence of the aspect ratio and of the alcohol concentration were investigated. Detailed velocity field was determined at the steady state under normal gravity conditions by Laser Doppler Anemometry (LDA).

The aspect ratio was of 0.3 and the temperatures imposed to the lateral sides of the cell were respectively 45°C and 60°C. With these experimental conditions, two superposed contrarotative cells were observed with rapid motions in the surface from the cold to the hot side. This convective pattern was also observed during the normal and high gravity periods of parabolic flights but during the low gravity period of the parabola the motions stopped everywhere in the fluid even in the surface and reappeared immediatly at the pull out of the parabola.     

The first dedicated Life Sciences mission--Spacelab 4.

Spacelab is a large versatile laboratory carried in the bay of the Shuttle Orbiter. The first Spacelab mission dedicated entirely to Life Sciences is known as Spacelab 4. It is scheduled for launch in late 1985 and will remain aloft for seven days. This payload consists of 25 tentatively selected investigations combined into a comprehensive integrated exploration of the effects of acute weightlessness on living systems. An emphasis is placed on studying physiological changes that have been previously observed in manned space flight. This payload has complementary designs in the human and animal investigations in order to validate animal models of human physiology in weightlessness. The experimental subjects include humans, squirrel monkeys, laboratory rats, several species of plants, and frog eggs. The primary scientific objectives include study of the acute cephalic fluid shift, cardiovascular adaptation to weightlessness, including postflight reductions in orthostatic tolerance and exercise capacity, and changes in vestibular function, including space motion sickness, associated with weightlessness. Secondary scientific objectives include the study of red cell mass reduction, negative nitrogen balance, altered calcium metabolism, suppressed in vitro lymphocyte reactivity, gravitropism and photropism in plants, and fertilization and early development in frog eggs. The rationale behind this payload, the selection process, and details of the individual investigations are presented in this paper.     

Summary of current radiation dosimetry results on manned spacecraft.

Measurements of radiation exposures aboard manned space flights of various altitudes, orbital inclinations and durations were performed by means of passive radiation detectors, thermoluminescent detectors (TLD's), and in some cases by active electronic counters. The TLD's and electronic counters covered the lower portion of the LET (linear energy transfer) spectra, while the nuclear track detectors measured high-LET produced by HZE particles. In Spacelab (SL-1), TLD's recorded a range of 102 to 190-millirad, yielding an average low-LET dose rate of 11.2 mrad per day inside the module, about twice the dose rate measured on previous space shuttle flights. Because of a higher inclination of the SL-1 orbit (57 degrees versus 28.5 degrees for previous shuttle flights), substantial fluxes of highly ionizing HZE particles were also observed, yielding an overall average mission dose-equivalent of about 135 millirem, about three times higher than measured an previous shuttle missions. A dose rate more than an order of magnitude higher than for any other space shuttle light was obtained for mission STS-41C, reflecting the highest orbital altitude to date of 519 km.     

ESA microgravity payloads for the 1990s

Analysis of flight opportunities of existing and new microgravity multi-user facilities on Eureca and Spacelab and design studies of new experimental facilities for Columbus are presently in progress.

The materials and fluid sciences research community is likely to be a major user of the permanently manned Space Station/Columbus elements such as the European Attached Pressurised Module (APM) and the Man-Tended Free Flyer (MTFF).

In metallurgy, crystal growth and bioengineering initial research will be performed in the manned laboratory, whereas later on the processing will be automated and executed on unmanned platforms.

At present ESA prepares - in close cooperation with the scientific community - the hardware development of microgravity experimental facilities/laboratories for all Columbus elements through design studies. Preliminary studies which have been carried out to date are the following : Crystallisation Laboratory, Fluid Sciences Laboratory, Containerless Processing Laboratory, Thermophysical Properties Measurement Facility, Metallurgy Laboratory.

In 1998 it is planned to deepen these studies covering laboratories for the APM and for the MTFF. Details on flight opportunities in the pre-Columbus period will also be provided.     

Effects of gravity on early development.

The development of embryonic and larval stages of the South African Toad Xenopus laevis D, was investigated in hyper-g up to 5 g (centrifuge), in simulated 0 g (fast-rotating clinostat), in alternating low g, hyper-g (parabolic flights) and in microgravity (Spacelab missions D1, D-2). The selected developmental stages are assumed to be very sensitive to environmental stimuli. The results showed that the developmental reaction processes run normal also in environments different to 1 g and that aberrations in behavior and morphology normalize after return to 1 g. Development, differentiation, and morphology of the gravity perceiving parts of the vestibular system (macula-organs) had not been affected by exposure to different g-levels.     

Fluid physics experiments under microgravity conditions

The proposals for the detailed investigations of the Marangoni Bénard instability problem are described. It will be performed during the Spacelab D2 mission and prepared during Texus sounding rocket flight.     

Influence of gravitoinertial force on vestibular nystagmus in man observed in a centrifuge.

The influence of gravity load on the vestibular system in man was investigated in a centrifuge operating on the free swing principle. The vertical vestibular nystagmus induced by acceleration to 3G was analyzed and compared with reference measurements during 1G. Our data indicate that the effects of increased gravity load include a prolonged decay time constant of upbeat nystagmus and a subject-dependent persisting upbeat nystagmus. In an attempt to explain these findings, an extension of the velocity storage model is proposed, with gravity as a second stimulus function in addition to angular acceleration.     

Measurement of the partial oxygen pressure and oxygen utilization in the skin of cosmonauts aboard Salyut 6

The oxygen tension (PO₂) in the dorsal skin surface of the forearm was studied during the stay of cosmonauts on board Salyut 6. Between the fourth and fifth day of stay on the orbital station a considerable reduction of the PO₂ level was observed. The oxygen utilization values were also reduced. In the early postflight period the low PO₂ level persisted, with gradual normalization.     

Experimental analysis of the breakage of a liquid bridge under microgravity conditions

The experimental results obtained in experiment “STACO” made on board the Spacelab D-2 are re-visited, with image-analysis tools not then available. The configuration consisted of a liquid bridge between two solid supporting discs. An expected breakage occurred during the experiment. The recorded images are analysed and the measured behaviour compared with the results of a three dimensional model of the liquid dynamics, obtaining a much better fit than with linear models.     

Influence of long-term altered gravity on the swimming performance of developing cichlid fish: including results from the 2nd German Spacelab Mission D-2.

This study presents qualitative and quantitative data concerning gravity-dependent changes in the swimming behaviour of developing cichlid fish larvae (Oreochromis mossambicus) after a 9 resp. 10 days exposure to increased acceleration (centrifuge experiments), to reduced gravity (fast-rotating clinostat), changed accelerations (parabolic aircraft flights) and to near weightlessness (2nd German Spacelab Mission D-2). Changes of gravity initially cause disturbances of the swimming performance of the fish larvae. With prolonged stay in orbit a step by step normalisation of the swimming behaviour took place in the fish. After return to 1g earth conditions no somersaulting or looping could be detected concerning the fish, but still slow and disorientated movements as compared to controls occurred. The fish larvae adapted to earth gravity within 3-5 days. Fish seem to be in a distinct early developmental stages extreme sensitive and adaptable to altered gravity; However, elder fish either do not react or show compensatory behaviour e.g. escape reactions.     

Neuroplastic reactivity of fish induced by altered gravity conditions: a review of recent results.

A review is being presented concerning behavioural, biochemical, histochemical and electronmicroscopical data on the influence of altered gravitational forces on the swimming performance and on the neuronal differentiation of the brain of cichlid fish larvae and adult swordtail fish that had been exposed to hyper-gravity (3g in laboratory centrifuges), hypo-gravity (>10(-2) g in a fast-rotating clinostat) and to near weightlessness (10(-4) g aboard the Spacelab D-2 mission). After long-term alterations of gravity (and parallel light deprivation), initial disturbances in the swimming behaviour followed by a stepwise regain of normal swimming modes are induced. Parallel, neuroplastic reactivities on different levels of investigation were found, such as adaptive alterations of activities of various enzymes in whole brain as well as in specific neuronal integration centers and an intraneuronal reactivity on ultrastructural level in individual brain parts and in the sensory epithelia of the inner ear. Taken together, these data reveal distinct adaptive neuroplastic reactions of fish to altered gravity conditions.     

Remote sensing of the atmospheric from scientific stations “Salyut”

A review of the four-channel teleradiometer “Micron” calibration and data processing techniques has been presented. The sensor validation of the space-borne teleradiometer “Micron” was based on the following: the preflight absolute calibration with the state certificated standard, the secondary onboard standard (miniature filament lamp), the inflight measurements of the Moon's brightness. The procedure of the extinction coefficient determination from the daytime horizon profiles has been developed. The validity of the used techniques was estimated by carring out model calculations. An optimal measuring procedure has been recommended. The proposed simple techniques are used for processing the space measured horizon brightness data. The results have been compared with the earlier published ones.     

Development of the Infrared Telescope in Space: IRTS

Infrared Telescope in Space (IRTS) is a cryogenically cooled small infrared telescope aboard the small space platform, SFU (Space Flyer Unit). IRTS has a telescope of 15 cm diameter, which is rather small compared with other big space missions. IRTS, however, is optimized to observe extended diffuse sources with four focal plane instruments which have wide wavelength coverage from the near infrared to the submillimeter region.

All instruments have been calibrated with a test cryostat, and integrated into the flight cryostat. Cooling tests of the whole IRTS system have confirmed that instruments and cryostat will perform as expected. Integration of the IRTS on the SFU will soon begin and the ground tests of the SFU system will be conducted in the coming year.

The launch of the SFU will be in early 1995. The IRTS will survey the 10% of the sky during the three week mission and provide significant scientific results on cosmology, galactic structure, interstellar matter, stars, and solar system.     

Microorganisms and biomolecules in space environment experiment ES 029 on Spacelab-1.

Bacterial spores are proper test organisms for studying problems of space biology and exobiology. During the Spacelab 1 mission, studies on the limiting factors for survival of Bacillus subtilis spores in free space have been performed. An exposure tray on the pallet of Spacelab 1 accomodated 316 samples of dry spores for treatment with space vacuum and/or the following selected wavelengths of solar UV: > 170 nm, 220 nm, 240nm, 260nm and 280 nm. After recovery, inactivation, mutation induction, reparability, and photochemical damages in DNA and protein have been studied. The results contribute to the understanding of the mechanisms of increased UV sensitivity of bacterial spores in vacuo and to a better assessment of the chance of survival of resistant forms in space and of interplanetary transfer of life.     

SMESE: A SMall Explorer for Solar Eruptions

The SMall Explorer for Solar Eruptions (SMESE) mission is a microsatellite proposed by France and China. The payload of SMESE consists of three packages: LYOT (a Lyman imager and a Lyman coronagraph), DESIR (an Infra-Red Telescope working at 35–80 and 100–250 μm), and HEBS (a High-Energy Burst Spectrometer working in X- and γ-rays).

The status of research on flares and coronal mass ejections is briefly reviewed in the context of on-going missions such as SOHO, TRACE and RHESSI. The scientific objectives and the profile of the mission are described. With a launch around 2012–2013, SMESE will provide a unique tool for detecting and understanding eruptions (flares and coronal mass ejections) close to the maximum phase of activity.     

Instrument concept and preliminary performance analysis of GLORIA

The Global Radiance Limb Imager Experiment for the Atmosphere (GLORIA) shall provide a detailed global picture of the upper troposphere/lower stratosphere region (UTLS) and make available novel information on small-scale atmospheric dynamics.

The instrument will be a space borne imaging Fourier Transform Spectrometer operating in the thermal infrared spectral region. It will produce spectrally resolved images of the earth’s limb with a vertical extension of 60 km and a horizontal extension of 400 km. The paper focuses on the preliminary instrument concept and on results of studies concerning sensitivity and spectrometric performance. GLORIA has been proposed as a national German space mission. An aircraft version is currently under development.     

Bioscience experiments in the German Spacelab mission D-1: introduction and summary.

The German Spacelab mission D-l was performed from 30 October through 6 November 1985. Payload operation in orbit was managed by DFVLR for the Federal Ministry of Research and Technology. The scientific program of the mission placed emphasis on microgravity research. In bioscience, the role of gravity in vital functions of biological systems was investigated, such as intracellular and intercellular interactions, developmental processes as well as regulation and adaptation in highly organized systems including human beings. In addition, the biological significance of cosmic radiation or altered zeitgeber within the complex matrix of all relevant spaceflight components were studied. Most of the experiments were accommodated in the following three payload elements: The Bioscience Experiment Package, and the ESA facilities Vestibular Sled and BIORACK. The information gained from the individual experiments will be compiled to help answer pending questions of space bioscience.