Analysis of mutant quantity and quality in human-hamster hybrid AL and AL-179 cells exposed to 137Cs-gamma or HZE-Fe ions. |
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| Authors: | C Waldren D Vannais R Drabek D Gustafson S Kraemer M Lenarczyk A Kronenberg T Hei A Ueno |
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| Institution: | Department of Radiological Health Sciences (MRB), Colorado State University, Fort Collins 80523, USA. |
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| Abstract: | We measured the number of mutants and the kinds of mutations induced by 137Cs-gamma and by HZE-Fe (56Fe 600 MeV/amu, LET = 190 KeV/micrometer) in standard AL human hamster hybrid cells and in a new variant hybrid, AL-179. We found that HZE-Fe was more mutagenic than 137Cs-gamma per unit dose (about 1.6 fold), but was slightly less mutagenic per mean lethal dose, DO, at both the S1 and hprt- loci of AL cells. On the other hand, HZE-Fe induced about nine fold more complex S1- mutants than 137Cs-gamma rays, 28% vs 3%. 137Cs-gamma rays induced about twice as many S1- mutants and hprt-mutants in AL-179 as in AL cells, and about nine times more of the former were complex, and potentially unstable kinds of mutations. |
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