Hypergravity suppresses bone resorption in ovariectomized rats

The effects of gravity on bone metabolism are unclear, and little has been reported about the effects of hypergravity on the mature skeleton. Since low gravity has been shown to decrease bone volume, we hypothesized that hypergravity increases bone volume. To clarify this hypothesis, adult female rats were ovariectomized and exposed to hypergravity (2.9G) using a centrifugation system. The rats were killed 28 days after the start of loading, and the distal femoral metaphysis of the rats was studied. Bone architecture was assessed by micro-computed tomography (micro-CT) and bone mineral density was measured using peripheral quantitative CT (pQCT). Hypergravity increased the trabecular bone volume of ovariectomized rats. Histomorphometric analyses revealed that hypergravity suppressed both bone formation and resorption and increased bone volume in ovariectomized rats.     

Korean space food development: Ready-to-eat Kimchi, a traditional Korean fermented vegetable,sterilized with high-dose gamma irradiation

Addition of calcium lactate and vitamin C, a mild heating, deep-freezing, and gamma irradiation at 25 kGy were conducted to prepare Kimchi as a ready-to-eat space food. It was confirmed that the space food was sterilized by an irradiation at 25 kGy through incubation at 37 °C for 30 days. The hardness of the Space Kimchi (SK) was lower than the untreated Kimchi (CON), but higher than the irradiated Kimchi (IR). Also, this result was supported by the scanning electron microscopic observation. Sensory attributes of the SK were similar to CON, and maintained during preservation at 35 °C for 30 days. According to the Ames test, Kimchi sterilized with a high-dose irradiation exerted no mutagenic activity in the bacterial strains of Salmonella typhimurium. And, the SK was certificated for use in space flight conditions during 30 days by the Russian Institute of Biomedical Problems.     

Effects of simulated weightlessness on the intestinal mucosal barrier of rats

This study employed a rat tail-suspension model to investigate the effects of simulated weightlessness on the intestinal mucosal barrier. Twenty-four Wistar rats were randomly divided into control (CON), 14-day tail-suspension (SUS-14d), and 21-day tail-suspension (SUS-21d) groups (n = 8 per group). Expression of occludin and zonula occludins-1 (ZO-1), proteins of the tight junction (TJ), in the intestinal mucosa was measured by immunohistochemical analysis, Western blotting, and mRNA fluorescent quantitation PCR. Plasma concentrations of diamine oxidase (DAO) and d-lactate were determined using an enzymatic spectrophotometric assay. Expression of occludin and ZO-1 was reduced in the SUS-14d and SUS-21d groups as compared to the CON group, with lowest expression observed in the SUS-21d group (P < 0.01). Examination by transmission electron microscopy (TEM) of the jejunal epithelium revealed increased intercellular space, decreased TJ and desmosome densities, and destruction of microvilli in the SUS-14d and SUS-21d groups. Plasma DAO and d-lactate concentrations in the SUS-21d group were higher than those in SUS-14d group and significantly higher than those in the CON group (P < 0.01). In all three groups, the expression of occludin and ZO-1 was found to correlate negatively with DAO (P < 0.01) and d-lactate (P < 0.01) concentrations. It is concluded that simulated weightless results in down-regulation of expression of TJ proteins in the rat intestinal mucosa. Simulated weightlessness is proposed to increase intestinal permeability through damage to the TJ.     

Probing the method of correcting Faraday rotation in vector magnetograms

By analyzing the vector magnetograms of Huairou Solar Observing Station (HSOS) taken at the line center (0.0 Å) and the line wing (−0.12 Å) of FeI λ5324.19 Å, we make an estimate of the measured errors in transversal azimuths (δ?) caused by Faraday rotation. Since many factors, such as the magnetic saturation and scattered light, can affect the measurement accuracy of the longitudinal magnetic field in the umbrae of sunspots, we limit our study in the region ∣B_z∣ < 800 G. The main mean azimuth rotations are about 4°, 6°, 7° and 9°, while ∣B_z∣ are in the ranges of 400–500 G, 500–600 G, 600–700 G and 700–800 G, respectively. Moreover, we find there is also an azimuth rotation of about 8° at the wavelength offset −0.12 Å of the line compared against a previous numerical simulation.     

Plasma electron temperature variability in lunar surface potential and in electric field under average solar wind conditions

The Moon is immersed in plasma environment. The most interesting challenge of the lunar plasma– field environment is that it is alternatively dominated by the extended but variable outer atmosphere of the Earth – the magnetosphere – and by the extended but highly variable solar atmosphere – the solar wind. Understanding the plasma environment and its interaction with the lunar surface will be beneficial to both manned and robotic surface exploration activities and to scientific investigations. Presented is a preliminary map of variations of lunar surface electric potential over the day side and night side using probe equations and a discussion on dust dynamics in this E-field structure using the data from Electron Reflectometer in Lunar Prospector spacecraft during 1998–1999. On the day side, potential is around 5 V and on the night side it reaches up to −82 V. On the night side region, only highly energetic electrons can overcome this large negative potential. The variation at electron temperature (T_e) strongly reflects in the surface potential. The potential reaches to a value of −82 V for T_e = 58 eV. Surface charging causes the electrostatic transport of charged dust grains. Dust grain size of 0.1 μm shows a levitation height of 4.92 m on lunar day side, 748 m on terminator region and 3.7 km on the night side. The radius of maximum sized grain to be lofted, R_max, peaks at the terminator region (R_max = 0.83 μm). At the transition region dust levitation is almost absent. This region is most suited for exploration activities as the region is free from hazards caused by lunar dust.     

Search for antihelium: Progress with BESS

In this paper, we report searches for antihelium in cosmic rays using two recently flown magnetic rigidity spectrometers. BESS-TeV had extended rigidity with an MDR of 1.4 TV and had a flight duration of one day. BESS-Polar was optimized for collecting power. It was flown for 8.5 days and had an MDR of 240 GV. The former flight allows us to explore a previously unexplored rigidity band and the latter flight yields a factor of three improvement in the overall BESS limit. No antihelium candidate was found in the rigidity ranges of 1–500 GV, and 0.6–20 GV, among 7 × 10⁴ events taken with BESS-TeV, and 8 × 10⁶ events taken with BESS-Polar, respectively.     

Inhibitory effect of simulated microgravity on differentiating preosteoblasts

The bone loss induced by microgravity is partly due to the decrease of mature osteoblasts. In the present study, we employed the random positioning machine (RPM) to simulate microgravity and investigated the acute effects of simulated microgravity on the differentiation of 2T3 preosteoblasts. Following 7 days’ culture under normal (1 g) condition, cells were exposed to simulated microgravity for 24 h. The results showed that 24 h treatment of simulated microgravity significantly decreased alkaline phosphatase (ALP) activity without changing the cell morphology. In addition, the mRNA expressions of osteogenic genes, including runt-related gene 2 (Runx2), osterix, osteocalcin (OC), type I collagen (Col I) and bone morphogenetic protein (BMP), were dramatically downregulated. Moreover, western blot analysis of total extracellular signal-regulated kinase (Erk) and phosphorylated Erk (p-Erk) indicated that p-Erk level, which represents the Erk activation status, was increased. Taken together, our results suggested that acute exposure to simulated microgravity inhibited osteoblast differentiation through modulating the expression of osteogenic genes and the Erk activity. These findings provide new insight for bone loss due to microgravity and unloading.     

The role of radial perpendicular diffusion and latitude dependent acceleration along the solar wind termination shock

A numerical model, based on Parker’s transport equation, describing the modulation of anomalous cosmic rays and containing diffusive shock acceleration is applied. The role of radial perpendicular diffusion at the solar wind termination shock, and as the dominant diffusion coefficient in the outer heliosphere, is studied, in particular the role it plays in the effectiveness of the acceleration of anomalous protons and helium when its latitude dependence is changed. It is found that the latitudinal enhancement of radial perpendicular diffusion towards the heliospheric poles and along the termination shock has a prominent effect on the acceleration of these particles. It results in a ‘break’ in the energy spectrum for anomalous protons at ∼6.0 MeV, causing the spectral index to change from E^−1.38 to E^−2.23, but for anomalous helium at ∼3.0 MeV, changing the spectral index from E^−1.38 to E^−2.30. When approaching the simulated TS, the changes in the modulated spectra as they unfold to a ‘steady’ power law shape at energies below 50 MeV are much less prominent as a function of radial distances when radial perpendicular diffusion is increased with heliolatitude.     

Differential emission measure distributions in X-ray solar flares

X-ray spectrometer RESIK has observed spectra in the four wavelength bands from 3.3 Å to 6.1 Å. This spectral range contains many emission lines of H- and He-like ions for Si, S, Ar and K. These lines are formed in plasma of coronal temperatures (T > 3 MK). Analysis of their intensities allows studying differential emission measure distributions (DEM) in temperature range roughly between 3 MK and 30 MK. The aim of present study was to check whether any relationship exists between the character of DEM distribution, the event phase and the X-ray flare class. To do this we have calculated and analyzed the DEM distributions for a set of flares belonging to different GOES classes from the range B5.6–X1. The DEM distributions have been calculated using “Withbroe–Sylwester” multiplicative, maximum likelihood iterative algorithm. As the input data we have used absolute fluxes observed by RESIK in several spectral bands (lines + continuum). Respective emission functions have been calculated using the CHIANTI v. 5.2 atomic data package.     

Variability of the ionosphere over Irkutsk at low solar activity

Statistical and spectral analyses are performed to investigate variations of two ionosphere F2 layer key parameters, the critical frequency (foF2) and the peak height (hmF2), that were measured over Irkutsk (52.5°N, 104.0°E) from December 2006 to January 2008 under solar minimum. The analyses showed that both parameters contain quasi-harmonic oscillations with periods of T_n = 24/n hours (n = 1–7), among which the diurnal (n = 1) and semidiurnal (n = 2) ones are the strongest. Seasonal variations are explored of mean and median values, spectrum, amplitude, and phase of the diurnal and semidiurnal components of foF2 and hmF2.     

Planetary wave coupling of the atmosphere–ionosphere system during the Northern winter of 2008/2009

This paper presents the global spatial (latitude and altitude) structure and temporal variability of the ∼23-day ionospheric zonally symmetric (s = 0) planetary wave (PW) seen in the Northern winter of 2008/2009 (October 2008–March 2009). It is shown that these ∼23-day ionospheric oscillations are forced from PWs propagating from below. The COSMIC ionospheric parameters f_oF2 and h_mF2 and electron density at fixed altitudes and the SABER temperatures were utilized in order to define the waves which are present simultaneously in the atmosphere and ionosphere. The long-period PWs from the two data sets have been extracted through the same data analysis method. The similarity between the lower thermospheric ∼23-day (s = 0) temperature PW and its ionospheric electron density response provides valuable and strong experimental evidence for confirming the paradigm of atmosphere–ionosphere coupling.     

Temperature variability in the tropical mesosphere during the northern hemisphere winter

Temperature observations at 20–90 km height and 5°N–15°N during the period of December 1992–March 1993 from the WINDII and MLS experiments on the UARS satellite are analysed together with MF radar winds and UKMO assimilated fields of temperature and zonal and meridional winds. The correlation between the different datasets at the tropics and zonal mean wind data at mid latitudes is examined for period February–March 1993, when series of stratospheric warming events were observed at middle and high latitudes. Wavelet analysis is applied to investigate coupling between stationary and travelling planetary waves in the stratosphere and the upper mesosphere. Planetary waves m = 1 with periods of 4–7 days, 8–12 days and 13–18 days are found to dominate the period. Westward 7- and 16–18 day waves at the tropics appear enhanced by stationary planetary waves during sudden stratospheric warming events.     

Dependence of the 27-day variation of cosmic rays on the global magnetic field of the Sun

We show that the higher range of the heliolongitudinal asymmetry of the solar wind speed in the positive polarity period (A > 0) than in the negative polarity period (A < 0) is one of the important reasons of the larger amplitudes of the 27-day variation of the galactic cosmic ray (GCR) intensity in the period of 1995–1997 (A > 0) than in 1985–1987 (A < 0). Subsequently, different ranges of the heliolongitudinal asymmetry of the solar wind speed jointly with equally important corresponding drift effect are general causes of the polarity dependence of the amplitudes of the 27-day variation of the GCR intensity. At the same time, we show that the polarity dependence is feeble for the last unusual minimum epoch of solar activity 2007–2009 (A < 0); the amplitude of the 27-day variation of the GCR intensity shows only a tendency of the polarity dependence. We present a three dimensional (3-D) model of the 27-day variation of GCR based on the Parker’s transport equation. In the 3-D model is implemented a longitudinal variation of the solar wind speed reproducing in situ measurements and corresponding divergence-free interplanetary magnetic field (IMF) derived from the Maxwell’s equations. We show that results of the proposed 3-D modeling of the 27-day variation of GCR intensity for different polarities of the solar magnetic cycle are in good agreement with the neutron monitors experimental data. To reach a compatibility of the theoretical modeling with observations for the last minimum epoch of solar activity 2007–2009 (A < 0) a parallel diffusion coefficient was increased by ∼40%.     

Ionospheric reflection of the magnetic activity described by the index η

Differences in the external part of the vertical geomagnetic component point to the existence of local inhomogeneities in the magnetosphere or the ionosphere. Usually used magnetic indices are not sufficient to express the state of ionosphere, the common used global Kp index derived in the three-hour interval does not indicate much more rapidly changes appearing in ionosphere. Magnetic index η reflects ionospheric disturbances when other indices show very quiet conditions. Data of ionospheric characteristics (foE, foEs, h’E, h’F2) during 28-day long quiet day conditions (Kp = 0–2) in 2004 were analyzed. The correlations between strong local disturbances in ionosphere during very quiet days and high values of magnetic index η were found. The most sensitive to magnetic influence – ionospheric E layer data (foE characteristic) – reaches median deviations up to (+0.8 MHz and −0.8 MHz) during very low magnetic activity (Kp = 0–1). The high peaks (2–2.7) of the magnetic index η correlate in time with large local median deviations of foE. Such local deviations can suggest local inhomogeneities (vertical drifts) in the ionosphere. The correlation in space is not trivial. The strong peak of η is situated between the positive and negative deviations of foE. Additional observation is connected with correlation in time of the high η value with the negative median deviations of h’F2 (in some cases up to −90 km). The analysis was based on one-minute data recorded at each of 20 European Magnetic Observatories working in the INTERMAGNET network and from 19 ionosondes for 2004. Ionospheric data are sparse in time and in space in opposite to the magnetic data. The map of the magnetic indices can suggest the behavior of ionospheric characteristics in the areas where we have no data.     

Spaceflight-relevant types of ionizing radiation and cortical bone: Potential LET effect?

Extended exposure to microgravity conditions results in significant bone loss. Coupled with radiation exposure, this phenomenon may place astronauts at a greater risk for mission-critical fractures. In a previous study, we identified a profound and prolonged loss of trabecular bone (29–39%) in mice following exposure to an acute, 2 Gy dose of radiation simulating both solar and cosmic sources. However, because skeletal strength depends on trabecular and cortical bone, accurate assessment of strength requires analysis of both bone compartments. The objective of the present study was to examine various properties of cortical bone in mice following exposure to multiple types of spaceflight-relevant radiation. Nine-week old, female C57BL/6 mice were sacrificed 110 days after exposure to a single, whole body, 2 Gy dose of gamma, proton, carbon, or iron radiation. Femora were evaluated with biomechanical testing, microcomputed tomography, quantitative histomorphometry, percent mineral content, and micro-hardness analysis. Compared to non-irradiated controls, there were significant differences compared to carbon or iron radiation for only fracture force, medullary area and mineral content. A greater differential effect based on linear energy transfer (LET) level may be present: high-LET (carbon or iron) particle irradiation was associated with a decline in structural properties (maximum force, fracture force, medullary area, and cortical porosity) and mineral composition compared to low-LET radiation (gamma and proton). Bone loss following irradiation appears to be largely specific to trabecular bone and may indicate unique biological microenvironments and microdosimetry conditions. However, the limited time points examined and non-haversian skeletal structure of the mice employed highlight the need for further investigation.     

First astrometric observations of space debris with the MéO telescope

The MéO (for Métrologie Optique) telescope is the Satellite and Lunar Laser Ranging (SLR) dedicated telescope of Observatoire de la Côte d’Azur (France) located at plateau de Calern. The telescope uses an altazimuth mount. The motorization of the mount has a capability of 6 deg/s allowing the follow up of Low Earth Orbits (LEO) satellites, as well as Medium Earth Orbits (MEO) and geostationary (GEO) satellites, and the Moon. The telescope has a primary mirror of 1.54 m. It uses a Nasmyth focus equipped with an EMCCD camera. The telescope field of view, defined by the equivalent focal length and the size of the camera, is currently 3.4 arcmin × 3.4 arcmin.     

Cluster observations of earthward propagating plasmoid and flux ropes in the near-tail during the course of a substorm event

We analyze the magnetic structures in the near-tail at Xgsm = −17.5 Re on September 19, 2003 by Cluster. During the course of a substorm event, the earthward propagating plasmoid and flux ropes in the near-tail are observed. The earthward propagating plasmoid is associated with the bipolar Bz and By signatures. The two flux ropes are embedded within the earthward plasma flows, which might be referred to the population as ‘‘BBF-type’’ flux ropes. The first flux rope diameter is about 0.7 Re and duration based upon the Bz signature is ∼20 s, while the second one diameter is about 1.4 Re and duration is ∼30 s. The earthward propagating plasmoid and flux ropes could have influence upon the dipolarization and injection in inner magnetosphere. The Cluster observations of earthward propagating plasmoid and flux ropes can be interpreted as strong evidence for multiple X-lines. Our observations are consistent with that multiple plasmoids or flux ropes are formed repeatedly and ejected tailward in the course of geomagnetically active time.     

Investigation of precursory phenomena in the ionosphere,atmosphere and groundwater before large earthquakes of M > 6.5

Precursory phenomena in the ionosphere, atmosphere and groundwater before large earthquakes (M > 6.5) are extensively investigated toward the earthquake prediction. Upward tornado type seismic clouds occurred near the epicenter associated with strong LF-VLF radio noises from lightning discharges in the evening of January 9, 1995 [Yamada, T., Oike, K. On the increase of electromagnetic noises before and after the 1995 Hyogo-Ken Nanbu earthquake. In: Hayakawa M. (Ed.), Atmospheric and Ionospheric Electromagnetic Phenomena Associated with Earthquakes. TERRAPUB, Tokyo, pp. 417–427, 1999] and anomalous foEs increases up to 10 MHz were detected at Shigaraki, 90 km of the epicenter and at Kokubunji, 500 km east of the epicenter [Ondoh, T. Anomalous sporadic-E layers observed before M7.2 Hyogo-ken Nanbu earthquake; Terrestrial gas emanation model. Adv. Polar Upper Atmos. Res. 17, 96–108, 2003; Ondoh, T. Anomalous sporadic-E ionization before a great earthquake, Adv. Space Research 34, 1830–1835, 2004] associated with strong ELF noises from lightning discharges in the daytime on January 15, 1995 [Hata, M., Fujii, T., Takumi, I. EM precursor of large-scale earthquakes in Japan, in: Abstracts of International Workshop on Seismo Electromagnetics (IWSE 2005), Univ. Electro-Communications, Chofu, Tokyo, Japan, March 15–17, pp. 182–186, 2005] before the M7.2 Hyogoken–Nanbu earthquake of January 17, 1995. The anomalous foEs increases occurred at epicentral distances within 500 km that are the same as those of the terrestrial gas emanations along active faults before large earthquakes [King, C.-Y. Gas geochemistry applied to earthquake prediction: An overview. J. Geophys. Res. 91(B12), 12269–12281, 1986]. The anomalous foEs increases seem to be a seismic precursor because geomagnetic and solar conditions were very quiet all day on January 15,1995 and the normal foEs in Japanese winter is below 6 MHz. No significant pre-seismic geomagnetic field variation was detected at epicentral distance of 100 km before this earthquake [Ondoh, T., Hayakawa, M. Anomalous occurrence of sporadic-E layers before the Hyogoken–Nanbu earthquake, M7.2 of January 17, 1995. In: Hayakawa, M. (Ed.), Atmospheric and Ionospheric Electromagnetic Phenomena Associated with Earthquakes, TERRAPUB, Tokyo, pp. 629–639, 1999; Ondoh, T., Hayakawa, M. Seismo discharge model of anomalous sporadic E ionization before great earthquakes. In: Hayakawa, M., O.A. Molchanov, (Eds.), Seismo Electromagnetics: Lithosphere–Atmosphere–Ionosphere Couplings, TERRAPUB, Tokyo, pp. 385–390, 2002; Ondoh. T., Hayakawa, M. Synthetic study of precursory phenomena of the M7.2 Hyogo-ken Nanbu earthquake. Phys. Chem. Earth 31, 378–388, 2006]. The foF2 decrease and h’F increase occurred before the M7.8 Hokkaido Nansei-Oki earthquake of July 12,1993 in a geomagnetic quiet period [Ondoh, T. Ionospheric disturbances associated with great earthquake of Hokkaido southwest coast, Japan of July 12, 1993. Phys. Earth Planet. Interiors. 105, 261–269, 1998; Ondoh, T. Seismo ionospheric phenomena. Adv. Space Res. 26, 8, 1267–1272, 2000]. Characteristic phase changes at terminator times of Omega 10.2 kHz waves passing 70 km of the epicenter extended toward darker local times by 1 h for 3 days before this earthquake due to lowering of the wave reflection height or ion density increases in the D region [Hayakawa, M., Molchanov, O. A., Ondoh, T., Kawai, E. The precursory signature effect of the Kobe earthquake on VLF subionospheric signals. J. Commun. Res. La., 43, 00. 169–180, 1996]. The radon concentration in the atmosphere over Ashiya fault, Kobe [Yasuoka, Y., Shinogi, M. Anomaly in atmospheric radon concentration: a possible precursor of the 1995 Kobe, Japan, earthquake. Health Phys. 72(5), 759–761, 1997] and in the groundwater at 17 m well in Nishinomiya, Japan [Igarashi, G., Saeki, S., Takahata, N., Sumikawa, K., Tasaki, S., Sasaki, Y., Takahashi, M., Sano, Y. Ground-water radon anomaly before the Kobe earthquake in Japan. Science 269, 60–61, 1995] had gradually increased since 2 months before the M7.2 earthquake, increased suddenly in December 1994, and rapidly returned to the normal low level of October, 1994 [Yasuoka, Y., Shinogi, M. 1997. Anomaly in atmospheric radon concentration: a possible precursor of the 1995 Kobe. Japan, earthquake. Health Phys. 72(5), 759–761.]. Radon concentration changes in the groundwater before the M 7.0 Izu-Oshima-kinkai earthquake, Japan on January 14, 1978 [Wakita, H., Nakamura, Y., Notsu, K., Noguchi, M., Asada, T. 1980. Radon anomaly: a possible precursor of the 1978 Izu-Oshima-kinkai earthquake. Science 207, 882–883] and the M6.8 Chengkung earthquake, Taiwan on December 10, 2003 [Kuo, T., Fan, K., Chen, W., Kuochen, H., Han, Y., Wang, C., Chang, T., Lee, Y. Radon anomaly at the Antung Hot Spring before the Taiwan M6.8 Chengkung earthquake. Proceedings, Thirty-First Workshop on Geothermal Reservoir Engineering, Stanford University, Stanford, California, January 30–February 1, 2006, SGP-TR-179, 2006] are also investigated to find common features of the groundwater radon concentration changes before large earthquakes (M > 6.5) in comparison with those before the M7.2 Hyogoken–Nanbu earthquake. Groundwater radon concentrations before the 3 large earthquakes had shown common characteristic changes of gradually initial ones from the normal level since about 2 months before the earthquake onsets, rapid decreases down to the minimum, and quick increases up to the maximum at 7–20 days before the earthquake onsets, respectively. These are very useful characteristics of pre-seismic radon anomaly for the earthquake prediction or warning. Promising observations toward the earthquake prediction are also discussed.     

Advanced architectures for real-time Delay-Doppler Map GNSS-reflectometers: The GPS reflectometer instrument for PAU (griPAU)

In recent years Global Navigation Satellite System’s signals Reflectometry (GNSS-R) has stood as a potential powerful remote sensing technique to derive scientifically relevant geophysical parameters such as ocean altimetry, sea state or soil moisture. This has brought out the need of designing and implementing appropriate receivers in order to track and process this kind of signals in real-time to avoid the storage of huge volumes of raw data. This paper presents the architecture and performance of the Global Positioning System (GPS) Reflectometer Instrument for PAU (griPAU), a real-time high resolution Delay-Doppler Map reflectometer, operating at the GPS L1 frequency with the C/A codes. The griPAU instrument computes 24 × 32 complex points DDMs with configurable resolution (Δf_Dmin = 20 Hz, Δτ_min = 0.05 chips) and selectable coherent (minimum = 1 ms, maximum = 100 ms for correlation loss Δρ < 90%) and incoherent integration times (minimum of one coherent integration period and maximum not limited but typically <1 s). A high sensitivity (DDM peak relative error = 0.9% and DDM volume relative error = 0.03% @ T_i = 1 s) and stability (Δρ/Δt = −1 s⁻¹) have been achieved by means of advanced digital design techniques.