Induction of high grade astrocytoma (HGA) by protons: molecular mechanisms and RBE considerations.

Protons of a specific energy, 55 MeV, have been found to induce primary high grade astrocytomas (HGA) in the Rhesus monkey (Macaca mulatta). Brain tumors of this type were not induced by protons of other energies (32-2,300 MeV). Induction of HGA has been identified in human patients who have had radiation therapy to the head. We believe that the induction of HGA in the monkey is a consequence of dose distribution, not some unique "toxic" property of protons. Comparison of the human experience with the monkey data indicates the RBE for induction of brain tumors to be about one. It is unlikely that protons cause an unusual change in oncogenic expression, as compared to conventional electromagnetic radiation.     

Pulsations of the R Coronae Borealis stars

The radial pulsations of very luminous, low-mass models (L/M 10⁴, solar units), which are possible representatives of the R CrB stars, have been examined. These pulsations are extremely nonadiabatic. We find that there are in some cases at least one extra (strange) mode which makes interpretation difficult. The blue instability edges are also peculiar, in that there is an abrupt excursion of the blue edge to the blue for L/M sufficiently large. The range of periods of the model encompasses observed periods of the Cepheid-like pulsations of actual R CrB stars.     

Microsatellites And Improved Acquisition Of Space Systems

Traditional practices of the United States Department of Defense (DoD) in the acquisition of space systems have focused on advanced versions of proven technology, meaning large satellites. This paradigm contributes to dependence on a handful of satellites, program schedules measured in decades, and the expensive oversight and program management functions which must be applied to systems which, since there are so few assets, cannot countenance failures. The escape from this paradigm is offered by Microsatellites (Microsats). Microsats are not only useful technology, but technology which enables a different approach to acquisition. What the authors call the Microsat Acquisition Paradigm (MAP) is partly modeled on NASA's Faster, Better, Cheaper approach and takes lessons from NASA's successes and failures. Now that some space functions can be undertaken by low-cost Microsats, the advantages of mass production, reduced government oversight, and acceptance of a reasonable failure rate can be applied to space system acquisition. This paper explores the three pillars of the MAP approach: requirements, technology, and acquisition, which together support the Holy Grail of space system affordability. Understanding the military's space requirements is the first pillar of this approach. The second pillar is the ability to correlate the requirements to the current and projected state of Microsat technology and explain what space functions can be accomplished with Microsats. Finally, historical examples, as well as recent studies. demonstrate that streamlined, cost-effective acquisition is a reality for Microsats, enabling savings in time and money compared to the acquisition system used for traditional space systems.     

NOAA -14 September 28, 2006 (DOY 271) tumble anomaly

This describes a NOAA-14 spacecraft loss of control event and the lessons learned. The lessons learned are in two categories: contingency recovery operations; and on-orbit propulsion system isolation methods. The work is motivated in recognition of the effort of the NOAA off-line engineering support team and their NOAA civil servant mission leads and operations support staff.     

The role of repair in the survival of mammalian cells from heavy ion irradiation: approximation to the ideal case of target theory.

Theories of cellular radiation sensitivity that preclude a significant role for cellular repair processes in the final biological expression of cellular damage induced by ionizing radiation are unsound. Experiments are discussed here in which the cell-cycle dependency of the repair deficiency of the S/S variant, of the L5178Y murine leukemic lymphoblast was examined by treatment with the heavy ions, 20Ne, 28Si, 40Ar, 56Fe and 93Nb. Evidence from those studies, which will be described in detail elsewhere, provide support for the notion that as the linear energy transfer (LET infinity) of the incident radiation increases the ability of the S/S cell to repair radiation damage decreases until effectively it is eliminated around 500 keV/micrometer. In the region of the latter LET infinity value, the behavior of the S/S cell approximates the ideal case of target theory where post-irradiation metabolism (repair) does not influence cell survival. The expression of this phenomenon among different cell types and tissues will depend upon the actual repair systems involved and other considerations.     

Taking space to the public

The UK space industry is an important part of the British economy and likely to become more so, but it needs well-educated graduates, government support and investment. Such an effort would be aided by an educated public. Education is an important part of a successful space industry policy. The Space Education Council, supported by the BNSC, is doing important work talking to the public about space. This article argues that there is a need for more space education work and reports on the Space Education Council's recent symposium.     

Telerobotics: problems and research needs

With major emphasis on simulation, a university laboratory telerobotics facility permits problems to be approached by groups of graduate students. Helmet-mounded displays provide realism; the slaving of the display to the human operator's viewpoint gives a sense of `telepresence' that may be useful for prolonged tasks. Using top-down 3-D model control of distant images allows distant images to be reduced to a few parameters to update the model used for display to the human operator in a preview model to circumvent, in part, the communication delay. Also, the model can be used as a format for supervisory control and permit short-term local autonomous operations. Image processing algorithms can be made simpler and faster without trying to construct sensible images from the bottom. Control studies of telerobots lead to preferential manual control modes and, in this university environment, to basic paradigms for human motion and thence, perhaps, to redesign of robotic control, trajectory path planning, and rehabilitation prosthetics. Speculation as to future industrial drives for this telerobotic field suggests efficient roles for government agencies such as NASA     

Social desirability bias in personality testing: implications for astronaut selection

The assessment of personality is recognized by space agencies as an approach to identify candidates likely to perform optimally during spaceflights. In the use of personality scales for selection, the impact of social desirability (SD) has been cited as a concern. Study 1 addressed the impact of SD on responses to the Personality Characteristic Inventory(PCI) and NEO-FFI. This was achieved by contrasting scores from active astronauts (N=65) with scores of successful astronaut applicants (N=63), and between pilots applicants (N=1271) and pilot research subjects (N=120). Secondly, personality scores were correlated with scores on the Marlow Crown Social Desirability Scale among applicants to managerial positions (N=120). The results indicated that SD inflated scores on PCI scales assessing negative interpersonal characteristics, and impacted on four of five scales in NEO-FFI. Still, the effect sizes were small or moderate. Study 2 addressed performance implications of SD during an assessment of males applying to work as rescue personnel operations in the North Sea (N=22). The results showed that SD correlated negatively with cognitive test performance, and positively with discrepancy in performance ratings between self and two observers. In conclusion, caution is needed in interpreting personality scores in applicant populations. SD maybe a negative predictor for performance under stress.