Anesthesia, surgical aid and resuscitation in manned space missions.

When discussing problems related to medical service in space flight, particular attention should be given to the specific living conditions and changes associated with space flight. In disease and injury, surgery can be provided only after conservative therapy has failed. In this context gnotobiological chambers allowing surgery in aseptic conditions seem promising. A portable set of interchangeable surgical tools should be made of light-weight alloys that can be readily sterilized. Electroanalgesia in combination with auriculoacupuncture as well as peridureal anesthesia may be used as they allow normal operations in autonomous space flight conditions. Changes in the sympatho-adrenal and kallikrein-kinin systems, as well as water-electrolyte balance, should be taken into account in developing methods and means of medical service in critical situations. Special attention should be given to the prevention and treatment of brain edema in view of weightlessness-induced cephalad fluid shifts.     

Physiology, medicine, long-duration space flight and the NSBRI

The hazards of long-duration space flight are real and unacceptable. In order for humans to participate effectively in long-duration orbital missions or continue the exploration of space, we must first secure the health of the astronaut and the success of such missions by assessing in detail the biomedical risks of space flight and developing countermeasures to these hazards. Acquiring the understanding necessary for building a sound foundation for countermeasure development requires an integrated approach to research in physiology and medicine and a level of cooperative action uncommon in the biomedical sciences. The research program of the National Space Biomedical Research Institute (NSBRI) was designed to accomplish just such an integrated research goal, ameliorating or eliminating the biomedical risks of long-duration space flight and enabling safe and productive exploration of space. The fruits of these labors are not limited to the space program. We can also use the gained understanding of the effects and mechanisms of the physiological changes engendered in space and the applied preventive and rehabilitative methods developed to combat these changes to the benefit of those on Earth who are facing similar physiological and psychological difficulties. This paper will discuss the innovative approach the NSBRI has taken to integrated research management and will present some of the successes of this approach.     

Predictors of immune function in space flight

Of all of the environmental conditions of space flight that might have an adverse effect upon human immunity and the incidence of infection, space radiation stands out as the single-most important threat. As important as this would be on humans engaged in long and deep space flight, it obviously is not possible to plan Earth-bound radiation and infection studies in humans. Therefore, we propose to develop a murine model that could predict the adverse effects of space flight radiation and reactivation of latent virus infection for humans. Recent observations on the effects of gamma and latent virus infection demonstrate latent virus reactivation and loss of T cell mediated immune responses in a murine model. We conclude that using this small animal method of quantitating the amounts of radiation and latent virus infection and resulting alterations in immune responses, it may be possible to predict the degree of immunosuppression in interplanetary space travel for humans. Moreover, this model could be extended to include other space flight conditions, such as microgravity, sleep deprivation, and isolation, to obtain a more complete assessment of space flight risks for humans.     

Plasma and urine catecholamine levels in cosmonauts during long-term stay on Space Station Salyut-7.

The activity of the sympathetic adrenal system in cosmonauts exposed to a stay in space lasting for about half a year has so far been studied only by measuring catecholamine levels in plasma and urine samples taken before space flight and after landing. The device "Plasma 01", specially designed for collecting and processing venous blood from subjects during space flight on board the station Salyut-7 rendered it possible for the first time to collect and freeze samples of blood from cosmonauts in the course of a long-term 237-day space flight. A physician-cosmonaut collected samples of blood and urine from two cosmonauts over the period of days 217-219 of their stay in space. The samples were transported to Earth frozen. As indicators of the sympathetic adrenal system activity, plasma and urine concentrations of epinephrine and norepinephrine as well as urine levels of the catecholamine metabolites metanephrine, normetanephrine, and vanillylmandelic acid were determined before, during and after space flight. On days 217-219 of space flight plasma epinephrine and norepinephrine levels were slightly increased, yet not substantially different from normal. During stress situations plasma norepinephrine and epinephrine levels usually exhibit a manifold increase. On days 217-219 of space flight norepinephrine and epinephrine levels in urine were comparable with pre-flight values and the levels of their metabolites were even significantly decreased. All the parameters studied, particularly plasma norepinephrine as well as urine norepinephrine, normetanephrine, and vanillylmandelic acid, reached the highest values 8 days after landing. The results obtained suggest that, in the period of days 217-219 of the cosmonauts stay in space in the state of weightlessness, the sympathetic adrenal system is either not activated at all or there is but a slight activation induced by specific activities of the cosmonauts, whereas in the process of re-adaptation after space flight on Earth this system is considerably more markedly activated.     

利用地月间空间站的载人登月飞行模式分析

为提高空间站利用率，降低载人登月任务成本，有效开发地月空间，研究了基于地月空间不同轨道空间站的载人登月飞行模式。首先对比直接往返登月飞行模式，对基于空间站的载人登月飞行模式进行任务分析，通过空间站将载人登月任务解耦为载人天地往返任务和登月任务两部分；其次通过轨道设计和稳定性分析提出考虑登月任务需求的地月间空间站可运行轨道和停泊点；最后建立一套飞行模式评价模型，从速度增量需求、飞行时间、空间环境、登月任务窗口、测控条件、交会对接技术难度、后续任务支持性和任务可靠性方面对6种不同位置空间站的登月飞行模式进行分析和定量评价。评价结果表明基于L2点Halo轨道空间站的载人登月飞行模式为更优飞行模式。     

空间短时飞行试验工具的应用与展望

空间短时飞行试验是指以探空火箭、气球、亚轨道重复发射工具等为主要实现手段,将待试验对象发射到一定高度,进行科学实验和技术验证的研究方法。对空间短时飞行试验工具的发展历史和应用现状进行综述,对探空火箭、气球、亚轨道重复发射工具在科学观测、新技术试验中发挥的作用进行总结和概括,以NASA飞行机会计划FOP为例,对其在有效载荷技术成熟度评估中的应用情况进行了重点阐述,结合我国空间科学探测和空间技术试验的迫切需求,对空间短时飞行试验工具在我国的应用前景进行了展望和预测。     

发展X-37B空间飞机的背后动因分析

文章通过对X-37B飞行器的飞行试验任务分析,指出了X-37B飞行器不是空天飞机,也不是全球快速打击平台,而是一种低成本太空进入能力的飞行验证器,它的作用定位在空间而不是在空中。通过飞行试验和验证试验,旨在打造一个可重复使用的轨道转移运载器。将美国2010年航天战略的重大调整、国际空间站的运行延期和航天飞机退役等事件结合起来,对X-37B发展的背后动因进行分析,有助于了解美国航天发展的未来趋势。经过动因的详尽分析,指出要特别关注美国航天战略调整的两个重心转向,尤其是两个转向背后的动机。如何正确地认识国际空间站的作用定位,对于审视载人航天的未来发展有重要意义。美国航天战略的调整使载人航天的重心回到近地轨道上。基于中国目前的能力现实,建议中国的载人航天重心放在地球轨道上,做好各种能力的建设,并利用这些能力把地球轨道上的事做得更好。     

Metabolic changes in the animals subjected to space flight

The activity of the enzymes involved in aminoacid metabolism (tyrosine aminotransferase, TAT, tryptophan pyrrolase TP, serine dehydratase, SD) with rapid response to glucocorticoids and enzymes requiring for activity increase repeated administration of corticosterone (alanine aminotransferase, ALT, aspartate aminotransferase, AST) in liver, the changes of lipolysis in adipose tissue and the plasma corticosterone levels were studied in rats subjected to space flight (F), in animals from synchron model experiments (SM, simulated conditions of space flight in laboratory) and in intact controls (C). The increase of plasma corticosterone concentration and of the activity of rapidly (TAT, TP, SD) and slowly activating enzymes (ALT, AST) was found in F group 6-10 hr after space flight (18.5 days on biosatellite COSMOS 1129). This suggested the presence of acute-stress (associated primarily with the landing) and chronic stress induced hypercorticosteronemia during the flight. After the short 6-day period of recovery the plasma corticosterone concentrations and the activities of liver enzymes returned to control levels. The exposition of animals to repeated immobilization stress showed higher response of corticosterone levels in flight rats as compared to intact controls. No changes in basal lipolysis were observed in flight rats in comparison to intact controls, however the stimulation of lipolysis by norepinephrine was lower in animals from F and SM groups. This lower response of lipolytic processes to norepinephrine was found in flight animals also after six days period of recovery. These results showed that there are important changes in the regulation of lipolytic processes in adipose tissue of rats after space flight and in the conditions of model experiments.     

载人航天可靠性与空间环境试验

文章通过对国外载人航天事故统计,分析各种空间环境条件对航天器及航天员的影响,阐述了空间环境试验对提高载人航天可靠性的重要意义,提出为了提高载人航天的可靠性,应进行充分和严格的空间环境模拟试验。     

Attached payloads on SPACEHAB, growing from the Space Shuttle to the Space Station

Although NASA's Space Shuttle is largely dedicated in the near term to Space Station assembly, 10–16 day flight opportunities still abound for spacecraft technology demonstration payloads, and experiments for the established earth and space science communities. This paper will present the latest developments of SPACEHAB flight systems in order to accommodate the flight needs of these communities on the Space Shuttle today and the Space Station tomorrow. In particular, some examples of payloads from these disciplines will be introduced together with the accommodation and experiment objectives.     

The cost of space flight

Estimates of the cost of human space flight continue to generate controversy in the effort to set US space policy. Estimates vary widely, depending upon the position of the observer. This article identifies the real cost of major space flight programs and traces the heterofore unsuccessful efforts to cut the expense of space operations.     

A Ticket pricing strategy for an oligopolistic space tourism market

It is important for any new launch system to develop a successful pricing strategy and to optimize launch system parameters to receive a high economic profit. A question arises, what will happen when an existing suborbital flight market (the first likely to be established in space) is interfered with by a new established orbital flight market for space tourism. There is a risk that the suborbital space tourism market could be almost instantly displaced when a product capable of reaching orbit was introduced. This is best discussed using the following three cases whose results are presented in this paper. Case A presents a ticket pricing strategy for a suborbital and orbital vehicle if the two vehicles do not compete in the same market. Case B shows the necessary ticket pricing strategy for a suborbital vehicle if there is competition from an orbital flight operator. However, the suborbital vehicle would not be able to keep up with a drop in ticket prices due to its obsolete characteristics. Thus, the suborbital vehicle would be forced to stop operation in the year when flight costs became higher than flight receipts as shown in case C.     

空间飞行器目标电磁散射特性分析

根据某空间飞行器及目标几何模型,用高频近似法计算飞行器的电磁散射和角散射线偏差等,计算结果与矩量法(MOM)及暗室测试结果吻合,验证了算法的正确性,并给出了该空间飞行器雷达散射截面积(RCS)的统计结果、角闪烁在近距离的变化,以及模拟运动过程中散射特性随时间的变化。结果表明:该空间飞行器点频后向RCS满足χ2分布模型;在远场,角闪烁引起的线偏差与距离基本无关,在近场,线偏差与距离密切相关;动态散射特性与运动中的相对姿态和距离等密切相关。     

Will China become a military space superpower?

China's ambitious space program was born in extremely poor national conditions in 1956. By 15 October 2003, with the successful return of the Shenzhou-4 manned space flight, it had developed dramatically. While this flight is a milestone in China's space capabilities, the Shenzhou-4 mission should be considered not as an end, but as the entry ticket to the space power club of the USA and Russia. China may now be a space power, but it is not yet a military space superpower in the way of the latter two countries. This paper investigates whether China will become a military space superpower by reviewing the development of its space program. It examines Chinese military space capabilities in terms of their military space potential, and discusses the political, military and economic implications of this issue. Finally, the paper suggests that China should continue to take the road to openness, focusing on commercial and economic efforts. This will be an alternative direction in which the country can consider exactly what space capabilities it needs in order to continue its economic development.     

二级入轨空天飞机上升轨迹优化

以最小燃料消耗量为性能指标,考虑了多种约束条件(过载、动压、加热率等 ),采用了组合优化方法对空天飞机上升轨迹进行优化。该组合优化算法包括静态参数与动 态参数优化方法。其中,静态参数优化算法采用了全范围搜索方法,动态参数优化算法包 括动态规划法与共轭梯度法。通过数值仿真计算,得到飞行分离状态数据及相应的最 优 上升轨迹。数值仿真表明,该组合算法对航天器轨迹优化具有良好的适用性及实际工程价 值。
     

U.S. manned space flight: the first twenty years, a biomedical status report.

In the last 20 years, the biomedical problems facing man in space have been brought into sharper focus. Space motion sickness is presently our most serious problem. Its etiology remains obscure, but the "sensory conflict" theory appears most plausible. No valid predictive tests of susceptibility exist and presently we must rely on medication for prevention or mitigation of symptoms. Adaptation/biofeedback techniques may prove useful. Cardiovascular "deconditioning" may be effectively attenuated by use of anti-g suits or plasma expanding techniques. Recent bedrest simulation studies would seem to indicate that concerns about chronically elevated central venous pressure during space flight are unfounded. The loss of red cell mass in space flight appears to be self-limited, independent of mission duration, and not of clinical concern, based on recent Soviet experiences. And finally, clodronate, a new diphosphonate effective in preventing hypercalciuria and negative calcium balance in normal human bedrested subjects, may prove effective in preventing or lessening skeletal mineral loss in space.     

Haploid deletion strains of Saccharomyces cerevisiae that determine survival during space flight

This study identifies genes that determine survival during a space flight, using the model eukaryotic organism, Saccharomyces cerevisiae. Select strains of a haploid yeast deletion series grew during storage in distilled water in space, but not in ground based static or clinorotation controls. The survival advantages in space in distilled water include a 133-fold advantage for the deletion of PEX19, a chaperone and import receptor for newly- synthesized class I peroxisomal membrane proteins, to 77–40 fold for deletion strains lacking elements of aerobic respiration, isocitrate metabolism, and mitochondrial electron transport. Following automated addition of rich growth media, the space flight was associated with a marked survival advantage of strains with deletions in catalytically active genes including hydrolases, oxidoreductases and transferases. When compared to static controls, space flight was associated with a marked survival disadvantage of deletion strains lacking transporter, antioxidant and catalytic activity. This study identifies yeast deletion strains with a survival advantage during storage in distilled water and space flight, and amplifies our understanding of the genes critical for survival in space.