Thyroid cell growth: sphingomyelin metabolism as non-invasive marker for cell damage acquired during spaceflight

Prolonged spaceflights are known to elicit changes in human cardiovascular, musculoskeletal, and nervous systems, whose functions are regulated by the thyroid gland. It is known that sphingomyelin metabolism is involved in apoptosis (programmed cell death) of thyroid cells induced by UVC radiation, but at present no data exists with regard to this phenomenon, which occurs during space missions. The aim of this study was to analyze, for the first time, the effect of spaceflight on the enzymes of sphingomyelin metabolism, sphingomyelinase, and sphingomyelin synthase, and to determine whether the ratio between the two enzymes might be used as a possible marker for thyroid activity during space missions. Both quiescent thyroid cells and thyroid cells stimulated to proliferate with thyrotropin (TSH) were cultured during the Eneide and Esperia missions on the International Space Station. The results show that during space missions the cells treated with TSH grew only 1.5?±?0.65-fold and, thus, behave similarly to quiescent cells, while on the ground the same cells, maintained in experimental conditions that reproduced those of the flight, grew 7.71?±?0.67-fold. Comparison of the sphingomyelinase/sphingomyelin-synthase ratio and the levels of Bax, STAT3, and RNA polymerase II in proliferating, quiescent, pro-apoptotic, or apoptotic cells demonstrated that thyroid cells during space missions were induced into a pro-apoptotic state. Given its specificity and the small amount of cells needed for analysis, we propose the use of the sphingomyelinase/sphingomyelin-synthase ratio as a marker of functional status of thyroid cells during space missions. Further studies could lead to its use in real time during prolonged spaceflights.     

A survey and assessment of the capabilities of Cubesats for Earth observation

In less than a decade, Cubesats have evolved from purely educational tools to a standard platform for technology demonstration and scientific instrumentation. The use of COTS (Commercial-Off-The-Shelf) components and the ongoing miniaturization of several technologies have already led to scattered instances of missions with promising scientific value. Furthermore, advantages in terms of development cost and development time with respect to larger satellites, as well as the possibility of launching several dozens of Cubesats with a single rocket launch, have brought forth the potential for radically new mission architectures consisting of very large constellations or clusters of Cubesats. These architectures promise to combine the temporal resolution of GEO missions with the spatial resolution of LEO missions, thus breaking a traditional trade-off in Earth observation mission design. This paper assesses the current capabilities of Cubesats with respect to potential employment in Earth observation missions. A thorough review of Cubesat bus technology capabilities is performed, identifying potential limitations and their implications on 17 different Earth observation payload technologies. These results are matched to an exhaustive review of scientific requirements in the field of Earth observation, assessing the possibilities of Cubesats to cope with the requirements set for each one of 21 measurement categories. Based on this review, several Earth observation measurements are identified that can potentially be compatible with the current state-of-the-art of Cubesat technology although some of them have actually never been addressed by any Cubesat mission. Simultaneously, other measurements are identified which are unlikely to be performed by Cubesats in the next few years due to insuperable constraints. Ultimately, this paper is intended to supply a box of ideas for universities to design future Cubesat missions with high scientific payoff.     

天问一号环绕器中继轨道受摄共振特性分析

“天问一号”环绕器在环火中继轨道为“祝融”火星车提供中继服务时,星下点出现了过着陆点纬度时的经度先增大再减小的特殊漂移现象,需要对该现象产生的原因进行深入分析。基于摄动理论设计了一系列数值实验,提出了一种星下点过指定纬度时经度的简化计算方法;并结合对田谐项引力场位函数的解析推导发现,由于中继轨道周期与火星自转周期比接近1:3,导致3阶3次田谐项产生了轨道共振,从而使得半长轴长周期运动有着较为显著的振荡,进而与带谐项摄动联合导致了该特殊现象。研究揭示了“天问一号”环绕器的轨道共振现象,发现了高阶田谐项对非同步轨道上的环火卫星仍能产生较为明显的轨道共振现象。研究结果可为后续火星环绕探测任务轨道设计提供重要参考。     

The roles of humans and robots in exploring the solar system

Historically, advocates of solar system exploration have disagreed over whether program goals could be entirely satisfied by robotic missions. Scientists tend to argue that robotic exploration is most cost-effective. However, the human space program has a great deal of support in the general public, thereby enabling the scientific element of exploration to be larger than it might be as a stand-alone activity. A comprehensive strategy of exploration needs a strong robotic component complementing and supporting human missions. Robots are needed for precursor missions, for crew support on planetary surfaces, and for probing dangerous environments. Robotic field assistants can provide mobility, access to scientific sites, data acquisition, visualization of the environment, precision operations, sample acquisition and analysis, and expertise to human explorers. As long as space exploration depends on public funds, space exploration must include an appropriate mix of human and robotic activity.     

核热推进载人火星探测方案设计

针对载人火星探测任务,结合我国现有技术基础,提出我国载人火星探测方案,重点研究载人火星探测任务推进系统的设计。首先,综合考虑载人深空探测任务的约束,采用Pork-Chop图设计了适用于不同任务场景的转移轨迹;然后,参考我国空间站技术,基于核热推进系统设计了我国载人火星探测任务的飞船;最后,对核热推进系统的发动机台数和推力进行了优化,得到了适用于不同任务场景的最优推进系统组合方案。本文所研究内容为我国未来载人火星探测任务提供了有益参考。     

自主卫星系统基于Agent的建模与仿真研究

为满足越来越高的航天任务要求,卫星系统必须具有一定程度自主性;但自主卫星系统是复杂系统,研究困难,仿真往往成为唯一的有效手段.本文提出使用基于agent的建模与仿真(ABMS)方法研究自主卫星系统的策略.首先分析了3个有代表性的自主航天任务系统,然后详细讨论了卫星系统的自主性,最后介绍了作者独立开发的支持自主卫星系统ABMS的模型体系结构和软件平台--ABSSA和absimlib,为仿真研究自主卫星系统提供了理论和实践支持.     

Radiation protection guidelines for space activities

At the beginning of the space age the dangers of hurtling into space were considerable. Despite this fact, radiation risks were examined in the U.S.S.R. and the U.S.A. and recommendations were made to limit the exposure of the crews to radiation. To date the radiation exposures of crews on missions in low-Earth orbits have been low. Now that missions in low-Earth orbit are becoming longer in duration and new missions into deep space are being considered, radiation protection guidelines become more important. Recently the estimates of the risks of radiation-induced cancer have been increased and new guidelines on radiation exposure limits for crew members must be developed. For deep space missions the guidelines take into account the risks posed by heavy ions. Unfortunately, knowledge about these risks is insufficient. If the new risk estimates are applied, current career dose limits may have to be reduced by a factor of two.     

Aeroshell design techniques for aerocapture entry vehicles

A major goal of NASA's In-Space Propulsion Program is to shorten trip times for scientific planetary missions. To meet this challenge arrival speeds will increase, requiring significant braking for orbit insertion, and thus increased deceleration propellant mass that may exceed launch lift capabilities. A technology called aerocapture has been developed to expand the mission potential of exploratory probes destined for planets with suitable atmospheres. Aerocapture inserts a probe into planetary orbit via a single pass through the atmosphere using the probe's aeroshell drag to reduce velocity. The benefit of an aerocapture maneuver is a large reduction in propellant mass that may result in smaller, less costly missions and reduced mission cruise times. The methodology used to design rigid aerocapture aeroshells will be presented with an emphasis on a new systems tool under development. Current methods for fast, efficient evaluations of structural systems for exploratory vehicles to planets and moons within our solar system have been under development within NASA having limited success. Many systems tools that have been attempted applied structural mass estimation techniques based on historical data and curve fitting techniques that are difficult and cumbersome to apply to new vehicle concepts and missions. The resulting vehicle aeroshell mass may be incorrectly estimated or have high margins included to account for uncertainty. This new tool will reduce the guesswork previously found in conceptual aeroshell mass estimations.     

深空导航相位参考干涉测量技术研究

针对深空导航不断提高的测角精度需求和传统无线电干涉测量技术所面临的局限,介绍了相位参考干涉技术用于深空导航的优势,重点分析了该技术的基本原理和两个关键观测参数的影响,综述了该技术在国外的研究进展情况,最后介绍了我国开展该技术研究的软硬件基础和利用嫦娥三号任务数据开展的相位参考干涉测量试验情况,试验结果表明了基于我国深空测控资源开展该技术研究的可行性和高精度,有助于推动该技术转向实际工程应用,提高我国深空导航无线电干涉测量水平。     

Aeroshell design techniques for aerocapture entry vehicles

A major goal of NASA's In-Space Propulsion Program is to shorten trip times for scientific planetary missions. To meet this challenge arrival speeds will increase, requiring significant braking for orbit insertion, and thus increased deceleration propellant mass that may exceed launch lift capabilities. A technology called aerocapture has been developed to expand the mission potential of exploratory probes destined for planets with suitable atmospheres. Aerocapture inserts a probe into planetary orbit via a single pass through the atmosphere using the probe's aeroshell drag to reduce velocity. The benefit of an aerocapture maneuver is a large reduction in propellant mass that may result in smaller, less costly missions and reduced mission cruise times. The methodology used to design rigid aerocapture aeroshells will be presented with an emphasis on a new systems tool under development. Current methods for fast, efficient evaluations of structural systems for exploratory vehicles to planets and moons within our solar system have been under development within NASA having limited success. Many systems tools that have been attempted applied structural mass estimation techniques based on historical data and curve fitting techniques that are difficult and cumbersome to apply to new vehicle concepts and missions. The resulting vehicle aeroshell mass may be incorrectly estimated or have high margins included to account for uncertainty. This new tool will reduce the guesswork previously found in conceptual aeroshell mass estimations.     

Cost-driven design of small satellite remote sensing systems*

Earth remote sensing (alongside communications) is one of the key application of Earth-orbiting satellites. Civilian satellites in the LANDSAT and SPOT series provide Earth images which have been used for a vast spectrum of applications in agriculture, meteorology, hydrology, urban planning and geology, to name but a few. In the defence sector, satellite remote sensing systems are a critical tool in strategic and tactical planning – for the countries which can afford them. To date, remote sensing satellites have fallen into one of these two categories: military missions driven by the requirement for very high resolution and orbital agility; and multipurpose civil satellites using general purpose sensors to serve a diverse community of end users. For military-style missions, the drive to high resolution sets the requirements for optics, attitude control and downlink data bandwidth. For civil missions, the requirement to satisfy multiple, diverse user applications forces compromises on spectral band and orbit selection. Although there are exceptions, many small satellite remote sensing missions carry on in this tradition, concentrating on ultra high resolution products for multiple user communities. This results in satellites costing on the order of US $100 M, not optimised for any particular application. This paper explores an alternative path to satellite remote sensing, aiming simultaneously to reduce cost and to optimise imaging products for specific applications. By decreasing the cost of the remote sensing satellite system to a critical point, it becomes appropriate to optimise the sensor's spectral and temporal characteristics to fit the requirements of a small, specialised user base. The critical engineering trade-off faced in a cost driven mission is how to reduce mission cost while still delivering a useful product to the selected user. At the Surrey Space Centre, we have pursued an engineering path using two dimensional CCD array sensors, commercial off-the-shelf lenses and gravity-gradient stabilised microsatellites. In spite of the inherent limitations of such systems, recent successes with the Thai Microsatellite Company's Thai-Phutt satellite show that a system costing in the region of US $3 million, can approach the spectral and spatial characteristics of LANDSAT. Surrey's UoSAT-12 minisatellite (to be launched April, 1999) will further develop this cost-driven approach to provide 10 m panchromatic resolution and 30 m multi-spectral resolution. This paper describes the Thai-Phutt and UoSAT-12 imaging systems, explaining the engineering methods and trade-offs. Although Surrey is presently the only centre presently pursuing such implementations, our paper shows that they deserve wider consideration.     

Social and cultural issues during Shuttle/Mir space missions.

A number of interpersonal issues relevant to manned space missions have been identified from the literature. These include crew tension, cohesion, leadership, language and cultural factors, and displacement. Ground-based studies by others and us have clarified some of the parameters of these issues and have indicated ways in which they could be studied during actual space missions. In this paper, we summarize some of our findings related to social and cultural issues from a NASA-funded study conducted during several Shuttle/Mir space missions. We used standardized mood and group climate measures that were completed on a weekly basis by American and Russian crew and mission control subjects who participated in these missions. Our results indicated that American subjects reported more dissatisfaction with their interpersonal environment than their Russian counterparts, especially American astronauts. Mission control personnel were more dysphoric than crewmembers, but both groups were significantly less dysphoric than other work groups on Earth. Countermeasures based on our findings are discussed which can be applied to future multicultural space missions.     

CCSDS标准在军用航天任务中的应用

空间数据系统咨询委员会(CCSDS)标准已经在民用航天任务中得到广泛应用,然而对其是否也同时适用于军用航天任务,仍存在着许多的疑虑和争论。文章通过对军用航天任务采用CCSDS标准现状的调研,分析了其实现途径和可行性,提出了在军用航天任务中采用CCSDS标准的措施和建议。     

Orbit selection and its impact on radiation warning architecture for a human mission to Mars

With the recent announcement of the discovery of the possibility of life on Mars, there is renewed interest in Mars missions, perhaps eventually in human missions. Astronauts on such missions are at risk to occasional periods of enhanced high energy particle flux from the sun known as Solar Particle Events. These events can pose a substantial risk to the health of the astronauts and to the on-board electronics. Effective forecast and warning of these events could provide time to take steps to minimize the risk (retreating to a safe haven, shutting down sensitive equipment, etc.) Providing that forecast capability, will require additional monitoring capability. The extent of this architecture is sensitive to the orbit selected for the transfer to and from Mars. This paper looks at the major classes of Mars missions (Conjunction and Opposition) and sub-categories of these classes and draws conclusions on the number of monitoring satellites needed for each, with a goal to reducing total system cost through optimum orbit selection.     

行星际空间环境对探测器可靠性影响分析

空间环境是影响航天器可靠性的重要因素。与地球轨道航天器相比,行星际探测任务可能会遭受更加恶劣的空间环境,例如极端温度环境,辐射环境,腐蚀性大气环境、宇宙尘等,再加上行星际任务寿命长,采用先进的器件和材料,空间环境对行星际探测器的可靠性构成严重的威胁,直接关系到探测目标能否实现。因此考虑空间环境对行星际探测器的影响,开展相关的预先研究无论是对于制定行星际空间探测计划,还是搭载仪器的设计都具有非常重要的意义。文章分析了极端温度、辐射环境和行星表面综合环境对探测器的影响,并对开展相关研究提出了建议。     

The liquid annular reactor system (LARS) for deep space exploration

A new propulsion concept for high Δ V space missions, termed LARS (Liquid Annular Reactor System), uses liquid nuclear fuel elements to heat hydrogen propellant to very high temperatures (-6000 K). The molten fuel is contained in a lower-temperature solid container which rotates to stabilize and hold in the liquid layer by centripetal force. Containment of ultra high temperature molten refractories, using this method, has been experimentally demonstrated by A.V. Grosse. The specific impulse of a rocket exhausting hydrogen at 6000 K is 2000 seconds, approximately double that of solid-core nuclear rockets. A LARS-powered space probe could accomplish extra-solar missions to 550 A.U. in approximately 35 years.     

Ophthalmic changes and increased intracranial pressure associated with long duration spaceflight: An emerging understanding

For many years, there have been anecdotal reports of vision changes by astronauts following short and long-duration spaceflight. Much of this was attributed to hyperopic shifts related to the age of the flying population. However, it has recently been recognized that vision changes are actually quite common in astronauts and are associated with a constellation of findings including elevated intracranial pressure, optic disc edema, globe flattening, optic nerve sheath thickening, hyperopic shifts and retinal changes. With advanced imaging modalities available on the ground along with the fidelity of in-flight diagnostic capabilities previously unavailable, information on this newly recognized syndrome is accumulating. As of this writing, 11 cases of visual impairment experienced by astronauts during missions on-board the International Space Station (ISS) have been documented and studied. Although the exact mechanisms of the vision changes are unknown, it is hypothesized that increased intracranial pressure (ICP) is a contributing factor.Microgravity is the dominant cause of many physiological changes during spaceflight and is thought to contribute significantly to the observed ophthalmic changes. However, several secondary factors that could contribute to increased ICP and vision changes in spaceflight have been proposed. Possible contributors include microgravity-induced cephalad fluid shift, venous obstruction due to microgravity-induced anatomical shifts, high levels of spacecraft cabin carbon dioxide, heavy resistive exercise, and high sodium diet. Individual susceptibility to visual impairment is not fully understood, though a demographic of affected astronauts is emerging.This paper describes the current understanding of this newly recognized syndrome, presents data from 11 individual cases, and discusses details of potential contributing factors. The occurrence of visual changes in long duration missions in microgravity is one of the most significant clinical issues to date for the human spaceflight community, and a comprehensive understanding of the issue at whole is critical to ensure safe space exploration in the future.     

Hypothetical flora and fauna of Venus

Hypothetical habitability of some of extrasolar planets is a fundamental question of science. Some of exoplanets possess physical conditions close to those of Venus. Therefore, the planet Venus, with its dense and hot (735 K) oxygen-free atmosphere of CO₂, having a high pressure of 9.2 MPa at the surface, can be a natural laboratory for this kind of studies. The only existing data on the planet׳s surface are still the results obtained by the Soviet VENERA landers in the 1970s and 1980s. The TV experiments of Venera-9 and 10 (October, 1975) and Venera-13 and 14 (March, 1982) delivered 41 panoramas of Venus surface (or their fragments). There have not been any similar missions to Venus in the subsequent 39 and 32 years. In the absence of new landing missions to Venus, the VENERA panoramas have been re-processed. The results of these missions are studied anew. A dozen of relatively large objects, from a decimeter to half a meter in size, with an unusual morphology have been found which moved very slowly or changed slightly their shape. Their emergence by chance could hardly be explained by noise. Certain unusual findings that have similar structure were found in different areas of the planet. This paper presents the last results obtained of a search for hypothetical flora and fauna of Venus.     

Radiation transport modeling and assessment to better predict radiation exposure, dose, and toxicological effects to human organs on long duration space flights.

NASA is very interested in improving its ability to monitor and forecast the radiation levels that pose a health risk to space-walking astronauts as they construct the International Space Station and astronauts that will participate in long-term and deep-space missions. Human exploratory missions to the moon and Mars within the next quarter century, will expose crews to transient radiation from solar particle events which include high-energy galactic cosmic rays and high-energy protons. Because the radiation levels in space are high and solar activity is presently unpredictable, adequate shielding is needed to minimize the deleterious health effects of exposure to radiation. Today, numerous models have been developed and used to predict radiation exposure. Such a model is the Space Environment Information Systems (SPENVIS) modeling program, developed by the Belgian Institute for Space Aeronautics. SPENVIS, which has been assessed to be an excellent tool in characterizing the radiation environment for microelectronics and investigating orbital debris, is being evaluated for its usefulness with determining the dose and dose-equivalent for human exposure. Thus far. the calculations for dose-depth relations under varying shielding conditions have been in agreement with calculations done using HZETRN and PDOSE, which are well-known and widely used models for characterizing the environments for human exploratory missions. There is disagreement when assessing the impact of secondary radiation particles since SPENVIS does a crude estimation of the secondary radiation particles when calculating LET versus Flux. SPENVIS was used to model dose-depth relations for the blood-forming organs. Radiation sickness and cancer are life-threatening consequences resulting from radiation exposure. In space. exposure to radiation generally includes all of the critical organs. Biological and toxicological impacts have been included for discussion along with alternative risk mitigation methods--shielding and anti-carcinogens.     

Roadmap to a human Mars mission

We propose a new roadmap for the preparation of the first human mission to Mars. This proposal is based on the work of ISECG and several recent recommendations on human Mars mission architectures. A table is proposed to compare the possible benefits of different preparatory missions. Particular attention is paid to the possibility of qualifying important systems thanks to a heavy Mars sample return mission. It is shown that this mission is mandatory for the qualification of Mars aerocapture at scale-1, EDL systems at scale 1 and Mars ascent. Moreover, it is a good opportunity to test many other systems, such as the heavy launcher and the transportation systems for the trips beyond LEO. These tests were not mentioned in the last ISECG report. This strategy is facilitated in the case of the simplified Mars mission scenarios that have recently been presented because it is suggested that relatively small vehicles with small crew sizes are used in order to optimize the payload mass fraction of the landing vehicles and to avoid the LEO assembly. An important finding of the study is that a human mission to the surface of the Moon is not required for the qualification of the systems of a human mission to Mars. Since affordability is a key criterion, two important missions are proposed in the roadmap. The first is a heavy Mars sample return mission and the second is a manned mission to a high Earth orbit or eventually to the vicinity of the Moon. It is shown that both missions are complementary and sufficient to qualify all the critical systems of the Mars mission.