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Spaceflight results in increase of thick filament but not thin filament proteins in the paramyosin mutant of Caenorhabditis elegans |
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| Authors: | R Adachi T Takaya K Kuriyama A Higashibata N Ishioka H Kagawa |
| Institution: | 1. Biomolecular Science, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan;2. Office of Space Flight and Operations, Japan Aerospace Exploration Agency, Ibaraki 305-8505, Japan;3. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency, Ibaraki 305-8505, Japan;4. Department of Biology, Faculty of Science, Okayama University, Okayama 700-8530, Japan |
| Abstract: | We have investigated the effect of microgravity during spaceflight on body-wall muscle fiber size and muscle proteins in the paramyosin mutant of Caenorhabditis elegans. Both mutant and wild-type strains were subjected to 10 days of microgravity during spaceflight and compared to ground control groups. No significant change in muscle fiber size or quantity of the protein was observed in wild-type worms; where as atrophy of body-wall muscle and an increase in thick filament proteins were observed in the paramyosin mutant unc-15(e73) animals after spaceflight. We conclude that the mutant with abnormal muscle responded to microgravity by increasing the total amount of muscle protein in order to compensate for the loss of muscle function. |
| Keywords: | Spaceflight Microgravity Myosin heavy chain Paramyosin C elegans Mutation |
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