选择中国载人航天发展目标的讨论

回顾人类载人航天 40余年的历程 ,出现过一些弯路 ,究其原因是多方面的 ,但主要的是如何合理选择各自的发展目标。发展载人航天的目标大致可有6项 :开发利用空间微重力环境物质资源 ,开发利用空间轨道能源资源 ,开发利用月球能源资源 ,发展天基航天利用空间位置资源 ,在月球上扩大人类生存空间 ,在火星上扩大人类生存空间。文章系统分析了国际上现有载人航天工程的经验和教训 ,认为结合中国的具体实际 ,中国载人航天发展的目标应重点考虑开发利用空间微重力环境物质资源和发展天基航天。     

空间站微重力流体实验设备需求分析

对国际空间站和中国科学实验卫星及载人飞行器上开展的微重力流体实验情况进行论述和分析,重点分析了国际空间站（ISS）微重力流体科学实验设备情况.根据中国空间微重力流体物理科学发展需求,结合国际空间站微重力流体科学实验对设备的需求,提出了未来在中国空间站开展微重力流体实验时空间实验设备需要重点考虑和解决的问题,同时提出相关设计建议.      

Experiments with small animals in BIOLAB and EMCS on the International Space Station.

Two ESA facilities will be available for animal research and other biological experiments on the International Space Station: the European Modular Cultivation System (EMCS) in the US Lab "Destiny" and BIOLAB in the European "Columbus" Laboratory. Both facilities use standard Experiment Containers, mounted on two centrifuge rotors allowing either research in microgravity or acceleration studies with variable g-levels from 0.001 to 2.0 x g. Standard interface plates provide each container with power and data lines, gas supply (controlled CO2, O2 concentration and relative humidity), and--for EMCS only--connectors to fresh and waste water reservoirs. The experiment hardware inside the containers will be developed by the user, but ESA conducted a feasibility study for several kinds of Experiment Support Equipment with potential use for research on small animals: design concepts for experiments with insects, with aquatic organisms like rotifers and nematodes, and with small aquatic animals (sea urchin larvae, tadpoles, fish youngsters) are described in detail in this presentation. Also ESA's initial steps to support experiments with rodents on the Space Station are presented.     

Progress on Microgravity Sciences in China

The main progress of the research activities on microgravity fluid physics, combustion, biotechnology research and fundamental Physics in China are briefly summarized in the present paper. The major space missions and experimental results obtained on board the Chinese recoverable/nonrecoverable satellites and the Chinese manned spaceship named "Shen Zhou" are presented summarily. The recent main activities of the ground-based studies in China are introduced in brief.     

微重力环境中哺乳动物细胞分子生物学效应研究进展

随着载人航天事业的不断发展,空间失重环境引起的航天员健康问题（心血管疾病、免疫抑制、肌肉萎缩、骨质疏松等）日益突出,这已成为人类探索空间的一大阻碍.越来越多的研究关注到微重力条件下机体及细胞的变化.近期的研究表明,在细胞水平上,微重力会引起细胞降解,改变细胞骨架,并造成细胞在分子水平（如细胞增殖、分化、迁移、粘附、信号转导等过程）的一系列改变.本文对微重力条件下免疫细胞、内皮细胞、骨细胞、癌细胞的相关研究进行了归纳总结,研究结果可为微重力条件下机体及相关细胞的研究提供指导,为治疗或缓解微重力条件造成的疾病提供方法和思路.      

The optical bidirectional accelerometer

A new Optical Bidirectional Accelerometer (O.B.A.) is described in this paper.

This accelerometer gives in real time the acceleration level in two orthogonal axis.

The advantages of this instrument in microgravity environment during a parabolic flight experiment (e.g. in fluid mechanics) are explained. The capability of O.B.A. to detect variations of the gravity level is studied. Theoretical curves give the sensibility and accuracy of the accelerometer for different parameters.

We describe the prototype and the different tests realized on it. The experimental results of the ground investigations are compared with the theoretical curves described in the previous section. The second part of the tests has been realized during a ESA parabolic flight campaign with the NASA KC 135 aircraft and in collaboration with the Belgian Air Force on a Fouga Magister.     

An experimental system for determining the influence of microgravity on B lymphocyte activation and cell fusion.

The influence of microgravity on lymphocyte activation is central to the understanding of immunological function in space. Moreover, the adaptation of groundbased technologies to microgravity conditions presents opportunities for biotechnological applications including high efficiency production of antibody forming hybridomas. Because the emerging technology of microgravity hybridoma generation is dependent upon activation and cultivation of B lymphocytes during flight, we have adapted mitogen-driven B lymphocyte stimulation and culture that allows for the in vitro generation of large numbers of antibody forming cells suitable for cell fusion over a period of 1-2 weeks. We believe that this activation and cultivation system can be flown on near-term space flights to test fundamental hypotheses about mammalian cell activation, cell fusion, metabolism, secretion, growth, and bio-separation.     

展望21世纪中国空间技术

中国发展空间技术的目的是为国民经济建设服务。到下世纪初的目标是逐步建成几个急需的、长期稳定运行的应用卫星系统：通信广播,环境资源勘测,减灾,微重力资源,小卫星等;优先发展卫星的有效载荷技术和公用平台技术,加强卫星应用研究,重视预研和基础技术开发,加深国际交流和合作;中国也将在载人航天和深空探测领域进行探索和研究。     

The effects of simulated microgravity on the seminiferous tubules of rats

Space flight has been shown to have many adverse effects on various systems throughout the body. Because the opportunity to place research animals on board a Space Shuttle or the International Space Station is infrequent, various techniques have been designed to simulate the effects of microgravity in Earth based laboratories. A commonly used technique is known as antiorthostatic suspension, also often referred to as hind limb suspension. In this technique the hind portion of the animal is raised so that its hind limbs are non-weight bearing. This places the animal in roughly a 30° head down tilt position. This results in cephalic fluid shifts similar to those seen in actual space flight. This technique has also been shown to mimic other physiological parameters that are affected during space flight. This study examined testicular tissue from rats subjected to a 7 day antiorthostatic suspension. This tissue was acquired through a tissue sharing program and some of the experimental animals were injected with Interleukin 1 receptor antagonist (IL-1ra) which was hoped to ameliorate some of the effects of antiorthostatic suspension. The injection of IL-1ra was not expected to have any effect on testicular tissue, however this tissue was included in the morphological and statistical analysis to conduct a more complete study. All tissues were embedded in paraffin, sectioned, and stained using standard H&E staining. The tissue was then qualitatively ranked according to the “health” of the seminiferous tubules. Our findings indicate that 7 days of antiorthostatic suspension had adverse effects on the tissue that comprises the walls of the seminiferous tubules. It has long been known that antiorthostatic suspension has deleterious effects on testicular tissue, however this research indicates that these effects occur much faster than indicated by previous researchers. This is a significant finding because it indicates that meaningful earth based studies in this area can be carried out in a shorter time span. This could result in more studies per year as well as saving money by avoiding longer than necessary animal suspensions. This is especially important as we enter an era when, without Space Shuttle, flight opportunities will become scarce. These antiorthostatic suspension studies indicate that space flight, even short duration spaceflight, may have harmful effects on the seminiferous tubules and blood-testis barrier of astronauts.     

中国航天医学进展

航天医学是随着载人航天事业的发展而兴起的一门特种医学学科、随着人类对太空的不断探索,从学科创建至今的短短几十年时间取得了巨大的发展,我国的载人航天工程于20世纪90年代初启动,但航天医学发展的历史却可追溯到50年代末,特别是近10年来,我国载人航天工程的启动为航天医学的发展带来了重大机遇,目前,我国首次载人航天飞行已获圆满成功,首飞航天员也已安全、健康地重返地球,航天医学专家们与航天员一同经受住了首次载人航天飞行的考验、本文简要介绍了我国航天医学的基础研究和应用研究,以及取得的进展,并展望了今后将面临的挑战和机遇。     

Metabolic energy required for flight.

This paper reviews data available from U.S. and U.S.S.R. studies on energy metabolism in the microgravity of space flight. Energy utilization and energy availability in space seem to be similar to those on Earth. However, negative nitrogen balances in space in the presence of adequate energy and protein intakes and in-flight exercise, suggest that lean body mass decreases in space. Metabolic studies during simulated (bed rest) and actual microgravity have shown changes in blood glucose, fatty acids, and insulin levels, suggesting that energy metabolism may be altered during flight. Future research should focus on the interactions of lean body mass, diet, and exercise in space and their roles in energy metabolism during space flight.     

Planning for the scientific use of the international space station complex

The United States has begun the development of an international Space Station complex in cooperation with Japan, Canada, and the European Space Agency. The planned uses of the facility encompass a broad spectrum of research disciplines including life sciences, material sciences, astrophysics, earth sciences and planetary sciences. Activity has already started on the preparation of scientific proposals, and in some cases on specific pieces of instrumentation, in many of these areas. Long-duration, continuous research in space in a manned facility presents situations, problems and opportunities which have never before needed to be addressed. This paper presents current thinking in the United States on several of these issues related specifically to the microgravity sciences and an initial paradigm for their solution.     

Space Research Plan of China's Space Stationormalsize

China's manned spaceflight missions have been introduced briefly, and the research planning of space sciences for China's Space Station (CSS) has been presented with the topics in the research areas, including:life science and biotechnology, microgravity fluid physics and combustion science, space material science, fundamental physics, space astronomy and astrophysics, earth sciences and application, space physics and space environment, experiments of new space technology. The research facilities, experiment racks, and supporting system planned in CSS have been described, including:multifunctional optical facility, research facility of quantum and optic transmission, and a dozen of research racks for space sciences in pressurized module, etc. In the next decade, significant breakthroughs in space science and utilization will hopefully be achieved, and great contributions will be made to satisfy the need of the social development and people's daily life.      

Achievements of Space Scientific Experiments Aboard SJ-8 Satellite

As scientific experiment payloads, microgravity experiments of fluid physics, life science,combustion science, physics and accelerator measurement were conducted on board the Chinese recoverable satellite SJ-8 during 18-day orbital flight. The experimental payloads and an experiment support system constituted the microgravity experiment system of the flight mission. This article has presented the briefs of the scientific achievements of these space experiments, the composition and performance of the Microgravity Experimental System (MES) and the general picture of the overall flight mission, respectively.      

Investigations on-board the biosatellite Cosmos-83.

The program of the 5 day flight of the biosatellite Cosmos-1514 (December 1983) envisaged experimental investigations the purpose of which was to ascertain the effect of short-term microgravity on the physiology, growth and development of various animal and plant species. The study of Rhesus-monkeys has shown in that they are an adequate model for exploring the mechanisms of physiological adaptation to weightlessness of the vestibular apparatus and the cardiovascular system. The rat experiment has demonstrated that mammalian embryos, at least during the last term of pregnancy, can develop in microgravity. This finding has been confirmed by fish studies. The experiment on germinating seeds and adult plants has given evidence that microgravity produces no effect on the metabolism of seedlings and on the flowering stage.     

Approaches in the determination of plant nutrient uptake and distribution in space flight conditions.

The effective growth and development of vascular plants rely on the adequate availability of water and nutrients. Inefficiency in either the initial absorption, transportation, or distribution of these elements are factors which impinge on plant structure and metabolic integrity. The potential effect of space flight and microgravity conditions on the efficiency of these processes is unclear. Limitations in the available quantity of space-grown plant material and the sensitivity of routine analytical techniques have made an evaluation of these processes impractical. However, the recent introduction of new plant cultivating methodologies supporting the application of radionuclide elements and subsequent autoradiography techniques provides a highly sensitive investigative approach amenable to space flight studies. Experiments involving the use of gel based 'nutrient packs' and the radionuclides calcium-45 and iron-59 were conducted on the Shuttle mission STS-94. Uptake rates of the radionuclides between ground and flight plant material appeared comparable.     

Effects of gravity perturbation on developing animal systems

Developing systems provide unique opportunities for analyzing the effects of microgravity on animals. Several unusual types of cells as well as various extraordinary cellular behavior patterns characterize the embryos of most animals. Those features have been exploited as test systems for space flight. The data from previous experiments are reviewed, and considerations for the design of future experiments are presented.     

卫星搭载导线着火前期特性实验研究

导线绝缘层的过热及由此发生的着火和燃烧是载人航天飞行器中引起火灾的主要原因.研究微重力下导线绝缘层的可燃性对于预防飞船中火灾的发生有重要意义.本文描述了SJ-8卫星搭载实验项目导线着火前期特性硬件研制以及实验情况.实验中获得了导线着火前期的温度和辐射特性.在搭载实验中,研究了导线过载电流和导线捆绑方式对导线绝缘层着火前期特性的影响.同时将微重力下的实验结果与地面功能模拟的实验结果进行了对比.实验结果表明,微重力环境下自然对流基本消失,导线和电子电气元件的散热情况恶化,在过载的情况下,就可能过热,从而导致失火.搭载实验中导线先期着火征兆的获得,将为开发我国微重力下的着火监测和早期报警装置提供新的技术途径,为我国载人航天飞行器内安全防火的工程技术工作提供科学依据和基础数据资料.