| 7T磁共振seipin鼠活体无损显型 |
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| 引用本文： | 陈春晓,刘雯卿,彭新桂,居胜红.7T磁共振seipin鼠活体无损显型[J].南京航空航天大学学报(英文版),2010,27(1):21-26. |
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| 作者姓名： | 陈春晓 刘雯卿 彭新桂 居胜红 |
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| 作者单位： | 1. 南京航空航天大学自动化学院,南京,210016,中国
2. 东南大学附属中大医院磁共振室,南京,210096,中国 |
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| 基金项目： | Supported by the National Natural Science Foundation of China (30830039);;the National High Technology Research and Development Program of China (“863”Program) (2007AA02Z211)~~ |
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| 摘 要： | 因遗传突变作用引起皮下脂肪组织缺失可导致脂肪萎缩。本文利用7T小动物磁共振仪对seipin鼠进行了活体无损显型的研究。通过伪彩及加权图像融合技术对采集的seipin鼠和野生鼠图像的处理，可清楚观察到seipin组老鼠的脂肪组织明显少于野生组。同时利用自行开发的7T小动物三维可视化系统中的stroke—based分类方法可方便提取感兴趣组织。为了对两组老鼠的脂肪组织进行定量比较，利用t检验对两组老鼠总的脂肪组织、皮下脂肪及内脏脂肪占总体积的比例进行统计。统计结果表明，seipin组老鼠的脂肪组织及皮下脂肪明显少于野生组，但在本次实验中没有发现两组鼠在内脏组织中脂肪含量存在明显差异。7T小动物磁共振仪为活体研究seipin鼠的显型提供了可靠的手段。
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| 关 键 词： | 磁共振仪 油脂与脂肪 seipin鼠 野生鼠 |
NON-INVASIVE IN VIVO PHENOTYPING OF SEIPIN MOUSE BY 7T MRI |
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| Chen Chunxiao,Liu Wenqing,Peng Xingui,Ju Shenghong.NON-INVASIVE IN VIVO PHENOTYPING OF SEIPIN MOUSE BY 7T MRI[J].Transactions of Nanjing University of Aeronautics & Astronautics,2010,27(1):21-26. |
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| Authors: | Chen Chunxiao Liu Wenqing Peng Xingui Ju Shenghong |
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| Institution: | 1.College of Automation Engineering/a>;NUAA/a>;29 Yudao Street/a>;Nanjing/a>;210016/a>;P.R.China/a>;2.Department of MRI/a>;Zhongda Hospital of Southeast University/a>;210096/a>;P.R.China |
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| Abstract: | Lipodystrophies are clinically heterogeneous acquired or inherited disorders characterized by selective loss of the adipose tissue.Non-invasive in vivo phenotyping of adipose tissue deposits in small animal models of the disease is studied using 7T magnetic resonance imaging (MRI).Pseudo image and multi-weight MRI methods show that the fat of seipin mice is virtually absent compared with WT mice.The three-dimensional (3-D) small animal visualization system for 7T MRI developed in this project facilitates to... |
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| Keywords: | magnetic resonance imaging (MRI) oils and fats seipin mice WT mice |
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