Leg venous hemodynamics and leg volumes during a 42 day -6 degrees head-down bedrest |
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Authors: | Louisy F Schroiff P Guezennec C Y Guell A |
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Affiliation: | 1 Institut de Médecine Aérospatiale du Service de Santé des armées, 91223, Brétigny sur Orge, France 2 Centre National d'Etudes Spatiales, 31055, Toulouse, France |
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Abstract: | Seven healthy subjects were submitted to a 42-day head down bedrest, where leg venous compliance (venous distensibity index VDI) and leg volumes were assessed by mercury strain gauge plethysmography with venous occlusion and optoelectronic plethysmography, respectively. Plethysmographic and volometric measurements were made, before, during (at days 1, 4, 7, 14, 21, 26, 34 and 41), and after bedrest (days 1, 4, 7, 11 and 30 of the recovery period). Results showed a continuous decrease in leg volumes throughout bedrest, when VDI increased until day 26 of bedrest, and then decreased afterwards. The recovery period was characterized by a rapid return of VDI to prebedrest levels while leg volumes progressively normalised. These results showed that leg venous compliance changes are not always dependant upon skeletal muscle changes, and that factors other than size of muscle compartment are able to determine increases in leg venous compliance during long-term bedrest. |
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