选择中国载人航天发展目标的讨论

回顾人类载人航天 40余年的历程 ,出现过一些弯路 ,究其原因是多方面的 ,但主要的是如何合理选择各自的发展目标。发展载人航天的目标大致可有6项 :开发利用空间微重力环境物质资源 ,开发利用空间轨道能源资源 ,开发利用月球能源资源 ,发展天基航天利用空间位置资源 ,在月球上扩大人类生存空间 ,在火星上扩大人类生存空间。文章系统分析了国际上现有载人航天工程的经验和教训 ,认为结合中国的具体实际 ,中国载人航天发展的目标应重点考虑开发利用空间微重力环境物质资源和发展天基航天。     

Space Life Science of China

With the human space exploration activities, space life science is an emerging interdiscipline, which covers a wide range of researches. Based on our country's manned space station and recoverable satellite science experimental platform, the development of space life science research is very important to acquire new knowledge or new technological innovation, to give further services to the human space exploration activities, to improve the national economic and social development. Both ground-based and flight applied studies were continuously performed in the previous 2 years. Here, we review and summarize the researches on space life sciences contributed by Chinese scientists.      

一种通用的航天器在轨分离设计方法

随着空间探测任务的多样化和复杂化,利用单个航天器的多舱段实现多任务、多目标探测已成为航天技术的发展趋势。通常情况下,舱段分离信号将触发航天器的后续自主控制,直接影响航天器的自身安全和后续任务执行。本文从保证分离信号可靠和分离过程安全的角度提出了一种典型的分离信号配置与通用的分离信号触发控制逻辑,并建立了航天器在轨分离安全性数学模型。该模型和逻辑控制方法经过仿真分析和实际在轨飞行任务验证,确认了方法的可行性和正确性,可以作为后续航天任务的参考。     

Radiation-induced health effects on atmospheric flight crew members: clues for a radiation-related risk analysis.

There are few human data on low-dose-rate-radiation exposure and the consequent acute and late effects. This fact makes it difficult to assess health risks due to radiation in the space environment, especially for long-term missions. Epidemiological data on civilian flight personnel cohorts can provide information on effects due to the low-dose and low-dose rate mixed high- and low-LET radiation environment in the earth's atmosphere. The physical characteristics of the radiation environment of the atmosphere make the results of the studies of commercial flight personnel relevant to the studies of activities in space. The cooperative international effort now in progress to investigate dose reconstructions will contribute to our understanding of radiation risks for space exploration.     

火星探测无人机任务规划与建模分析

利用无人机进行火星探测, 具有探测范围广、可看到地形变化等优点. 介绍了火星探测无人机总体任务规划的情况, 讨论了探测无人机在火星与地球上飞行的区别, 建立了火星探测无人机纵向非线性模型, 并在平衡点对非线性模型进行泰勒展开, 得到线性化模型. 通过对线性模型的进一步分析, 掌握了火星探测无人机的稳态性能及飞行特点.      

Changes in the central nervous system during long-duration space flight: implications for neuro-imaging.

The purpose of this paper is to review the potential functional and morphological effects of long duration space flight on the human central nervous system (CNS) and how current neuroimaging techniques may be utilized to study these effects. It must be determined if there will be any detrimental changes to the CNS from long term exposure to the space environment if human beings are to plan interplanetary missions or establish permanent space habitats. Research to date has focused primarily on the short term changes in the CNS as the result of space flight. The space environment has many factors such as weightlessness, electromagnetic fields, and radiation, that may impact upon the function and structure of the CNS. CNS changes known to occur during and after long term space flight include neurovestibular disturbances, cephalic fluid shifts, alterations in sensory perception, changes in proprioception, psychological disturbances, and cognitive changes. Animal studies have shown altered plasticity of the neural cytoarchitecture, decreased neuronal metabolism in the hypothalamus, and changes in neurotransmitter concentrations. Recent progress in the ability to study brain morphology, cerebral metabolism, and neurochemistry in vivo in the human brain would provide ample opportunity to investigate many of the changes that occur in the CNS as a result of space flight. These methods include positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetic resonance imaging (MRI).     

Development of New Capabilities Using Machine Learning for Space Weather Prediction

With the development of space exploration and space environment measurements, the numerous observations of solar, solar wind, and near Earth space environment have been obtained in last 20 years. The accumulation of multiple data makes it possible to better use machine learning technique, which has achieved unforeseen results in industrial applications in last decades, for developing new approaches and models in space weather investigation and prediction. In this paper, the efforts on the forecasting methods for space weather indices, events, and parameters using machine learning are briefly introduced based on the study works in recent years. These investigations indicate that machine learning, especially deep learning technique can be used in automatic characteristic identification, solar eruption prediction, space weather forecasting for solar and geomagnetic indices, and modeling of space environment parameters.      

有大气行星悬飞探测初步设想与可行性探讨

提出了一种有大气地外行星悬飞探测方式,该探测方式是利用被探测天体存在大气的环境特点,实现探测器在被测天体的"飞行"机动,克服目前已有的环绕探测、着陆探测、巡视探测和采样返回探测四类无人深空探测方式受地形、地貌约束无法实现大范围机动就位探测的不足。提出了悬飞探测器的典型任务工作模式设想,建立了悬飞探测器的六自由度动力学模型,并针对太阳系内典型的有大气行星环境(火星和土卫六)特点,给出了悬飞探测器的动力学特性并开展了仿真分析。在此基础上,首次提出了悬飞探测器的可行性约束系数,为悬飞探测器在深空探测的可行性研究提供了理论依据。     

深空探测人工智能技术应用及发展建议

深空探测任务的探测目标距离地球越来越远,测控延时逐步增大,并且目标的先验知识有限,在遥远、未知、不确定环境下开展科学探索对探测器的自主性能需求日益强烈。随着人工智能技术的快速发展并逐步实用,在深空探测领域中应用人工智能技术提高和改进航天器自主性也将成为必须和可能。简要介绍了人工智能技术的发展历程,分析了航天领域中人工智能技术的应用实例,重点结合规划的深空探测任务特点和应用场景,梳理分析了各具体任务对人工智能技术应用的潜在需求,并提出了对深空探测人工智能技术应用的一些看法和发展建议。     

空间小鼠实验有效载荷研究进展

啮齿动物是空间研究中常见的模型对象,已开展的空间生物实验中,小鼠表现出对飞行条件的有效适应.通过空间培养,研究者可对失重环境下小鼠的生理行为、骨骼和神经系统变化做进一步研究分析.本文对空间小鼠实验有效载荷的研究进展及其空间飞行实验进行了概述,为中国空间站上的小鼠培养箱设计提供参考.概述了地面小鼠培养技术和装置,为空间小...     

日地L1点探测任务设计与结果分析

日地L1点是太阳观测任务的理想观测点,对于中国后续太阳观测任务具有重要意义,因此在嫦娥五号的拓展任务阶段设计并实施了中国首次日地L1点探测任务,通过在轨飞行验证了日地L1点转移轨道、环绕轨道设计的正确性,对日地L1点的测控链路环境、太阳辐照环境、三体动力学环境、空间辐射环境等飞行环境进行了探测和验证。轨道飞行和各项环境探测的结果与设计模型的预示结果之间比对一致性较好,通过在轨飞行数据验证了设计模型的正确性。各项试验获得了预期的技术成果,进一步丰富了嫦娥五号任务的成果产出,对中国后续深空探测任务和产品的设计具有重要借鉴意义。     

Effects of space flight exposure on cell growth,tumorigenicity and gene expression in cancer cells

It is well recognized that harsh outer space environment, consisting of microgravity and radiation, poses significant health risks for human cells. To investigate potential effects of the space environment exposure on cancer cells we examined the biological changes in Caski cells carried by the “Shen Zhou IV” spaceship. After exposure for 7 days in spaceflight, 1440 survival subclonal cell lines were established and 4 cell lines were screened. 44F10 and 17E3 were selected because of their increased cell proliferation and tumorigenesis, while 48A9 and 31F2 had slower cytological events. Experiments with cell proliferation assay, flow cytometry, soft agar assay, tumorigenesis assay and DNA microarray analysis have shown that selected cell lines presented multiple biological changes in cell morphology, cell growth, tumorigenicity and gene expression. These results suggest that space environment exposure can make significant biological impact on cancer cells and provide an entry point to find the immunological target of tumorigenesis.     

微重力环境中哺乳动物细胞分子生物学效应研究进展

随着载人航天事业的不断发展,空间失重环境引起的航天员健康问题（心血管疾病、免疫抑制、肌肉萎缩、骨质疏松等）日益突出,这已成为人类探索空间的一大阻碍.越来越多的研究关注到微重力条件下机体及细胞的变化.近期的研究表明,在细胞水平上,微重力会引起细胞降解,改变细胞骨架,并造成细胞在分子水平（如细胞增殖、分化、迁移、粘附、信号转导等过程）的一系列改变.本文对微重力条件下免疫细胞、内皮细胞、骨细胞、癌细胞的相关研究进行了归纳总结,研究结果可为微重力条件下机体及相关细胞的研究提供指导,为治疗或缓解微重力条件造成的疾病提供方法和思路.      

Space flight, microgravity, stress, and immune responses.

Exposure of animals and humans to space flight conditions has resulted in numerous alterations in immunological parameters. Decreases in lymphocyte blastogenesis, cytokine production, and natural killer cell activity have all been reported after space flight. Alterations in leukocyte subset distribution have also been reported after flight of humans and animals in space. The relative contribution of microgravity conditions and stress to the observed results has not been established. Antiorthostatic, hypokinetic, hypodynamic, suspension of rodents and chronic head-down tilt bed-rest of humans have been used to model effects of microgravity on immune responses. After use of these models, some effects of space flight on immune responses, such as decreases in cytokine function, were observed, but others, such as alterations in leukocyte subset distribution, were not observed. These results suggest that stresses that occur during space flight could combine with microgravity conditions in inducing the changes seen in immune responses after space flight. The biological/biomedical significance of space flight induced changes in immune parameters remains to be established. Grant Numbers: NCC2-859, NAG2-933.     

中国探月工程

"嫦娥4号"于2019年1月3日成功实现人类航天器首次在月球背面软着陆,"玉兔2号"月球车率先在月背刻上了中国足迹。至今,国际月球探测活动共实施126次,期间出现两个探月高潮。20世纪50—70年代,美苏两个航天大国之间的竞争引起第一轮探月高潮。20世纪末至今,各航天国家意识到月球探测的战略意义,纷纷提出月球探测计划并积极实施,月球成为各国争先探测的热点,掀起第二轮探月热潮。中国自2004年首次绕月探测工程立项实施以来,共开展了"嫦娥1号""嫦娥2号""嫦娥3号""嫦娥4号"及再入返回飞行试验共5次月球探测任务,实现"五战五捷",在空间技术、空间科学与应用、国际合作等方面取得了非凡成就,积累了丰富的经验,后续将继续开展以无人月球科研站为主的月球探测活动。