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981.
Accumulation of tumor suppressor p53 in rat muscle after a space flight.   总被引:2,自引:0,他引:2  
Tumor suppressor p53 functions as a cell cycle checkpoint under stressful conditions. Early studies have shown that genotoxic stress activates p53 pathway. Recently, many kinds of non-genotoxic stress such as heat shock, cold shock, and low pH also have been found to activate p53 pathway. The effects on living organism remains to be explored. Here, we show that an 18-day space flight induced a 3.6 fold accumulation of p53 in rat skeletal muscle. This results suggests that the p53 pathway plays a role in safeguarding genomic stability against the stressful space environments and supports our previous observation of p53 accumulation in rat skin after a space flight.  相似文献   
982.
A technological process of removing a complex-shaped ceramic core from the interior of GTE thin-walled blade castings is considered. We propose an aluminium oxide-based method for removing a core by leaching accompanied by process intensification with a carboxylic acid additive.  相似文献   
983.
A problem on dynamic determination of a time interval in scheduling aperiodic requests in real-time systems is considered. It is shown that the application of a combined approach based on the combination of the probability method and the method of fuzzy sets provides an effective problem solution.  相似文献   
984.
In this paper, we analyzed the thermal and energy characteristics of the plasma components observed during the magnetic dipolarizations in the near tail by the Cluster satellites. It was previously found that the first dipolarization the ratio of proton and electron temperatures (T p/T e) was ~6–7. At the time of the observation of the first dipolarization front T p/T e decreases by up to ~3–4. The minimum value T p/T e (~2.0) is observed behind the front during the turbulent dipolarization phase. Decreases in T p/T e observed at this time are associated with an increase in T e, whereas the proton temperature either decreases or remains unchanged. Decreases of the value T p/T e during the magnetic dipolarizations coincide with increase in wave activity in the wide frequency band up to electron gyrofrequency f ce. High-frequency modes can resonantly interact with electrons causing their heating. The acceleration of ions with different masses up to energies of several hundred kiloelectron-volts is also observed during dipolarizations. In this case, the index of the energy spectrum decreases (a fraction of energetic ions increases) during the enhancement of low-frequency electromagnetic fluctuations at frequencies that correspond to the gyrofrequency of this ion component. Thus, we can conclude that the processes of the interaction between waves and particles play an important role in increasing the energy of plasma particles during magnetic dipolarizations.  相似文献   
985.
Based on the data on composition and calorific power of diesel fuel and solar oil, the conditional expressions of fuels and values of their enthalpies are considered. The data on thermodynamic properties of combustion products are obtained and generalized by calculating the process of air-fuel mixture combustion in a wide range of parameter variations.  相似文献   
986.
987.
After the major modernization of the data acquisition electronics of the particle detectors operated at Aragats Space Environmental Center (ASEC) calculations of the barometric coefficients of all the monitors were performed in the beginning of the 24th solar activity cycle. The barometric coefficients of particle detectors located at altitudes of 1000 m, 2000 m and 3200 m a.s.l. measuring various secondary cosmic ray fluxes were compared with theoretical expectations and monitors operated on different longitudes and latitudes. The barometric coefficients were also calculated for the several neutron monitors of recently established Eurasian database (NMDB) and SEVAN particle detector networks. The latitude and altitude dependencies of the barometric coefficients were investigated, as well as the dependence of coefficients on energy of the primary particles.  相似文献   
988.
989.
Non-standard situation on a spacecraft (Earth’s satellite) is considered, when there are no measurements of the spacecraft’s angular velocity component relative to one of its body axes. Angular velocity measurements are used in controlling spacecraft’s attitude motion by means of flywheels. The arising problem is to study the operation of standard control algorithms in the absence of some necessary measurements. In this work this problem is solved for the algorithm ensuring the damping of spacecraft’s angular velocity. Such a damping is shown to be possible not for all initial conditions of motion. In the general case one of two possible final modes is realized, each described by stable steady-state solutions of the equations of motion. In one of them, the spacecraft’s angular velocity component relative to the axis, for which the measurements are absent, is nonzero. The estimates of the regions of attraction are obtained for these steady-state solutions by numerical calculations. A simple technique is suggested that allows one to eliminate the initial conditions of the angular velocity damping mode from the attraction region of an undesirable solution. Several realizations of this mode that have taken place are reconstructed. This reconstruction was carried out using approximations of telemetry values of the angular velocity components and the total angular momentum of flywheels, obtained at the non-standard situation, by solutions of the equations of spacecraft’s rotational motion.  相似文献   
990.
The spatial motion relative to the center of mass is considered for a capsule on an elastic tether, when it is unrolled from a spacecraft by a special program. The spacecraft is in a circular orbit and oriented relative to the local vertical, which is guaranteed by operation of its own stabilization system. Angular motion of the capsule relative to the tether direction is studied, and the main factors influencing the stability of this motion are analyzed. An approximate quasi-linear mathematical model of the capsule attitude motion is obtained, which allows one to estimate the influence of major disturbances of its motion. The results of numerical simulations are presented for characteristic cases of the capsule motion.  相似文献   
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