Potential vascular damage from radiation in the space environment.

Cultured endothelial cells of blood vessels have a Do of 2 Gy for X-rays. A dose of 0.5 Gy of X-rays has an acute effect on vessel diameter. The vessels may show other acute effects such as change in permeability including a change in the blood brain barrier. Changes occurring from late effects of chronic exposure in vascular architecture include telangiectasia and decrease in vascular density. Changes in the perivascular connective tissue particularly collagen may play a role in these changes. After charged particle exposure of 15 and 30 Gy, radiation changes in the blood brain barrier and vascular changes are noted in the nervous system. These long term changes are recorded by PET, MRI, and CT imaging. Chronic exposure to alpha particles causes vascular damage in compact bone resulting in bone infarcts. Using tandem scanning confocal microscopy in-situ imaging of the capillaries and collagen of the papillary dermis provides a non-invasive method of serial recording of changes in irradiated microvasculature.     

Soybean cotyledon starch metabolism is sensitive to altered gravity conditions.

We have demonstrated that etiolated soybean seedlings grown under the altered gravity conditions of clinorotation (1 rpm) and centrifugation (5xg) exhibit changes in starch metabolism. Cotyledon starch concentration was lower (-28%) in clinorotated plants and higher (+24%) in centrifuged plants than in vertical control plants. The activity of ADP-glucose pyrophosphorylase in the cotyledons was affected in a similar way, i.e. lower (-37%) in the clinorotated plants and higher (+22%) in the centrifuged plants. Other starch metabolic enzyme activities, starch synthase, starch phosphorylase and total hydrolase were not affected by the altered gravity treatments. We conclude that the observed changes in starch concentrations were primarily due to gravity-mediated differences in ADP-glucose pyrophosphorylase activity.     

Particle trajectories in seeds of Lactuca sativa and chromosome aberrations after exposure to cosmic heavy ions on Cosmos Biosatellites 8 and 9.

The potentially specific importance of the heavy ions of the galactic cosmic radiation for radiation protection in manned spaceflight continues to stimulate in situ, i.e., spaceflight experiments to investigate their radiobiological properties. Chromosome aberrations as an expression of a direct assault on the genome are of particular interest in view of cancerogenesis being the primary radiation risk for man in space. In such investigations the establishment of the geometrical correlation between heavy ions' trajectories and the location of radiation sensitive biological substructures is an essential task. The overall qualitative and quantitative precision achieved for the identification of particle trajectories in the order of approximately 10 micrometers as well as the contributing sources of uncertainties are discussed. We describe how this was achieved for seeds of Lactuca sativa as biological test organisms, whose location and orientation had to be derived from contact photographies displaying their outlines and those of the holder plates only. The incidence of chromosome aberrations in cells exposed during the COSMOS 1887 (Biosatellite 8) and the COSMOS 2044 (Biosatellite 9) mission was determined for seeds hit by cosmic heavy ions. In those seeds the incidence of both single and multiple chromosome aberrations was enhanced. The results of the Biosatellite 9 experiment, however, are confounded by spaceflight effects unrelated to the passage of heavy ions.     

Synthetic vision for enhancing poor visibility flight operations

Visibility is important for the pilot controlling an aircraft in flight conditions close to the ground, particularly when landing. Therefore, poor visibility yields a great restriction for aircraft operations. Restrictions exist for landing sites which are equipped with facilities providing a landing approach aid like ILS since a minimum is required for visibility. For landing sites providing no approach aids, restrictions are much more severe. This holds even if aircraft are equipped with modern instrumentation and navigation devices. The natural view of the pilot is dependent on various meteorological conditions like darkness, dust, fog, rain etc. The degradation in view caused by these conditions can be compensated for partially or even completely by technical means providing artificial vision cues. Such technical means may be based on radar or optical sensor information. Concepts which employ these techniques are known as “Synthetic Visual Systems” or “Enhanced Visual Systems,” . The present paper is concerned with computer generated vision as a further technique providing visual cues for the pilot. Computer generated vision may be used in combination with the aforementioned sensor based techniques. Thus, it is possible to compensate for limitations which sensor based visual systems have in providing sufficient visibility range or in generating a normal looking image. In addition, computer generated imagery has the potential providing additional information to the pilot for controlling the flight path or for warning purposes. This potential can yield improved and/or more information as compared with the natural view when looking out of the cockpit window     

The development of a series hybrid electric vehicle for near-termapplications

The design of a feasible hybrid electric vehicle for use in near-term applications is presented. The challenge involved cost effectiveness, acceleration, range, safety, and emissions, which were incorporated into the vehicle design. The relationship of the design goals was studied, and compromises were made to provide near-optimal system design. This process resulted in the selection and design of the major vehicle components. The design decisions and the actual vehicle components are reviewed     

Influence of gravity on the circadian timing system.

The circadian timing system (CTS) is responsible for daily temporal coordination of physiological and behavioral functions both internally and with the external environment. Experiments in altered gravitational environments have revealed changes in circadian rhythms of species ranging from fungi to primates. The altered gravitational environments examined included both the microgravity environment of spaceflight and hyperdynamic environments produced by centrifugation. Acute exposure to altered gravitational environments changed homeostatic parameters such as body temperature. These changes were time of day dependent. Exposure to gravitational alterations of relatively short duration produced changes in both the homeostatic level and the amplitude of circadian rhythms. Chronic exposure to a non-earth level of gravity resulted in changes in the period of the expressed rhythms as well as in the phase relationships between the rhythms and between the rhythms and the external environment. In addition, alterations in gravity appeared to act as a time cue for the CTS. Altered gravity also affected the sensitivity of the pacemaker to other aspects of the environment (i.e., light) and to shifts of time cues. Taken together, these studies lead to the conclusion that the CTS is indeed sensitive to gravity and its alterations. This finding has implications for both basic biology and space medicine.     

The Freja wave and plasma density experiment

The Wave Experiment, F4, on the Swedish/German satelliteFreja, is designed to measure the electric wave fields up to 4 MHz, the magnetic wave fields up to 16 kHz and the plasma density and its relative variations up to 2 kHz. Six wave signals and four density probe signals can be measured simultaneously. The wave forms of all signals are transmitted to ground without any analysis onboard. The limited TM allocation does not allow continuous sampling of the wave signals, so normally the measurements are made in snapshots of various lengths dependent on sampling frequency, etc. Continuous sampling can be made for shorter time periods by using a 6 Mbyte memory as a buffer.     

A modified Gaussian sum approach to estimation of non-Gaussiansignals

A Gaussian sum estimation algorithm has previously been developed to deal with noise processes that are non-Gaussian. Inherent in this algorithm is a serious growing memory problem that causes the number of terms in the Gaussian sum to increase exponentially at each iteration. A modified Gaussian sum estimation algorithm using an adaptive filter is developed that avoids the growing memory problem of the previous algorithm while providing effective state estimation. The adaptive filter is comprised of a fixed set of estimators operating in parallel with each individual estimate possessing its own corresponding weighting term. A simulation example illustrates the new non-Gaussian estimation technique     

Mutual coupling effects and their reduction in wideband directionof arrival estimation

The performance of multiple signal classification (MUSIC) algorithm using three different inputs over a wideband of frequencies is considered. These inputs are: 1) ideal voltages, 2) actual voltages which include coupling effects and are obtained with the method or moments, and 3) corrected voltages which are obtained from the actual voltages so that the mutual coupling effects are removed. Linear arrays of dipoles, sleeve dipoles, and spiral antennas are considered over 200 MHz to 400 MHz band     

Fusion of sensors with dissimilar measurement/tracking accuracies

The case of data fusion of sensors dissimilar in their measurement/tracking errors is considered. It is shown that the fused track performance is similar whether the sensor data are fused at the track level or at the measurement level. The case of a cluster of targets, resolved by one sensor but not the other, is also considered. Under certain conditions the fused track may perform worse than the worst of the sensors. A remedy to this problem through modifications of the association algorithm is presented