载人深空探测任务的空间环境工程关键问题

对载人深空探测过程中将遭受的太阳宇宙射线、银河宇宙射线、微重力、尘与尘暴、深空微生物等环境进行分析。对不同深空环境给航天员带来的威胁进行了探讨。从物理屏蔽防护、辐射风险的监测和预警、辐射防护药物、航天员选拨等角度对采取的措施进行了阐述。从空间辐射对航天员的损伤机理、抗辐射和微重力药物开发、空间辐射屏蔽防护结构与材料、航天服自清洁、抗微生物侵蚀材料的研发等多个角度对需要进一步开展的工作进行了讨论。     

Radiation measured during ISS-Expedition 13 with different dosimeters

Radiation in low Earth orbit (LEO) is mainly composed of galactic cosmic rays (GCR), solar energetic particles and particles in SAA (South Atlantic Anomaly). The biological impact of space radiation to astronauts depends strongly on the particles’ linear energy transfer (LET) and is dominated by high LET radiation. It is important to measure the LET spectrum for the space radiation field and to investigate the influence of radiation on astronauts. At present, the preferred active dosimeters sensitive to all LET are the tissue equivalent proportional counter (TEPC) and the silicon detectors in various configurations; the preferred passive dosimeters are CR-39 plastic nuclear track detectors (PNTDs) sensitive to high LET and thermoluminescence dosimeters (TLDs) as well as optically stimulated luminescence dosimeters (OSLDs) sensitive to low LET. The TEPC, CR-39 PNTDs, TLDs and OSLDs were used to investigate the radiation field for the ISS mission Expedition 13 (ISS-12S) in LEO. LET spectra and radiation quantities (fluence, absorbed dose, dose equivalent and quality factor) were measured for the space mission with different dosimeters. This paper introduces the role of high LET radiation in radiobiology, the operational principles for the different dosimeters, the LET spectrum method using CR-39 detectors, the method to combine the results measured with TLDs/OSLDs and CR-39 PNTDs, and presents the LET spectra and the radiation quantities measured and combined.     

Neurobiological problems in long-term deep space flights.

Future missions in space may involve long-term travel beyond the magnetic field of the Earth, subjecting astronauts to radiation hazards posed by solar flares and galactic cosmic rays, altered gravitation fields and physiological stress. Thus, it is critical to determine if there will be any reversible or irreversible, detrimental neurological effects from this prolonged exposure to space. A question of particular importance focuses on the long-term effects of the space environment on the central nervous system (CNS) neuroplasticity, with the potential acute and/or delayed effects that such perturbations might entail. Although the short-term effects of microgravity on neural control were studied on previous low earth orbit missions, the late consequences of stress in space, microgravity and space radiation have not been addressed sufficiently at the molecular, cellular and tissue levels. The possibility that space flight factors can interact influencing the neuroplastic response in the CNS looms critical issue not only to understand the ontogeny of the CNS and its functional integrity, but also, ultimately the performance of astronauts in extended space forays. The purpose of this paper is to review the neurobiological modifications that occur in the CNS exposed to the space environment, and its potential consequences for extended deep space flight.     

Long-term effects of microgravity and possible countermeasures.

It is well known that long-term exposure to microgravity causes a number of physiological and biochemical changes in humans; among the most significant are: 1) negative calcium balance resulting in the loss of bone; 2) atrophy of antigravity muscles; 3) fluid shifts and decreased plasma volume; and 4) cardiovascular deconditioning that leads to orthostatic intolerance. It is estimated that a mission to Mars may require up to 300 days in a microgravity environment; in the case of an aborted mission, the astronauts may have to remain in reduced gravity for up to three years. Although the Soviet Union has shown that exercise countermeasures appear to be adequate for exposures of up to one year in space, it is questionable whether astronauts could or should have to maintain such regimes for extremely prolonged missions. Therefore, the NASA Life Sciences Division has initiated a program designed to evaluate a number of methods for providing an artificial gravity environment.     

Adaptive response studies may help choose astronauts for long-term space travel.

Long-term manned exploratory missions are planned for the future. Exposure to high-energy neutrons, protons and high charge and energy particles during a deep space mission, needs protection against the detrimental effects of space radiation. It has been suggested that exposure to unpredictable extremely large solar particle events would kill the astronauts without massive shielding. To reduce this risk to astronauts and to minimize the need for shielding, astronauts with highest significant adaptive responses should be chosen. It has been demonstrated that some humans living in very high natural radiation areas have acquired high adaptive responses to external radiation. Therefore, we suggest that for a deep space mission the adaptive response of all potential crew members be measured and only those with high adaptive response be chosen. We also proclaim that chronic exposure to elevated levels of radiation can considerably decrease radiation susceptibility and better protect astronauts against the unpredictable exposure to sudden and dramatic increase in flux due to solar flares and coronal mass ejections.     

Radiation hazards on space missions outside the magnetosphere.

Future space missions outside the magnetosphere will subject astronauts to a hostile and unfamiliar radiation environment. An annual dose equivalent to the blood-forming organs (BFOs) of approximately 0.5 Sv is expected, mostly from heavy ions in the galactic cosmic radiation. On long-duration missions, an anomalously-large solar energetic particle event may occur. Such an event can expose astronauts to up to approximately 25 Gy (skin dose) and up to approximately 2 Sv (BFO dose) with no shielding. The anticipated radiation exposure may necessitate spacecraft design concessions and some restriction of mission activities. In this paper we discuss our model calculations of radiation doses in several exo-magnetospheric environments. Specific radiation shielding strategies are discussed. A new calculation of aluminum equivalents of potential spacecraft shielding materials demonstrates the importance of low-atomic-mass species for protection from galactic cosmic radiation.     

Heavy ion contributions to organ dose equivalent for the 1977 galactic cosmic ray spectrum

Estimates of organ dose equivalents for the skin, eye lens, blood forming organs, central nervous system, and heart of female astronauts from exposures to the 1977 solar minimum galactic cosmic radiation spectrum for various shielding geometries involving simple spheres and locations within the Space Transportation System (space shuttle) and the International Space Station (ISS) are made using the HZETRN 2010 space radiation transport code. The dose equivalent contributions are broken down by charge groups in order to better understand the sources of the exposures to these organs. For thin shields, contributions from ions heavier than alpha particles comprise at least half of the organ dose equivalent. For thick shields, such as the ISS locations, heavy ions contribute less than 30% and in some cases less than 10% of the organ dose equivalent. Secondary neutron production contributions in thick shields also tend to be as large, or larger, than the heavy ion contributions to the organ dose equivalents.     

Simulations of MATROSHKA experiment outside the ISS using PHITS

The radiation environment at the altitude of the International Space Station (ISS) is substantially different than anything typically encountered on Earth in both the character of the radiation field and the significantly higher dose rates. Concerns about the biological effects on humans of this highly complex natural radiation field are increasing due to higher amount of astronauts performing long-duration missions onboard the ISS and especially if looking into planned future manned missions to Mars. In order to begin the process of predicting the dose levels seen by the organs of an astronaut, being the prerequisite for radiation risk calculations, it is necessary to understand the character of the radiation environment both in- and outside of the ISS as well as the relevant contributions from the radiation field to the organ doses.     

Radiation environments and absorbed dose estimations on manned space missions.

In order to make an assessment of radiation risk during manned missions in space, it is necessary first to have as accurate an estimation as possible of the radiation environment within the spacecraft to which the astronauts will be exposed. Then, with this knowledge and the inclusion of body self-shielding, estimations can be made of absorbed doses for various body organs (skin, eye, blood-forming organs, etc.). A review is presented of our present knowledge of the radiation environments and absorbed doses expected for several space mission scenarios selected for our development of the new radiation protection guidelines. The scenarios selected are a 90-day mission at an altitude (450 km) and orbital inclinations (28.5 degrees, 57 degrees and 90 degrees) appropriate for NASA's Space Station, a 15-day sortie to geosynchronous orbit and a 90-day lunar mission. All scenarios chosen yielded dose equivalents between five and ten rem to the blood forming organs if no large solar particle event were encountered. Such particle events could add considerable exposure particularly to the skin and eye for all scenarios except the one at 28.5 degrees orbital inclination.     

Preparation of the Biochip experiment on the EXPOSE-R2 mission outside the International Space Station

Biochips might be suited for planetary exploration. Indeed, they present great potential for the search for biomarkers – molecules that are the sign of past or present life in space – thanks to their size (miniaturized devices) and sensitivity. Their detection principle is based on the recognition of a target molecule by affinity receptors fixed on a solid surface. Consequently, one of the main concerns when developing such a system is the behavior of the biological receptors in a space environment. In this paper, we describe the preparation of an experiment planned to be part of the EXPOSE-R2 mission, which will be conducted on the EXPOSE-R facility, outside the International Space Station (ISS), in order to study the resistance of biochip models to space constraints (especially cosmic radiation and thermal cycling). This experiment overcomes the limits of ground tests which do not reproduce exactly the space parameters. Indeed, contrary to ground experiments where constraints are applied individually and in a limited time, the biochip models on the ISS will be exposed to cumulated constraints during several months. Finally, this ISS experiment is a necessary step towards planetary exploration as it will help assessing whether a biochip can be used for future exploration missions.     

舱外活动中航天员利用扶手移动的路径规划

航天员在舱外活动中,常常需要从一个工作点向另一个工作点移动.提出了一种用于搜寻两个工作点间最短通路的路径规划的方法.该方法利用人工智能中的启发式搜索A^*算法,在用栅格法对三维工作环境进行离散化的基础上,采用路径最短原则,完成了航天员在舱外活动中依靠扶手移动的路径规划.对一个例子进行了研究,并对结果进行了分析.规划的路径可为航天员舱外活动扶手的安装位置提供参考依据,以减少航天员舱外作业的工作时间、降低能量消耗以及提高航天员舱外作业的工作效率.     

Analysis of the space radiation doses obtained simultaneously at two different locations outside the ISS

Space weather and related ionizing radiation has been recognized as one of the main health concerns for the International Space Station (ISS) crew. The estimation of the radiation effect on humans outside the ISS requires at first order accurate knowledge of their accumulated absorbed dose rates, which depend on the global space radiation distribution, solar cycle and local variations generated by the 3D mass distribution surrounding the ISS. The R3DE (Radiation Risks Radiometer-Dosimeter for the EXPOSE-E platform) on the European Technological Exposure Facility (EuTEF) worked successfully outside of the European Columbus module between February 2008 and September 2009. A very similar instrument named R3DR for the EXPOSE-R platform worked outside the Russian Zvezda module of the ISS between March 2009 and August 2010. Both are Liulin-type detectors, Bulgarian-built miniature spectrometer-dosimeters. The acquired approximately 5 million deposited energy spectra from which the flux and absorbed dose rate were calculated with 10 s resolution behind less than 0.41 g cm⁻² shielding. This paper analyses the spectra collected in 2009 by the R3DE/R instruments and the long-term variations in the different radiation environments of Galactic Cosmic Rays (GCR), inner radiation belt trapped protons in the region of the South Atlantic Anomaly (SAA) and relativistic electrons from the Outer Radiation Belt (ORB). The R3DE instrument, heavily shielded by the surrounding structures, measured smaller primary fluxes and dose rates from energetic protons from the SAA and relativistic electrons from the ORB but higher values from GCRs because of the contribution from secondary particles. The main conclusion from this investigation is that the dose rates from different radiation sources around the International Space Station (ISS) have a large special and temporal dynamic range. The collected data can be interpreted as possible doses obtained by the cosmonauts and astronauts during Extra Vehicular Activities (EVA) because the R3DE/R instruments shielding is very similar to the Russian and American space suits average shielding (,  and ). Fast, active measurements are required to assess accurately the dose accumulated by astronauts during EVA.     

空间站微重力流体实验设备需求分析

对国际空间站和中国科学实验卫星及载人飞行器上开展的微重力流体实验情况进行论述和分析,重点分析了国际空间站（ISS）微重力流体科学实验设备情况.根据中国空间微重力流体物理科学发展需求,结合国际空间站微重力流体科学实验对设备的需求,提出了未来在中国空间站开展微重力流体实验时空间实验设备需要重点考虑和解决的问题,同时提出相关设计建议.      

On the radiosensitivity of man in space.

Astronauts' radiation exposure limits are based on experimental and epidemiological data obtained on Earth. It is assumed that radiation sensitivity remains the same in the extraterrestrial space. However, human radiosensitivity is dependent upon the response of the hematopoietic tissue to the radiation insult. It is well known that the immune system is affected by microgravity. We have developed a mathematical model of radiation-induced myelopoiesis which includes the effect of microgravity on bone marrow kinetics. It is assumed that cellular radiosensitivity is not modified by the space environment, but repopulation rates of stem and stromal cells are reduced as a function of time in weightlessness. A realistic model of the space radiation environment, including the HZE component, is used to simulate the radiation damage. A dedicated computer code was written and applied to solar particle events and to the mission to Mars. The results suggest that altered myelopoiesis and lymphopoiesis in microgravity might increase human radiosensitivity in space.     

Preliminary results of space experiment: Implications for the effects of space radiation and microgravity on survival and mutation induction in human cells

In view of the concern for the health of astronauts that may one day journey to Mars or the Moon, we investigated the effect that space radiation and microgravity might have on DNA damage and repair. We sent frozen human lymphoblastoid TK6 cells to the International Space Station where they were maintained under frozen conditions during a 134-day mission (14 November 2008 to 28 March 2009) except for an incubation period of 8 days under 1G or μG conditions in a CO₂ incubator. The incubation period started after 100 days during which the cells had been exposed to 54 mSv of space radiation. The incubated cells were then refrozen, returned to Earth, and compared to ground control samples for the determination of the influence of microgravity on cell survival and mutation induction. The results for both varied from experiment to experiment, yielding a large SD, but the μG sample results differed significantly from the 1G sample results for each of 2 experiments, with the mean ratio of μG to 1G being 0.55 for the concentration of viable cells and 0.59 for the fraction of thymidine kinase deficient (TK⁻) mutants. Among the mutants, non-loss of zygosity events (point mutations) were less frequent (31%) after μG incubation than after 1G incubation, which might be explained by the influence of μG on cellular metabolic or physiological function. Additional experiments are needed to clarify the effect of μG interferes on DNA repair.     

航天员出舱可伸缩安全系绳设计与验证

随着中国神舟飞船系列任务和空间站建设任务的稳步进行，中国航天员将面临频繁的在轨出舱作业任务，航天员出舱活动范围将逐渐增大，作业位置也将频繁变换，传统安全绳已无法满足使用要求。提出了一种基于恒力矩弹簧驱动的航天员出舱可伸缩安全系绳设计方案，并优化设计方法。对可伸缩安全系绳的核心部分——驱动单元进行设计，研制航天员出舱可伸缩安全系绳样机，并完成功能性能、环境适应性和驱动单元寿命试验验证。结果表明:所提方案可顺利完成钢丝绳收放，且实测收绳力、放绳力与理论值基本吻合。方案具有体积小、质量轻、可耐大量级振动和高低温环境等优点，其驱动单元满足10 000次的长寿命使用要求，可用于后续工程产品中。      

空间站机械臂研究

空间极端环境下, 大多数舱外活动必须借助于机械臂. 机械臂是国际空间站的主要组成部分, 其对空间站的在轨组装、外部维修以及运行起着至关重要的作用, 同时机械臂可以减少航天员在舱外的工作时间和频率. 通过对国际空间站成员国关于机械臂研究概况的介绍, 包括航天飞机机械臂、空间站机械臂、欧洲机械臂、日本实验舱机械臂以及德国机械臂, 为中国空间机械臂的设计提供参考.      

Materials trade study for lunar/gateway missions.

The National Aeronautics and Space Administration (NASA) administrator has identified protection from radiation hazards as one of the two biggest problems of the agency with respect to human deep space missions. The intensity and strength of cosmic radiation in deep space makes this a 'must solve' problem for space missions. The Moon and two Earth-Moon Lagrange points near Moon are being proposed as hubs for deep space missions. The focus of this study is to identify approaches to protecting astronauts and habitats from adverse effects from space radiation both for single missions and multiple missions for career astronauts to these destinations. As the great cost of added radiation shielding is a potential limiting factor in deep space missions, reduction of mass, without compromising safety, is of paramount importance. The choice of material and selection of the crew profile play major roles in design and mission operations. Material trade studies in shield design over multi-segmented missions involving multiple work and living areas in the transport and duty phase of space mission's to two Earth-Moon co-linear Lagrange points (L1) between Earth and the Moon and (L2) on back side of the moon as seen from Earth, and to the Moon have been studied. It is found that, for single missions, current state-of-the-art knowledge of material provides adequate shielding. On the other hand, the choice of shield material is absolutely critical for career astronauts and revolutionary materials need to be developed for these missions. This study also provides a guide to the effectiveness of multifunctional materials in preparation for more detailed geometry studies in progress.     

航天员失重环境下运动策略与效能分析

航天员在空间执行任务过程中由于受到空间微重力环境的影响,其运动的协调性以及平衡性均会与地面环境下的表现有所差异.以研究失重环境下航天员运动特点为目标,对航天员姿态调整策略进行动力学分析,并对运动过程人体效能进行评价.具体而言,在无外力/力矩驱动下,人体必须依靠四肢按一定的协调运动策略才能实现对躯干姿态的主动控制.而运动...