Due to the special characteristics of the liquid phase environment, the conventional quartz crystal microbalance (QCM) cannot completely describe the physical properties of the liquid phase by only relying on the resonant frequency f. The introduced new parameter, dissipation factor D, can relatively completely characterize the mechanical properties of the solution and the adsorption membrane, so it is important to study the dissipative quartz crystal microbalance based on the dissipation factor D (QCM-D) is of great importance. In this paper, the QCM oscillator circuit is combined with the dissipation factor D. By using parallel capacitance compensation and automatic gain control technology, an oscillator circuit suitable for QCM-D and corresponding system debugging and experimental verification schemes are designed, which can stabilize the oscillation at 80% concentration in glycerol solution.