Genetic and physiological damage induced by cosmic radiation on dry plant seeds during space flight

Total evaluation of cosmic radiation effect with or without discrimination of individualized HZE-ion effects in dry seeds flown for 10 days on STS-9, yielded significant evidence for radiation damage in space. They depend on the biological criteria tested (seed germination, morphogenesis, embryo lethality, mutation rate) which stand for early, physiological and late genetic effects. They are also related to the radiation shielding environment in the space shuttle. Proceeding from these results three direct questions can be posed for present (LDEF-1) and future (ERA-1, D-2) experiments in space: What is the influence of cosmic radiation on cytogenetic repair and ontogenetic restitution processes? Does microgravity disorder the morphogenesis (i.e. growth and cell differentiation)? Is there an interaction between the effects of cosmic radiation and microgravity in eukaryotic plant systems?     

深空辐射条件下EDFA波分复用性能研究

随着对空间试验卫星光通信系统数据容量需求的逐年增加,空间波分复用技术将成为拓展通信容量的有效手段,需要研究掺铒光纤放大器(Erbium Doped Fiber Amplifier,EDFA)波分复用特性在深空辐射条件下的性能变化情况。研究了深空辐射及温度场对EDFA的性能影响、非均匀特性,建立了深空辐射条件下EDFA的波分复用(Wavelength Division Multiplexing,WDM)技术信号之间的增益影响模型,给出了增益的非均匀变化影响的评估方法。并分别采用电子和中子作为辐射源,进行了地面模拟深空辐射环境的辐射电离效应和辐射位移效应实验,实验结果进一步验证了该模型正确性。利用该模型,可获得深空辐射环境中,不同辐射类型、不同温度下,EDFA在WDM应用时各波长增益的非均匀特性,可为深空光通信中EDFA的WDM应用提供参考。     

航天员受银河宇宙线辐射的剂量计算

在近地空间(LEO)和深空探测中,航天员遭受的辐射风险主要来自于银河宇宙线(GCR)照射.银河宇宙线的辐射剂量是航天员辐射风险评价的基础.国际放射防护委员会(ICRP)于2013年提出了新的航天员空间辐射剂量估算方法,以更准确给出空间重离子辐射的剂量.基于此方法,开发了宇宙线粒子在物质中输运的蒙特卡罗程序,并在程序中实现用中国成年男性人体数字模型来仿真航天员.采用该程序计算了粒子(Z=1~92)各向同性照射航天员时器官的通量-器官剂量转换因数,并估算出航天员在近地轨道空间受银河宇宙线辐射的剂量.     

Estimation of a cosmonaut's radiation hazard during long-term space missions on the basis of a generalized dosimetric function.

This paper presents a new concept of radiation hazard assessment for spacecraft crew members during long term space missions on the basis of a generalized dosimetric function. This new dosimetric function enables a complicated nature of space radiation exposure to be reduced to the conditions of a standard irradiation. It can be obtained on the basis of mean-tissue equivalent dose values calculated for each space radiation source and transmission coefficients describing the influence of the complex spatial and temporal distribution of the absorbed dose in the cosmonaut's body on the radiobiological effects. The combination of cosmic ionizing radiation with other non-radiation nature factors in flight can also be accounted for. In terms of the generalized dose, it is possible to assess the nature and extent of lowering a crew working capacity, as well as radiation risk, both during a flight and post flight period.     

High frequency electromagnetic radiation in CRRES geostationary injections

It is shown that experiments with geostationary injections of dense barium plasma clouds after CRRES program presented a unique opportunity for investigation of Earth's space environment radiation generation mechanism at frequencies 100 to1000 times higher than the usual plasma frequency signal. We present electromagnetic noise or radiostorm data obtained in Havana in broad frequency bands 45–90 MHz, 235MHz and 280 MHz after Ba injection. It is proposed that signals appearing with 7 to 10 min delay after injection possibly caused a substorm initiated by the injection, during which the radiation is generated by local energetic particles flowing through the irregular barium cloud. Another possibility is connected with irradiation of the barium cloud by the Jicamarca radar. Modulation of radioburst at barium gyrofrequency is typical for both cases.     

相变储热/辐射器式热沉的传热特性研究

对一种用于舱外活动的相变储热/辐射器式热沉进行了实验研究和数值模拟.设计了相变储热器的实验件和实验方案,进行了储热器的冷却实验.建立了具有导热与对流换热耦合边界的相变储热器数学模型,模型中考虑了自然对流及空穴的影响.编制了相变储热器的性能分析计算程序.通过实验值与计算值的比较分析,验证了程序的可靠性.该模型及计算程序为相变储热器的设计和优化提供了有利的分析工具.     

Unique radiobiological aspects of high-LET radiation.

Since the beg inning of manned space flight the potentially unique radiobiological properties of the heavy ions of the cosmic radiation had been, apart from possible interactions of radiation effects with biological effects of weightlessness, of major concern with respect to the assessment of radiation hazards in manned space flight. Radiobiological findings obtained from space flight experiments and ground based experiments with densely ionizing radiation are discussed, which suggest qualitative differences between the radiobiological mechanisms of sparsely ionizing and densely ionizing radiation. These findings comprise the observation of a long lateral range of radiobiological effectiveness around tracks of single heavy ions, the observation of micro lesions induced in biological targets by the penetration of heavy ions, the nonadditivity of radiobiological effects from sparsely and densely ionizing radiation, the different kinetics for the expression of late effects induced by sparsely or densely ionizing radiation, and the observation of a reversed dose rate effect for early and late effects induced by densely ionizing radiation. These findings bear on the radiation protection standards to be installed for a general public in manned space flight and on the design of experiments, which intend to contribute to their specification.     

Survival of microorganisms in space protected by meteorite material: results of the experiment 'EXOBIOLOGIE' of the PERSEUS mission.

During the early evolution of life on Earth, before the formation of a protective ozone layer in the atmosphere, high intensities of solar UV radiation of short wavelengths could reach the surface of the Earth. Today the full spectrum of solar UV radiation is only experienced in space, where other important space parameters influence survival and genetic stability additionally, like vacuum, cosmic radiation, temperature extremes, microgravity. To reach a better understanding of the processes leading to the origin, evolution and distribution of life we have performed space experiments with microorganisms. The ability of resistant life forms like bacterial spores to survive high doses of extraterrestrial solar UV alone or in combination with other space parameters, e.g. vacuum, was investigated. Extraterrestrial solar UV was found to have a thousand times higher biological effectiveness than UV radiation filtered by stratospheric ozone concentrations found today on Earth. The protective effects of anorganic substances like artificial or real meteorites were determined on the MIR station. In the experiment EXOBIOLOGIE of the French PERSEUS mission (1999) it was found that very thin layers of anorganic material did not protect spores against the deleterious effects of energy-rich UV radiation in space to the expected amount, but that layers of UV radiation inactivated spores serve as a UV-shield by themselves, so that a hypothetical interplanetary transfer of life by the transport of microorganisms inside rocks through the solar system cannot be excluded, but requires the shielding of a substantial mass of anorganic substances.     

X-ray, γ-emission and energetic particles in near-Earth space as measured by CORONAS-F satellite: From maximum to minimum of the last solar cycle

The Russian solar observatory CORONAS-F was launched into a circular orbit on July 31, 2001 and operated until December 12, 2005. Two main aims of this experiment were: (1) simultaneous study of solar hard X-ray and γ-ray emission and charged solar energetic particles, (2) detailed investigation of how solar energetic particles influence the near-Earth space environment. The CORONAS-F satellite orbit allows one to measure both solar energetic particle dynamics and variations of the solar particle boundary penetration as well as relativistic electrons of the Earth’s outer radiation belt during and after magnetic storms. We have found that significant enhancements of relativistic electron flux in the outer radiation belt were observed not only during strong magnetic storms near solar maximum but also after weak storms caused by high speed solar wind streams. Relativistic electrons of the Earth’s outer radiation belt cause volumetric ionization in the microcircuits of spacecraft causing them to malfunction, and solar energetic particles form an important source of radiation damage in near-Earth space. Therefore, the present results and future research in relativistic electron flux dynamics are very important.     

Self-restoration as fundamental property of CES providing their sustainability.

Sustainability is one of the most important criteria in the creation and evaluation of human life support systems intended for use during long space flights. The common feature of biological and physicochemical life support systems is that basically they are both catalytic. But there are two fundamental properties distinguishing biological systems: 1) they are auto-catalytic: their catalysts--enzymes of protein nature--are continuously reproduced when the system functions; 2) the program of every process performed by enzymes and the program of their reproduction are inherent in the biological system itself--in the totality of genomes of the species involved in the functioning of the ecosystem. Actually, one cell with the genome capable of the phenotypic realization is enough for the self-restoration of the function performed by the cells of this species in the ecosystem. The continuous microalgal culture of Chlorella vulgaris was taken to investigate quantitatively the process of self-restoration in unicellular algae population. Based on the data obtained, we proposed a mathematical model of the restoration process in a cell population that has suffered an acute radiation damage.     

Solar cosmic rays as a specific source of radiation risk during piloted space flight.

Solar cosmic rays present one of several radiation sources that are unique to space flight. Under ground conditions the exposure to individuals has a controlled form and radiation risk occurs as stochastic radiobiological effects. Existence of solar cosmic rays in space leads to a stochastic mode of radiation environment as a result of which any radiobiological consequences of exposure to solar cosmic rays during the flight will be probabilistic values. In this case, the hazard of deterministic effects should also be expressed in radiation risk values. The main deterministic effect under space conditions is radiation sickness. The best dosimetric functional for its analysis is the blood forming organs dose equivalent but not an effective dose. In addition, the repair processes in red bone marrow affect strongly on the manifestation of this pathology and they must be taken into account for radiation risk assessment. A method for taking into account the mentioned above peculiarities for the solar cosmic rays radiation risk assessment during the interplanetary flights is given in the report. It is shown that radiation risk of deterministic effects defined, as the death probability caused by radiation sickness due to acute solar cosmic rays exposure, can be comparable to risk of stochastic effects. Its value decreases strongly because of the fractional mode of exposure during the orbital movement of the spacecraft. On the contrary, during the interplanetary flight, radiation risk of deterministic effects increases significantly because of the residual component of the blood forming organs dose from previous solar proton events. The noted quality of radiation responses must be taken into account for estimating radiation hazard in space.     

Cellular changes in microgravity and the design of space radiation experiments.

Cell metabolism, secretion and cell-cell interactions can be altered during space flight. Early radiobiology experiments have demonstrated synergistic effects of radiation and microgravity as indicated by increased mutagenesis, increased chromosome aberrations, inhibited development, and retarded growth. Microgravity-induced changes in immune cell functions include reduced blastogenesis and cell-mediated, delayed-type hypersensitivity responses, increased cytokine secretions, but inhibited cytotoxic effects and macrophage differentiation. These effects are important because of the high radiosensitivity of immune cells. It is difficult to compare ground studies with space radiation biology experiments because of the complexity of the space radiation environment, types of radiation damage and repair mechanisms. Altered intracellular functions and molecular mechanisms must be considered in the design and interpretation of space radiation experiments. Critical steps in radiocarcinogenesis could be affected. New cell systems and hardware are needed to determine the biological effectiveness of the low dose rate, isotropic, multispectral space radiation and the potential usefulness of radioprotectants during space flight.     

地气光辐射对空间目标成像特性影响分析

为分析地气光辐射对空间目标成像特性的影响,以地球同步轨道(GEO)卫星搭载的可见光成像器为探测平台,利用卫星工具包(STK)设计高椭圆轨道(HEO)及近地轨道(LEO)目标运动场景,根据空间目标、地球、太阳、探测平台之间的位置关系,采用微元法建立空间目标与地气光背景等效星等模型,推导出空间目标信噪比(SNR)计算公式。分析了距离、角度参数变化对不同轨道空间目标、地气光背景等效星等及空间目标信噪比的影响。仿真结果表明:当探测平台距离空间目标较远时,地气光背景等效星等低于空间目标等效星等,地气光辐射比空间目标信号强。当地气光辐射进入和离开空间目标探测视场时,空间目标信噪比最大,该时间段是进行空间目标探测的最佳“观测窗口”。仿真得出的空间目标信噪比值为空间目标探测识别提供了理论计算依据。      

Embryogenesis and organogenesis of Carausius morosus under spaceflight conditions

The influence of cosmic radiation and/or microgravity on insect development was studied during the 7 day German Spacelab Mission D1. Eggs of Carausius morosus of five stages differing in sensitivity to radiation and in capacity to regeneration were allowed to continue their development in the BIORACK 22°C incubator, either at microgravity conditions or on the 1 g reference centrifuge. Using the Biostack concept - eggs in monolayers were sandwiched between visual track detectors - and the 1 g reference centrifuge, we were able to separate radiation effects from microgravity effects and also from combined effects of these two factors in space. After retrieval, hatching rates, growth kinetics and anomaly frequencies were determined in the different test samples. The early stages of development turned out to be highly sensitive to single hits of cosmic ray particles as well as to the temporary exposure to microgravity during their development. In some cases, the combined action of radiation and microgravity even amplified the effects exerted by the single parameters of space. Hits by single HZE particles caused early effects, such as body anomalies, as well as late effects, such as retarded growth after hatching. Microgravity exposure lead to a reduced hatching rate. A synergistic action of HZE particle hits and microgravity was established in the unexpectedly high frequency of anomal larvae. However, it cannot be excluded, that cosmic background radiation or low LET HZE particles are also causally involved in damage observed in the microgravity samples.     

Radiation risk estimation and its application to human beings in space.

The number of human beings likely to spend time in space will increase as time goes on. While exposures vary according to missions, orbits, shielding, etc., an average space radiation fluence (ignoring solar flares, radiation belts and anomalous regions in space) in locations close to earth is about 10 rad/year with a quality factor of about 5.5. The potential effects of exposure to these fluences include both non-stochastic effects and stochastic effects (cancer and genetic damage). Non-stochastic effects, damage to the lens of the eye, bone marrow or gonads, can be avoided by keeping radiation limits below threshold values. Stochastic effects imply risk at all levels. The magnitude of these risks has been discussed in a number of reports by the UNSCEAR Committee and the BEIR Committee in the USA during 1970-1980. The uncertainties associated with these risks and information which has become available since the last BEIR report is discussed. In considering reasonable limits for exposure in space, acceptable levels for stochastic risks must be based on appropriate comparisons. In view of the limited term of duty of most space workers, a lifetime limit may be appropriate. This lifetime limit might be comparable in terms of risks with limits for radiation workers on the ground but received at a higher annual rate for a shorter time. These and other approaches are expected to be considered by an NCRP Committee currently examining the problem of space radiation hazards.     

Radiation-induced health effects on atmospheric flight crew members: clues for a radiation-related risk analysis.

There are few human data on low-dose-rate-radiation exposure and the consequent acute and late effects. This fact makes it difficult to assess health risks due to radiation in the space environment, especially for long-term missions. Epidemiological data on civilian flight personnel cohorts can provide information on effects due to the low-dose and low-dose rate mixed high- and low-LET radiation environment in the earth's atmosphere. The physical characteristics of the radiation environment of the atmosphere make the results of the studies of commercial flight personnel relevant to the studies of activities in space. The cooperative international effort now in progress to investigate dose reconstructions will contribute to our understanding of radiation risks for space exploration.     

移位损伤剂量模型及其应用

首先描述了移位损伤的机理及其影响器件性能的机制,引入了适合航天器工程抗辐射加固设计使用的移位损伤剂量模型,探讨了其在CCD器件电荷传输效率CTE,Si器件平均暗电流以太阳电池阵输出功率等工程参数衰降中的应用,介绍了建立的基于移位损伤剂量模型的空间环境中CCD器件CTE衰降预测模式,其结果与欧空局空间环境信息系统的计算结果相吻合．该程序在光电器件抗辐射加固设计中具有重要的应用价值．     

World-wide radiation dosage calculations for air crew members.

A greatly improved version of the computer program to calculate radiation dosage to air crew members is now available. Designated CARI-6, this program incorporates an updated geomagnetic cutoff rigidity model and a revision of the primary cosmic ray spectrum based on recent work by Gaisser and Stanev (1998). We believe CARI-6 provides the most accurate available method for calculating the radiation dosage to air crew members. The program is now utilized by airline companies around the world and provides unification for subsequent world-wide studies on the effects of natural radiation on aircrew members.     

How Galactic Cosmic Ray models affect the estimation of radiation exposure in space

The radiation environment in space is a major concern for human spaceflight because of the adverse effects of high levels of radiation on astronauts’ health. Therefore, it is essential to perform radiation risk assessments already during the concept studies of a manned mission. Galactic Cosmic Rays (GCR) have been identified to be one of the primary sources of radiation exposure in space.