Right ventricular tissue Doppler assessment in space during circulating volume modification using the Braslet device |
| |
| Authors: | DR Hamilton IV Alferova AE Sargsyan EM Fincke SH Magnus YV Lonchakov SA Dulchavsky D Ebert K Garcia D Martin VP Matveev YI Voronkov SL Melton VV Bogomolov JM Duncan |
| |
| Institution: | 1. Wyle Integrated Science and Engineering Group, 1290 Hercules Ave, Houston, TX 77058, USA;2. National Aeronautics and Space Administration Lyndon B. Johnson Space Center, 2101 NASA Rd 1, Houston, TX 77058, USA;3. Yuri A. Gagarin Cosmonaut Training Center (GCTC), Moscow Region 141160, Russia;4. Institute for Biomedical Problems, Russian Academy of Sciences, 76-A Khoroshevskoye sh., Moscow 123007, Russia;5. Department of Surgery, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA;1. Department of Electronics and Communication, K.L.University, Green Fields, Vaddeswaram 522002, A.P., India;2. Department of Electrical and Electronics Engineering, Coimbatore Institute of Technology, Coimbatore 641014, India;3. Department of Electronics and Communication Engineering, Vasireddy Venkatadri Institute of Technology, Nambur 522508, India;4. Department of Innovating Engineering, University of Salento, Italy;1. Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba-city 263-8555, Japan;2. Medical Faculty, Trakia University, 11 Armeiska Street, Stara Zagora 6000, Bulgaria;3. Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 21 Acad. G. Bonchev Str., Sofia 1113, Bulgaria;1. Technological Institute of Informatics, Polytechnic University of Valencia, Alcoi Campus, Plaza Ferrandiz y Carbonell 2, Alcoi, Spain;2. Department of Statistics, Polytechnic University of Valencia, Alcoi Campus, Alcoi, Spain;3. Department of Electrical Engineering at Oregon Institute of Technology, Portland, OR, USA |
| |
| Abstract: | Introduction: This joint US–Russian work aims to establish a methodology for assessing cardiac function in microgravity in association with manipulation of central circulating volume. Russian Braslet-M (Braslet) occlusion cuffs were used to temporarily increase the volume of blood in the lower extremities, effectively reducing the volume in central circulation. The methodology was tested at the International Space Station (ISS) to assess the volume status of crewmembers by evaluating the responses to application and release of the cuffs, as well as to modified Valsalva and Mueller maneuvers. This case study examines the use of tissue Doppler (TD) of the right ventricular (RV) free wall. Results: Baseline TD of the RV free wall without Braslet showed early diastolic E′ (16 cm/s), late diastolic A′ (14 cm/s), and systolic S′ (12 cm/s) velocities comparable with those in normal subjects on Earth. Braslet application caused 50% decrease of E′ (8 cm/s), 45% increase of A′, and no change to S′. Approximately 8 beats after the Braslet release, TD showed E′ of 8 cm/s, A′ of 12 cm/s, and S′ of 13 cm/s. At this point after release, E′ did not recover to baseline values while l A′ and S′ did recover. The pre-systolic cross-sectional area of the internal jugular vein without Braslet was 1.07 cm2, and 1.13 cm2 10 min after the Braslet was applied. The respective cross-sectional areas of the femoral vein were 0.50 and 0.54 cm2. The RV myocardial performance Tei index was calculated by dividing the sum of the isovolumic contraction time and isovolumic relaxation time by the ejection time ((IVCT+IVRT)/ET); baseline and Braslet-on values for Tei index were 0.25 and 0.22, respectively. Braslet Tei indices are within normal ranges found in healthy terrestrial subjects and temporarily become greater than 0.4 during the dynamic Braslet release portion of the study. Conclusions: TD modality was successfully implemented in space flight for the first time. TD of RV revealed that the Braslet influenced cardiac preload and that fluid was sequestered in the lower extremity interstitial and vascular space after only 10 min of application. This report demonstrates that Braslet application has an effect on RV physiology in long-duration space flight based on TD, and that this effect is in part due to venous hemodynamics. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
