| 动脉内皮血流动力学微环境建模分析和体外模拟方法与技术研究进展 |
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| 引用本文： | 覃开蓉,梁夫友,那景童.动脉内皮血流动力学微环境建模分析和体外模拟方法与技术研究进展[J].实验流体力学,2020,34(2):11-24. |
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| 作者姓名： | 覃开蓉 梁夫友 那景童 |
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| 作者单位： | 1.大连理工大学 光电工程与仪器科学学院, 辽宁 大连 116024 |
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| 基金项目： | 国家重点研发计划;中央高校基本科研业务费专项;国家自然科学基金 |
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| 摘 要： | 动脉内皮微环境中的血压、壁面剪应力和牵张应力等血流动力学参量在维持内皮的正常生理功能中扮演着至关重要的角色。在体（in vivo）动脉内皮血流动力学微环境的建模分析与体外（in vitro）模拟研究不仅为心脑血管疾病早期诊断与预防、治疗与康复提供重要的生理指标，而且是深入理解心脑血管疾病发生发展机制不可或缺的基础，具有重要的科学意义和临床应用价值。本文综述了在体动脉内皮微环境的血流动力学建模分析、体外评估动脉内皮微环境血流动力学特性的模拟循环系统（Mock Circulatory System，MCS）以及用于细胞力学生物学研究的体外内皮细胞培养模型（Endothelial Cell Culture Model，ECCM）三方面的研究进展。通过对该领域的主要文献进行归纳和系统分析，指出了亟待解决的方法与技术问题，为进一步开展相关研究提供参考。
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| 关 键 词： | 动脉内皮 微环境 血流动力学 建模分析 体外模拟 |
| 收稿时间： | 2020-03-01 |
State of the art of the methods and techniques in modeling analysis and in vitro simulation of arterial endothelial hemodynamic microenvironment |
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| Affiliation: | 1.School of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology, Dalian Liaoning 116024, China2.Department of Engineering Mechanics, School of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai 200240, China3.School of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian Liaoning 116024, China |
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| Abstract: | Hemodynamic variables in arterial endothelial microenvironment, such as blood pressure, wall shear stress and tensile stress, play critical roles in maintaining the normal physiological function of endothelium. Modeling analysis and in vitro simulation of in vivo arterial endothelial hemodynamic microenvironment may not only offer important physiological parameters for early diagnosis and prevention, treatment and rehabilitation of cardiovascular diseases but also establish a fundamental basis for further understanding the underlying mechanisms of disease initiation and progression, and therefore have important scientific significance and value of clinic application. This paper provides an overall review of research progresses in this area from three perspectives, i.e. modeling analysis of in vivo arterial endothelial hemodynamic microenvironment, in vitro mock circulatory system (MCS) for studying the characteristics of arterial endothelial hemodynamic microenvironment, and endothelial cell culture model (ECCM) for investigating cell mechanobiology under controlled in vitro conditions. We raise several methodological and technical problems of urgent need for better solution based on a summary and systematic analysis of major literatures in this field aiming to offer some references for relevant future studies. |
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