Interaction of mental and orthostatic stressors

We assessed hemodynamic responses induced by orthostatic and mental stressors, using passive head up tilt (HUT) and mental arithmetic (MA), respectively. The 15 healthy males underwent three protocols: (1) HUT alone, (2) MA in supine position and (3) MA+HUT, with sessions randomized and ≥2 weeks apart. In relation to baseline, HUT increased heart rate (HR) (+20.4±7.1 bpm; p<0.001), mean blood pressure (MBP) (+4.7±11.3 mmHg; p<0.05), diastolic blood pressure (DBP) (+6.1±11.6 mmHg; p<0.05) and total peripheral resistance (TPR) (+155±232 dyne*s/cm⁵; p<0.001) but decreased stroke volume (SV) (?33.1±13.4 ml; p<0.001) and cardiac output (CO) (?0.6±1.0 l/min; p<0.01). MA increased HR (+8.0±6.0 bpm; p<0.001), systolic blood pressure (SBP) (+9.0±7.7 mmHg; p<0.001), MBP (+10.0±6.5 mmHg; p<0.001), DBP (+9.5±7.2 mmHg; p<0.001) and CO (+0.6±0.8 l/min; p<0.01). MA+HUT increased HR (+28.8±8.4 bpm; p<0.001), SBP (+4.6±14.3 mmHg; p<0.05), MBP (+11.2±11.6 mmHg; p<0.001), DBP (+13.5±10.1 mmHg; p<0.001) and TPR (+160±199 dyne*s/cm⁵; p<0.001) but SV (?34.5±14.6 ml; p<0.001) decreased. Mental challenge during orthostatic challenge elicited greater increases in heart rate, despite similar reductions in stroke volume such as those during orthostatic stress alone. Overall, cardiac output decreases were less with combinations of mental and orthostatic challenges in comparison to orthostasis alone. This would suggest that carefully chosen mental stressors might affect orthostatic responses of people on standing up. Therefore, additional mental loading could be a useful countermeasure to alleviate the orthostatic responses of persons, particularly in those with histories of dizziness on standing up or on return to earth from the spaceflight environment of microgravity.     

Altered expression of mRNAs implicated in osteogenesis under conditions of simulated microgravity is regulated by CD200:CD200R

Mouse calvarial cells grown under simulated microgravity conditions (neutral buoyancy) show preferential differentiation towards the osteoclast lineage, as defined by surrogate mRNAs, bone nodule growth and TRAP⁺ cells, when compared with cells cultured under normal gravity conditions. This effect was suppressed in cultures which contained the immunoregulatory molecule CD200, and conversely enhanced by anti-CD200 mAb. Concomitant increases occur in expression of inflammatory cytokines, and their mRNAs, under simulated microgravity conditions. Again cultures containing exogenous CD200 showed suppressed cytokine and cytokine mRNA expression. Further alterations in osteoclastogenesis were seen using cells isolated from cytokine-receptor knockout mice. We conclude that, as assessed by altered expression of mRNAs associated with osteoblast differentiation, CD200:CD200R interactions play an important regulatory role in the enhanced osteoclastogenesis seen under simulated microgravity conditions, with changes in cytokine expression further modulating this effect.     

Acceleration and particle transport in collisionless plasma in the process of dipolarization and nonstationary turbulence

This work is devoted to studying the processes of the acceleration of plasma particles in thin current sheets that appear during magnetospheric substorms in the Earth’s magnetosphere tail. A numerical model of magnetic dipolarization accompanied by plasma turbulence has been constructed and studied. The model allows one to investigate the particle acceleration due to the action of three principal mechanisms: (1) plasma turbulence; (2) magnetic dipolarization; (3) their simultaneous action. For the given velocity kappa-distributions, we obtained energy spectra of three types of accelerated particles, i.e., protons p⁺, ions of oxygen O⁺, and electrons e^–. It has been shown that the combined mechanism of dipolarization with turbulence (3) makes the largest contribution to the increase in the energy of protons and heavy ions as compared with a separate action of each of mechanisms (1) and (2); in this case, electrons accelerate less. The consideration of the joint action of acceleration mechanisms (1) and (2) can explain the apparition of particles with energies on the order of magnitude equal to hundreds keV in the Earth’s magnetosphere tail.     

Prevention of muscle fibers atrophy during gravitational unloading: The effect of l-arginine administration

Gravitational unloading results in pronounced atrophy of m.soleus. Probably, the output of NO is controlled by the muscle activity. We hypothesized that NO may be involved in the protein metabolism and increase of its concentration in muscle can prevent atrophic changes induced by gravitational unloading. In order to test the hypothesis we applied NO donor l-arginine during gravitational unloading. 2.5-month-old male Wistar rats weighing 220–230g were divided into sedentary control group (CTR, n=7), 14-day hindlimb suspension (HS, n=7), 14 days of hindlimb suspension+l-arginine (HSL, n=7) (with a daily supplementation of 500 mg/kg wt l-arginine) and 14 days of hindlimb suspension+l-NAME (HSN, n=7) (90 mg/kg wt during 14 days). Cross sectional area (CSA) of slow twitch (ST) and fast twitch (FT) soleus muscle fibers decreased by 45% and 28% in the HS group (p<0.05) and 40% and 25% in the HSN group, as compared to the CTR group (p<0.05), respectively. CSA of ST and FT muscle fibers were 25% and 16% larger in the HSL group in comparison with the HS group (p<0.05), respectively. The atrophy of FT muscle fibers in the HSL group was completely prevented since FT fiber CSA had no significant differences from the CTR group. In HS group, the percentage of fibers revealing either gaps/disruption of the dystrophin layer of the myofiber surface membrane increased by 27% and 17%, respectively, as compared to the controls (CTR group, p<0.05). The destructions in dystrophin layer integrity and reductions of desmin content were significantly prevented in HSL group. NO concentration decreased by 60% in the HS group (as well as HSN group) and at the same time no changes were detectable in the HSL group. This fact indicates the compensation of NO content in the unloaded muscle under l-arginine administration. The levels of atrogin-1 mRNA were considerably altered in suspended animals (HS group: plus 27%, HSL group: minus 13%) as compared to the control level. Conclusion: l-arginine administration allows maintaining NO concentration in m.soleus at the level of cage control group, prevents from dystrophin layer destruction, decreases the atrogin mRNA concentration in the muscle and atrophy level under gravitational unloading.     

Numerical simulation of effects of the August 11, 1999 solar eclipse in the outer ionosphere

The results of a numerical simulation of such parameters of the topside ionosphere as concentration N _e and temperature T _e of electrons, and concentration n(H⁺) and fluxes along the magnetic field lines Φ(H⁺) of H⁺ ions at an altitude of ～2000 km for the conditions of the August 11, 1999 solar eclipse are presented. The calculations were performed using the Global Self-consistent Model of the Thermosphere, Ionosphere, and Protonosphere of the Earth (GSM TIP). It is shown that during the eclipse, in addition to a region of decreased values of T _e in the Northern Hemisphere and in the magnetically conjugate region in the Southern Hemisphere, regions of electron heating emerge in both hemispheres. Simultaneously, an extended region of decreased values of N _e comes into existence and moves behind the Moon’s shadow. Regions with decreased (down to ～30%) and enhanced (up to ～50%) concentrations of H⁺ ions are detected in the global distribution of these ions.     

An explanation of variable peculiarities in spectra of electrons and positrons of cosmic rays

It is shown that the excesses in the sum of fluxes (e ⁺ + e ^?) in cosmic rays in the energy range (10–1000) GeV and in the flux ratio e ⁺/(e ⁺ + e ^?) in the range > 10 GeV, observed both in recent and old experiments, can be explained by an accelerator of charged particles operating on the heliosphere periphery, in the region beyond the termination shock of the solar wind (～100 AU). Variations in the value and position of peculiarities in the spectra (e ⁺ + e ^?), as well as increasing ratio of fluxes e ⁺/(e ⁺ + e ^?), can be associated with variations of solar activity (and, as a consequence, of acceleration regimes) on different phases of the 11-years solar cycle. The results of numerical simulation of capture and acceleration of charged particles by packets of plasma waves in the heliospheric magnetic field are presented.     

Sleep and cognitive function of crewmembers and mission controllers working 24-h shifts during a simulated 105-day spaceflight mission

The success of long-duration space missions depends on the ability of crewmembers and mission support specialists to be alert and maintain high levels of cognitive function while operating complex, technical equipment. We examined sleep, nocturnal melatonin levels and cognitive function of crewmembers and the sleep and cognitive function of mission controllers who participated in a high-fidelity 105-day simulated spaceflight mission at the Institute of Biomedical Problems (Moscow). Crewmembers were required to perform daily mission duties and work one 24-h extended duration work shift every sixth day. Mission controllers nominally worked 24-h extended duration shifts. Supplemental lighting was provided to crewmembers and mission controllers. Participants' sleep was estimated by wrist-actigraphy recordings. Overall, results show that crewmembers and mission controllers obtained inadequate sleep and exhibited impaired cognitive function, despite countermeasure use, while working extended duration shifts. Crewmembers averaged 7.04±0.92 h (mean±SD) and 6.94±1.08 h (mean±SD) in the two workdays prior to the extended duration shifts, 1.88±0.40 h (mean±SD) during the 24-h work shift, and then slept 10.18±0.96 h (mean±SD) the day after the night shift. Although supplemental light was provided, crewmembers’ average nocturnal melatonin levels remained elevated during extended 24-h work shifts. Naps and caffeine use were reported by crewmembers during ∼86% and 45% of extended night work shifts, respectively. Even with reported use of wake-promoting countermeasures, significant impairments in cognitive function were observed. Mission controllers slept 5.63±0.95 h (mean±SD) the night prior to their extended duration work shift. On an average, 89% of night shifts included naps with mission controllers sleeping an average of 3.4±1.0 h (mean±SD) during the 24-h extended duration work shift. Mission controllers also showed impaired cognitive function during extended duration work shifts.These findings indicate that extended duration work shifts present a significant challenge to crewmembers and mission support specialists during long-duration space mission operations. Future research is needed to evaluate the efficacy of alternative work schedules and the development and implementation of more effective countermeasures will be required to maintain high levels of performance.     

Ballistics, navigation, and motion control for a spacecraft during its landing on the surface of Phobos

Basic concepts and algorithms laid as foundations of the scheme of landing on the Martian moon Phobos (developed for the Phobos-Grunt project) are presented. The conditions ensuring the landing are discussed. Algorithms of onboard navigation and control are described. The equations of spacecraft motion with respect to Phobos are considered, as well as their use for correction of the spacecraft motion. The algorithm of estimation of the spacecraft’s state vector using measurements with a laser altimeter and Doppler meter of velocity and distance is presented. A system for modeling the landing with a firmware complex including a prototype of the onboard computer is described.     

Large-scale irregularities of the winter polar topside ionosphere according to data from <Emphasis Type="Italic">Swarm</Emphasis> satellites

An analysis of the electron density measurements (Ne) along the flyby trajectories over the high-latitude region of the Northern Hemisphere under winter conditions in 2014 and 2016 has shown that the main large-scale structure observed by Swarm satellites is the tongue of ionization (TOI). At the maximum of the solar cycle (F_10.7 = 160), the average value of Ne in the TOI region at an altitude of 500 km was 8 × 10⁴ cm^–3. Two years later, at F_10.7 = 100, Ne ~ 5 × 10⁴ cm^–3 and Ne ~2.5 × 10⁴ cm^–3 were observed at altitudes of 470 and 530 km, respectively. During the dominance of the azimuthal component of the interplanetary magnetic field, the TOI has been observed mainly on the dawn or dusk side depending on the sign of B _y . Simultaneous observations of the convective plasma drift velocity in the polar cap show the transpolar flow drift to the dawn (B_y < 0) or dusk side (B _y < 0). Observations and numerical simulation of the Ne distribution have confirmed the significant role of the electric field of the magnetospheric convection in the generation of large-scale irregularities in the polar ionosphere.     

Sсheme of rendezvous mission to lunar orbital station by spacecraft launched from Earth

In recent years, great experience has been accumulated in manned flight astronautics for rendezvous in near-Earth orbit. During flights of Apollo spacecraft with crews that landed on the surface of the Moon, the problem of docking a landing module launched from the Moon’s surface with the Apollo spacecraft’s command module in a circumlunar orbit was successfully solved. A return to the Moon declared by leading space agencies requires a scheme for rendezvous of a spacecraft launched from an earth-based cosmodromee with a lunar orbital station. This paper considers some ballistic schemes making it possible to solve this problem with minimum fuel expenditures.     

Physicochemical model of the auroral ionosphere

A physicochemical model of excited polar ionosphere has been presented. The model makes it possible to calculate vertical profiles of concentrations of the following excited and ionized constituents: O₂ ⁺, N₂ ⁺, O⁺(⁴S), O⁺(²D), O⁺(²P), O(¹D), O(¹S), N(⁴S), N(²D), N(²P), NO, NO⁺, N⁺, N₂(A³Σ_u ⁺), N₂(B³П_g), N₂(W³Δ_u), and N₂(B′³Σ_u ^-) and the electron concentration during electron precipitations. The energy spectrum of the electrons at the upper boundary of the ionosphere and concentrations of neutral constituents are the input parameters of the model. A model has been compiled based on available publications and includes 56 physicochemical reactions that influence concentrations of the aforementioned constituents in the polar ionosphere. The method of calculating vertical profiles of the excitation rates of atmospheric gases and proper allowance for the electron-vibrational kinetics in the processes of exciting the triplet states of N₂ are specific features of the presented model. The ionospheric model has been approbated using the results of the coordinated rocket–satellite experiment. The agreement between the modeling results and experimental data best for the time being is achieved.     

Fine structure of the interplanetary shock front according to measurements of the ion flux of the solar wind with high time resolution

According to the data of the BMSW/SPEKTR-R instrument, which measured the density and velocity of solar wind plasma with a record time resolution, up to ~3 ×10^–2 s, the structure of the front of interplanetary shocks has been investigated. The results of these first investigations were compared with the results of studying the structure of the bow shocks obtained in previous years. A comparison has shown that the quasi-stationary (averaged over the rapid oscillations) distribution of plasma behind the interplanetary shock front was significantly more inhomogeneous than that behind the bow-shock front, i.e., in the magnetosheath. It has also been shown that, to determine the size of internal structures of the fronts of quasi-perpendicular (θ_BN > 45°) shocks, one could use the magnetic field magnitude, the proton density, and the proton flux of the solar wind on almost equal terms. A comparison of low Mach (М _А < 2), low beta (β₁ < 1) fronts of interplanetary and bow shocks has shown that the dispersion of oblique magnetosonic waves plays an essential role in their formation.     

Longitudinal dependence of the H<Superscript>+</Superscript> concentration distribution in the plasmasphere according to <Emphasis Type="Italic">INTERBALL-1</Emphasis> satellite data

The paper has presented a study of the dependence of the H⁺ ions concentration in the plasmasphere on geographic longitude. A vast database of measurements of the cold plasma density by the Alpha-3 instrument on board the INTERBALL-1 satellite has been used for the study. Based on these measurements, a dependence of the H⁺ ions concentration in the filled magnetic flux tube in the plasmasphere in the equatorial plane under quiet geomagnetic conditions has been obtained as a function of geographic longitude. Studies have been performed for two seasons, summer and winter. It has been shown that, during the summer in the near-midnight sector, the minimum in the H⁺ concentration falls within geographic longitudes of 270°–315°. The ratio of the concentration of H⁺ ions at various longitudes could reach a factor of three. During the winter, in the near-noon sector, the maximum of the H⁺ ions concentration falls within longitudes of 180°–225°, whereas the concentration ratio could reach a factor of 2.2.     

Right ventricular tissue Doppler assessment in space during circulating volume modification using the Braslet device

Introduction: This joint US–Russian work aims to establish a methodology for assessing cardiac function in microgravity in association with manipulation of central circulating volume. Russian Braslet-M (Braslet) occlusion cuffs were used to temporarily increase the volume of blood in the lower extremities, effectively reducing the volume in central circulation. The methodology was tested at the International Space Station (ISS) to assess the volume status of crewmembers by evaluating the responses to application and release of the cuffs, as well as to modified Valsalva and Mueller maneuvers. This case study examines the use of tissue Doppler (TD) of the right ventricular (RV) free wall. Results: Baseline TD of the RV free wall without Braslet showed early diastolic E′ (16 cm/s), late diastolic A′ (14 cm/s), and systolic S′ (12 cm/s) velocities comparable with those in normal subjects on Earth. Braslet application caused 50% decrease of E′ (8 cm/s), 45% increase of A′, and no change to S′. Approximately 8 beats after the Braslet release, TD showed E′ of 8 cm/s, A′ of 12 cm/s, and S′ of 13 cm/s. At this point after release, E′ did not recover to baseline values while l A′ and S′ did recover. The pre-systolic cross-sectional area of the internal jugular vein without Braslet was 1.07 cm², and 1.13 cm² 10 min after the Braslet was applied. The respective cross-sectional areas of the femoral vein were 0.50 and 0.54 cm². The RV myocardial performance Tei index was calculated by dividing the sum of the isovolumic contraction time and isovolumic relaxation time by the ejection time ((IVCT+IVRT)/ET); baseline and Braslet-on values for Tei index were 0.25 and 0.22, respectively. Braslet Tei indices are within normal ranges found in healthy terrestrial subjects and temporarily become greater than 0.4 during the dynamic Braslet release portion of the study. Conclusions: TD modality was successfully implemented in space flight for the first time. TD of RV revealed that the Braslet influenced cardiac preload and that fluid was sequestered in the lower extremity interstitial and vascular space after only 10 min of application. This report demonstrates that Braslet application has an effect on RV physiology in long-duration space flight based on TD, and that this effect is in part due to venous hemodynamics.     

Study of notches in the Earth’s plasmasphere based on data of the <Emphasis Type="Italic">MAGION-5</Emphasis> satellite

Depleted narrow (localized in longitude) regions (field tubes) in the plasmasphere, recently discovered in He⁺ radiation measurements on the IMAGE spacecraft, were first directly observed by the Magion-5 satellite. The low-density regions (notches) occupy <～ 10–30° in longitude and extend from L ～ 2–3 to the plasmasphere boundary in neighboring plasmasphere regions with larger densities. The Magion-5 data give evidence that in the low-density regions temperature is enhanced as compared to the neighboring denser plasmasphere regions. Formation of notches in the plasmasphere is, apparently, associated with AE intensification during weak magnetic storms, while strong magnetic storms usually result in the overall reduction of plasmasphere dimensions. However, even a strong magnetic storm on April 6–7, 2000 (max K _p = 9-and min D _st ～ ?290 nT), but accompanied by an isolated AE impulse, resulted in a density decrease only in the longitudinally limited post-midnight sector of the plasmasphere.     

Acceleration of solar cosmic rays and the fine spectral structure of type II radio bursts

On the basis of data, obtained by means of the ground-based solar service RSTN (Radio Solar Telescope Network) and the geostationary satellite system GOES, the relationship between the solar cosmic rays (SCR) intensity I _p with the proton energy E _p > 1 MeV and parameters of meter-decameter type II radio bursts in the frequency range of 25–180 MHz is studied. The process of proton acceleration by shock waves was characterized by the frequency drift velocity of radio bursts V _mII and the relative difference between radio emission frequencies at the first two harmonics b. It is shown that the coefficient of correlation between I _p and b increases with E _p growing from 0.40 to 0.70, while a similar coefficient between I _p and V _mII does not exceed 0.30. Indications in favor of the two-stage SCR acceleration model are obtained.     

Vascular functions in humans following cardiovascular adaptations to spaceflight

Purpose: Diminished vascular function is a primary cardiovascular risk of spaceflight identified in the 2004 NASA Bioastronautics Critical Path Roadmap based on: (1) structural and functional alterations in arterial vessels of animals undergoing hindlimb unloading and; (2) lower peripheral vascular resistance (PVR) in astronauts who became presyncopal after spaceflight.Methods: We conducted a critical review of published data obtained from spaceflight and relevant ground-based microgravity simulations in an effort to interpret the meaning of altered responses in PVR and their relationship to postflight presyncope.Results: Presyncope reported in astronauts on landing day was associated with lower peripheral resistance. However, non-presyncopal astronauts demonstrated significantly elevated vascular resistance in the upright posture after compared with before spaceflight. Results from both space and ground experiments suggest that preflight maximal vasoconstrictor capacity is inherently lower in presyncopal astronauts, but unaltered by spaceflight.Conclusions: Vasoconstrictor reserve is associated with lower blood volume adaptation to microgravity. Rather than reduced vascular function, low inherent maximal vasoconstrictor capacity and reduced vasoconstrictor reserve secondary to decreased circulating vascular volume explain lower peripheral vascular resistance in astronauts who experience presyncopal episodes on landing day.     

Stability of resonance rotation of a satellite with respect to its center of mass in the orbit plane

The stability of resonance oscillations and rotations of a satellite in the plane of its orbit in the case when the difference of the moments of inertia with respect to the principal axes lying in the orbit plane is small is determined at a given rotation number m by the sign of function Φ_m(e), introduced by F.L. Chernous’ko in 1963. In this paper, convenient analytical representations of functions Φ_m(e) are described in the form of integrals and series of Bessel functions regular at e → 1^?. Values of Φ_m(1) are calculated in explicit form. A theorem about the double asymptotic form of functions Φ_m(e) at m → ∞ and e → 1^? is proved by the saddlepoint method.     

<Emphasis Type="Italic">Luna-5</Emphasis> (1965): Some Results of a Failed Mission to the Moon

Luna-5 was the second Soviet spacecraft to reach the Moon. During the first decade of space exploration of the Moon, the Luna probe series was the main part of the Soviet scientific program. The tasks of the Luna-5 probe launched to the Moon in May 1965 were to land softly on the lunar surface, take photos, and study the surface. Before the Luna-5 landing, the prospective coordinates of the landing site were telegraphed to observatories so that they would observe the event. However, during its descent, the braking engine failed and the probe crash landed at 22 h 13 min on May 12, 1965. Later, new supposed coordinates of the impact were reported. All the experiments were undoubtedly lost; nevertheless, successive television images of the failed landing made at the Abastumani Astrophysical Observatory (AbAO) of the Georgian Academy of Sciences can be considered a specific scientific result of the mission. In the images, a changeable object was detected near the large Lansberg crater; for obscure secrecy reasons, almost nothing was reported to specialists about this object. It has been identified as a small, gradually spreading impact cloud. An analysis of the reprocessed images taken at the AbAO has revealed the exact coordinates of the Luna-5 impact for the first time to be 1.35° S, 25.48° W, which differ substantially the calculation data published earlier. Some properties of the regolith at the Luna-5 impact site are compared to the results of the Lunar Crater Observation and Sensing Satellite (LCROSS) related to the region near the south pole of the Moon and reported in 2010.