Can late effects of neutron irradiation in man be estimated from early responses?1 |
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Authors: | H R Withers |
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Institution: | Department of Radiation Oncology, University of California, Los Angeles, CA 90024, USA. |
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Abstract: | Slowly-developing tissue changes after neutron irradiation should be more easily predicted from acutely-developing injury than is the case with X rays. The difference between tissue responses to neutrons and X rays is that cell survival in both rapidly and slowly responding tissues is a direct logarithmic function of neutron dose, at least up to about 3 Gy, whereas the X-ray dose-survival relationship differs between the two types of tissue: the target cells for late injury are more susceptible to killing from accumulation of sub-lethal X-ray injury and hence the survival curve diverges from its initial essentially linear region more rapidly than does that for the target cells for acute injury. |
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