Comparison of hindlimb unloading and partial weight suspension models for spaceflight-type condition induced effects on white blood cells

Animal models are frequently used to assist in the determination of the long- and short-term effects of space flight. The space environment, including microgravity, can impact many physiological and immunological system parameters. It has been found that ground based models of microgravity produce changes in white blood cell counts, which negatively affects immunologic function. As part of the Center of Acute Radiation Research (CARR), we compared the acute effects on white blood cell parameters induced by the more traditionally used animal model of hindlimb unloading (HU) with a recently developed reduced weightbearing analog known as partial weight suspension (PWS). Female ICR mice were either hindlimb unloaded or placed in the PWS system at 16% quadrupedal weightbearing for 4 h, 1, 2, 7 or 10 days, at which point complete blood counts were obtained. Control animals (jacketed and non-jacketed) were exposed to identical conditions without reduced weightbearing. Results indicate that significant changes in total white blood cell (WBC), neutrophil, lymphocyte, monocyte and eosinophil counts were observed within the first 2 days of exposure to each system. These differences in blood cell counts normalized by day 7 in both systems. The results of these studies indicate that there are some statistically significant changes observed in the blood cell counts for animals exposed to both the PWS and HU simulated microgravity systems.     

按需提供的数字化培训

随着年轻的“互联网一代”加入航空维修业,通用电气公司（GE）提供的按需式数字化“即时培训”非常实用。通过互联网访问GEnx-1B的中央维护计算机,即可获得最先进的技术培训资料,学习燃油系统的进修课程,选择压气机和高压涡轮叶片涂层修理的专业课程,以及GE90风扇叶片尖隙的检查程序课程等。     

The Burst Alert Telescope (BAT) on the SWIFT Midex Mission

he burst alert telescope (BAT) is one of three instruments on the Swift MIDEX spacecraft to study gamma-ray bursts (GRBs). The BAT first detects the GRB and localizes the burst direction to an accuracy of 1–4 arcmin within 20 s after the start of the event. The GRB trigger initiates an autonomous spacecraft slew to point the two narrow field-of-view (FOV) instruments at the burst location within 20–70 s so to make follow-up X-ray and optical observations. The BAT is a wide-FOV, coded-aperture instrument with a CdZnTe detector plane. The detector plane is composed of 32,768 pieces of CdZnTe (4×4×2 mm), and the coded-aperture mask is composed of ∼52,000 pieces of lead (5×5×1 mm) with a 1-m separation between mask and detector plane. The BAT operates over the 15–150 keV energy range with ∼7 keV resolution, a sensitivity of ∼10⁻⁸ erg s⁻¹ cm⁻², and a 1.4 sr (half-coded) FOV. We expect to detect > 100 GRBs/year for a 2-year mission. The BAT also performs an all-sky hard X-ray survey with a sensitivity of ∼2 m Crab (systematic limit) and it serves as a hard X-ray transient monitor.     

Processes that Promote and Deplete the Exosphere of Mercury

It has been speculated that the composition of the exosphere is related to the composition of Mercury’s crustal materials. If this relationship is true, then inferences regarding the bulk chemistry of the planet might be made from a thorough exospheric study. The most vexing of all unsolved problems is the uncertainty in the source of each component. Historically, it has been believed that H and He come primarily from the solar wind (Goldstein, B.E., et al. in J. Geophys. Res. 86:5485–5499, 1981), Na and K come from volatilized materials partitioned between Mercury’s crust and meteoritic impactors (Hunten, D.M., et al. in Mercury, pp. 562–612, 1988; Morgan, T.H., et al. in Icarus 74:156–170, 1988; Killen, R.M., et al. in Icarus 171:1–19, 2004b). The processes that eject atoms and molecules into the exosphere of Mercury are generally considered to be thermal vaporization, photon-stimulated desorption (PSD), impact vaporization, and ion sputtering. Each of these processes has its own temporal and spatial dependence. The exosphere is strongly influenced by Mercury’s highly elliptical orbit and rapid orbital speed. As a consequence the surface undergoes large fluctuations in temperature and experiences differences of insolation with longitude. Because there is no inclination of the orbital axis, there are regions at extreme northern and southern latitudes that are never exposed to direct sunlight. These cold regions may serve as traps for exospheric constituents or for material that is brought in by exogenic sources such as comets, interplanetary dust, or solar wind, etc. The source rates are dependent not only on temperature and composition of the surface, but also on such factors as porosity, mineralogy, and space weathering. They are not independent of each other. For instance, ion impact may create crystal defects which enhance diffusion of atoms through the grain, and in turn enhance the efficiency of PSD. The impact flux and the size distribution of impactors affects regolith turnover rates (gardening) and the depth dependence of vaporization rates. Gardening serves both as a sink for material and as a source for fresh material. This is extremely important in bounding the rates of the other processes. Space weathering effects, such as the creation of needle-like structures in the regolith, will limit the ejection of atoms by such processes as PSD and ion-sputtering. Therefore, the use of laboratory rates in estimates of exospheric source rates can be helpful but also are often inaccurate if not modified appropriately. Porosity effects may reduce yields by a factor of three (Cassidy, T.A., and Johnson, R.E. in Icarus 176:499–507, 2005). The loss of all atomic species from Mercury’s exosphere other than H and He must be by non-thermal escape. The relative rates of photo-ionization, loss of photo-ions to the solar wind, entrainment of ions in the magnetosphere and direct impact of photo-ions to the surface are an area of active research. These source and loss processes will be discussed in this chapter.     

Loss-of-Consciousness&Spatial Disorientation Auto-Recovery System

A G-induced loss-of-consciousness (GLOC) and spatial disorientation auto-recovery system has been developed and tested on the Advanced Fighter Technology Integration (AFTI)/F-16 aircraft. The pilot controls the operation of this system by entering an MSL altitude and manually arming the system. Engagement conditions of the auto-recovery maneuver are controlled by aircraft speed, altitude, attitude, and the set recovery altitude and do not depend upon any determination of pilot physiological condition. Initiation of the recovery maneuver is preceded by visual and aural warnings which continue until the pilot resumes control. The pilot always has the capability to override or disengage the autorecovery maneuver. This system, as developed on the AFTI/F-16, is directly and quickly applicable to other analog or digital flight control systems such as found in the F-16 or F-18. This system provides the pilot protection from ground collision in most air-to-air training environments.     

发动机维修:成本与性能的平衡

在燃油价格上涨时,航空公司所期望的性能改进多与节省燃油有关;在燃油价格冲高回落、世界经济大衰退的今日,各航空公司关心的是如何获得最佳的运营成本.     

创新的接触式记忆按钮

美国航空公司成为全球首家在民用飞机的舱门、安定面、方向舵、升降舵等可更换结构部件上安装具有自动识别(AIT)功能的接触式记忆按钮的航空公司。这种接触式记忆按钮的几何外形只有美元的一角硬币那么大,具有大容量和自动化数据采集等特点,可以帮助航空公司高效地监控飞机可更换结构部件的运营历史,为航空公司节约运营成本、提高数据的精确度。据美国航空公司介绍,在这类结构     

发动机大修市场

航空发动机大修业务开始企稳,而且预计未来还将有所增加。据MRO Prospector统计,目前在役的窄体飞机机队数量约是宽体飞机的3倍,2011年窄体飞机的发动机返厂维修量将会有大幅增加。2010年1月至9月,窄体飞机发动机的MRO市值增长了2.914亿美元,达到101亿美元,增幅约为3%;在此期间,     

2020年MRO需求分布预测

据《航空周刊2020年机队及维修市场预测》,2020年商用飞机、军用飞机、公务机和民用直升机的维修市场总价值为1843亿美元,其中仅商用飞机和军用飞机维修业务就达1658亿美元。但是,预测显示商用飞机产生9120万飞行小时,军用飞机仅产生990万飞行小时,因此军用飞机的飞行小时成本要高得多。而且预计军机维修支出中外场维修占49%,位居首位,其次是零部件、机体和发动机维修。