Theories and models on the biology of cells in space.

A wide variety of observations on cells in space, admittedly made under constraining and unnatural conditions in many cases, have led to experimental results that were surprising or unexpected. Reproducibility, freedom from artifacts, and plausibility must be considered in all cases, even when results are not surprising. The papers in the symposium on "Theories and Models on the Biology of Cells in Space" are dedicated to the subject of the plausibility of cellular responses to gravity--inertial accelerations between 0 and 9.8 m/s2 and higher. The mechanical phenomena inside the cell, the gravitactic locomotion of single eukaryotic and prokaryotic cells, and the effects of inertial unloading on cellular physiology are addressed in theoretical and experimental studies.     

Combating fatigue to enhance safety

Methods of fighting fatigue in airline pilots are reviewed. Recommendations include maintaining home base time, monitoring sleep, and time adjustments on extended layovers. Disorders related to the circadian rhythm include sleep disturbances, altered biological rhythms, and weakened mental performance. Drug therapy includes the use of stimulants such as coffee, tea, and cola; sleep pills; and oral administration of melatonin.     

The Suess-Urey mission (return of solar matter to Earth)

The Suess-Urey (S-U) mission has been proposed as a NASA Discovery mission to return samples of matter from the Sun to the Earth for isotopic and chemical analyses in terrestrial laboratories to provide a major improvement in our knowledge of the average chemical and isotopic composition of the solar system. The S-U spacecraft and sample return capsule will be placed in a halo orbit around the L1 Sun-Earth libration point for two years to collect solar wind ions which implant into large passive collectors made of ultra-pure materials. Constant Spacecraft-Sun-Earth geometries enable simple spin stabilized attitude control, simple passive thermal control, and a fixed medium gain antenna. Low data requirements and the safety of a Sun-pointed spinner, result in extremely low mission operations costs.     

3D nonlinear wave heating of coronal loops

The heating of solar coronal loops by the resonant absorption or phase-mixing of incident wave energy is investigated in the framework of 3D nonlinear magnetohydrodynamics (MHD) by means of numerical simulations.     

Induction of high grade astrocytoma (HGA) by protons: molecular mechanisms and RBE considerations.

Protons of a specific energy, 55 MeV, have been found to induce primary high grade astrocytomas (HGA) in the Rhesus monkey (Macaca mulatta). Brain tumors of this type were not induced by protons of other energies (32-2,300 MeV). Induction of HGA has been identified in human patients who have had radiation therapy to the head. We believe that the induction of HGA in the monkey is a consequence of dose distribution, not some unique "toxic" property of protons. Comparison of the human experience with the monkey data indicates the RBE for induction of brain tumors to be about one. It is unlikely that protons cause an unusual change in oncogenic expression, as compared to conventional electromagnetic radiation.     

Ulysses observations of latitude gradients in the heliospheric magnetic field: Radial component and variances

The radial component of the magnetic field at Ulysses, over latitudes from –10° to –45° and distances from 5.3 to 3.8 AU, compares very well with corresponding measurements being made by IMP-8 in the ecliptic at 1AU. There is little, if any, evidence of a latitude gradient. Variances in the field, normalized to the square of the field magnitude, show little change with latitude in variations in the magnitude but a large increase in the transverse field variations. The latter are shown to be caused by the presence of large amplitude, long period Alfvénic fluctuations. This identification is based on the close relation between the magnetic field and velocity perturbations including the effect of anisotropy in the solar wind pressure. The waves are propagating outward from the Sun, as in the ecliptic, but variance analysis indicates that the direction of propagation is radial rather than field-aligned. A significant long-period component of 10 hours is present.     

IMF connection for energetic protons observed at Ulysses via mid-latitude solar wind rarefaction regions

As Ulysses moved inward and southward from mid-1992 to early 1994 we noticed the occasional occurrence of inter-events, lasting about 10 days and falling between the recurrent events, observed at proton energies of 0.48–97 MeV, associated with Corotating Interaction Regions (CIR). These inter-events were present for several sequences of two or more solar rotations at intensity levels around 1% of those of the neighbouring main events. When we compared the Ulysses events with those measured on IMP-8 at 1 AU we saw that the inter-events appeared at Ulysses after the extended emission (>10 days) of large fluxes of solar protons of the same energy that lasted at least one solar rotation at 1 AU. The inter-events fell completely within the rarefaction regions (dv/dt<0) of the recurrent solar wind streams. The interplanetary magnetic field (IMF) lines in the rarefactions map back to the narrow range of longitudes at the Sun which mark the eastern edge of the source region of the high speed stream. Thus the inter-events are propagating at mid-latitudes to Ulysses along field lines free from stream-stream interactions. They are seen in the 0.39–1.28 MeV/nucleon He, which exhibit a faster decay, but almost never in the 38–53 keV electrons. We show that the inter-events are unlikely to be accelerated by reverse shocks associated with the CIRs and that they are more likely to be accelerated by sequences of solar events and transported along the IMF in the rarefactions of the solar wind streams.     

Leg venous hemodynamics and leg volumes during a 42 day -6 degrees head-down bedrest

Seven healthy subjects were submitted to a 42-day head down bedrest, where leg venous compliance (venous distensibity index VDI) and leg volumes were assessed by mercury strain gauge plethysmography with venous occlusion and optoelectronic plethysmography, respectively. Plethysmographic and volometric measurements were made, before, during (at days 1, 4, 7, 14, 21, 26, 34 and 41), and after bedrest (days 1, 4, 7, 11 and 30 of the recovery period). Results showed a continuous decrease in leg volumes throughout bedrest, when VDI increased until day 26 of bedrest, and then decreased afterwards. The recovery period was characterized by a rapid return of VDI to prebedrest levels while leg volumes progressively normalised. These results showed that leg venous compliance changes are not always dependant upon skeletal muscle changes, and that factors other than size of muscle compartment are able to determine increases in leg venous compliance during long-term bedrest.     

Tracking multiple objects with particle filtering

We address the problem of multitarget tracking (MTT) encountered in many situations in signal or image processing. We consider stochastic dynamic systems detected by observation processes. The difficulty lies in the fact that the estimation of the states requires the assignment of the observations to the multiple targets. We propose an extension of the classical particle filter where the stochastic vector of assignment is estimated by a Gibbs sampler. This algorithm is used to estimate the trajectories of multiple targets from their noisy bearings, thus showing its ability to solve the data association problem. Moreover this algorithm is easily extended to multireceiver observations where the receivers can produce measurements of various nature with different frequencies.     

Experimental Aspects of Mid-Frequency Pulsations (f≈10–100 mHz) in the Southern Polar Cap

We review the results obtained in the frequency range of Pc3 (22-100 mHz) and Pc4 (7-22 mHz) pulsations at Italian Antarctic stations in the southern polar cap (“Mario Zucchelli”, at Terra Nova Bay, TNB, 80^˚.S; “Concordia”, the Italian/French base at Dome C, DMC, 89^˚.S). The absence of a midnight enhancement in the pulsation power suggests a negligible substorm influence at extreme latitudes, while the sharp noon enhancement, which appears only at TNB, is determined by the closer proximity of the station to cusp related phenomena. The relationship between the frequency of the band-limited signals and the interplanetary magnetic field strength, the cone angle influence, and the higher correlation of the Pc3 power with the solar wind speed in the morning hours suggest a global scenario in which upstream waves would be mainly responsible for the mid-frequency activity in the polar cap. However, the polarization pattern is odd with respect to the predictions for tailward propagating modes.