A model of the effects of heavy ion radiation on human tissue

In heavy ion radiotherapy and space travel humans are exposed to energetic heavy ions (C, Si, Fe and others). This type of irradiation often produces more severe biological effects per unit dose than more common X-rays. A new Monte Carlo model generates a physical space with the complex geometry of human tissue or a cell culture based model of tissue, which is affected by the passage of ionizing radiation. For irradiation, the model relies on a physical code for the ion track structure; for tissues, cellular maps are derived from two- or three-dimensional confocal microscopy images using image segmentation algorithm, which defines cells as pixilated volumes. The model is used to study tissue-specific statistics of direct ion hits and the remote ion action on cells. As an application of the technique, we considered the spatial pattern of apoptotic cells after heavy ion irradiation. The pattern of apoptosis is modeled as a stochastic process, which is defined by the action cross section taken from available experimental data. To characterize the degree of apoptosis, an autocorrelation function that describes the spatial correlation of apoptotic cells is introduced. The values of the autocorrelation function demonstrate the effect of the directionality of the radiation track on the spatial arrangements of inactivated cells in tissue. This effect is intrinsic only to high linear-energy-transfer radiation.     

Design of a canard configured TransCruiser using CEASIOM

CEASIOM is a multidisciplinary software environment for aircraft design that has been developed as part of the European Framework 6 SimSAC project. It closely integrates discipline-specific tools such as those used for CAD, grid generation, CFD, stability analysis and control system design. The environment allows the user to take an initial design from geometry definition and aerodynamics generation through to full six degrees of freedom simulation and analysis. Key capabilities include variable fidelity aerodynamics tools and aeroelasticity modules. The purpose of this paper is to demonstrate the potential of CEASIOM by presenting the results of a Design, Simulate and Evaluate (DSE) exercise applied to a novel, project specific, transonic cruiser configuration called the TCR. The baseline TCR configuration is first defined using conventional methods, which is then refined and improved within the CEASIOM software environment. A wind tunnel model of this final configuration was then constructed, tested and used to verify the results generated using CEASIOM.     

Characteristics of Icy Surfaces

The surfaces of the Solar System’s icy satellites show an extraordinary variety of morphological features, which bear witness to exchange processes between the surface and subsurface. In this paper we review the characteristics of surface features on the moons of Jupiter, Saturn, Uranus and Neptune. Using data from spacecraft missions, we discuss the detailed morphology, size, and topography of cryovolcanic, tectonic, aeolian, fluvial, and impact features of both large moons and smaller satellites.     

Editorial: Cognitive Semantics and Spatio-Temporal Ontologies

How do people describe the location of a target object to another? This task requires a reference object or frame and terms of reference. Traditional linguistic analyses have loosely organized perspectives around people, objects, or environments as reference objects, using reference terms based on a viewpoint or the intrinsic sides of an object, such as left, right, front, and back or based on the environment, such as north, south, east, and west. In actual communication, social, spatial, and cognitive factors may also affect perspective choice. We examine those factors by varying the spatial information (landmarks and cardinal directions), the communication task (relative cognitive burden to speakers and addressees), and the culture of participants (American and Japanese). Speakers used addressees' perspectives more when addressees had the greater cognitive burden. They also used landmarks and cardinal directions when they were available, especially to avoid difficult discriminations like left/right. Some cases appearing to be perspective taking can be interpreted as using a person as a landmark. Finally, terms like near indicating close proximity were preferred to far and to terms requiring projection of directions. Globally, perspective choices of American and Japanese samples were strikingly similar; that is, Japanese did not select addressees' perspectives more than Americans. The traditional linguistic analyses need to be enhanced to account for effects of cognitive, situational, and social factors.     

1. Transport of Mass,Momentum and Energy in Planetary Magnetodisc Regions

The rapid rotation of the gas giant planets, Jupiter and Saturn, leads to the formation of magnetodisc regions in their magnetospheric environments. In these regions, relatively cold plasma is confined towards the equatorial regions, and the magnetic field generated by the azimuthal (ring) current adds to the planetary dipole, forming radially distended field lines near the equatorial plane. The ensuing force balance in the equatorial magnetodisc is strongly influenced by centrifugal stress and by the thermal pressure of hot ion populations, whose thermal energy is large compared to the magnitude of their centrifugal potential energy. The sources of plasma for the Jovian and Kronian magnetospheres are the respective satellites Io (a volcanic moon) and Enceladus (an icy moon). The plasma produced by these sources is globally transported outwards through the respective magnetosphere, and ultimately lost from the system. One of the most studied mechanisms for this transport is flux tube interchange, a plasma instability which displaces mass but does not displace magnetic flux—an important observational constraint for any transport process. Pressure anisotropy is likely to play a role in the loss of plasma from these magnetospheres. This is especially the case for the Jovian system, which can harbour strong parallel pressures at the equatorial segments of rotating, expanding flux tubes, leading to these regions becoming unstable, blowing open and releasing their plasma. Plasma mass loss is also associated with magnetic reconnection events in the magnetotail regions. In this overview, we summarise some important observational and theoretical concepts associated with the production and transport of plasma in giant planet magnetodiscs. We begin by considering aspects of force balance in these systems, and their coupling with the ionospheres of their parent planets. We then describe the role of the interaction between neutral and ionized species, and how it determines the rate at which plasma mass and momentum are added to the magnetodisc. Following this, we describe the observational properties of plasma injections, and the consequent implications for the nature of global plasma transport and magnetodisc stability. The theory of the flux tube interchange instability is reviewed, and the influences of gravity and magnetic curvature on the instability are described. The interaction between simulated interchange plasma structures and Saturn’s moon Titan is discussed, and its relationship to observed periodic phenomena at Saturn is described. Finally, the observation, generation and evolution of plasma waves associated with mass loading in the magnetodisc regions is reviewed.     

Element Separation in the Chromosphere Ionization-Diffusion Models for the FIP-Effect

Ionization-diffusion mechanisms to understand the first ionization potential (FIP) fractionation as observed in the solar corona and the solar wind are reviewed. The enrichment of the low-FIP elements (<10 eV) compared to the high-FIP elements, seen in e.g. slow and fast wind or polar plumes, is explained. The behaviour of the heavy noble gases becomes understandable. The absolute fractionation, i.e. in relation to hydrogen, can be calculated and fits well to the measurements. The theoretical velocity-dependence of the fractionation will with used to determine the velocities of the solar wind in the chromosphere. This revised version was published online in June 2006 with corrections to the Cover Date.     

Gene Transfer and the Reconstruction of Life’s Early History from Genomic Data

The metaphor of the unique and strictly bifurcating tree of life, suggested by Charles Darwin, needs to be replaced (or at least amended) to reflect and include processes that lead to the merging of and communication between independent lines of descent. Gene histories include and reflect processes such as gene transfer, symbioses and lineage fusion. No single molecule can serve as a proxy for the tree of life. Individual gene histories can be reconstructed from the growing molecular databases containing sequence and structural information. With some simplifications these gene histories can be represented by furcating trees; however, merging these gene histories into web-like organismal histories, including the transfer of metabolic pathways and cell biological innovations from now-extinct lineages, has yet to be accomplished. Because of these difficulties in interpreting the record retained in molecular sequences, correlations with biochemical fossils and with the geological record need to be interpreted with caution. Advances to detect and pinpoint transfer events promise to untangle at least a few of the intertwined histories of individual genes within organisms and trace them to the organismal ancestors. Furthermore, analysis of the shape of molecular phylogenetic trees may point towards organismal radiations that might reflect early mass extinction events that occurred on a planetary scale.     

Fixed membrane wings for micro air vehicles: Experimental characterization,numerical modeling,and tailoring

Fixed wing micro air vehicles (wingspan between 10 and 15 cm) are aerodynamically challenging due to the low Reynolds number regime (10⁴–10⁵) they operate in. The low aspect ratio wings (typically used to maximize area under a size constraint) promote strong tip vortices, and are susceptible to rolling instabilities. Wind gusts can be of the same order of magnitude as the flight speed (10–15 m/s). Standard control surfaces on an empennage must be eliminated for size considerations and drag reduction, and the range of stable center of gravity locations is only a few millimeters long. Membrane aeroelasticity has been identified as a tenable method to alleviate these issues: flexible wing structures with geometric twist (adaptive washout for gust rejection, delayed stall) and aerodynamic twist (adaptive inflation for high lift, larger stability margins) are both considered here. Recent investigations in static aeroelastic characterization, including flight loads, wing deformation, flow structures, aeroelastic-tailoring studies through laminate orientation, as well as unconventional techniques based on membrane pre-tension, are reviewed. Multi-objective optimization aimed at improving lift, drag, and pitching moment considerations is also discussed.