Vestibular function in the space environment

Adaptation to the weightless state and readaptation after space flight to the 1-G environment on the ground are accompanied by various transitory symptoms of vestibular instability, kinetosis, and illusory sensations. Aside from the problem of how to treat and if possible prevent such symptoms, they offer a clue to a better understanding of normal vestibular functions. Weightlessness is a powerful new "tool" of vestibular research. Graybiel reported as early as 1952 that human subjects observed the illusion that a real target and the visual afterimage seemed to raise in the visual field during centrifugation when the subjects were looking toward the axis of rotation (oculogravic illusion). In aircraft parabolic-flight weightlessness, human subjects observed that fixed real targets appeared to have moved downward while visual afterimages appeared to have moved upward (oculoagravic illusion). It can be shown by electronystagmography as well as by a method employing double afterimages that part of this illusion is caused by eye movements that are triggered by the changing input from the otolith system. Another part of the illusion is based on a change of the subjective horizontal and must be caused by convergence of vestibular and visual impulses "behind" the eyes. This part was measured independently of the first one by using a new method. Eye movements could be prevented during these experiments by optical fixation with the right eye on a target at the end of a 24-in. long tube which was rigidly attached parallel to the longitudinal axis of an aircraft. At the same time the subject tried to line up a shorter tube, which was pivoting around his left eye, with the subjective horizon.     

Function-morphological investigations of fish inner ear otoliths as basis for interpretation of human space sickness

In man, altered gravity may lead to a vestibular dysfunction causing space motion sickness. A hypothesis was developed, according to which asymmetric inner ear statoliths might be the morphological basis of space sickness. The animal model, fish, revealed further information: inner ear "stone" (otolith) growth is dependent on the amplitude and the direction of gravity, regulated by a negative feedback mechanism. The present study was focused on the question, where the regulation centre of adaptive otolith growth may be situated. Therefore, the vestibular nerve was unilaterally transected in neonate swordtail fish (Xiphophorus helleri). As growth marker, the calcium tracer alizarin-complexone was used. It was found that otolith growth had ceased on the operated head sides indicating that the brain is significantly involved in regulating otolith growth. About 2 weeks after nerve transection, otoliths had regained normal growth, probably due to nerve regeneration. Concerning fish, it has now to be tested, if this regeneration is affected by altered gravity, e.g. in a long-term experiment on the International Space Station. Regarding mammals, it has to be proved if asymmetric statoliths are the basis of kinetosis and whether or not the mammalian brain has an effect on statolith growth in the course of compensating altered gravity.     

Artificial gravity--head movements during short-radius centrifugation: influence of cognitive effects

Short-radius centrifugation is a potential countermeasure against the effects of prolonged weightlessness. Head movements in a rotating environment, however, induce serious side effects: inappropriate vestibular ocular reflexes (VOR), body-tilt illusions and motion sickness induced by cross-coupled accelerations on a rotating platform. These are well predicted by a semicircular canal model. The present study investigates cognitive effects on the inappropriate VOR and the illusory sensations experienced by subjects rotating on a short-radius centrifuge (SRC). Subjects (N=19) were placed supine on a rotating horizontal bed with their head at the center of rotation. To investigate the extent to which they could control their sensations voluntarily, subjects were asked alternatively to "fight" (i.e. to try to resist and suppress) those sensations, or to "go" with (i.e. try to enhance or, at least, acquiesce in) them. The only significant effect on the VOR of this cognitive intervention was to diminish the time constant characterizing the decay of the nystagmus in subjects who had performed the "go" (rather than the "fight") trials. However, illusory sensations, as measured by reported subjective intensities, were significantly less intense during the "fight" than during the "go" trials. These measurements also verified an asymmetry in illusory sensation known from earlier experiments: the illusory sensations are greater when the head is rotated from right ear down (RED) to nose up (NU) posture than from NU to RED. The subjects habituated, modestly, to the rotation between their first and second sequences of trials, but showed no better (or worse) suppression of illusory sensations thereafter. No significant difference in habituation was observed between the "fight" and "go" trials.     

过载对固体火箭发动机性能影响试验研究(英文)

建立了立式旋转试车台,研究了高过载对固体火箭发动机性能的影响。通过地面静止及不同过载(15gn,15gn;35gn,15gn)条件下点火对比试验,获得固体火箭发动机在不同过载条件下内弹道性能以及绝热层和喉衬的烧蚀规律。试验表明,随着过载增加,发动机压强增大、工作时间缩短;横向与轴向的组合过载恶化了烧蚀环境,使喉衬出现偏心烧蚀。     

Motion sickness susceptibility during rotation at 30 rpm in free-fall parabolic flight

Free fall per se whether in parabolic or orbital flight may be regarded as a "partial" motion environment with respect to eliciting motion sickness, requiring an additional component to render this environment "complete" or stressful. Parabolic flight in toto falls in the category of a "complete" motion environment in that some persons became motion sick with head fixed and eyes closed. In the present experiment we selected subjects who were symptom free or nearly symptom free in the KC-135 with head fixed. All tests were conducted with the subject rotating at 30 rpm in a rotating litter chair, and comparisons were made between head-fixed and head-moving conditions (right-left) in the free-fall phase of parabolic flight and under simulated free-fall phases in the laboratory. With head fixed most subjects were insusceptible; with head moving left-right susceptibility was slightly higher in the laboratory than aloft. An additional comparison was made correlating susceptibility in the free-fall phases of parabolic flight with susceptibility to experimental motion sickness in Skylab. In both situations cross-coupled angular accelerations were generated by executing head and body movements out of the plane of rotation. In parabolic flight 9 of 15 subjects reached an endpoint just short of frank motion sickness. In the Skylab workshop all eight of the astronauts tested were symptom free at the end of the test. The explanation for the difference in susceptibility rests in two factors: (1) Basic susceptibility in free fall is lower than on the ground, and (2) in Skylab the astronauts who needed to adapt had achieved this goal prior to the first test on Mission-Day 8.     

Development of space motion sickness in a ground-based human centrifuge

Adaptation of the vestibular system, specifically the otolith organs, to a non-terrestrial environment can result in space motion sickness-like symptoms when the human is reintroduced to the normal, 1 Gz, terrestrial environment. This premise was investigated by exposing nine subjects to 90 min of sustained 2 Gz acceleration in a human centrifuge and then observing and evaluating them at 1 Gz. Five of the subjects developed slight SMS symptoms, three developed moderate, and one developed frank sickness. Postural instabilities in two of the most affected subjects were also observed using the Equitest System post exposure. Long duration exposure to a non-terrestrial G(2Gz) appears to be a potential means for developing SMS-like symptoms in a ground-based human centrifuge.     

Reflex contributions to the assessment of the vertical

On the ground the vertical directions "up" and "down" have significance in relation to the strategy for avoiding collision of the skull with the planet. Voluntary acts to this end may be based on the experienced result of reflexly generated motor commands. Relevant receptors lie in the otolith organs of the labyrinth, but the head is seldom steady in waking life. A revised scheme of labyrinth reflexes on the limbs--"downhill limbs extend"--replaces the classical scheme of Magnus. Interactions with neck reflexes according to this scheme serve to stabilize the trunk. In an orbiting spacecraft the pattern of afferent signals from the labyrinth differs from that on the ground, and predictions based on the new scheme are to be tested in the project "Operation Push-Pull" proposed for ESRO's Spacelab. Other activities of the Council of Europe's Working Party on Aerospace Physiology and Medicine are briefly described.     

Static torsional otolith–cervical–ocular reflex after prolonged exposure to weightlessness and a 7-day immersion

To determine the role of the support-proprioceptive factor in the functioning of the vestibular system, in particular the static torsional otolith–cervical–ocular reflex (OCOR), comparative OCOR studies with videooculography recording were performed after a 7-day “dry” horizontal immersion (16 subjects) and after a prolonged (126–195 days) exposure to weightlessness (13 cosmonauts). For the first time, it was demonstrated that minimization of the support and proprioceptive afferentation may result in an inversion or absence of the static torsional OCOR and the development of a positional nystagmus with an inverted reflex. A comparative OCOR data analysis of cosmonauts and immersion subjects has revealed similarity of responses. However, changes in OCOR after immersion were noted in only 60% of the subjects, while after space flight, 90% of cosmonauts showed them. Post-flight changes were more frequent, marked and long-lasting. Statistical analysis has shown that there were significant differences between pre- and post-flight data according to both parametric and non-parametric methods of multiple comparisons, whereas only parametric methods have found significant differences within immersion data.     

Superluminous supernovae: no threat from eta Carinae

Recently, Supernova 2006gy was noted as the most luminous ever recorded, with a total radiated energy of approximately 10(44) Joules. It was proposed that the progenitor may have been a massive evolved star similar to eta Carinae, which resides in our own Galaxy at a distance of about 2.3 kpc. eta Carinae appears ready to detonate. Although it is too distant to pose a serious threat as a normal supernova, and given that its rotation axis is unlikely to produce a gamma-ray burst oriented toward Earth, eta Carinae is about 30,000 times nearer than 2006gy, and we re-evaluate it as a potential superluminous supernova. We have found that, given the large ratio of emission in the optical to the X-ray, atmospheric effects are negligible. Ionization of the atmosphere and concomitant ozone depletion are unlikely to be important. Any cosmic ray effects should be spread out over approximately 10(4) y and similarly unlikely to produce any serious perturbation to the biosphere. We also discuss a new possible effect of supernovae-e-ndocrine disruption induced by blue light near the peak of the optical spectrum. This is a possibility for nearby supernovae at distances too large to be considered "dangerous" for other reasons. However, due to reddening and extinction by the interstellar medium, eta Carinae is unlikely to trigger such effects to any significant degree.     

基于遗传算法的卫星载荷舱最大偏心力矩计算

在计算卫星载荷舱最大偏心力矩时, 若只考虑位于载荷舱保持架转轴上部的设备产生的偏心力矩, 则在某些特殊情况下得到的并不是最大偏心力矩。文章综合考虑载荷舱设备安装实际情况, 采用遗传算法来确定最大偏心力矩, 并通过实例计算表明:利用遗传算法寻优的方式, 能够得到更准确的最大偏心力矩, 避免欠设计的隐患。     

The response of structure and function of the gravireceptor in a vertebrate to near weightlessness.

The paper sums up results of a 7-day space flight experiment (D-l-Mission-BW-STA 00-STATEX) using growing frog embryos and larvae (Xenopus laevis) as a model system. Evaluation of photographs taken from the surface of sectioned deep-frozen objects, and micrographs using TEM and SEM show no aberrations in the shape, size, position, or respective electron density of the otolith membranes in larvae developed for 154 h under near-zero g. The further evaluation of the "weightless larvae" revealed a probably not yet described otolith-like formation below the dorsal wall of the vestibulum. In the weightless larvae this formation outnumbers, also qualitatively, strongly the 1-g control samples. The swimming behavior of the tadpoles which was observed about one hour after landing of the Space Shuttle showed a typical anomaly (loop swimming), which is known from larvae developed on the clinostat or from fish flown aboard Apollo capsules. An extra result is the lack of striking effects of cosmic radiation on the embryonic development of the flown Xenopus eggs.     

偏心销结构舱段连接方式强度计算及试验验证

基于某型导弹偏心销结构舱段连接方式,推导了连接面上偏心销的最大剪力公式,并对该结构开展了有限元分析和静力试验。有限元结果表明在给定载荷作用下,偏心销材料进入塑性,偏心销限位环发生强度破坏;连接面舱体结构局部材料进入塑形,但不会发生强度破坏;试验结果验证了上述仿真结果,并根据最大剪力公式建立单个偏心销有限元计算模型是一种比较稳妥的方法。     

Effects of vestibular nerve transection on the calcium incorporation of fish otoliths.

Previous investigations revealed that the growth of fish inner ear otoliths (otolith size and calcium-incorporation) depends on the amplitude and the direction of gravity, suggesting the existence of a (negative) feedback mechanism. In search for the regulating unit, the vestibular nerve was transacted unilaterally in neonate swordtail fish (Xiphophorus helleri) which were subsequently incubated in the calcium-tracer alizarin-complexone. Calcium incorporation ceased on the transacted head sides, indicating that calcium uptake is neurally regulated. Grant numbers: 50 WB 9533, 50 WB 9997.     

On the Precession of Saturn

The precession of Saturn under the effect of the gravity of the Sun, Jupiter and planet’s satellites has been investigated. Saturn is considered to be an axisymmetric (A = B) solid body close to the dynamically spherical one. The orbits of Saturn and Jupiter are considered to be Keplerian ellipses in the inertial coordinate system. It has been shown that the entire set of small parameters of the problem can be reduced to two independent parameters. The averaged Hamiltonian function of the problem and the integrals of evolutionary equations are obtained disregarding the effect of satellites. Using the small parameter method, the expressions for the precession frequency and the nutation angle of the planet’s axis of rotation caused by the gravity of the Sun and Jupiter are obtained. Considering the planet with satellites as a whole preceding around the normal to the unmovable plane of Saturn’s orbit, the satellites effect on the Saturn rotation is taken into account via the corrections in the formula for the undisturbed precession frequency. The satellites are shown to have no effect on the nutation angle (in the framework of the accepted model), and the disturbances from Jupiter to make the main contribution to the nutation angle evolution. The effect of Jupiter on the nutation angle and the precession period is described with regard to the attraction of satellites.     

Force and power characteristics of a resistive exercise device for use in space

We have developed a non-gravity dependent mechanical device, which provides resistance during coupled concentric and eccentric muscle actions, through the inertia of a spinning fly-wheel (Fly-Wheel Ergometry; FWE). Our research shows that lower-limb FWE exercise can produce forces and thus muscular stress comparable to what is typical of advanced resistance training using free weights. FWE also offers greater training stimuli during eccentric relative to concentric muscle actions, as evidenced by force and electromyographic (EMG) measurements. Muscle use of specific muscle groups, as assessed by the exercise-induced contrast shift of magnetic resonance images, is similar during lower-limb FWE and the barbell squat. Unlike free-weight exercise, FWE allows for maximal voluntary effort in each repetition of an exercise bout. Likewise, FWE exercise, not unassisted free-weight exercise, produces eccentric "overload". Collectively, the inherent features of this resistive exercise device and the results of the physiological evaluations we have performed, suggest that resistance exercise using FWE could be used as an effective exercise counter-measure in space. The flywheel principle can be employed to any exercise configuration and designed into a compact device allowing for exercises stressing those muscles and bone structures, which are thought to be most affected by long-duration spaceflight.     

基于标准磁块模型的赤道作图法误差分析

赤道作图法是卫星及其部件磁矩测量和计算的主要方法,其测试结果受到多种因素的影响。文章首先介绍赤道作图法（亦称近场分析法）的基本原理,分析该方法在测量和计算磁矩过程中的部分误差来源;然后基于标准磁块模型研究模型磁偏心距、环境磁场波动与赤道作图法测试误差的关系;同时提出近远场梯度差分的方法以提升磁矩计算结果的准确度。利用改进方法对标准磁块模型进行测量和数据处理的结果表明,该方法的测量（计算）误差可控制在3%以内。     

Mental Object Rotation and Egocentric Body Transformation: Two Dissociable Processes?

An important question in studies on mental rotation is whether the mental object rotation and the egocentric body transformation rely on dissociable mechanisms. We tested non-dancers and professional dancers as experts in the mental object rotation task (MORT, 3D-cubes used by Shepard & Metzler, 1971) and the mental body transformation task (MBRT, line drawings of human bodies similar to those used by Parsons, 1987). The cubes and body figures were presented in exactly the same rotation conditions; in the picture plane, 0 degree, 45 degrees, 90 degrees, 135 degrees, and 180 degrees, and in combination with a rotation in depth, 0 degree (the stimuli are rotated in the picture plane only) and 180 degrees. We could replicate the linear increase in RT with increasing angle for the cubes whereas the RT for rotated body figures increased for not depth-rotated bodies only (back view). Though, the RTs for inverted body figures were faster when they were rotated in depth (front view) compared to when they were rotated in the picture plane only (back view). This finding suggests that participants use different strategies depending on the perceived orientation of the stimulus. The results indicate impaired performance in the MORT for the experts.     

航天密封舱设备安装精度仿真分析方法

针对航天密封舱设备安装精度受密封舱内压影响却没有实用的理论预示方法,提出了仿真分析设备安装精度的方法。该方法根据有限元结构仿真分析得到的位移,导出设备的安装精度;另外,提出了精测数据的分析方法,使设备的安装精度变化规律更明显,更容易看出设备旋转的旋转轴、旋转方向、旋转角度,也使精测数据与仿真数据的对比更容易,可为验证仿真分析的准确性提供前提条件。利用一个算例对文章提出的仿真分析方法进行了验证。结果表明,仿真分析方法能准确地确定设备安装角度变化的旋转轴和旋转方向,计算出的旋转角度值与精测结果也基本一致。     

Internal reference frames for representation and storage of visual information: the role of gravity.

Experimental studies of visual mechanisms suggests that the CNS represents image information with respect to preferred horizontal and vertical axes, as shown by a phenomenon known as the "oblique effect". In the current study we used this effect to evaluate the influence of gravity on the representation and storage of visual orientation information. Subjects performed a psychophysical task in which a visually-presented stimulus line was aligned with the remembered orientation of a reference stimulus line presented moments before. The experiments were made on 5 cosmonauts during orbital space flight and additionally on 13 subjects in conditions of normal gravity with a tilting chair. Data were analyzed with respect to response variability and timing. On earth, these measurements for this task show a distinct preference for horizontally and vertically oriented stimuli when the body and gravitational axes were aligned. This preference was markedly decreased or disappeared when the body axis was tilted with respect to gravity; this effect was not connected with ocular counter-rolling nor could we find a preference of any other intermediate axis between the gravity and body aligned axes. On the other hand, the preference for vertical and horizontal axes was maintained for tests performed in microgravity over the course of a 6 month flight, starting from flight day 6. We concluded that subjects normally process visual orientation information in a multi-modal reference frame that combines both proprioceptive and gravitational cues when both are available, but that a proprioceptive reference frame is sufficient for this task in the absence of gravity after a short period of adaptation. Some of the results from this study have been previously published in a preliminary report. Grant numbers: 99-04-48450.     

Uncontrollable Rotational Motion of the Mir Orbital Station

The results of determining the rotational motion of the Mir orbital station are presented for four long segments of its unmanned uncontrolled flight in 1999–2000. The determination was carried out using the data of onboard measurements of the Earth's magnetic field intensity. These data, taken for a time interval of several hours, were jointly processed by the least squares method with the help of integration of the equations of station motion relative to its center of mass. As a result of this processing, the initial conditions of motion and the parameters of the mathematical model used were evaluated. The technique of processing is verified using the telemetry data on angular velocity of the station and its attitude parameters. Two types of motion were applied on the investigated segments. One of them (three segments) presents a rotation around the axis of the minimum moment of inertia. This axis executes small oscillations with respect to a normal to the orbit plane. Such a motion was used for the first time on domestic manned orbital complexes. The second type of motion begins with a biaxial rotation which, in a few weeks, goes over into a motion very similar to the rotation around the normal to the orbit plane, but around the axis of the maximum moment of inertia.