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Perspectives of long-term space programs make it necessary to develop autonomous computer expert system for crew-members physical state control. The purpose of the work--to develop a set of objective formalizable physiological indices of working capacity suitable for reliable algorithmization of physical state control. Investigations were performed in on-earth microgravity simulation (3- and 7-day dry immersion, 6 subjects; 4-month antiorthostatic hypokinesy, 10 subjects) with volunteers' participation as well with 34 members of MIR-station expeditions during flights. Model exercise investigations were made also with 20 young male volunteers to evaluate the validity of different physical state indices. A set of indices was found which, being simple enough for measuring, performs to get satisfactory adequate evaluations of current organism physical state in long-term real or simulated microgravity. It was proved that some ergometric indices along with heart rate derivatives could reflect real working ability even better than traditional characteristics of organism energy systems state.  相似文献   
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