Modelling of galactic Carbon in an asymmetrical heliosphere: Effects of asymmetrical modulation conditions

Observations of galactic cosmic rays (GCRs) from the two Voyager spacecraft inside the heliosheath indicate significant differences between them, suggesting that in addition to a possible global asymmetry in the north–south dimensions (meridional plane) of the heliosphere, it is also possible that different modulation (turbulence) conditions could exist between the two hemispheres of the heliosphere. We focus on illustrating the effects on GCR Carbon of asymmetrical modulation conditions combined with a heliosheath thickness that has a significant dependence on heliolatitude. To reflect different modulation conditions between the two heliospheric hemispheres in our numerical model, the enhancement of both polar and radial perpendicular diffusion off the ecliptic plane is assumed to differ from heliographic pole to pole. The computed radial GCR intensities at polar angles of 55° (approximating the Voyager 1 direction) and 125° (approximating the Voyager 2 direction) are compared at different energies and for both particle drift cycles. This is done in the context of illustrating how different values of the enhancement of both polar and radial perpendicular diffusion between the two hemispheres contribute to causing differences in radial intensities during solar minimum and moderate maximum conditions. We find that in the A > 0 cycle these differences between 55° and 125° change both quantitatively and qualitatively for the assumed asymmetrical modulation condition as reflected by polar diffusion, while in the A < 0 cycle, minute quantitative differences are obtained. However, when both polar and radial perpendicular diffusion have significant latitude dependences, major differences in radial intensities between the two polar angles are obtained in both polarity cycles. Furthermore, significant differences in radial intensity gradients obtained in the heliosheath at lower energies may suggest that the solar wind turbulence at and beyond the solar wind termination shock must have a larger latitudinal dependence.     

The heliospheric modulation of 3–10 MeV electrons: Modeling of changes in the solar wind speed in relation to perpendicular polar diffusion

The discrepancy between cosmic ray model predictions representing solar minimum conditions in the heliosphere and the 3–10 MeV post-1998 electrons observations by the Kiel Electron Telescope (KET) onboard Ulysses suggests the need for consistent changes in model parameters with increasing solar activity. In order to reduce this discrepancy, an effort is made to model the KET observations realistically during periods of increased solar activity by applying an advanced three-dimensional, steady-state electron modulation model based on Parker’s transport equation including the Jovian electron source. Some elements of the diffusion tensor which were not previously emphasized are revisited. A new relation is also established between the latitudinal dependence of the solar wind speed and the perpendicular polar diffusion. Based on this relation, a transition of an average solar wind speed from solar minimum to solar maximum conditions, as observed on board the Ulysses spacecraft, is modeled on the concept of the time-evolution of large polar coronal holes. These changes are correlated to different scenarios of the enhancement of perpendicular polar diffusion. Effects of these scenarios are illustrated, as a series of steady-state solutions, on the computed 7 MeV Jovian and galactic electrons in comparison with 3–10 MeV electrons observed from the period 1998 to the end of 2003. It is shown that this approach improves compatibility with the KET observations but it also points to the need for a time-dependent electron modulation model to fully describe modulation during moderate to extreme solar maximum conditions.     

Effects of the position of the solar wind termination shock and the heliopause on the heliospheric modulation of cosmic rays

The effects of changing the position of the solar wind termination shock and the position of the heliopause, and therefore the extent of the heliosheath, on the modulation of cosmic ray protons are illustrated. An improved numerical model with diffusive termination shock acceleration, a heliosheath and drifts is used. The modulation is computed in the equatorial plane and at 35 heliolatitude using recently derived diffusion coefficients applicable to a number of cosmic ray species during both magnetic polarity cycles of the Sun. It was found that qualitatively the modulation results for the different heliopause positions are similar although they differ quantitatively, e.g., clearly different radial gradients are predicted for the regions beyond the termination shock compared to inside the shock. The difference between the modulation for the two solar polarity cycles are less significant at a heliolatitude of 35° than in the equatorial plane. We found that moving the termination shock from 90 to 100 AU, with the heliopause fixed at 120 AU, caused only quantitative differences so that the exact position of the TS in the outer heliosphere seems not crucially important to global modulation. Moving the heliopause outwards, to represent the modulation in the tail region of the heliosphere, causes overall decreases in the cosmic ray intensities but not linearly as a function of energy, e.g., at 1 GeV the effect is insignificant. We conclude from this modelling that the modulation of protons in the heliospheric nose and tail regions are qualitatively similar although, clear quantitative and interesting differences occur.     

From mechanisms to risk estimation--bridging the chasm.

We have a considerable amount of work ahead of us to determine the importance of the wealth of new information emerging in the fields of sub-cellular, cellular and tissue biology in order to improve the estimation of radiation risk at low dose and protracted dose-rate. In this paper, we suggest that there is a need to develop models of the specific health effects of interest (e.g., carcinogenesis in specific tissues), which embody as much of the mechanistic (i.e., biological) information as is deemed necessary. Although it is not realistic to expect that every radiation-induced process should or could be included, we can hope that the major factors that shape the time dependence of evolution of damage can be identified and quantified to the point where reasonable estimations of risk can be made. Regarding carcinogenesis in particular, the structure of the model itself plays a role in determining the relative importance of various processes. We use a specific form of a multi-stage carcinogenic model to illustrate this point. We show in a review of the application of this model to lung cancer incidence and mortality in two exposed populations that for both high- and low-LET radiation, there is evidence of an "inverse dose-rate" or protraction effect. This result could be of some considerable importance, because it would imply that risk from protracted exposure even to low-LET radiation might be greater than from acute exposure, an opinion not currently held in the radiation protection community. This model also allows prediction of the evolution of the risk over the lifetimes of the exposed individuals. One inference is that radiation-induced initiation (i.e., the first cellular carcinogenic event(s) occurring in normal tissue after the passage of the radiation) may not be the driving factor in the risk, but more important may be the effects of the radiation on already-initiated cells in the tissue. Although present throughout the length of the exposure, radiation-induced initiation appears to play a dominating role only very late in life, and only for those individuals who began their exposure early in life. These conclusions are very dependent, of course, on the hypotheses embodied in the initiation-promotion-conversion paradigm of carcinogenesis. We suggest that recently identified processes, such as the "bystander effect", might affect initiation, promotion, and malignant conversion in different ways. Finally, the manner in which the quality of radiation affects these processes must be understood in the context of the mixed high- and low-LET radiations that are found in the space environment. Important directions in critical experiment definition are suggested, including a renewed emphasis on well-designed animal experiments over extended periods of time.     

Invariant Modulation of IMF Clock Angle on the Solar Wind Energy Input into the Magnetosphere

By use of the global PPMLR Magnetohydrodynamics (MHD) model, a serial of quasisteady- state numerical simulations were conducted to examine the modulation property of the interplanetary magnetic field clock angle θ on the solar wind energy input into the magnetosphere. All the simulations can be divided into seven groups according to different criteria of solar wind conditions. For each group, 37 numerical examples are analyzed, with the clock angle varying from 0° to 360° with an interval of 10°, keeping the other solar wind parameters (such as the solar wind number density, velocity, and the magnetic field magnitude) unchanged. As expected, the solar wind energy input into the magnetosphere is modulated by the IMF clock angle. The axisymmetrical bell-shaped curve peaks at the clock angle of 180°. However, the modulation effect remains invariant with varying other solar wind conditions. The function form of such an invariant modulation is found to be sin(θ/2)2.70 + 0.25.      

频率分集阵列负型模糊函数特性仿真

现有研究主要是关于频率分集阵列（FDA）基于阵元发射窄带条件下单载频信号的假设而展开的，缺乏对线性调频（LFM）信号是否适用于FDA问题的研究。考虑到基于模糊函数的优化是雷达波形设计的重要手段，在建立FDA数据模型的基础上，建立线阵发射、单天线接收模型下的FDA负型模糊函数，系统分析其主要特性。在此基础上，仿真分析了基于矩形脉冲、线性调频信号以及采用不同非线性频控函数的FDA负型模糊函数特性，对比了采用不同非线性频控函数的FDA的目标距离-角度二维联合估计性能。仿真结果在验证FDA模糊函数建立正确性的同时，得出采用正弦频控函数的FDA性能最优的结论。从而为基于模糊函数的复杂信号FDA波形设计以及基于FDA方向图解耦技术的发射波形设计奠定了重要基础。      

RBE for non-stochastic effects.

Evidence is reviewed concerning the variation of RBE values of high-LET radiations for non-stochastic effects, generally impairment of tissue integrity and function. The RBE values are dependent on the type of radiation, the type of tissue effect and the dose rate or fractionation schedule. RBE values depend strongly on the effect considered, with high values for late effects in lung, kidney and central nervous system. RBE values generally increase with decreasing dose rate or dose per fraction. Maximum values can be derived by extrapolation on the basis of a radiobiological model. These values are denoted RBEm to distinguish them from RBEM derived for stochastic effects, e.g. carcinogenesis. Values of RBEm are generally in the range of 2 to 10 and are considerably smaller by a factor of 2 to 5 than values of RBEM for various types of stochastic effects. RBE values for effects from actual exposures to mixtures of high-LET and low-LET radiations can be derived by considering the doses received and the tissue at risk. Applications of RBEm values will yield estimates of maximum values of equivalent doses and these should only be applied for planning medical interventions if the contribution from high-LET radiation is small. The selection of Q values for radiation protection is mostly based on RBE--values and the application of Q values in cases where non-stochastic effects are important might therefore result in an overestimate of the risks of exposure.     

Modeling the acceleration and modulation of anomalous cosmic ray oxygen

After the solar wind termination shock crossings of the Voyager spacecraft, the acceleration of anomalous cosmic rays has become a very contentious subject. In this paper we examine several topics pertinent to anomalous cosmic ray oxygen acceleration and transport using a numerical cosmic ray modulation model. These include the effects of drifts on a purely Fermi I accelerated spectra, the effects of introducing higher charge states of oxygen into the modulation model, examining the viability of momentum diffusion as a re-acceleration process in the heliosheath and examining energy spectra, and intensity gradients, in the inner heliosphere during consecutive drift cycles.     

Effects of exposure to different types of radiation on behaviors mediated by peripheral or central systems.

The effects of exposure to ionizing radiation on behavior may result from effects on peripheral or on central systems. For behavioral endpoints that are mediated by peripheral systems (e.g., radiation-induced conditioned taste aversion or vomiting), the behavioral effects of exposure to heavy particles (56Fe, 600 MeV/n) are qualitatively similar to the effects of exposure to gamma radiation (60Co) and to fission spectrum neutrons. For these endpoints, the only differences between the different types of radiation are in terms of relative behavioral effectiveness. For behavioral endpoints that are mediated by central systems (e.g., amphetamine-induced taste aversion learning), the effects of exposure to 56Fe particles are not seen following exposure to lower LET gamma rays or fission spectrum neutrons. These results indicate that the effects of exposure to heavy particles on behavioral endpoints cannot necessarily be extrapolated from studies using gamma rays, but require the use of heavy particles.     

Embryogenesis and organogenesis of Carausius morosus under spaceflight conditions

The influence of cosmic radiation and/or microgravity on insect development was studied during the 7 day German Spacelab Mission D1. Eggs of Carausius morosus of five stages differing in sensitivity to radiation and in capacity to regeneration were allowed to continue their development in the BIORACK 22°C incubator, either at microgravity conditions or on the 1 g reference centrifuge. Using the Biostack concept - eggs in monolayers were sandwiched between visual track detectors - and the 1 g reference centrifuge, we were able to separate radiation effects from microgravity effects and also from combined effects of these two factors in space. After retrieval, hatching rates, growth kinetics and anomaly frequencies were determined in the different test samples. The early stages of development turned out to be highly sensitive to single hits of cosmic ray particles as well as to the temporary exposure to microgravity during their development. In some cases, the combined action of radiation and microgravity even amplified the effects exerted by the single parameters of space. Hits by single HZE particles caused early effects, such as body anomalies, as well as late effects, such as retarded growth after hatching. Microgravity exposure lead to a reduced hatching rate. A synergistic action of HZE particle hits and microgravity was established in the unexpectedly high frequency of anomal larvae. However, it cannot be excluded, that cosmic background radiation or low LET HZE particles are also causally involved in damage observed in the microgravity samples.     

外形及工况参数对轴承柔性保持架动力学性能的影响

考虑保持架柔性处理及滚动轴承各组件间的相互作用关系,利用ADAMS/View平台构建了真空条件下不同保持架的轴承刚柔耦合多体动力学分析模型,采用正交试验法分析了转速、保持架厚度和兜孔形状对保持架动态特性的影响规律。结果表明：随着轴承转速增加,保持架转速稳定性降低,动态接触力和打滑率升高,质心轨迹呈“筒状”;保持架厚度对保持架动态性能影响最大,质心轨迹受兜孔形状影响最大;动量轮用保持架最优工况及设计为：轴承转速为2000 (r/min),厚度为2 mm,兜孔形状为方型兜孔。     

DME脉冲调制信号波形参数对空间频谱占用的影响分析

航空测距器DME的开发、调试和性能验证都要用到高斯双脉冲调制格式的DME信号。由于专用的DME信号模拟器技术复杂、价格昂贵,人们常用具有快沿双脉冲调制功能的模拟信号源替代。本文以航空测距器DME信号要求为依据,初步分析了这种替代可能存在的问题,并通过实验对不同边沿条件下高斯双脉冲、矩形双脉冲调制信号的功率频谱占用情况进行了验证。     

In vivo and in vitro studies of cartilage differentiation in altered gravities.

The in vivo model our laboratory uses for studies of cartilage differentiation in space is the rat growth plate. Differences between missions, and in rat age and recovery times, provided differing results from each mission. However, in all missions, proliferation and differentiation of chondrocytes in the epiphyseal plate of spaceflown rats was altered as was matrix organization. In vitro systems, necessary complements to in vivo work, provide some advantages over the in vivo situation. In vitro, centrifugation of embryonic limb buds suppressed morphogenesis due to precocious differentiation, and changes in the developmental pattern suggest the involvement of Hox genes. In space, embryonic mouse limb mesenchyme cells differentiating in vitro on IML-1 had smoother membranes and lacked matrix seen in controls. Unusual formations, possibly highly ruffled membranes, were found in flight cultures. These results, coupled with in vivo centrifugation studies, show that in vivo or in vitro, the response of chondrocytes to gravitational changes follows Hert's curve as modified by Simon, i.e. decreased loading decreases differentiation, and increased loading speeds it up, but only to a point. After that, additional increases again slow down chondrogenesis.     

Early and late mammalian responses to heavy charged particles.

This overview summarizes murine results on acute lethality responses, inactivation of marrow CFU-S and intestinal microcolonies, testes weight loss, life span shortening, and posterior lens opacification in mice irradiated with heavy charged particles. RBE-LET relationships for these mammalian responses are compared with results from in vitro studies. The trend is that the maximum RBE for in vivo responses tends to be lower and occurs at a lower LET than for inactivation of V79 and T-1 cells in culture. Based on inactivation cross sections, the response of CFU-S in vivo conforms to expectations from earlier studies with prokaryotic systems and mammalian cells in culture. Effects of heavy ions are compared with fission spectrum neutrons, and the results are consistent with the interpretation that RBEs are lower than for fission neutrons at about the same LET, probably due to differences in track structure. Issues discussed focus on challenges associated with assessments of early and late effects of charged particles based on dose, RBE and LET, and with the concordance or discordance of results obtained with in vivo and in vitro model systems. Models for radiation damage/repair and misrepair should consider effects observed with in vivo as well as in vitro model systems.     

Solar cosmic rays as a specific source of radiation risk during piloted space flight.

Solar cosmic rays present one of several radiation sources that are unique to space flight. Under ground conditions the exposure to individuals has a controlled form and radiation risk occurs as stochastic radiobiological effects. Existence of solar cosmic rays in space leads to a stochastic mode of radiation environment as a result of which any radiobiological consequences of exposure to solar cosmic rays during the flight will be probabilistic values. In this case, the hazard of deterministic effects should also be expressed in radiation risk values. The main deterministic effect under space conditions is radiation sickness. The best dosimetric functional for its analysis is the blood forming organs dose equivalent but not an effective dose. In addition, the repair processes in red bone marrow affect strongly on the manifestation of this pathology and they must be taken into account for radiation risk assessment. A method for taking into account the mentioned above peculiarities for the solar cosmic rays radiation risk assessment during the interplanetary flights is given in the report. It is shown that radiation risk of deterministic effects defined, as the death probability caused by radiation sickness due to acute solar cosmic rays exposure, can be comparable to risk of stochastic effects. Its value decreases strongly because of the fractional mode of exposure during the orbital movement of the spacecraft. On the contrary, during the interplanetary flight, radiation risk of deterministic effects increases significantly because of the residual component of the blood forming organs dose from previous solar proton events. The noted quality of radiation responses must be taken into account for estimating radiation hazard in space.     

Effects of heavy particle irradiation and diet on object recognition memory in rats

On long-duration missions to other planets astronauts will be exposed to types and doses of radiation that are not experienced in low earth orbit. Previous research using a ground-based model for exposure to cosmic rays has shown that exposure to heavy particles, such as ⁵⁶Fe, disrupts spatial learning and memory measured using the Morris water maze. Maintaining rats on diets containing antioxidant phytochemicals for 2 weeks prior to irradiation ameliorated this deficit. The present experiments were designed to determine: (1) the generality of the particle-induced disruption of memory by examining the effects of exposure to ⁵⁶Fe particles on object recognition memory; and (2) whether maintaining rats on these antioxidant diets for 2 weeks prior to irradiation would also ameliorate any potential deficit. The results showed that exposure to low doses of ⁵⁶Fe particles does disrupt recognition memory and that maintaining rats on antioxidant diets containing blueberry and strawberry extract for only 2 weeks was effective in ameliorating the disruptive effects of irradiation. The results are discussed in terms of the mechanisms by which exposure to these particles may produce effects on neurocognitive performance.     

Adaptations of the vestibular system to short and long-term exposures to altered gravity.

Long-term space flight creates unique environmental conditions to which the vestibular system must adapt for optimal survival of a given organism. The development and maintenance of vestibular connections are controlled by environmental gravitational stimulation as well as genetically controlled molecular interactions. This paper describes the effects of hypergravity on axonal growth and dendritic morphology, respectively. Two aspects of this vestibular adaptation are examined: (1) How does long-term exposure to hypergravity affect the development of vestibular axons? (2) How does short-term exposure to extremely rapid changes in gravity, such as those that occur during shuttle launch and landing, affect dendrites of the vestibulocerebellar system? To study the effects of longterm exposures to altered gravity, embryonic rats that developed in hypergravity were compared to microgravity-exposed and control rats. Examination of the vestibular projections from epithelia devoted to linear and angular acceleration revealed that the terminal fields segregate differently in rat embryos that gestated in each of the gravitational environments.To study the effects of short-term exposures to altered gravity, mice were exposed briefly to strong vestibular stimuli and the vestibulocerebellum was examined for any resulting morphological changes. My data show that these stimuli cause intense vestibular excitation of cerebellar Purkinje cells, which induce up-regulation of clathrin-mediated endocytosis and other morphological changes that are comparable to those seen in long-term depression. This system provides a basis for studying how the vestibular environment can modify cerebellar function, allowing animals to adapt to new environments.