Birthdates of patients affected by mental illness and solar activity: A study from Italy

Purpose

This epidemiologic study tested an hypothesized association between the year of birth of persons with major mental illnesses and solar activity over the past century.

Methods

We collected data on diagnoses and birthdates of psychiatric patients born between 1926 and 1975 (N = 1954) in south Italy for comparison to yearly solar activity as registered by the International Observatories.

Results

We found a strong inverse correlation between high solar activity (HSA) and incidence of schizophrenia and bipolar disorder in a 20-year period whereas the incidence of non-affective/non-psychotic disorders was moderately associated with HSA in the same period.

Conclusions

Interpretation of the observed correlations between HSA during years of birth and the incidence of mental illnesses remains unclear, but the findings encourage further study.     

Analysis of the space radiation doses obtained simultaneously at two different locations outside the ISS

Space weather and related ionizing radiation has been recognized as one of the main health concerns for the International Space Station (ISS) crew. The estimation of the radiation effect on humans outside the ISS requires at first order accurate knowledge of their accumulated absorbed dose rates, which depend on the global space radiation distribution, solar cycle and local variations generated by the 3D mass distribution surrounding the ISS. The R3DE (Radiation Risks Radiometer-Dosimeter for the EXPOSE-E platform) on the European Technological Exposure Facility (EuTEF) worked successfully outside of the European Columbus module between February 2008 and September 2009. A very similar instrument named R3DR for the EXPOSE-R platform worked outside the Russian Zvezda module of the ISS between March 2009 and August 2010. Both are Liulin-type detectors, Bulgarian-built miniature spectrometer-dosimeters. The acquired approximately 5 million deposited energy spectra from which the flux and absorbed dose rate were calculated with 10 s resolution behind less than 0.41 g cm⁻² shielding. This paper analyses the spectra collected in 2009 by the R3DE/R instruments and the long-term variations in the different radiation environments of Galactic Cosmic Rays (GCR), inner radiation belt trapped protons in the region of the South Atlantic Anomaly (SAA) and relativistic electrons from the Outer Radiation Belt (ORB). The R3DE instrument, heavily shielded by the surrounding structures, measured smaller primary fluxes and dose rates from energetic protons from the SAA and relativistic electrons from the ORB but higher values from GCRs because of the contribution from secondary particles. The main conclusion from this investigation is that the dose rates from different radiation sources around the International Space Station (ISS) have a large special and temporal dynamic range. The collected data can be interpreted as possible doses obtained by the cosmonauts and astronauts during Extra Vehicular Activities (EVA) because the R3DE/R instruments shielding is very similar to the Russian and American space suits average shielding (,  and ). Fast, active measurements are required to assess accurately the dose accumulated by astronauts during EVA.     

Cosmic Ray Energetics And Mass for the International Space Station (ISS-CREAM)

The Cosmic Ray Energetics And Mass (CREAM) instrument is configured with a suite of particle detectors to measure TeV cosmic-ray elemental spectra from protons to iron nuclei over a wide energy range. The goal is to extend direct measurements of cosmic-ray composition to the highest energies practical, and thereby have enough overlap with ground based indirect measurements to answer questions on cosmic-ray origin, acceleration and propagation. The balloon-borne CREAM was flown successfully for about 161 days in six flights over Antarctica to measure elemental spectra of Z = 1–26 nuclei over the energy range 10¹⁰ to >10¹⁴ eV. Transforming the balloon instrument into ISS-CREAM involves identification and replacement of components that would be at risk in the International Space Station (ISS) environment, in addition to assessing safety and mission assurance concerns. The transformation process includes rigorous testing of components to reduce risks and increase survivability on the launch vehicle and operations on the ISS without negatively impacting the heritage of the successful CREAM design. The project status, including results from the ongoing analysis of existing data and, particularly, plans to increase the exposure factor by another order of magnitude utilizing the International Space Station are presented.     

Relativistic electrons high doses at International Space Station and Foton M2/M3 satellites

The paper presents observation of relativistic electrons. Data are collected by the Radiation Risk Radiometer-Dosimeters (R3D) B2/B3 modifications during the flights of Foton M2/M3 satellites in 2005 and 2007 as well as by the R3DE instrument at the European Technology Exposure Facility (EuTEF) on the Columbus External Payload Adaptor at the International Space Station (ISS) in the period February 20 – April 28, 2008. On the Foton M2/M3 satellites relativistic electrons are observed more frequently than on the ISS because of higher (62.8°) inclination of the orbit. At both Foton satellites the usual duration of the observations are a few minutes long. On the ISS the duration usually is about 1 min or less. The places of observations of high doses due to relativistic electrons are distributed mainly at latitudes above 50° geographic latitude in both hemispheres on Foton M2/M3 satellites. A very high maximum is found in the southern hemisphere at longitudinal range 0°–60°E. At the ISS the maximums are observed between 45° and 52° geographic latitude in both hemispheres mainly at longitudes equatorward from the magnetic poles. The measured absolute maximums of dose rates generated by relativistic electrons are found to be as follows: 304 μGy h⁻¹ behind 1.75 g cm⁻² shielding at Foton M2, 2314 μGy h⁻¹ behind 0.71 g cm⁻² shielding at Foton M3 and 19,195 μGy h⁻¹ (Flux is 8363 cm⁻² s⁻¹) behind les than 0.4 g cm⁻² shielding at ISS.     

Studying the evolution of the hot universe with the X-ray evolving universe spectroscopy mission – XEUS

Europe is one of the major partners building the International Space Station (ISS) and European industry, together with ESA, is responsible for many station components including the Columbus Orbital Facility, the Automated Transport Vehicle, two connecting modules and the European Robotic Arm. Together with this impressive list of contributions there is a strong desire within the ESA Member States to benefit from this investment by utilizing the unique capabilities of the ISS to perform world-class science. XEUS is one of the astronomical applications being studied by ESA to utilize the capabilities of the ISS. XEUS will be a long-term X-ray observatory with an initial mirror area of 6 m² at 1 keV that will be expanded to 30 m² following a visit to the ISS. The 1 keV spatial resolution is expected to be 2–5″ half-energy-width. XEUS will consist of separate detector and mirror spacecraft (MSC) aligned by active control to provide a focal length of 50 m. A new detector spacecraft, complete with the next generation of instruments, will also be added after visiting the ISS. The limiting 0.1–2.5 keV sensitivity will then be 4 × 10⁻¹⁸ erg cm⁻² s⁻¹, around 200 times better than XMM-Newton, allowing XEUS to study the properties of the hot baryons and dark matter at high redshift.     

Simulations of absorbed dose on the phantom surface of MATROSHKA-R experiment at the ISS

The health risks associated with exposure to various components of space radiation are of great concern when planning manned long-term interplanetary missions, such as future missions to Mars. Since it is not possible to measure the radiation environment inside of human organs in deep space, simulations based on radiation transport/interaction codes coupled to phantoms of tissue equivalent materials are used. However, the calculated results depend on the models used in the codes, and it is therefore necessary to verify their validity by comparison with measured data. The goal of this paper is to compare absorbed doses obtained in the MATROSHKA-R experiment performed at the International Space Station (ISS) with simulations performed with the three-dimensional Monte Carlo Particle and Heavy-Ion Transport code System (PHITS). The absorbed dose was measured using passive detectors (packages of thermoluminescent and plastic nuclear track detectors) placed on the surface of the spherical tissue equivalent phantom MATROSHKA-R, which was exposed aboard the ISS in the Service Zvezda Module from December 2005 to September 2006. The data calculated by PHITS assuming an ISS shielding of 3 g/cm² and 5 g/cm² aluminum mass thickness were in good agreement with the measurements. Using a simplified geometrical model of the ISS, the influence of variations in altitude and wall mass thickness of the ISS on the calculated absorbed dose was estimated. The uncertainties of the calculated data are also discussed; the relative expanded uncertainty of absorbed dose in phantom was estimated to be 44% at a 95% confidence level.     

Method for the prediction of the effective dose equivalent to the crew of the International Space Station

This paper describes a methodology for assessing the pre-mission exposure of space crew aboard the International Space Station (ISS) in terms of an effective dose equivalent. In this approach, the PHITS Monte Carlo code was used to assess the particle transport of galactic cosmic radiation (GCR) and trapped radiation for solar maximum and minimum conditions through an aluminum shield thickness. From these predicted spectra, and using fluence-to-dose conversion factors, a scaling ratio of the effective dose equivalent rate to the ICRU ambient dose equivalent rate at a 10 mm depth was determined. Only contributions from secondary neutrons, protons, and alpha particles were considered in this analysis.     

Relativistic electron fluxes and dose rate variations during April–May 2010 geomagnetic disturbances in the R3DR data on ISS

Space radiation has been monitored successfully using the Radiation Risks Radiometer-Dosimeter (R3D) installed at the ESA EXPOSE-R (R3DR) facility outside of the Russian Zvezda module of the International Space Station (ISS) between March 2009 and January 2011. R3DR is a Liulin type spectrometer–dosimeter with a single Si PIN detector 2 cm² of area and 0.3 mm thick. The R3DR instrument accumulated about 2 million measurements of the absorbed dose rate and flux of 10 s resolution. The total external and internal shielding before the detector of R3DR device is 0.41 g cm⁻². The calculated stopping energy of normally incident particles to the detector is 0.78 MeV for electrons and 15.8 MeV for protons. After the Coronal Mass Ejection (CME) at 09:54 UTC on 3 April 2010, a shock was observed at the ACE spacecraft at 0756 UTC on 5 April, which led to a sudden impulse on Earth at 08:26 UTC. Nevertheless, while the magnetic substorms on 5 and 6 of April were moderate; the second largest in history of GOES fluence of electrons with energy >2 MeV was measured. The R3DR data show a relatively small amount of relativistic electrons on 5 April. The maximum dose rate of 2323 μGy day⁻¹ was reached on 7 April; by 9 April, a dose of 6600 μGy was accumulated. By the end of the period on 7 May 2010 a total dose of 11,587 μGy was absorbed. Our data were compared with AE-8 MIN, CRESS and ESA-SEE1 models using SPENVIS and with similar observations on American, Japanese and Russian satellites.     

Expression of p53-regulated genes in human cultured lymphoblastoid TSCE5 and WTK1 cell lines after spaceflight in a frozen state

The 53 kDa tumor suppressor protein p53 is generally thought to contribute to the genetic stability of cells and to protect cells from DNA damage through the activity of p53-centered signal transduction pathways. To clarify the effect of space radiation on the expression of p53-dependent regulated genes, gene expression profiles were compared between two human cultured lymphoblastoid cell lines: one line (TSCE5) has a wild-type p53 gene status, and the other line (WTK1) has a mutated p53 gene status. Frozen human lymphoblastoid cells were stored in a freezer in the International Space Station (ISS) for 133 days. Gene expression was analyzed using DNA chips after culturing the space samples for 6 h on the ground after their return from space. Ground control samples were also cultured for 6 h after being stored in a frozen state on the ground for the same time period that the frozen cells were in space. p53-Dependent gene expression was calculated from the ratio of the gene expression values in wild-type p53 cells and in mutated p53 cells. The expression of 50 p53-dependent genes was up-regulated, and the expression of 94 p53-dependent genes was down-regulated after spaceflight. These expression data identified genes which could be useful in advancing studies in basic space radiation biology. The biological meaning of these results is discussed from the aspect of gene functions in the up- and down-regulated genes after exposure to low doses of space radiation.     

Space Shuttle drops down the SAA doses on ISS

Long-term analysis of data from two radiation detection instruments on the International Space Station (ISS) shows that the docking of the Space Shuttle drops down the measured dose rates in the region of the South Atlantic Anomaly (SAA) by a factor of 1.5–3. Measurements either by the R3DE detector, which is outside the ISS at the EuTEF facility on the Columbus module behind a shielding of less than 0.45 g cm⁻², and by the three detectors of the Liulin-5 particle telescope, which is inside the Russian PEARS module in the spherical tissue equivalent phantom behind much heavier shielding demonstrate that effect. Simultaneously the estimated averaged incident energies of the incoming protons rise up from about 30 to 45 MeV. The effect is explained by the additional shielding against the SAA 30–150 MeV protons, provided by the 78 tons Shuttle to the instruments inside and outside of the ISS. An additional reason is the ISS attitude change (performed for the Shuttle docking) leading to decreasing of dose rates in two of Liulin-5 detectors because of the East–West proton fluxes asymmetry in SAA. The Galactic Cosmic Rays dose rates are practically not affected.     

Influence of dark matter on light propagation in solar system

We investigated the influence of dark matter on light propagation in the solar system. We assumed the spherical symmetry of spacetime and derived the approximate solution of the Einstein equation, which consists of the gravitational attractions caused by the central celestial body, i.e. the Sun, and the dark matter surrounding it. We expressed the dark matter density in the solar system in the following simple power-law form, ?(t,r)=ρ(t)(?/r)^k$?(t\text{,}r)=\rho (t)(?/r{)}^k$, where t is the coordinate time; r, the radius from the central body; ?, the normalizing factor; k, the exponent characterizing r  -dependence of dark matter density; and ρ(t)$\rho (t)$, the arbitrary function of time t. On the basis of the derived approximate solution, we focused on light propagation and obtained the additional corrections of the gravitational time delay and the relative frequency shift caused by the dark matter. As an application of our results, we considered the secular increase in the astronomical unit reported by Krasinsky and Brumberg (2004) and found that it was difficult to provide an explanation for the observed dAU/dt = 15 ± 4 m/century.     

The ORGANIC experiment on EXPOSE-R on the ISS: Flight sample preparation and ground control spectroscopy

In March of 2009, the ORGANIC experiment integrated into the European multi-user facility EXPOSE-R, containing experiments dedicated to Astrobiology, was mounted through Extra Vehicular Activity (EVA) externally on the International Space Station (ISS). The experiment exposed organic samples of astronomical interest for a duration of 97 weeks (∼22 months) to the space environment. The samples that were returned to Earth in spring 2011, received a total UV radiation dose during their exposure including direct solar irradiation of >2500 h, exceeding the limits of laboratory simulations. We report flight sample preparation and pre-flight ultraviolet–visible (UV–Vis) characterization of the ORGANIC samples, which include 11 polycyclic aromatic hydrocarbons (PAHs) and three fullerenes. The corresponding time-dependent ground control monitoring experiments for ORGANIC measured over ∼19 months are presented and the results anticipated upon return of the samples are discussed. We present the first UV–Vis spectrum of solid circobiphenyl (C₃₈H₁₆). Further, we present the first published UV–Vis spectra of diphenanthro[9,10-b′,10′-d]thiophene (C₂₈H₁₆S), dinaphtho[8,1,2-abc,2′,1′,8′-klm]coronene (C₃₆H₁₆), tetrabenzo[de,no,st,c′d′]heptacene (C₄₂H₂₂), and dibenzo[jk,a′b′]octacene (C₄₀H₂₂) in solid phase and in solution. The results of the ORGANIC experiment are expected to enhance our knowledge of the evolution and degradation of large carbon-containing molecules in space environments.