Summary of medical investigations in the U.S.S.R. manned space missions.

The results of biomedical investigations carried out in the U.S.S.R. manned space missions are discussed. Their basic result is well-documented evidence that man can perform space flights of long duration. The investigations have demonstrated no direct correlation between inflight or postflight physiological reactions of crewmembers and flight duration. In all likelihood, this can be attributed to the fact that special exercises done inflight efficiently prevented adverse effects of weightlessness. However, human reactions to weightlessness need further study. They include negative calcium balance and anemia as well as vestibulo-autonomic disorders shown by crewmembers at early stages of weightlessness. Attention should be given to psychological, social-psychological and ethical problems that may also limit further increase in flight duration.     

Otorhinolaryngological problems in medical support of space flights

At present the main trends among the most important problems of otorhinolaryngology in space medicine have become defined as vestibulology, audiology and clinical aspects (prophylaxis, diagnosis and treatment of ENT diseases in flight). The principal result of recent vestibular studies has probably been the establishment of an apparent relationship between the resistance of the vestibular system to adequate ground-based stimulation and tolerance to space flight. The findings of the studies formed the basis for the development of a new system of vestibular selection, as well as demonstrated the usefulness of special vestibular training of astronauts by active and passive methods. In audiology certain urgency is acquired by the problem of noise limitation in space cabins and auditory system reliability prediction for preserving a high work capability in crew members. The hemodynamic changes in weightlessness, as well as the possibility for allergic lesions, create conditions for distorted course of the ENT diseases and vaso-motor disorders. The prophylaxis of aspirations also deserves close attention since the possibilities of their onset increase in weightlessness. The rendering of immediate, timely aid will depend not only on the presence of the necessary medical equipment but also on the ability of the crew members to render the appropriate otorhinolaryngological aid.     

Male and female characteristics in vestibular testing: a step toward the selection of the best participants for space flight

Vestibular disturbances in connection with space flight were reported by a majority of participating astronauts and cosmonauts. These include motion sickness symptoms in the first few days of the space flight, as well as standing, gait and orientation disturbances after the return to Earth. The Aerospace Medical Community has been trying to select those people that are particularly adapted to the above stresses or that can be further adapted through training programs. As the circle of selectees extends to women, the problem arises as to whether differences between men and women exist under the conditions of space flight. In seeking answers to this question we studied a group of 42 women and 44 men, who were further subdivided according to their subjective motion sickness sensitivity, as determined by a questionnaire. Using this material, 26 men and 22 women were designated as motion sickness resistant, and 18 men and 20 women were designated as nonresistant. The vestibular test battery given these test subjects consisted of caloric, rotatory, optokinetic, vestibulo-spinal and vestibulo-vegetative testing. Because of the mixed orthostatic and vestibular problems seen after space flights, we also studied the response of the vestibular apparatus during peripheral blood pooling as induced by lower body negative pressure. The collected historical and test data are analyzed in this paper with emphasis on the relationship to motion sickness tendency.     

Will China become a military space superpower?

China's ambitious space program was born in extremely poor national conditions in 1956. By 15 October 2003, with the successful return of the Shenzhou-4 manned space flight, it had developed dramatically. While this flight is a milestone in China's space capabilities, the Shenzhou-4 mission should be considered not as an end, but as the entry ticket to the space power club of the USA and Russia. China may now be a space power, but it is not yet a military space superpower in the way of the latter two countries. This paper investigates whether China will become a military space superpower by reviewing the development of its space program. It examines Chinese military space capabilities in terms of their military space potential, and discusses the political, military and economic implications of this issue. Finally, the paper suggests that China should continue to take the road to openness, focusing on commercial and economic efforts. This will be an alternative direction in which the country can consider exactly what space capabilities it needs in order to continue its economic development.     

The future of space medicine.

In November 2000, the National Aeronautics and Space Administration (NASA) and its partners in the International Space Station (ISS) ushered in a new era of space flight: permanent human presence in low-Earth orbit. As the culmination of the last four decades of human space flight activities. the ISS focuses our attention on what we have learned to date. and what still must be learned before we can embark on future exploration endeavors. Space medicine has been a primary part of our past success in human space flight, and will continue to play a critical role in future ventures. To prepare for the day when crews may leave low-Earth orbit for long-duration exploratory missions, space medicine practitioners must develop a thorough understanding of the effects of microgravity on the human body, as well as ways to limit or prevent them. In order to gain a complete understanding and create the tools and technologies needed to enable successful exploration. space medicine will become even more of a highly collaborative discipline. Future missions will require the partnership of physicians, biomedical scientists, engineers, and mission planners. This paper will examine the future of space medicine as it relates to human space exploration: what is necessary to keep a crew alive in space, how we do it today, how we will accomplish this in the future, and how the National Aeronautics and Space Administration (NASA) plans to achieve future goals.     

Isolation,confinement, and sensory deprivation

Long-duration space flight involves sensory monotony, isolation, and confinement. Obviously, data from other such environments are relevant to our concerns; and the application of the concept of arousal both to interpersonal relations and to task performance in space can point to appropriate selection, training, and spacecraft design features. In the context of space flight, all of these leads remain conjectural--simulation as well as laboratory research and initiation of long-duration flights will be the crucial test of the hypotheses.     

On the contribution of space medicine in the public health care

With the beginning of space era, a new branch of medicine has arisen and has been developing along with human exploration of outer space. And even though space medicine mainly faces the same problems as traditional medicine--cosmonauts health care and their high efficiency--this branch, has its own features, associated with the unusual factors of space flight, of which weightlessness is the major one. During the development of manned cosmonautics (duration of a human stay in space has reached already 438 days), methods of cosmonauts medical support and monitoring of their condition have been developed, knowledge of human possibilities and methods of process of organism adaptation to various and frequently severe conditions of external environment have increased. All this led to the fact that nowadays space medicine can become useful for improvement of human health care not only in space but also on the Earth. Moreover, the problem of implementation of cosmonautics achievements, and in particular of space medicine, in practice of public health care presents one of the most important issues concerning human health care. It is also connected with public opinion which is more and more concerned about the efficiency of significant expenses on space activities, especially lately. People often are set by the questions: what has space given, what fruits has space research provided to mankind, which results of this research can be used on the Earth already today for improvement of their life, for discussion of many difficult earthly problems? In terms of using cosmonautics possibilities, its achievements for health care and treatment, it is possible to define a few branches, in which purposeful studies are carried out.     

发展X-37B空间飞机的背后动因分析

文章通过对X-37B飞行器的飞行试验任务分析,指出了X-37B飞行器不是空天飞机,也不是全球快速打击平台,而是一种低成本太空进入能力的飞行验证器,它的作用定位在空间而不是在空中。通过飞行试验和验证试验,旨在打造一个可重复使用的轨道转移运载器。将美国2010年航天战略的重大调整、国际空间站的运行延期和航天飞机退役等事件结合起来,对X-37B发展的背后动因进行分析,有助于了解美国航天发展的未来趋势。经过动因的详尽分析,指出要特别关注美国航天战略调整的两个重心转向,尤其是两个转向背后的动机。如何正确地认识国际空间站的作用定位,对于审视载人航天的未来发展有重要意义。美国航天战略的调整使载人航天的重心回到近地轨道上。基于中国目前的能力现实,建议中国的载人航天重心放在地球轨道上,做好各种能力的建设,并利用这些能力把地球轨道上的事做得更好。     

The Russian experience in medical care and health maintenance of the International Space Station crews

The main purpose of the medical support system aboard International Space Station (ISS) is crew health maintenance and high level of work capability assurance prior to during and after in space flights. In the present communication the Russian point of view dealing with the problems and achievements in this branch is presented. An overview on medical operations during flight and after finalization of the space missions based on Russian data of crew health and environment state monitoring, as well as data on the inflight countermeasures (prophylaxis) jointly with data on operational problems that are specific to ISS is presented. The report summarizes results of the medical examination of Russian members of the ISS and taxi crews during and after visits to the ISS.     

Informed consent v. ITAR: Regulatory conflicts that could constrain commercial human space flight

The Human Space Flight Requirements (promulgated by the U.S. Federal Aviation Administration) seek to protect the fledgling commercial space flight industry by shifting risk from the operator to the space flight participants. However, in order to do this effectively the regulations require a great deal of information to be given to the participants. The information required might be extensive enough that it could be considered “technical data” under the International Traffic in Arms Regulations. If this is the case then commercial spaceflight companies will have to get export licenses for non-U.S. participants on their flights which could cause additional costs as well as other problems.     

Medical considerations for extending human presence in space

The prospects for extending the length of time that humans can safely remain in space depend partly on resolution of a number of medical issues. Physiologic effects of weightlessness that may affect health during flight include loss of body fluid, functional alterations in the cardiovascular system, loss of red blood cells and bone mineral, compromised immune system function, and neurosensory disturbances. Some of the physiologic adaptations to weightlessness contribute to difficulties with readaptation to Earth's gravity. These include cardiovascular deconditioning and loss of body fluids and electrolytes; red blood cell mass; muscle mass, strength, and endurance; and bone mineral. Potentially harmful factors in space flight that are not related to weightlessness include radiation, altered circadian rhythms and rest/work cycles, and the closed, isolated environment of the spacecraft. There is no evidence that space flight has long-term effects on humans, except that bone mass lost during flight may not be replaced, and radiation damage is cumulative. However, the number of people who have spent several months or longer in space is still small. Only carefully-planned experiments in space preceded by thorough ground-based studies can provide the information needed to increase the amount of time humans can safely spend in space.     

Predictors of immune function in space flight

Of all of the environmental conditions of space flight that might have an adverse effect upon human immunity and the incidence of infection, space radiation stands out as the single-most important threat. As important as this would be on humans engaged in long and deep space flight, it obviously is not possible to plan Earth-bound radiation and infection studies in humans. Therefore, we propose to develop a murine model that could predict the adverse effects of space flight radiation and reactivation of latent virus infection for humans. Recent observations on the effects of gamma and latent virus infection demonstrate latent virus reactivation and loss of T cell mediated immune responses in a murine model. We conclude that using this small animal method of quantitating the amounts of radiation and latent virus infection and resulting alterations in immune responses, it may be possible to predict the degree of immunosuppression in interplanetary space travel for humans. Moreover, this model could be extended to include other space flight conditions, such as microgravity, sleep deprivation, and isolation, to obtain a more complete assessment of space flight risks for humans.     

Space flight visual simulation.

In this paper, based on the scenes of stars seen by astronauts in their orbital flights, we have studied the mathematical model which must be constructed for CGI system to realize the space flight visual simulation. Considering such factors as the revolution and rotation of the Earth, exact date, time and site of orbital injection of the spacecraft, as well as its orbital flight and attitude motion, etc., we first defined all the instantaneous lines of sight and visual fields of astronauts in space. Then, through a series of coordinate transforms, the pictures of the scenes of stars changing with time-space were photographed one by one mathematically. In the procedure, we have designed a method of three-times "mathematical cutting." Finally, we obtained each instantaneous picture of the scenes of stars observed by astronauts through the window of the cockpit. Also, the dynamic conditions shaded by the Earth in the varying pictures of scenes of stars could be displayed.     

Overview of the Neurolab Spacelab mission

Neurolab is a NASA Spacelab mission with multinational cooperative participation that is dedicated to research on the nervous system. The nervous systems of all animal species have evolved in a one-g environment and are functionally influenced by the presence of gravity. The absence of gravity presents a unique opportunity to gain new insights into basic neurologic functions as well as an enhanced understanding of physiological and behavioral responses mediated by the nervous system. The primary goal of Neurolab is to expand our understanding of how the nervous system develops, functions in, and adapts to microgravity space flight. Twenty-six peer reviewed investigations using human and nonhuman test subjects were assigned to one of eight science discipline teams. Individual and integrated experiments within these teams have been designed to collect a wide range of physiological and behavior data in flight as well as pre- and postflight. Information from these investigations will be applicable to enhancing the well being and performance of future long duration space travelers, will contribute to our understanding of normal and pathological functioning of the nervous system, and may be applied by the medical community to enhance the health of humans on Earth.     

Vestibular tests in the selection of cosmonauts.

Vestibulo-vegetative disorders in cosmonauts and astronauts occurring during space flight compel otolaryngologists to search for vestibular tests enabling a precise evaluation of the activity of the vestibular apparatus and showing disposition to motion sickness. Otoneurological investigation of Polish candidates for cosmonaut status consisted of the following vestibular tests: caloric, rotatory, optokinetic, swinging torsion, statokinesimetric and vestibulo-vegetative. The value of various vestibular tests for aviation and space medicine is presented in this paper, taking into account the results of investigations of the equilibrium system with the group of pilots selected for space flight as well as extensive experience with candidates for the air service and also trained pilots and patients. The relatively frequent lack of correlation between the results of the applied tests, which renders difficult the proper evaluation of the equilibrium system, is emphasized in the paper. Finally, the results of investigations of acute habituation of the vestibular apparatus are discussed.     

RBCC发动机火箭推力增益之探讨

为提高火箭基冲压组合循环(RBCC)发动机火箭冲压模态下火箭推力增益,基于模拟飞行Ma=4来流条件的数值计算结果,分析了火箭射流与冲压主流超/超剪切流动的特性,探讨了火箭推力增益的组成,并给出了提高火箭推力增益的措施:1)冲压流道、火箭工作参数的选取必须确保两股超声速剪切流之间的流动匹配,在有限空间内快速、低损的实现高能火箭射流与低能冲压主流间的动量及质量输运,最大限度地提高发动机喷管排气速度及压力;2)采用高室压火箭,通过增加推力室室压,提高火箭燃气膨胀程度,减小火箭推力增益损失。     

Effects of space flights on human allergic status (IgE-mediated sensitivity)

Suppression of the immune system after space flights of different duration has been reported earlier by Konstantinova [Immune system in extreme conditions, Space immunology. B. 59. M. Science 1988. 289p. (in Russian) [4]; Immunoresistance of man in space flight, Acta Astronautica 23 (1991) 123–127 [5]]. Changes in T- and B-mediated activities of the immune system were demonstrated during and after space flight. However, the influence of the space flight conditions on the allergic status of cosmonauts and astronauts is still unclear. The goal of this investigation was to analyze total blood IgE levels, specific IgE-antibodies and interleukin-4 in blood of Russian crew members before and after space flights to the International Space Station (ISS) and during a long-term isolation study. For this purpose, we used the ELISA assays as well as other special kits. It was noticed that four out of nine cosmonauts had high total serum IgE (more than normal clinical values of 120 IU/ml). At the same time, there were no statistically significant changes in serum IgE levels before and after long-term space flights (128–195 days). A similar situation was observed regarding preflight IgE levels of cosmonauts who performed short-term flights (7–11 days). However, seven out of 11 cosmonauts had increased IgE level in blood post short flights as compared with pre-flight values. We also measured specific IgE-antibodies, because their high concentration may cause the increased production of total IgE indicating sensitization of cosmonauts. This becomes more important when humans spend a longer time in the closed environment of a space vehicle. Also our ground-based investigations showed that a stay in such conditions does not enhance sensitization to allergens (total number of tested allergens 27) including food, inhalants and cross-reactive proteins. Serum interleukin-4 level measured after short- and long-term space flights was identical. A linear correlation between levels of immunoglobulin E and interleukin-4 also was not significant. Despite the fact that our investigations did not establish any influence of space flight on sensitization and development of immediate-type allergic reactions, they demonstrated the necessity to control the allergic status of cosmonauts very carefully both before and after space flights. At the same time, it is necessary to pay special attention to outcomes of atopic individuals with high pre-flight level of total blood IgE.     

Oxygen regimen in the human peripheral tissue during space flights.

A survey of the results of the experiment "Oxygen," carried out within the scope of the INTER-KOSMOS program in members of the permanent crews and of international visiting expeditions to the Soviet orbital station Salyut-6, is given. During the 7-day space flights of the international visiting expeditions a significant decrease in pO2ic by 3.28 kPa was observed. Local oxygen utilization reduced significantly by 0.44 kPa. During hyperventilation testing after return to earth a statistically significant decrease in the peak value by 1.39 kPa was noted. In the long-term crews of the orbital station Salyut-6 the highest decrease in pO2ic of 3.8 kPa and the absolutely lowest value of 3.4 -/+ 0.5 kPa during space flight were observed. The decrease in local oxygen utilization during the flight of 0.8 kPa/min was greater than that of the visiting crews. The results indicate the importance of investigating the dynamics of the oxygen regimen for medical control of the crew members both during the space flight and during the readaptation phase after return to earth.     

固体动能拦截器助推段飞行方案研究

针对三维空间内的高速飞行目标,提出了一种可用于固体动能拦截器助推段的导引方法。建立了固体动能拦截器与目标的相对运动关系模型,分析确定了转移轨道的约束条件,并在此基础上推导出转移轨道的轨道根数计算方法。同时根据拦截器的待增速度给出了助推器推力矢量方向的确定方法。仿真结果表明,该方法能有效实现固体动能拦截器助推段的制导控制。