Radiosensitivity to high energy iron ions is influenced by heterozygosity for Atm, Rad9 and Brca1

Loss of function of DNA repair genes has been implicated in the development of many types of cancer. In the last several years, heterozygosity leading to haploinsufficiency for proteins involved in DNA repair was shown to play a role in genomic instability and carcinogenesis after DNA damage is induced, for example by ionizing radiation. Since the effect of heterozygosity for one gene is relatively small, we hypothesize that predisposition to cancer could be a result of the additive effect of heterozygosity for two or more genes critical to pathways that control DNA damage signaling, repair or apoptosis. We investigated the role of heterozygosity for Atm, Rad9 and Brca1 on cell oncogenic transformation and cell survival induced by 1 GeV/n⁵⁶Fe ions. Our results show that cells heterozygous for both Atm and Rad9 or Atm and Brca1 have high survival rates and are more sensitive to transformation by high energy iron ions when compared with wild-type controls or cells haploinsufficient for only one of these proteins. Since mutations or polymorphisms for similar genes exist in a small percentage of the human population, we have identified a radiosensitive sub-population. This finding has several implications. First, the existence of a radiosensitive sub-population may distort the shape of the dose–response relationship. Second, it would not be ethical to put exceptionally radiosensitive individuals into a setting where they may potentially be exposed to substantial doses of radiation.     

CFM56—7B型发动机衰退模型建立与研究

发动机从投入使用到返厂大修整体性能衰退是一个连续性过程．研究目的在于建立能精确反映该过程的模型。收集大量CFM56—7B型发动机数据,通过解码、修正、换算得到大量的发动机排气温度裕度数据点．分段拟合并比较得到最优的该型发动机衰退数学模型,并运用另一机队数据验证模型。验证表明模型能较好地反映该型发动机衰退规律,给系统工程师分析该型发动机提供了指导依据,对研究该型发动机的性能衰退过程具有实用和理论指导意义。     

CFM56系列发动机部件技术综述

综述了CFM56系列大涵道比发动机在风扇叶片、防冰、吞水、燃烧室、尾喷管方面所采用的结构技术。