Abstract: | The USA has adopted the long-term goal of exploring the space frontier, including establishing human settlements beyond Earth orbit. This article describes four candidate missions for developing pathways into the Solar System which have been identified by NASA's Office of Exploration: human expeditions to Phobos and Mars, a lunar observatory and a lunar outpost to assist Mars explorations. The requirements placed upon near-term programmes by each of these missions are outlined and the elements necessary for a long-term implementation strategy are analysed. |