| 帕金森大鼠模型的影像特性 |
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| 引用本文： | 胡光霞,钱志余,孙涛,杨天明,王文宏,谢捷如.帕金森大鼠模型的影像特性[J].南京航空航天大学学报(英文版),2010,27(1):39-44. |
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| 作者姓名： | 胡光霞 钱志余 孙涛 杨天明 王文宏 谢捷如 |
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| 作者单位： | 1. 南京航空航天大学自动化学院,南京,210016,中国
2. 东南大学附属中大医院,南京,210009,中国 |
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| 基金项目： | Supported by the National Natural Science Foundation of China (30671997)~~ |
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| 摘 要： | 利用影像技术对帕金森病（Parkinsondisease，PD）大鼠模型的脑形态与功能信息进行了系统研究。利用磁共振（Magneticresonance imaging。MRI）及磁共振血管成像（Magneticresonanceangiography，MRA）获取PD大鼠脑部形态影像资料，利用质子磁共振波谱（1H—magneticreso—nancespectroscopy，1H—MRS）及CT灌注（CTperfusion，CTP）成像获取波谱及血流变化等功能影像学资料。研究结果表明PD大鼠在形态上影像无特征性异常，在功能影像学纹状体存在局部脑血流降低和波谱变化。
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| 关 键 词： | 医学影像 脑形态 帕金森病 磁共振 CT灌注 |
IMAGING CHARACTERISTICS OF RAT MODELS OF PARKINSON DISEASE |
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| Hu Guangxia,Qian Zhiyu,Sun Tao,Yang Tianming,Wang Wenhong,Xie Jieru.IMAGING CHARACTERISTICS OF RAT MODELS OF PARKINSON DISEASE[J].Transactions of Nanjing University of Aeronautics & Astronautics,2010,27(1):39-44. |
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| Authors: | Hu Guangxia Qian Zhiyu Sun Tao Yang Tianming Wang Wenhong Xie Jieru |
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| Institution: | 1.College of Automation Engineering/a>;NUAA/a>;29 Yudao Street/a>;Nanjing/a>;210016/a>;P.R.China/a>;2.Zhongda Hospital/a>;Southeast University/a>;210009/a>;P.R.China |
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| Abstract: | Imaging technologies are utilized to study the brain morphology and the functions of rat models of Parkinson disease (PD).Magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) are used to obtain morphological imaging data.Functional imaging data,such as the spectrum and blood flow changes are obtained by proton magnetic resonance spectroscopy (1H-MRS) and CT perfusion (CTP).Results show that PD rat models have no characteristic morphological imaging abnormalities,but exist regional cereb... |
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| Keywords: | medical imaging brain morphology Parkinson disease magnetic resonance imaging CT perfusion |
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