Thyrotropin receptor and membrane interactions in FRTL-5 thyroid cell strain in microgravity

The aim of this work was to analyze the possible alteration of thyrotropin (TSH) receptors in microgravity, which could explain the absence of thyroid cell proliferation in the space environment. Several forms of the TSH receptor are localized on the plasma membrane associated with caveolae and lipid rafts. The TSH regulates the fluidity of the cell membrane and the presence of its receptors in microdomains that are rich in sphingomyelin and cholesterol. TSH also stimulates cyclic adenosine monophosphate (cAMP) accumulation and cell proliferation. Reported here are the results of an experiment in which the FRTL-5 thyroid cell line was exposed to microgravity during the Texus-44 mission (launched February 7, 2008, from Kiruna, Sweden). When the parabolic flight brought the sounding rocket to an altitude of 264?km, the culture media were injected with or without TSH in the different samples, and weightlessness prevailed on board for 6 minutes and 19 seconds. Control experiments were performed, in parallel, in an onboard 1g centrifuge and on the ground in Kiruna laboratory. Cell morphology and function were analyzed. Results show that in microgravity conditions the cells do not respond to TSH treatment and present an irregular shape with condensed chromatin, a modification of the cell membrane with shedding of the TSH receptor in the culture medium, and an increase of sphingomyelin-synthase and Bax proteins. It is possible that real microgravity induces a rearrangement of specific sections of the cell membrane, which act as platforms for molecular receptors, thus influencing thyroid cell function in astronauts during space missions.     

On the stabilization of ribose by silicate minerals

The RNA-world theory hypothesizes that early Earth life was based on the RNA molecule. However, the notion that ribose, the sugar in RNA, is unstable still casts a serious doubt over this theory. Recently, it has been found that the silicate-mediated formose reaction facilitates the stabilization of ribose. Using accurate quantum chemical calculations, we determined the relative stability of the silicate complexes of arabinose, lyxose, ribose, and xylose with the intent to determine which would form predominantly from a formose-like reaction. Five stereoisomers were investigated for each complex. The stereoisomers of 2:1 ribose-silicate are the more stable ones, to the extent that the least stable of these is even more stable than the most stable stereoisomer of the other 2:1 sugar-silicate complexes. Thus, thermodynamically, a formose-like reaction in the presence of silicate minerals should preferentially form the silicate complex of ribose over the silicate complex of arabinose, lyxose, and xylose.     

Is the presence of oxygen on an exoplanet a reliable biosignature?

We revisit the validity of the presence of O(2) or O(3) in the atmosphere of a rocky planet as being a biosignature. Up to now, the false positive that has been identified applies to a planet during a hot greenhouse runaway, which is restricted to planets outside the habitable zone (HZ) of the star that are closer to the star. In this paper, we explore a new possibility based on abiotic photogeneration of O(2) at the surface of a planet that could occur inside the HZ. The search for such a process is an active field of laboratory investigation that has resulted from an ongoing interest in finding efficient systems with the capacity to harvest solar energy on Earth. Although such a process is energetically viable, we find it to be a very unlikely explanation for the observation of O(2) or O(3) in the atmosphere of a telluric exoplanet in the HZ. It requires an efficient photocatalyst to be present and abundant under natural planetary conditions, which appears unlikely according to our discussion of known mineral photochemical processes. In contrast, a biological system that synthesizes its constituents from abundant raw materials and energy has the inherent adaptation advantage to become widespread and dominant (Darwinist argument). Thus, O(2) appears to continue to be a good biosignature.     

Prebiotic significance of extraterrestrial ice photochemistry: detection of hydantoin in organic residues

The delivery of extraterrestrial organic materials to primitive Earth from meteorites or micrometeorites has long been postulated to be one of the origins of the prebiotic molecules involved in the subsequent apparition of life. Here, we report on experiments in which vacuum UV photo-irradiation of interstellar/circumstellar ice analogues containing H(2)O, CH(3)OH, and NH(3) led to the production of several molecules of prebiotic interest. These were recovered at room temperature in the semi-refractory, water-soluble residues after evaporation of the ice. In particular, we detected small quantities of hydantoin (2,4-imidazolidinedione), a species suspected to play an important role in the formation of poly- and oligopeptides. In addition, hydantoin is known to form under extraterrestrial, abiotic conditions, since it has been detected, along with various other derivatives, in the soluble part of organic matter of primitive carbonaceous meteorites. This result, together with other related experiments reported recently, points to the potential importance of the photochemistry of interstellar "dirty" ices in the formation of organics in Solar System materials. Such molecules could then have been delivered to the surface of primitive Earth, as well as other telluric (exo-) planets, to help trigger first prebiotic reactions with the capacity to lead to some form of primitive biomolecular activity.     

装有自由旋转尾翼的鸭式导弹的滚动发散

用解析的方法研究有自由旋转尾翼和鸭式控制面的导弹的滚动运动,确定了运动的平衡状态;探讨在所施加的铰链力矩不变时小扰动的情况;利用对平衡状态小偏差的线性运动方程,推导出稳定的显式条件,并用全运动方程数值解考察了大扰动情况和在俯仰、偏航上导弹自由度的影响,证明了大偏差的发散特性.研究结果表明,滚动运动在很大的参数范围内是发散的,产生发散的主要因素是气动力滚动阻尼的减少和离心力对控制面的作用.     

多频段波纹圆锥喇叭天线

1.引言经过多年的研究,波纹圆锥喇叭天线(图1)已用于不同的系统中。波纹壁特性的边界条件:E_φ=Z_φH_r,E_r=-Z_rH_φ(1)且Z_φ=0,Z_v=jZ_o tan kd文献都证明了这种喇叭产生极好的圆极化波,当Z_r=∞时,意味着H_φ=0。实验中发现,在大约1:1.5的频宽内,波纹圆锥喇叭天线具有上述特性。该频宽对应于0.5π相似文献   

SABRE雷达及其观测的Pc5地磁脉动Ⅰ.统计分析结果

本文简要介绍了相干散射雷达SABRE及其观测Pc5地磁脉动的工作原理。1985—1989年观测数据的统计分析结果表明,相位向极传播脉动事件的出现率峰值在当地时间午夜附近,而向赤道传播事件的出现率峰值则在18:00LT左右。文中给出了上述两类脉动事件出现率的日变化,与地磁活动的相关,与背景电离层等离子体对流特性的关系等统计分析结果。     

对NASA指控中心软件测试度量的评定

软件度量用于软件开发过程和软件产品质量的评定。在NASA航天飞机指挥控制中心(MCC)改造(MCCU)工程的测试阶段,采用了五种度量,除一种度量之外,其它度量均提供了很有用的信息。根据我们的经验,我们建议在软件开发的测试阶段使用这些度量,同时提出另外的侯选度量供进一步研究。